A new ent-kaurane diterpenoid from Isodon japonica

One new ent-kaurane diterpenoid,named maoyecrystal L was isolated from the EtOAc extract of the dried leaves of lsodon japonica.Its structure was established by various spectroscopic means and confirmed by X-ray crystallographic analysis.

New ent-kaurane-type diterpenoids from Isodon nervosus

Two new ent-kaurane-type diterpenoids,6β,7β,13α-trihydroxy-1α-acetoxy-7α,20-epoxy-ent-kaur-16-en-15-one（1）and 15β- hydroxy-6,7-seco-6,11β：6,20-diepoxy-1α,7-olide-ent-kaur-16-ene（2）were isolated from the Isodon nervosus,and the structures were elucidated by spectroscopic analysis.

Two new 19-oxygenated ent-kaurane diterpenoids from Isodon pharicus

Two new 19-oxygenated ent-kaurane diterpenoids,pharicinins D and E(1 and 2),together with an artifact,pharicinin D acetal (3) were isolated from the leaves of Isodon pharicus.Their structures were determined by 1D and 2D NMR spectroscopic analysis. All of them were evaluated for their cytotoxicity.

Two New ent-Kaurane Diterpenoids from Isodon xerophilus

Two new ent-kaurane diterpenoids, xerophilusin E (1) and xerophilusin F (2), were isolated from the leaves of Isodon xerophilus. Their structures were determined as 3, 20: 7, 20-diepoxy-ent-kaur-16-en-15-one and 7 beta, 14 beta, 20 (R)-trihydroxy-11 beta-acetoxy-7,20-cyclo-ent-kaur-16-en-6, 15-dione, respectively, by spectral methods and X-ray crystallographic analysis.

Two new diterpenoids from Isodon serra

From the aerial part of Isodon serra, two new ent-6,7-seco-kaurane-type diterpenoids, 15α,20β-dihydroxy-6β- methoxy-6,7- seco-6,20-epoxy-1,7-olide-ent-kaur-16-ene （1） and 6α,15α-dihydroxy-20-aldehyde-6,7-seco-6,11α-epoxy-1,7-olide-ent-kaur-16- ene （2） were isolated. Their structures were elucidated by spectroscopic means.

Two New Diterpenoids from Isodon rubescens

Two new diterpenoids taibairubescensin A (1) and B (2) have been isolated from Isodon rubescens. The structures of compound 1 and 2 were elucidated as 2 beta,3 beta-diacetoxy-11 beta,13 alpha-dihydroxy-ent-kaur- 16-en-15-one (1) and 3 beta,11 beta-diacetoxy-2 beta,6 alpha-dihydroxy-ent-kaur-16-en-15-one (2) on the basis of spectroscopic analysis.

Three New Diterpenoids from Isodon Eriocalyx

Three new diterpenoids, eriocalyxins C-E, were isolated from Isodon eriocalyx. Their structures were elucidated as 66-hydroxy- 15β-acetoxy-3α, 20-epoxy-16β, 17-epoxy-ent-kaur-1,7-dione, 1α, 7β-dihydroxy-6β, 15β-diacetoxy-7, 20-epoxy-ent-kaur-16-ene, and 15β-acetoxy-1, 6-dioxo-6, 7-seco-ent-kaur-2, 16-dien-7, 20-olide by means of spectroscopic methods, including two-dimensional NMR techniques.

A New 1β-hydroxy-ent-kaurenoid From Isodon Enanderianus

A new 1β-hydroxy-ent-kauren diterpenoid, enanderianin C1, has been isolated from the leaves of Isodon enanderianus, and its structure has been elucidated by spectroscopic evidences.

Two Novel Sub-skeleton Types of ent-Kauranoids from Isodon gesneroides

Two novel ent-kauranoids with new sub-skeleton types, gesneroidins G and H were isolated as white powder from the ether extract of the leaves of Isodon gesneroides through normal phase column chromatography. Their structures were elucidated as 3b,6a,7b-triacetoxyl-15-hydroxyl-14-oxo-ent-15,16-seco-kaur-11,17-olide and 1a-hydroxyl-3b,6a,7b,11b-tetraacetoxyl-ent-nor-15,17-kaur-8,16-olide on the basis of the spectral evidences including 1D and 2D NMR spectra.

冬凌草中的新对映-贝壳杉烷二萜化合物

对河南省济源地区产冬凌草 [Isodonrubescens (Hemsl.)Hara]再次进行了深入的研究 ,从其叶的乙酸乙酯提取物中分离得到了 16个化合物 ,其中 1和 2为两个新的 7,2 0 环氧 -对映 -贝壳杉烷类二萜化合物 ,其结构通过波谱分析确定为16(S) 羟甲基 1α ,6β ,7β ,11β 四羟基 7α ,2 0 环氧 -对映 -贝壳杉烷 15 酮 (1)和 16(R) 羟甲基 1α ,6β ,7β ,14 β 四羟基 7α ,2 0 环氧 -对映 -贝壳杉烷 15 酮 (2 ) ,分别命名为冬凌草己素 (1)和庚素 (2 ) ;其余的已知化合物分别鉴定为lasiodonin (3) ,冬凌草甲素 (oridonin ,4) ,乙素 (ponicidin) ,丙素 (rubescensinC) ,丁素 (rubescensinD) ,牛尾草丙素 (rabdoterninC) ,荛花香茶菜乙素 (wikstroemioidinB) ,enmenol 1α O β D glucoside ,enmenol,胡麻素 (pedalitin) ,水杨酸 ,乌索酸 ,β

