According to phenological observation data of fourteen stations in Hunan,Hubei and Jiangxi provinces from 1994 to 2006,indices of suitable temperature at the booting stage and accumulated temperature(≥10 ℃)during th...According to phenological observation data of fourteen stations in Hunan,Hubei and Jiangxi provinces from 1994 to 2006,indices of suitable temperature at the booting stage and accumulated temperature(≥10 ℃)during the whole growth period in early or late rice in the south of China were analyzed by statistics and biological relationship between factors.Indices of the optimum daily mean temperature and the minimum temperature at the booting stage were as follows:Early convention rice variety was 25.7 ℃ and 22.3 ℃ respectively,hybrid variety was 26.5 ℃ and 23.3℃ respectively;while late convention rice variety was 25.6 ℃ and 22.3 ℃ respectively,hybrid variety was 25.8 ℃ and 22.6 ℃ respectively.Indexes of accumulated temperature during the whole growth period were as follows:The early-maturing variety,the middle-maturing variety and the late-maturing variety of early rice was 2 512.1 ℃,2 528.4 ℃ and 2 651.3 ℃ respectively,while the early-maturing variety,the middle-maturing variety and the late-maturing variety of late rice was 3 126.2 ℃,3 031.5 ℃ and 3 335.2 ℃ respectively.The above indexes all met the requirements of identification,which could provide reference for formulating the meteorological standard of rice in the south of China.展开更多
[Objective] The physiological characteristics and yield compensation effects of rice in booting stage were studied after water recovery when rice suffered water stress to provide references for improving rice water ut...[Objective] The physiological characteristics and yield compensation effects of rice in booting stage were studied after water recovery when rice suffered water stress to provide references for improving rice water utilization efficiency and its drought resistance. [Method] The pot experiments with five rice varieties under three different treatments of water stresses were conducted to study physical signs every six days after water water-recovery. [Result] Along with the increase of water recov- ery, leaf water potential, SPAD and Pn values in treatment B （light drought） in- creased fast, and its compensation effect of the soluble sugar content was higher than that of treatment C （severe drought）; all sap flow speeds in treatments with water stresses fell. As for yield components, panicles per plant and spikelets per panicle decreased with water stress degree, and the decline of spikelets per pani- cle, in particular, was greatly influenced by water stress. Seed setting percentages in treatment B most reached peaks of different varieties, except of D you No. 363. The thousand-seed weight and ear weight per plant in treatment B and C both dropped, compared with control group. [Conclusion] When regular management was resumed after rice underwent water stress at booting stage, many characteristics and yield traits of rice got favorable compensation effects in the light water-stress treatments.展开更多
Genetic analysis showed that cold tolerance at booting stage of near-isogenic lines （NILs） of Kunmingxiaobaigu was controlled by a gene with large phenotypic variance. One hundred and sixty-four simple sequence repe...Genetic analysis showed that cold tolerance at booting stage of near-isogenic lines （NILs） of Kunmingxiaobaigu was controlled by a gene with large phenotypic variance. One hundred and sixty-four simple sequence repeats （SSR） distributed over 12 chromosomes were used to screen polymorphism between Towata （recurrent parent, RP） and near-isogenic line pool （NILP）, and two SSR markers at the long arm of chromosome 5 showed polymorphism in comparison with RP genome. Of the two markers, RM31 was found possibly linked with the cold tolerance gene at booting stage through one-way ANOVA. Twelve SSR markers around RM31 were then used to detect polymorphism between RP and NIL, and only RM7452 had polymorphism. The gene of cold tolerance at booting stage was further mapped on chromosome 5 between RM7452 and RM31 with genetic distances of 4.8 cM and 8.0 cM, respectively. This gene explained 10.50% of phenotypic variance and 5.10% of phenotypic variance of fully filled grains, and was tentatively designated as Ctb（t）.展开更多
