Rock mechanical characteristics and landscape evolutionary mechanism of the slit-type Danxia landform on the Chinese Loess Plateau

Since 2015,the newly discovered slit-type Danxia landform on the Chinese Loess Plateau has become a hot topic in the field of geomorphology worldwide.However,the relationships among its formation,evolutionary mechanism,and mechanical characteristics of its strata and rocks are not clear.In this paper,the Ganquan canyon group is used as the research object.Basic physical and mechanical indices of sandstone in the Ganquan canyon group were measured through field investigation and indoor experiments,and the deterioration trends for the mechanical parameters of sandstone in this area under the action of infiltration,acid dry-wet cycles,and freeze-thaw cycles were revealed.Lastly,the formation and evolutionary mechanism of the slit-type Danxia landform were discussed.The results showed that:(1)The sandstone in the canyon group had a low cementation degree and weak cohesive force,which was easily weakened under the action of water,resulting in a decrease in compressive strength and elastic modulus.(2)Acidic dry-wet cycles caused the mineral composition of the sandstone to be dissolved,and the micropores continued to grow and develop until new cracks were produced.Macroscopically,the compressive strength and elastic modulus of sandstone were greatly reduced,and this damage was cumulative and staged.The greater the acidity,the greater the damage.(3)As the number of freeze-thaw cycles increased,the uniaxial compressive strength and elastic modulus of the sandstone decreased continuously.During the freeze-thaw cycle process,the growth and development of cracks were primarily in fracture mode and usually developed along parallel bedding positions.(4)The interaction of tectonic activity and lithology with different weathering processes was a key factor in the formation and evolution of the slit-type Danxia landform.In conclusion,the intricate process of weathering influenced by historical climatic fluctuations has been pivotal in shaping the topography of Danxia landform.

Study on the Photosynthetic Characteristics of Six Varieties(Strains)in Chinese Chestnut

[Objectives]This study was conducted to investigate the differences of photosynthetic physiological characteristics of different varieties(strains),which will provide a theoretical basis for high photosynthesis efficiency breeding and application in Chinese chestnut.[Methods]Six Chinese chestnut varieties of Castanea mollissima‘Yanbao’,C.mollissima‘Yanqiu’,C.mollissima‘Yanchang’,C.mollissima‘Yanjia’,C.mollissima‘Qianxi 37’,and C.mollissima‘Hybrid 22’were used as the materials.Using the portable photosynthesis system Li-6400,we measured the photosynthetic characteristics and diurnal variation of leaf samples of six different chestnut varieties or strains.We fitted the light response curves and photosynthetic parameters using the leaf floating model.Additionally,we determined the chlorophyll content in the leaves using a UV-visible spectrophotometer.[Results]Among the six chestnut varieties or strains,‘Yanqiu’exhibited a significantly higher photosynthetic light saturation point(P LSP)compared to other five varieties,and‘Hybrid 22’ranked second,indicating that these two varieties had the strongest adaptation to high light intensity.The photosynthetic light compensation point(P LCP)of‘Yanchang’was significantly higher than other five varieties,and"Qianxi 37"ranked second,indicating that these two varieties had the strongest adaptation to low light intensity.Additionally,they exhibited higher chlorophyll content and maintained good photosynthetic characteristics even in shaded environments with weak light stress.Varieties‘Yanbao’and‘Yanjia’showed higher P LSP and lower P LCP,indicating that these two varieties have a wider range of adaptation to light intensity.They were capable of efficiently utilizing light across a broader spectrum of intensities.‘Yanqiu’had the highest maximum net photosynthetic rate(P n,max)and the lowest dark respiration rate(R d),along with the highest chlorophyll content.It indicated that‘Yanqiu’has strong photosynthetic capacity and organic matter accumulation ability.It also had the highest P LSP,enabling it to fully utilize the high light environment of the Yanshan Mountains and possessed high light efficiency characteristics.The P n,max of‘Yanqiu’was significantly higher than other varieties.‘Hybrid 22’and‘Yanbao’also exhibited significantly higher P n,max compared with‘Yanjia’and‘Qianxi 37’.‘Yanchang’had the lowest P n,max.The order of P n,max among the six chestnut varieties or strains was as follows:‘Yanqiu’>‘Hybrid 22’>‘Yanbao’>‘Yanjia’>‘Qianxi 37’>‘Yanchang’.[Conclusions]

Characteristics and demographic factors of traditional Chinese medicine constitution types among elderly individuals in China:A national multistage cluster random study Author links open overlay panel

