Because of the powerful mapping ability, back propagation neural network (BP-NN) has been employed in computer-aided product design (CAPD) to establish the property prediction model. The backward problem in CAPD is to...Because of the powerful mapping ability, back propagation neural network (BP-NN) has been employed in computer-aided product design (CAPD) to establish the property prediction model. The backward problem in CAPD is to search for the appropriate structure or composition of the product with desired property, which is an optimization problem. In this paper, a global optimization method of using the a BB algorithm to solve the backward problem is presented. In particular, a convex lower bounding function is constructed for the objective function formulated with BP-NN model, and the calculation of the key parameter a is implemented by recurring to the interval Hessian matrix of the objective function. Two case studies involving the design of dopamine β-hydroxylase (DβH) inhibitors and linear low density polyethylene (LLDPE) nano composites are investigated using the proposed method.展开更多
Today’s product creative design has rendered many fe atures and has brought a great change in our everyday life, there are many new c hallenges in its traditional theory and principle. According to the traditional de...Today’s product creative design has rendered many fe atures and has brought a great change in our everyday life, there are many new c hallenges in its traditional theory and principle. According to the traditional design theory, the FBS design model pays more attention to the function and stru cture of the product. But this model still couldn’t strengthen the relation bet ween product appearance design and human-machine design effectively. This paper adopt converse design thinking and presents an improved design thinking methodo logy based on C: FBS for product appearance design and give a general summarizat ion for the features, methods and technology based on human-machine interaction and interface. Meanwhile it also combines with the behavior design of product r elated IT fields and constructs a new outline to improve the design of product a ppearance supported by the technology of computer aided design. So the new metho d about design thinking for computer aided design, the new abstract product design model and the key problem of design thinking based on human-machine inte raction and interface are addressed in this paper. This kind of creative design theory that is driven by human-machine interaction and interface will help the development of CAD software system and the research of product design and manufa cture. Additionally, this paper gives some beneficial characters to address the theory based on human-machine interaction and interface. Meanwhile, combining with the developing of computer technology, the trends of design thinking based on t he technology of human-machine interaction and interface are also analyzed and discussed at the end of this paper.展开更多
Patients with AIDS(Acquired Immunodeficiency Srudrome) have immunoldgic abnormalities resulting from functional defects in HIV(Human Immunodeficiency Virus)-infected CD4+lymphocytes and monocytes. Tumor necrosis facto...Patients with AIDS(Acquired Immunodeficiency Srudrome) have immunoldgic abnormalities resulting from functional defects in HIV(Human Immunodeficiency Virus)-infected CD4+lymphocytes and monocytes. Tumor necrosis factor-alpha(TNF-α)is known to mediate cachexcia.Todetermine if TNF is responsible for 'wasting syndrome' in AIDS.we studied serum levels and in vitro production of TNF-alpha in 21 HIV-seropositive men(10 AIDS,2 ARC, 9 HIV+)and 8 HIV seronreative controls.Both a bloassay and TNF-specific ELISA were used.All patiend except onebad undctectable levels of serum TNF. while control sera contained 4.2±2.5μg/L of TNF,Peripheral blood mononuclear cell(PBMNC)was tested for spontaneous,LPS-induced or PHA and PMA-induced TNF production at different times in culture(24-72h).Patients cells Produced significantlyless TNF than normal PBMNC under all experimental conditions:e.g,18-45μg/L in conttols vs.0.4～13μg/L in patients(P<0.001)at 72 hours using PHA and PMA as activators.Cell viabilitywas 85% in all cultures.No significant differences in TNF release were detected between AIDS patients with cachexia or opportunistic infectious and other HIV-seropositive men.This study showedthat most HIV-infected persons had no dctectable serum TNF-αand that their PBMNC produced subnormal quantities of this cytoklne in vitro,suggesting that TNF is not involved in the pathogenesis ofthe cacbexia associated with AIDS.展开更多
The simulation of a product development process for concurrent engineering has beenmotivated by the desire to increase productivity by improving the product development pro-cess.In this paper,the IDEF3 process descrip...The simulation of a product development process for concurrent engineering has beenmotivated by the desire to increase productivity by improving the product development pro-cess.In this paper,the IDEF3 process description capture method is discussed.On the basisof IDEF3 method,a simulation system of the product development process for concurrent en-gineering is developed.The architecture of the simulation system is proposed.The simula-tion model is built using object-oriented approach.It employs an event scheduling approachto emulate the product development process.The simulation mechanism based on messagepassing:is also presented.展开更多
A simulation tool named BITSIM orienting production engineering is developed in order to improve enterprise＇s productivity and making up the scarcity of computer application. The architecture of BITSIM is presented f...A simulation tool named BITSIM orienting production engineering is developed in order to improve enterprise＇s productivity and making up the scarcity of computer application. The architecture of BITSIM is presented first. Hierarchical technique, control strategy based on multi-agent and simulation output analysis are depicted in detail then. In the end, an application example is taken out to prove that this system could be used to analyzing different hypothetical situation and configuring the auxiliary manufacturing system before production.展开更多
文摘Because of the powerful mapping ability, back propagation neural network (BP-NN) has been employed in computer-aided product design (CAPD) to establish the property prediction model. The backward problem in CAPD is to search for the appropriate structure or composition of the product with desired property, which is an optimization problem. In this paper, a global optimization method of using the a BB algorithm to solve the backward problem is presented. In particular, a convex lower bounding function is constructed for the objective function formulated with BP-NN model, and the calculation of the key parameter a is implemented by recurring to the interval Hessian matrix of the objective function. Two case studies involving the design of dopamine β-hydroxylase (DβH) inhibitors and linear low density polyethylene (LLDPE) nano composites are investigated using the proposed method.