This study was carried out to identify molecular responses of the two varieties with different cold tolerance under cold water stress (13℃) at the booting stage. Transcriptional responses of the genes were analyzed in
Hepatocellular carcinoma(HCC)is a high mortality neoplasm which usually appears on a cirrhotic liver.The therapeutic arsenal and subsequent prognostic outlook are intrinsically linked to the HCC stage at diagnosis.Not...Hepatocellular carcinoma(HCC)is a high mortality neoplasm which usually appears on a cirrhotic liver.The therapeutic arsenal and subsequent prognostic outlook are intrinsically linked to the HCC stage at diagnosis.Notwithstanding the current deployment of treatments with curative intent(liver resection/local ablation and liver transplantation)in early and intermediate stages,a high rate of HCC recurrence persists,underscoring a pivotal clinical challenge.Emergent systemic therapies(ST),particularly immunotherapy,have demonstrate promising outcomes in terms of increase overall survival,but they are currently bound to the advanced stage of HCC.This review provides a comprehensive analysis of the literature,encompassing studies up to March 10,2024,evaluating the impact of novel ST in the early and intermediate HCC stages,specially focusing on the findings of neoadjuvant and adjuvant regimens,aimed at increasing significantly overall survival and recurrence-free survival after a treatment with curative intent.We also investigate the potential role of ST in enhancing the downstaging rate for the intermediate-stage HCC initially deemed ineligible for treatment with curative intent.Finally,we critically discuss about the current relevance of the results of these studies and the encouraging future implications of ST in the treatment schedules of early and intermediate HCC stages.展开更多
BACKGROUND Colorectal cancer(CRC)is a global health concern,with advanced-stage diagnoses contributing to poor prognoses.The efficacy of CRC screening has been well-established;nevertheless,a significant proportion of...BACKGROUND Colorectal cancer(CRC)is a global health concern,with advanced-stage diagnoses contributing to poor prognoses.The efficacy of CRC screening has been well-established;nevertheless,a significant proportion of patients remain unscreened,with>70%of cases diagnosed outside screening.Although identifying specific subgroups for whom CRC screening should be particularly recommended is crucial owing to limited resources,the association between the diagnostic routes and identification of these subgroups has been less appreciated.In the Japanese cancer registry,the diagnostic routes for groups discovered outside of screening are primarily categorized into those with comorbidities found during hospital visits and those with CRC-related symptoms.AIM To clarify the stage at CRC diagnosis based on diagnostic routes.METHODS We conducted a retrospective observational study using a cancer registry of patients with CRC between January 2016 and December 2019 at two hospitals.The diagnostic routes were primarily classified into three groups:Cancer screening,follow-up,and symptomatic.The early-stage was defined as Stages 0 or I.Multivariate and univariate logistic regressions were exploited to determine the odds of early-stage diagnosis in the symptomatic and cancer screening groups,referencing the follow-up group.The adjusted covariates were age,sex,and tumor location.RESULTS Of the 2083 patients,715(34.4%),1064(51.1%),and 304(14.6%)belonged to the follow-up,symptomatic,and cancer screening groups,respectively.Among the 2083 patients,CRCs diagnosed at an early stage were 57.3%(410 of 715),23.9%(254 of 1064),and 59.5%(181 of 304)in the follow-up,symptomatic,and cancer screening groups,respectively.The symptomatic group exhibited a lower likelihood of early-stage diagnosis than the follow-up group[P<0.001,adjusted odds ratio(aOR),0.23;95%confidence interval(95%CI):0.19-0.29].The likelihood of diagnosis at an early stage was similar between the follow-up and cancer screening groups(P=0.493,aOR for early-stage diagnosis in the cancer screening group vs follow-up group=1.11;95%CI=0.82-1.49).CONCLUSION CRCs detected during hospital visits for comorbidities were diagnosed earlier,similar to cancer screening.CRC screening should be recommended,particularly for patients without periodical hospital visits for comorbidities.展开更多