Objective:To reveal the distribution characteristics and demographic factors of traditional Chinese medicine(TCM)constitution among elderly individuals in China.Methods: Elderly individuals from seven regions in China were selected as samples in this study using a multistage cluster random sampling method.The basic information questionnaire and Constitution in Chinese Medicine Questionnaire(Elderly Edition)were used.Descriptive statistical analysis,chi-squared tests,and binary logistic regression analysis were used.Results: The single balanced constitution(BC)accounted for 23.9%.The results of the major TCM constitution types showed that BC(43.2%)accounted for the largest proportion and unbalanced constitutions ranged from 0.9%to 15.7%.East China region(odds ratio[OR]=2.097;95%confidence interval[CI],1.912 to 2.301),married status(OR=1.341;95%CI,1.235 to 1.457),and managers(OR=1.254;95%CI,1.044 to 1.505)were significantly associated with BC.Age>70 years was associated with qi-deficiency constitution and blood stasis constitution(BSC).Female sex was significantly associated with yang-deficiency constitution(OR=1.646;95%CI,1.52 to 1.782).Southwest region was significantly associated with phlegm-dampness constitution(OR=1.809;95%CI,1.569 to 2.086).North China region was significantly associated with inherited special constitution(OR=2.521;95%CI,1.569 to 4.05).South China region(OR=2.741;95%CI,1.997 to 1.3.763),Central China region(OR=8.889;95%CI,6.676 to 11.835),senior middle school education(OR=2.442;95%CI,1.932 to 3.088),and managers(OR=1.804;95%CI,1.21 to 2.69)were significantly associated with BSC.Conclusions: This study defined the distribution characteristics and demographic factors of TCM constitution in the elderly population.Adjusting and improving unbalanced constitutions,which are correlated with diseases,can help promote healthy aging through the scientific management of these demographic factors.

Effects of Hypergravity on Physiological and Biochemical Characteristics of Chinese Cabbage

The Chinese cabbage seed used in this study was Xinfengkang 90. The tested seeds were treated with 1 000×g, 2 000×g and 4 000×g of hypergravity for 20, 40 and 60 min respectively. The Chinese cabbage leaves were col ected at the early seedling stage for the determination of free proline content, POD activity and SOD activity. The results showed the free proline content was lowest in the seeds treated with 40-min 2 000-g gravity, while it was highest for the 60-min 4 000-g gravity treatment. Compared to the control, al the hypergravity treatments inhibited the synthesis of free proline. The POD activity was highest in the seeds treated with 20-min 1 000-g gravity, while it was lowest in the seeds treated with 60-min 2 000-g gravity. Considering the SOD activity, the 40-min 1 000-g gravity treatment was highest, and the 60-min 4 000-g gravity treatment was lowest. lt was indicated that appropriate hypergravity treatment was conducive to increasing the SOD activity.

Molecular mechanism and research progress of traditional Chinese medicine in the treatment of prostate cancer

Prostate cancer(PCa)is one of the most common malignant tumors in the male genitourinary system,ranking second in incidence worldwide.Traditional Chinese medicine(TCM),as an important component of complementary and alternative medicine,shows unique advantages in cancer treatment.Chinese herbal medicine is usually composed of multiple ingredients and involves multiple signaling pathways,which showed function of inducing apoptosis of cancer cells,arresting the cell cycle,inhibiting invasion and metastasis,reducing drug resistance,and regulating immune function.Physical therapy is also an important treatment of TCM.Currently,Physical therapy such as acupuncture or Tai Chi and Qigong are gaining increased recognition in the management of PCa,particularly in addressing issues like urinary incontinence and bone metastasis-related pain.This article reviews the TCM treatment and therapy of PCa,in order to provide new research avenues and treatment options for the treatment of PCa with TCM and improve the quality of life of patients.