文摘Today’s product creative design has rendered many fe atures and has brought a great change in our everyday life, there are many new c hallenges in its traditional theory and principle. According to the traditional design theory, the FBS design model pays more attention to the function and stru cture of the product. But this model still couldn’t strengthen the relation bet ween product appearance design and human-machine design effectively. This paper adopt converse design thinking and presents an improved design thinking methodo logy based on C: FBS for product appearance design and give a general summarizat ion for the features, methods and technology based on human-machine interaction and interface. Meanwhile it also combines with the behavior design of product r elated IT fields and constructs a new outline to improve the design of product a ppearance supported by the technology of computer aided design. So the new metho d about design thinking for computer aided design, the new abstract product design model and the key problem of design thinking based on human-machine inte raction and interface are addressed in this paper. This kind of creative design theory that is driven by human-machine interaction and interface will help the development of CAD software system and the research of product design and manufa cture. Additionally, this paper gives some beneficial characters to address the theory based on human-machine interaction and interface. Meanwhile, combining with the developing of computer technology, the trends of design thinking based on t he technology of human-machine interaction and interface are also analyzed and discussed at the end of this paper.
文摘Patients with AIDS(Acquired Immunodeficiency Srudrome) have immunoldgic abnormalities resulting from functional defects in HIV(Human Immunodeficiency Virus)-infected CD4+lymphocytes and monocytes. Tumor necrosis factor-alpha(TNF-α)is known to mediate cachexcia.Todetermine if TNF is responsible for 'wasting syndrome' in AIDS.we studied serum levels and in vitro production of TNF-alpha in 21 HIV-seropositive men(10 AIDS,2 ARC, 9 HIV+)and 8 HIV seronreative controls.Both a bloassay and TNF-specific ELISA were used.All patiend except onebad undctectable levels of serum TNF. while control sera contained 4.2±2.5μg/L of TNF,Peripheral blood mononuclear cell(PBMNC)was tested for spontaneous,LPS-induced or PHA and PMA-induced TNF production at different times in culture(24-72h).Patients cells Produced significantlyless TNF than normal PBMNC under all experimental conditions:e.g,18-45μg/L in conttols vs.0.4～13μg/L in patients(P<0.001)at 72 hours using PHA and PMA as activators.Cell viabilitywas 85% in all cultures.No significant differences in TNF release were detected between AIDS patients with cachexia or opportunistic infectious and other HIV-seropositive men.This study showedthat most HIV-infected persons had no dctectable serum TNF-αand that their PBMNC produced subnormal quantities of this cytoklne in vitro,suggesting that TNF is not involved in the pathogenesis ofthe cacbexia associated with AIDS.
基金Supported by the High Technology Research and Development Programme of China.
文摘The simulation of a product development process for concurrent engineering has beenmotivated by the desire to increase productivity by improving the product development pro-cess.In this paper,the IDEF3 process description capture method is discussed.On the basisof IDEF3 method,a simulation system of the product development process for concurrent en-gineering is developed.The architecture of the simulation system is proposed.The simula-tion model is built using object-oriented approach.It employs an event scheduling approachto emulate the product development process.The simulation mechanism based on messagepassing:is also presented.
文摘A simulation tool named BITSIM orienting production engineering is developed in order to improve enterprise＇s productivity and making up the scarcity of computer application. The architecture of BITSIM is presented first. Hierarchical technique, control strategy based on multi-agent and simulation output analysis are depicted in detail then. In the end, an application example is taken out to prove that this system could be used to analyzing different hypothetical situation and configuring the auxiliary manufacturing system before production.