Tree interactions are essential for the structure,dynamics,and function of forest ecosystems,but variations in the architecture of life-stage interaction networks(LSINs)across forests is unclear.Here,we constructed 16...Tree interactions are essential for the structure,dynamics,and function of forest ecosystems,but variations in the architecture of life-stage interaction networks(LSINs)across forests is unclear.Here,we constructed 16 LSINs in the mountainous forests of northwest Hebei,China based on crown overlap from four mixed forests with two dominant tree species.Our results show that LSINs decrease the complexity of stand densities and basal areas due to the interaction cluster differentiation.In addition,we found that mature trees and saplings play different roles,the first acting as“hub”life stages with high connectivity and the second,as“bridges”controlling information flow with high centrality.Across the forests,life stages with higher importance showed better parameter stability within LSINs.These results reveal that the structure of tree interactions among life stages is highly related to stand variables.Our efforts contribute to the understanding of LSIN complexity and provide a basis for further research on tree interactions in complex forest communities.展开更多
Piezoelectric stages use piezoelectric actuators and flexure hinges as driving and amplifying mechanisms,respectively.These systems have high positioning accuracy and high-frequency responses,and they are widely used ...Piezoelectric stages use piezoelectric actuators and flexure hinges as driving and amplifying mechanisms,respectively.These systems have high positioning accuracy and high-frequency responses,and they are widely used in various precision/ultra-precision positioning fields.However,the main challenge with these devices is the inherent hysteresis nonlinearity of piezoelectric actuators,which seriously affects the tracking accuracy of a piezoelectric stage.Inspired by this challenge,in this work,we developed a Hammerstein model to describe the hysteresis nonlinearity of a piezoelectric stage.In particular,in our proposed scheme,a feedback-linearization algorithm is used to eliminate the static hysteresis nonlinearity.In addition,a composite controller based on equivalent-disturbance compensation was designed to counteract model uncertainties and external disturbances.An analysis of the stability of a closed-loop system based on this feedback-linearization algorithm and composite controller was performed,and this was followed by extensive comparative experiments using a piezoelectric stage developed in the laboratory.The experimental results confirmed that the feedback-linearization algorithm and the composite controller offer improved linearization and trajectory-tracking performance.展开更多
基金Supported by Project for NewTechnology Generalization of China Meteorological Administration(CMATG2007M37)~~
文摘According to phenological observation data of fourteen stations in Hunan,Hubei and Jiangxi provinces from 1994 to 2006,indices of suitable temperature at the booting stage and accumulated temperature(≥10 ℃)during the whole growth period in early or late rice in the south of China were analyzed by statistics and biological relationship between factors.Indices of the optimum daily mean temperature and the minimum temperature at the booting stage were as follows:Early convention rice variety was 25.7 ℃ and 22.3 ℃ respectively,hybrid variety was 26.5 ℃ and 23.3℃ respectively;while late convention rice variety was 25.6 ℃ and 22.3 ℃ respectively,hybrid variety was 25.8 ℃ and 22.6 ℃ respectively.Indexes of accumulated temperature during the whole growth period were as follows:The early-maturing variety,the middle-maturing variety and the late-maturing variety of early rice was 2 512.1 ℃,2 528.4 ℃ and 2 651.3 ℃ respectively,while the early-maturing variety,the middle-maturing variety and the late-maturing variety of late rice was 3 126.2 ℃,3 031.5 ℃ and 3 335.2 ℃ respectively.The above indexes all met the requirements of identification,which could provide reference for formulating the meteorological standard of rice in the south of China.