Cohort study on the treatment of BRAF V600E mutant metastatic colorectal cancer with integrated Chinese and western medicine

BACKGROUND Patients with BRAF V600E mutant metastatic colorectal cancer(mCRC)have a low incidence rate,poor biological activity,suboptimal response to conventional treatments,and a poor prognosis.In the previous cohort study on mCRC conducted by our team,it was observed that integrated Chinese and Western medicine treatment could significantly prolong the overall survival(OS)of patients with colorectal cancer.Therefore,we further explored the survival benefits in the population with BRAF V600E mutant mCRC.AIM To evaluate the efficacy of integrated Chinese and Western medicine in the treatment of BRAF V600E mutant metastatic colorectal cancer.METHODS A cohort study was conducted on patients with BRAF V600E mutant metastatic colorectal cancer admitted to Xiyuan Hospital of China Academy of Chinese Medical Sciences and Traditional Chinese Medicine Hospital of Xinjiang Uygur Autonomous Region from January 2016 to December 2022.The patients were divided into two cohorts.RESULTS A total of 34 cases were included,with 23 in Chinese-Western medicine cohort(cohort A)and 11 in Western medicine cohort(cohort B).The median overall survival was 19.9 months in cohort A and 14.2 months in cohort B,with a statistically significant difference(P=0.038,hazard ratio=0.46).The 1-3-year survival rates were 95.65%(22/23),39.13%(9/23),and 26.09%(6/23)in cohort A,and 63.64%(7/11),18.18%(2/11),and 9.09%(1/11)in cohort B,respectively.Subgroup analysis showed statistically significant differences in median OS between the two cohorts in the right colon,liver metastasis,chemotherapy,and first-line treatment subgroups(P<0.05).CONCLUSION Integrated Chinese and Western medicine can prolong the survival and reduce the risk of death in patients with BRAF V600E mutant metastatic colorectal cancer,with more pronounced benefits observed in patients with right colon involvement,liver metastasis,combined chemotherapy,and first-line treatment.

ANALYSIS ON THE CHARACTERISTICS OF TROPICAL CYCLONES MAKING LANDFALL ON DIFFERENT REGIONS OF CHINESE MAINLAND

The locations(longitudes and latitudes)of the tropical cyclones(TCs)making landfall on the Chinese mainland from 1949 to 2008 are investigated in detail by using ArcGis and FORTRAN routine.The southeast coastline[110 to 122°E)with most landfall TCs was selected as the key region,which was divided into 12 subsections with 1°intervals of longitude.The study period was from July to September in each year.The result showed that the average sustaining time of TCs making landfall on the subsections east of 118°E is longer than those west of 118°E.Before landfall,the averaged TC intensity in the subsections east of118°E is stronger than that west of it.After landfall,however,the difference between the west and east is not significant.The index of destructive potential for the period before/after landfall was defined as TDP1/TDP2.The maximum of TDP1/TDP2 occurred in the subsection of[119,120°E)/[110,111°E).The ENSO impact on the frequency and average location of landfall TC over the whole region at 110 to 122°E is not obvious,but the effect varies with specific subsections.There is little differences of averaged TDP1 in the subsections between different phases of ENSO events,but the averaged TDP2 is larger in the warm events than that in the cold events.The rainstorm days of each station caused by TCs in different subsections were counted respectively.The results suggested that the rainstorm days of the subsections east of 118°E are much more than those west of 118°E.The larger values are primarily distributed at the subsections of[119,120°E)and[110,111°E).

Prevalence,histologic and clinical characteristics of heterotopic gastric mucosa in Chinese patients

AIM: To determine the prevalence, demographic, clinical and histopathologic features of heterotopic gastric mucosa (HGM) in Chinese patients.

Private Car Travel Characteristics and Influencing Factors in Chinese Cities——A Case Study of Guangzhou in Guangdong,China

Taking Guangzhou as a case,this paper adopted a questionnaire survey to gather first-hand data and analyzed the characteristics and influencing factors of private car travel in Chinese cities.As the research indicated,trip purposes of private car travel are mainly commute and business affairs with a more flexible trip in the urban core area.And trip intensities are concentrated in a certain extent,with trip frequency being lower in the urban core area than the peripheral area.In addition,the trip time has two significant peaks occurring in the morning and afternoon,and one trough in the midday.And trip spatial distribution is mainly within commute with both residence and employment in urban area and inward commute with residence in suburban area while employment in urban area.Both kinds of commutes direct to the urban area.The study also shows that the characteristics of private car travel are principally influenced by two aspects:travelers' attributes and urban characteristics.The main travelers' social and economic attributes influenced it include the gender,education attainment,age,driving experience and per capita monthly household income.The urban characteristics influenced it mainly cover the land use pattern,public traffic facilities and spatial attributes of residential environment.

