Lasers have been widely used for tattoo removal,but the limited light penetration depth calused by high skin scattering property restricts the therapeutic outcome of deep tattoo.Skin optical clearing method,by introdu...Lasers have been widely used for tattoo removal,but the limited light penetration depth calused by high skin scattering property restricts the therapeutic outcome of deep tattoo.Skin optical clearing method,by introducing optical clearing agent(OCA)into skin,has shown some im-provement in the effect of laser tattoo removal.In this study,the enhanced laser tattoo removal has been quantitatively assessed.OCA was applied to the skin of tattoo animal model and Q switched Nd:YAG laser(1064 nm)irradiation was used to remove the tattoo.The skin evaluation instrument(Mexameter probe,MPA580)was applied to measure the content of tattoo pigment before and after laser treatment,and then the clearance rate of pigment was calculated.Further,Monte Carlo(MC)method was utilized to simulate the efecet of skin optical clearing on light transmission in tattoo skin model.By comparing the pigment change of tattoo areas respectively treated with OCA plus laser and single laser,it was found that pigment clearance of the former tattoo area was increased by 1.5-fold.Further,the MC simulation verifed that the reduced light scattering in skin could increase the effective dose of lumninous fux reaching to the deep tattoo regions.It can be concluded from both experiment and theoretical simulations that skin optical clearing technique could improve the outcome of laser tattoo re moval,which should be beneficial for clinical laser tattoo removal and other laser pigment elimination.展开更多
Background: Previously described methods for removal of tattoos are chemical, mechanical, surgical, termal and laser assited methods. Invention of the Q-switch mode, advanced the laser method, to be one of the most ef...Background: Previously described methods for removal of tattoos are chemical, mechanical, surgical, termal and laser assited methods. Invention of the Q-switch mode, advanced the laser method, to be one of the most effective methods of tattoo removal. Objective: Comparing the tattoo removal and rate of lymphatic elimination of 3 different wavelengths of Q-switched Nd-YAG laser (532nm, 1064nm, combination 532 + 1064). Methods: In this study we examined lymphatic elimination and the effect of 532 nm, 1064 nm, and the combination (532 + 1064 nm) wavelength of laser pulse for the possible lymphatic cleansing mechanism of black pigmented tattoos. This study was performed on 18 New-Zealand rabbits, black pigmented tattoos were engraved on the back and the four extremities of the animals. 532 nm wavelength of Q switched Nd: YAG laser beam was applied on the left upper and bilateral lower extremities of the rabbits. During this period, excisional skin biopsies and lymph node biopsies were performed on days 7, 14 and 21. Results: Day 21 lymph node biopsies revealed mixed type of reactive hyperplasia and intracellular pigments were markedly seen in the laser treatment group and no intracellular tattoo pigment was seen in the control group. Conclusion: The findingd of this study indicate that lymphatic elimination may be one of the significant mechanisms of tattoo removal and the application of different wavelengths of Q-switched Nd-YAG laser do not show statistically significant differences in tattoo removal.展开更多
基金supported by the National Nature Science Foundation of China (Grant Nos.81171376,91232710,812111313)the Science Fund for Creative Research Group (Grant No.61121004)the Research Fund for the Doctoral Program of Higher Education of China (Grant No.20110142110073).
文摘Lasers have been widely used for tattoo removal,but the limited light penetration depth calused by high skin scattering property restricts the therapeutic outcome of deep tattoo.Skin optical clearing method,by introducing optical clearing agent(OCA)into skin,has shown some im-provement in the effect of laser tattoo removal.In this study,the enhanced laser tattoo removal has been quantitatively assessed.OCA was applied to the skin of tattoo animal model and Q switched Nd:YAG laser(1064 nm)irradiation was used to remove the tattoo.The skin evaluation instrument(Mexameter probe,MPA580)was applied to measure the content of tattoo pigment before and after laser treatment,and then the clearance rate of pigment was calculated.Further,Monte Carlo(MC)method was utilized to simulate the efecet of skin optical clearing on light transmission in tattoo skin model.By comparing the pigment change of tattoo areas respectively treated with OCA plus laser and single laser,it was found that pigment clearance of the former tattoo area was increased by 1.5-fold.Further,the MC simulation verifed that the reduced light scattering in skin could increase the effective dose of lumninous fux reaching to the deep tattoo regions.It can be concluded from both experiment and theoretical simulations that skin optical clearing technique could improve the outcome of laser tattoo re moval,which should be beneficial for clinical laser tattoo removal and other laser pigment elimination.
文摘Background: Previously described methods for removal of tattoos are chemical, mechanical, surgical, termal and laser assited methods. Invention of the Q-switch mode, advanced the laser method, to be one of the most effective methods of tattoo removal. Objective: Comparing the tattoo removal and rate of lymphatic elimination of 3 different wavelengths of Q-switched Nd-YAG laser (532nm, 1064nm, combination 532 + 1064). Methods: In this study we examined lymphatic elimination and the effect of 532 nm, 1064 nm, and the combination (532 + 1064 nm) wavelength of laser pulse for the possible lymphatic cleansing mechanism of black pigmented tattoos. This study was performed on 18 New-Zealand rabbits, black pigmented tattoos were engraved on the back and the four extremities of the animals. 532 nm wavelength of Q switched Nd: YAG laser beam was applied on the left upper and bilateral lower extremities of the rabbits. During this period, excisional skin biopsies and lymph node biopsies were performed on days 7, 14 and 21. Results: Day 21 lymph node biopsies revealed mixed type of reactive hyperplasia and intracellular pigments were markedly seen in the laser treatment group and no intracellular tattoo pigment was seen in the control group. Conclusion: The findingd of this study indicate that lymphatic elimination may be one of the significant mechanisms of tattoo removal and the application of different wavelengths of Q-switched Nd-YAG laser do not show statistically significant differences in tattoo removal.
