6/7-Seco rearranged spiro-indolone alkaloids,meloyunines A(1)and B(2)and a monoterpenoid quinoline alkaloid meloyunine C(3)together with its possible intermediate 14,15-dehydromelohenine B(4),and their precursorΔ14-v...6/7-Seco rearranged spiro-indolone alkaloids,meloyunines A(1)and B(2)and a monoterpenoid quinoline alkaloid meloyunine C(3)together with its possible intermediate 14,15-dehydromelohenine B(4),and their precursorΔ14-vincamenine(5)were isolated from Melodinus yunnanensis.All structures were elucidated based on NMR,FTIR,UV,and MS spectroscopic data.The isolation of monoterpenoid indole,quinoline,and its immediate from the same plant chemically supported the biosynthesis of quinoline from indole.Compound 2 was cytotoxic against several human cancer cell lines.展开更多
The plants of the genus Melodinus (Apocynaceae) are widely distributed, and have long been used in folk medicine for the treatment of various ailments such as meningitis in children and rheumatic heart diseases, herni...The plants of the genus Melodinus (Apocynaceae) are widely distributed, and have long been used in folk medicine for the treatment of various ailments such as meningitis in children and rheumatic heart diseases, hernia, infantile malnutrition, dyspepsia and testitis. Over 100 alkaloids together with flavonoids, lignans, steroids, terpenoids and coumarins have been identified in the genus, and many of these have been evaluated for biological activity. This review presents comprehensive information on the chemistry and pharmacology of the genus together with the traditional uses of many of its plants. In addition, this review discusses the structure-activity relationship of different compounds as well as recent developments and the scope for future research in this aspect.展开更多
Six different extracts of Melodinus eugeniifolus (a very rare medical plant belonging to Apocynaceae) leaves and barks were screened for their phytochemical composition, and free radical scavenging activities. Three d...Six different extracts of Melodinus eugeniifolus (a very rare medical plant belonging to Apocynaceae) leaves and barks were screened for their phytochemical composition, and free radical scavenging activities. Three different methods were used to test the antioxidant activity for extracts which include FRAP assay (Ferric reducing antioxidant potential), DPPH radical scavenging assay (1,1-diphenyl-2-picryl hydrazyl radical reducing power methods), and β-carotene bleaching assay. Among the different extracts tested, the ethanol extract of barks showed significant radical scavenging activities. Phytochemical analysis of the extracts revealed that the radical scavenging activities are mainly due to the presence of alkaloids, cardiac glycosides, sterols, steroids and flavonoids. The results obtained suggest that Melodinus eugeniifolus could be exploited in the management of various diseases like cancer, cardiovascular diseases and infection diseases. Highlights: Melodinus eugeniifolus, a very rare medical plant from South Asian rain forest which may be a potential drug for many diseases is first reported about its phytochemical characteristics and antioxidant activity by different methods.展开更多
Two new indole alkaloids named 152-hydroxy-14,15-dihydro-vindo- linine and 152-hydroxy-14,15-dihydro-16-epi-vindolinine were isolated from Melodinus morsei.Their structures were established by spectroscopic means and ...Two new indole alkaloids named 152-hydroxy-14,15-dihydro-vindo- linine and 152-hydroxy-14,15-dihydro-16-epi-vindolinine were isolated from Melodinus morsei.Their structures were established by spectroscopic means and comparison with related compounds.展开更多
基金This work was supported in part by the National Natural Science Foundation of China(2107298)the 973 Program of Ministry of Science and Technology of P.R.China(2009CB522300)Chinese Academy of Sciences(KSCX2-EW-R-15 and XiBuZhiGuang Project).
文摘6/7-Seco rearranged spiro-indolone alkaloids,meloyunines A(1)and B(2)and a monoterpenoid quinoline alkaloid meloyunine C(3)together with its possible intermediate 14,15-dehydromelohenine B(4),and their precursorΔ14-vincamenine(5)were isolated from Melodinus yunnanensis.All structures were elucidated based on NMR,FTIR,UV,and MS spectroscopic data.The isolation of monoterpenoid indole,quinoline,and its immediate from the same plant chemically supported the biosynthesis of quinoline from indole.Compound 2 was cytotoxic against several human cancer cell lines.
文摘The plants of the genus Melodinus (Apocynaceae) are widely distributed, and have long been used in folk medicine for the treatment of various ailments such as meningitis in children and rheumatic heart diseases, hernia, infantile malnutrition, dyspepsia and testitis. Over 100 alkaloids together with flavonoids, lignans, steroids, terpenoids and coumarins have been identified in the genus, and many of these have been evaluated for biological activity. This review presents comprehensive information on the chemistry and pharmacology of the genus together with the traditional uses of many of its plants. In addition, this review discusses the structure-activity relationship of different compounds as well as recent developments and the scope for future research in this aspect.
文摘Six different extracts of Melodinus eugeniifolus (a very rare medical plant belonging to Apocynaceae) leaves and barks were screened for their phytochemical composition, and free radical scavenging activities. Three different methods were used to test the antioxidant activity for extracts which include FRAP assay (Ferric reducing antioxidant potential), DPPH radical scavenging assay (1,1-diphenyl-2-picryl hydrazyl radical reducing power methods), and β-carotene bleaching assay. Among the different extracts tested, the ethanol extract of barks showed significant radical scavenging activities. Phytochemical analysis of the extracts revealed that the radical scavenging activities are mainly due to the presence of alkaloids, cardiac glycosides, sterols, steroids and flavonoids. The results obtained suggest that Melodinus eugeniifolus could be exploited in the management of various diseases like cancer, cardiovascular diseases and infection diseases. Highlights: Melodinus eugeniifolus, a very rare medical plant from South Asian rain forest which may be a potential drug for many diseases is first reported about its phytochemical characteristics and antioxidant activity by different methods.
文摘Two new indole alkaloids named 152-hydroxy-14,15-dihydro-vindo- linine and 152-hydroxy-14,15-dihydro-16-epi-vindolinine were isolated from Melodinus morsei.Their structures were established by spectroscopic means and comparison with related compounds.