Effects of different dietary energy and protein levels and sex on growth performance,carcass characteristics and meat quality of F1 Angus x Chinese Xiangxi yellow cattle

Background：The experiment evaluated the effect of nutrition levels and sex on the growth performance,carcass characteristics and meat quality of F1 Angus × Chinese Xiangxi yellow cattle.Methods：During the background period of 184 d,23 steers and 24 heifers were fed the same ration,then put into a2×2×2 factorial arrangement under two levels of- dietary energy（TON：70/80%DM）,protein（CP：11.9/14.3%DM）and sex（S：male/female） during the finishing phase of 146 d.The treatments were-（1） high energy/low protein（HELP）,（2） high energy/high protein（HEHP）,（3） low energy/low protein（LELP） and（4） low energy/high protein（LEHP）.Each treatment used 6 steers and 6 heifers,except for HELP- 5 steers and 6 heifers.Results：Growth rate and final carcass weight were unaffected by dietary energy and protein levels or by sex.Compared with the LE diet group,the HE group had significantly lower dry matter intake（DMI,6.76 vs.7.48 kg DM/d）,greater chest girth increments（46.1 vs.36.8 cm）,higher carcass fat（19.9 vs.16.3%） and intramuscular fat content（29.9 vs.22.8%DM）.The HE group also had improved yields of top and medium top grade commercial meat cuts（39.9 vs.36.5%）.The dressing percentage was higher for the HP group than the LP group（53.4 vs.54.9%）.Steers had a greater length increment（9.0 vs.8.3 cm）,but lower carcass fat content（16.8 vs.19.4%） than heifers.The meat quality traits（shear force value,drip loss,cooking loss and water holding capacity） were not affected by treatments or sex,averaging 3.14 kg,2.5,31.5 and 52.9%,respectively.The nutritive profiles（both fatty and amino acid composition） were not influenced by the energy or protein levels or by sex.Conclusions：The dietary energy and protein levels and sex significantly influenced the carcass characteristics and chemical composition of meat but not thegrowth performance,meat quality traits and nutritive profiles.

Acoustic characteristics of eight common Chinese anurans during the breeding season

Anurans often have species-specific vocalizations. To quantify and compare the characteristics of anuran calls in Gutianshan National Nature Reserve, Zhejiang Province, we recorded the advertisement calls of eight species belonging to four families （Ranidae, Microhylidae, Megophryidae and Bufonidae） from June to September 2012 using Sony ICD-FX8 IC recorders. All recordings were analyzed using the ＂Praat＂ software. Five acoustics parameters were measured, including temporal traits （call duration, number of notes or pulse number/call） and spectral traits （fundamental frequency, the first three formants and dominant frequency）. The characteristic parameters of Microhyla ornate and Fejervarya limnocharis calls were different as were the calls of some populations of the same species recorded in different regions. The advertisement calls of the eight species were specific. Our study has provided a useful reference for identifying the calls of some common Chinese anurans.

Effects of Chinese chestnut powder on starch digestion,texture properties,and staling characteristics of bread

Chestnut is a high nutritional value food that has been widely used as a tonic in traditional Chinese medicine.As an emerging functional food ingredient,Chinese chestnuts are rich in a range of bioactive nutrients such as starch,dietary fiber,fat,protein,trace metal element and vitamins A,B,C,D and other nutrients.In our study,Chinese chestnut powder(CCP)were added into bread formulation at 2%-6%levels(based on flour weight)to produce fresh bread with enhanced anti-staling characteristics and starch digestion inhibitory ability.The texture properties,retrogradation enthalpy,water distribution,and estimated glycemic index(eGI)of wheat bread containing CCP as a functional additive were also investigated.The results showed that incorporation of CCP apparently affected bread texture,resulting in increased hardness,as well as decreased the specific volume of wheat bread.These influences were generally proportional to the amount of CCP used.It was found that adding too much CCP resulted in a dark red color,showing increased significantly higher total color difference(ΔE)and L values.Conversely,addition of CCP significantly reduced starch digestion rate and digestion extent in bread,and the reduction degree was positively related to the amount of CCP applied.The greatest reduction in eGI value from 79.40(control)to 75.02(6%CPP bread)was observed.Meanwhile,the content of resistant starch of 6%CPP bread was about 1.36 times higher than that of control bread.CCP also reduced crumb water loss and drove the water shift from the bound to the mobile state after stored for 7 days.The retrogradation enthalpy analyses further confirmed that CCP inhibited starch retrogradation and recrystallization.These results suggested that Chinese chestnut powder could be incorporated into fresh bread to provide health functions,such as lowering potential glycaemic response and improving anti-staling characteristics of bread.