露珠香茶菜的化学成分研究

对云南丽江产的露珠香茶菜Isodonirrorata进行了化学成分的研究,从其叶子的乙醇提取物中分离得到了 3个化合物,利用IR,MS和NMR等波谱方法。

两个7,20-环氧-对映-贝壳杉烯型二萜

在紫毛香茶菜（Ｉｓｏｄｏｎ ｅｎａｎｄｅｒｉａｎｕｓ）叶子的乙醇提取物中，首次分离得到２个７，２０－环氧－对映－贝壳杉烯型二萜ｌｏｎｇｉｋａｕｒｉｎ Ｄ和Ｆ，用红外光谱、紫外光谱、质谱和核磁共振谱等波谱方法，对它们的结构进行了鉴定。

尾叶香茶菜中对映-贝壳杉烯型二萜

尾叶香茶菜中对映－贝壳杉烯型二萜王艳红１）陈耀祖２）孙汉董３）金东史４）（１）中山大学化学与化学工程学院，广州５１０２７５；２）浙江大学化学系；３）中国科学院昆明植物研究所植化室；４）朝鲜国家科学院植物研究所）关键词唇形科，香茶菜属，尾叶香茶菜，对...

旱生香茶菜中三个新的对映 -贝壳杉烷型二萜(英文)

从旱生香茶菜 (Isodonxerophilus)叶中分离得到 3个新的对映 -贝壳杉烷型二萜 ,旱生香茶菜素G ,H和I。通过波谱方法鉴定了它们的结构。

腺花香茶菜二萜成分研究

由腺花香茶菜全草的丙酮提取物中分离得到２个对映－贝壳杉烯型二萜，利用红外、紫外、质谱和核磁共振等光谱方法，对这２个化合物的结构进行了鉴定．

紫毛香茶菜二萜成分研究(英文)

从紫毛香茶菜干叶的乙醇提取物中分离得到２个二萜化合物，利用红外、紫外、质谱以及核磁共振波谱等光谱方法，对这２个化合物的结构进行了鉴定．紫毛香茶菜的化学成分尚未见文献报道．

冬凌草中新二萜化合物Jaridonin激活共济失调毛细血管扩张突变蛋白激酶诱导胃癌细胞周期阻滞

目的：探讨冬凌草中新型二萜化合物Jaridonin对人胃癌细胞周期的影响及其分子机制。方法采用流式细胞术检测Jaridonin对MGC-803细胞共济失调毛细血管扩张突变（ ATM）蛋白的表达和细胞周期的影响，采用Western blot法检测细胞周期调控相关蛋白的表达情况。结果 Jaridonin对胃癌MGC-803细胞细胞周期具有阻滞作用，10、20μmol／L Jaridonin作用MGC-803细胞6 h，G2／M期细胞比例分别为（18．2±2．5）％和（27．3±3．2）％，与对照组[（10．8±2．2）％]比较，差异有统计学意义（P＜0．05）；作用12 h后，G2／M期细胞比例分别为（24．1±2．0）％和（39．7±5．2）％，与对照组[（12．0±1．5）％]比较，差异有统计学意义（P＜0．01）。 Jaridonin将MGC-803细胞阻滞在G2／M期，且呈浓度和时间依赖性。 Jaridonin作用MGC-803细胞后，ATM、Chk1和Chk2以及磷酸化的Cdc2和CDK2蛋白的表达上调，而非磷酸化的Cdc2和CDK2水平则下降。 ATM抑制剂KU-55933逆转了Jaridonin诱导相关蛋白的表达和G2／M期阻滞。结论 Jaridonin可显著诱导胃癌细胞G2／M期阻滞，其机制与ATM介导的Chk1和Chk2活化，以及Cdc2和CDK2磷酸化失活有关。

腺花香茶菜地下部分抗血吸虫活性研究

目的:研究腺花香茶菜(Isodon adenantha)地下根茎的抗血吸虫活性作用。方法:用70%丙酮对腺花香茶菜地下根茎进行冷浸提取,采用体外抗血吸虫药敏实验测试腺花香茶菜地下根茎提取物及其中化合物的抗血吸虫活性。结果:腺花香茶菜粗提物、正丁醇部位和水部位的高浓度组(2 mg·mL-1)给药24 h后即起效,48 h后成虫死亡;中浓度组(0.5 mg·mL-1)给药48 h后未见成虫死亡;乙酸乙酯部位高浓度组(2 mg·mL-1)给药6 h后即起效,24 h后成虫死亡;中浓度组(0.5 mg·mL-1)给药6 h后即起效,48 h后成虫死亡;给药24 h后,化合物1高浓度组(200μg·mL-1)成虫全部死亡,显示出显著的杀虫活性;药物作用36 h后,化合物2高浓度组成虫全部死亡。结论:腺花香茶菜70%丙酮粗提物、乙酸乙酯部位、正丁醇部位、水部位以及单体化合物1和2均具有一定的体外抗血吸虫活性。本研究为深入了解腺花香茶菜的生物活性效果及可能的应用范围、开发植物来源的新型抗血吸虫天然产物提供了一定的参考。