基金Supported by Capacity Construction of Rice Breeding,Cultivation,and Industrialization Innovation Project in Guizhou([2011]4003)Rice Scientific Research Infrastructure Building Project in Mountainous Regions of Guizhou([2011]4005)Rice Genetics and Breeding Research and Innovation Team in Guizhou([2012]4020)~~
文摘[Objective] The physiological characteristics and yield compensation effects of rice in booting stage were studied after water recovery when rice suffered water stress to provide references for improving rice water utilization efficiency and its drought resistance. [Method] The pot experiments with five rice varieties under three different treatments of water stresses were conducted to study physical signs every six days after water water-recovery. [Result] Along with the increase of water recov- ery, leaf water potential, SPAD and Pn values in treatment B （light drought） in- creased fast, and its compensation effect of the soluble sugar content was higher than that of treatment C （severe drought）; all sap flow speeds in treatments with water stresses fell. As for yield components, panicles per plant and spikelets per panicle decreased with water stress degree, and the decline of spikelets per pani- cle, in particular, was greatly influenced by water stress. Seed setting percentages in treatment B most reached peaks of different varieties, except of D you No. 363. The thousand-seed weight and ear weight per plant in treatment B and C both dropped, compared with control group. [Conclusion] When regular management was resumed after rice underwent water stress at booting stage, many characteristics and yield traits of rice got favorable compensation effects in the light water-stress treatments.
基金supportedby China National Natural Science Foundation(30160043,30260060) the Natural ScienceFoundation of Yunnan Province(2004CO010Z).
文摘Genetic analysis showed that cold tolerance at booting stage of near-isogenic lines （NILs） of Kunmingxiaobaigu was controlled by a gene with large phenotypic variance. One hundred and sixty-four simple sequence repeats （SSR） distributed over 12 chromosomes were used to screen polymorphism between Towata （recurrent parent, RP） and near-isogenic line pool （NILP）, and two SSR markers at the long arm of chromosome 5 showed polymorphism in comparison with RP genome. Of the two markers, RM31 was found possibly linked with the cold tolerance gene at booting stage through one-way ANOVA. Twelve SSR markers around RM31 were then used to detect polymorphism between RP and NIL, and only RM7452 had polymorphism. The gene of cold tolerance at booting stage was further mapped on chromosome 5 between RM7452 and RM31 with genetic distances of 4.8 cM and 8.0 cM, respectively. This gene explained 10.50% of phenotypic variance and 5.10% of phenotypic variance of fully filled grains, and was tentatively designated as Ctb（t）.
文摘This study was carried out to identify molecular responses of the two varieties with different cold tolerance under cold water stress (13℃) at the booting stage. Transcriptional responses of the genes were analyzed in
文摘Hepatocellular carcinoma(HCC)is a high mortality neoplasm which usually appears on a cirrhotic liver.The therapeutic arsenal and subsequent prognostic outlook are intrinsically linked to the HCC stage at diagnosis.Notwithstanding the current deployment of treatments with curative intent(liver resection/local ablation and liver transplantation)in early and intermediate stages,a high rate of HCC recurrence persists,underscoring a pivotal clinical challenge.Emergent systemic therapies(ST),particularly immunotherapy,have demonstrate promising outcomes in terms of increase overall survival,but they are currently bound to the advanced stage of HCC.This review provides a comprehensive analysis of the literature,encompassing studies up to March 10,2024,evaluating the impact of novel ST in the early and intermediate HCC stages,specially focusing on the findings of neoadjuvant and adjuvant regimens,aimed at increasing significantly overall survival and recurrence-free survival after a treatment with curative intent.We also investigate the potential role of ST in enhancing the downstaging rate for the intermediate-stage HCC initially deemed ineligible for treatment with curative intent.Finally,we critically discuss about the current relevance of the results of these studies and the encouraging future implications of ST in the treatment schedules of early and intermediate HCC stages.
基金the Foundation for Cancer Research supported by Kyoto Preventive Medical Center and the Japan Society for the Promotion of Science(JSPS)Grants-in-Aid KAKENHI,No.JP 22K21080.