The regulatory pathways of distinct flowering characteristics in Chinese jujube

Flowering is the most important event in higher plants.Compared to most fruit tree species,Chinese jujube(Ziziphus jujuba Mill.),the most important member of the large,diverse Rhamnaceae family and a leading dry fruit-producing species,has unique characteristics that include a short juvenile phase and extremely fast flower bud differentiation.However,the distinct mechanism of flowering regulation in Chinese jujube is still unclear.The morphological and cytological development period of jujube flowering was first investigated,and the crucial developmental stages were defined.Flower bud differentiation in Chinese jujube took only approximately 11–13 days,which is a distinct characteristic of perennial fruit trees.Afterward,44 genes related to six flowering pathways were identified in the jujube genome and were found to be randomly distributed among 11 of the 12 chromosomes.Tissue-specific and spatiotemporal expression patterns showed that all these genes were expressed in the flowers.Overall,photoperiodrelated genes were highly expressed during flower bud differentiation.These genes were also positively responsive to photoperiod regulation and phase change processes,indicating that photoperiod-related genes play crucial roles in jujube flower bud differentiation.Under protected cultivation,ZjPIF4,a temperature-related gene,was expressed in the early stages of flowering and responded to increasing temperatures.Moreover,STRING analysis and yeast two-hybrid screening indicated that photoperiod-related(ZjCO)and temperature-related(ZjPIF4)proteins could interact with ZjFT,the key protein involved in the determination of flowering time,indicating crosstalk between photoperiodrelated pathways and ambient temperature-related pathways in jujube.This study is the first report to comprehensively analyze the flowering pathways in Chinese jujube and revealed that photoperiod-related and ambient temperature-related pathways are the main mechanisms regulating the distinct flowering process and that members of the ZjPHY family(ZjPIF4,ZjFT,and ZjCO5)are the key factors involved in the regulatory network.These results will increase our understanding of the molecular and genetic mechanisms of flowering in Chinese jujube and provide meaningful clues for the flowering regulation of other fruit tree species.

Investigation on Pasting Characteristics of Spring-sown Chinese Bread Wheats

Forty-seven spring wheat Triticumaestivum cultivars and advanced lines from spring-sown spring wheat regions, at twelve locations in 1998 and 1999, were used to investigate pasting properties of Chinese spring wheats. Starch pasting properties were closely associated with noodle quality. Significant differences were observed for all pasting characteristics. Samples collected from Harbin, Shenyang, Beijing, Ba-meng, Yongning, and Urumqi had better pasting quality than those from other locations. Genotype, environment, and genotype by environment interaction had large effects on all pasting characteristics. Significant correlations among pasting characteristics were observed and peak viscosity was considered the most important pasting characteristics.

Effect of thermal processing and fermentation with Chinese traditional starters on characteristics and allergenicity of wheat matrix

Wheat allergy has become a serious health threat worldwide and its prevalence has increased alarmingly in the past few years.Factors such as food matrix and food processing may alter the structure of wheat proteins,and hence affect its allergenic properties.However,few reports have focused on the influence of Chinese traditional starter fermentation on wheat allergy.In this study,5 starters from different regions of China were used for fermentation,and protein characteristics were monitored by sodium dodecyl sulfate polyacrylamide gel electropheresis,and immunoreactivity analyzed by immunoassay with allergenic serum was obtained from New Zealand white rabbits.The allergenicity of steamed and baked matrices was also evaluated.The results showed that the allergenicity of wheat dough was basically increased at the beginning and then decreased during fermentation,but specific trends depend on different starters.With the progress of fermentation,especially as pH value decreased to 3.0-4.0,the allergenicity decreased significantly.Baking and steaming can reduce the allergenicity of wheat matrix,but fermentation is not a key factor affecting the allergenic activity of proteins.Our results can provide a theoretical basis for controlling wheat allergenicity in food proces sing or producing hypoallergenic food.

Relation between the characteristics of strong earthquake activities in Chinese mainland and the Wenchuan earthquake