文摘BACKGROUND Colorectal cancer(CRC)is a global health concern,with advanced-stage diagnoses contributing to poor prognoses.The efficacy of CRC screening has been well-established;nevertheless,a significant proportion of patients remain unscreened,with>70%of cases diagnosed outside screening.Although identifying specific subgroups for whom CRC screening should be particularly recommended is crucial owing to limited resources,the association between the diagnostic routes and identification of these subgroups has been less appreciated.In the Japanese cancer registry,the diagnostic routes for groups discovered outside of screening are primarily categorized into those with comorbidities found during hospital visits and those with CRC-related symptoms.AIM To clarify the stage at CRC diagnosis based on diagnostic routes.METHODS We conducted a retrospective observational study using a cancer registry of patients with CRC between January 2016 and December 2019 at two hospitals.The diagnostic routes were primarily classified into three groups:Cancer screening,follow-up,and symptomatic.The early-stage was defined as Stages 0 or I.Multivariate and univariate logistic regressions were exploited to determine the odds of early-stage diagnosis in the symptomatic and cancer screening groups,referencing the follow-up group.The adjusted covariates were age,sex,and tumor location.RESULTS Of the 2083 patients,715(34.4%),1064(51.1%),and 304(14.6%)belonged to the follow-up,symptomatic,and cancer screening groups,respectively.Among the 2083 patients,CRCs diagnosed at an early stage were 57.3%(410 of 715),23.9%(254 of 1064),and 59.5%(181 of 304)in the follow-up,symptomatic,and cancer screening groups,respectively.The symptomatic group exhibited a lower likelihood of early-stage diagnosis than the follow-up group[P<0.001,adjusted odds ratio(aOR),0.23;95%confidence interval(95%CI):0.19-0.29].The likelihood of diagnosis at an early stage was similar between the follow-up and cancer screening groups(P=0.493,aOR for early-stage diagnosis in the cancer screening group vs follow-up group=1.11;95%CI=0.82-1.49).CONCLUSION CRCs detected during hospital visits for comorbidities were diagnosed earlier,similar to cancer screening.CRC screening should be recommended,particularly for patients without periodical hospital visits for comorbidities.
基金This study was supported by the National Water Pollution Control and Treatment Science and Technology Major Project(2017ZX07101-002).
文摘Tree interactions are essential for the structure,dynamics,and function of forest ecosystems,but variations in the architecture of life-stage interaction networks(LSINs)across forests is unclear.Here,we constructed 16 LSINs in the mountainous forests of northwest Hebei,China based on crown overlap from four mixed forests with two dominant tree species.Our results show that LSINs decrease the complexity of stand densities and basal areas due to the interaction cluster differentiation.In addition,we found that mature trees and saplings play different roles,the first acting as“hub”life stages with high connectivity and the second,as“bridges”controlling information flow with high centrality.Across the forests,life stages with higher importance showed better parameter stability within LSINs.These results reveal that the structure of tree interactions among life stages is highly related to stand variables.Our efforts contribute to the understanding of LSIN complexity and provide a basis for further research on tree interactions in complex forest communities.
基金supported by the National Key R&D Program of China (Grant No.2022YFB3206700)the Independent Research Project of the State Key Laboratory of Mechanical Transmission (Grant No.SKLMT-ZZKT-2022M06)the Innovation Group Science Fund of Chongqing Natural Science Foundation (Grant No.cstc2019jcyj-cxttX0003).
文摘Piezoelectric stages use piezoelectric actuators and flexure hinges as driving and amplifying mechanisms,respectively.These systems have high positioning accuracy and high-frequency responses,and they are widely used in various precision/ultra-precision positioning fields.However,the main challenge with these devices is the inherent hysteresis nonlinearity of piezoelectric actuators,which seriously affects the tracking accuracy of a piezoelectric stage.Inspired by this challenge,in this work,we developed a Hammerstein model to describe the hysteresis nonlinearity of a piezoelectric stage.In particular,in our proposed scheme,a feedback-linearization algorithm is used to eliminate the static hysteresis nonlinearity.In addition,a composite controller based on equivalent-disturbance compensation was designed to counteract model uncertainties and external disturbances.An analysis of the stability of a closed-loop system based on this feedback-linearization algorithm and composite controller was performed,and this was followed by extensive comparative experiments using a piezoelectric stage developed in the laboratory.The experimental results confirmed that the feedback-linearization algorithm and the composite controller offer improved linearization and trajectory-tracking performance.