This paper studies the relations between the great Wenchuan earthquake and the active-quiet periodic characteristics of strong earthquakes, the rhythmic feature of great earthquakes, and the grouped spatial distribution of Ms8.0 earthquakes in Chinese mainland. We also studied the relation between the Wenchuan earthquake and the stepwise migration characteristics of Ms≥7.0 earthquakes on the North-South seismic belt, the features of the energy releasing acceleration in the active crustal blocks related to the Wenchuan earthquake and the relation between the Wenchuan earthquake and the so called second-arc fault zone. The results can be summarized as follows： ① the occurrence of the Wenchuan earthquake was consistent with the activequiet periodic characteristics of strong earthquakes; ② its occurrence is consistent with the features of grouped occurrence of Ms8.0 earthquakes and follows the 25 years rhythm （each circulation experiences the same time） of great earthquakes; ③ the Wenchuan Ms8.0 earthquake follows the well known stepwise migration feature of strong earthquakes on the North-South seismic belt; ④ the location where the Wenchuan Ms8.0 earthquake took place has an obvious consistency with the temporal and spatial characteristic of grouped activity of Ms≥7.0 strong earthquakes on the second-arc fault zone; ⑤ the second-arc fault zone is not only the lower boundary for earthquakes with more than 30 km focal depth, but also looks like a lower boundary for deep substance movement; and ⑥ there are obvious seismic accelerations nearby the Qaidam and Qiangtang active crustal blocks （the northern and southern neighbors of the Bayan Har active block, respectively）, which agrees with the GPS observation data.

Characteristics of Soil Organic Carbon, Total Nitrogen, and C/N Ratio in Chinese Apple Orchards

Soil organic carbon and nitrogen are used as indexes of soil quality assessment and sustainable land use management. At the same time, soil C/N ratio is a sensitive indicator of soil quality and for assessing the carbon and nitrogen nutrition balance of soils. We studied the characteristics of soil organic carbon and total nitrogen by investigating a large number of apple orchards in major apple production areas in China. High apple orchard soil organic carbon content was observed in the provinces of Heilongjiang, Xinjiang, and Yunnan, whereas low content was found in the provinces of Shandong, Henan, Hebei, and Shaanxi, with the values ranging between 6.44 and 7.76 g·kg-1. Similar to soil organic carbon, soil total nitrogen content also exhibited obvious differences in the 12 major apple producing provinces. Shandong apple orchard soil had the highest total nitrogen content (1.26 g·kg-1), followed by Beijing (1.23 g·kg-1). No significant difference was noted between these two regions, but their total nitrogen content was significantly higher than the other nine provinces, excluding Yunnan. The soil total nitrogen content for Xinjiang, Heilongjiang, Hebei, Henan, and Gansu was between 0.87 and 1.03 g·kg-1, which was significantly lower than that in Shandong and Beijing, but significantly higher than that in Liaoning, Shanxi, and Shaanxi. Six provinces exhibited apple orchard soil C/N ratio higher than 10, including Heilongjiang (15.42), Xinjiang (13.38), Ningxia (14.45), Liaoning (12.24), Yunnan (11.03), and Gansu (10.63). The soil C/N ratio was below 10 in the remaining six provinces, in which the highest was found in Shaanxi (9.47), followed by Beijing (8.98), Henan (7.99), and Shanxi (7.62), and the lowest was found in Hebei (6.80) and Shandong (6.05). Therefore, the improvement of soil organic carbon should be given more attention to increase the steady growth of soil C/N ratio.

Characteristics of Chinese male patients with breast cancer:summary of the published papers

Objective:The extremely low incidence of male breast cancer (MBC) leads to lack of prospective randomized phase III studies worldwide. Especially in China,all studies on Chinese patients with MBC were based on small sample size and single institute experience. The aim of this study was to provide overall view of characteristics of Chinese patients with MBC by means of summarizing all related papers published in Chinese journals. Methods: An online search was made in CBM,VIP,CNKI,and CBA databases to find all published articles of interest on Chinese patients with MBC. And eight subjects including the proportion of MBC in all breast cancer,age,tumor location,clinical stages,pathological subtypes,treatment modalities,ER/PR expression,and 5-year survival rate were selected to calculate the proportion and their 95% interval confidence. Results: There were 122 papers with 2584 patients enrolled. The basic features of Chinese patients with MBC included:(1) MBC only with a proportion of 1.06% of all the breast cancer; (2) The mean age at diagnosis was 57.6 years old; (3) Tumor mainly located in the areolar region (74.83%) with obvious nipple and/or skin involvement; (4) Nearly 62.62% patients were in early stage before accepting treatment; (5) Infiltrating ductal carcinoma accounted for 79.05% of all pathological subtypes; (6) ER/PR expression rate was 65.86%; (7) Radical resection was up to 86.06% in all surgical modalities; (8) The 5-year survival rate was 57.33%. Conclusion: The results showed in this study were an overall view of Chinese patients with MBC whose characteristics were similar to that reported in the West. Though this study provided a little bit stronger confidence than a single study collected in this paper,studies with more powerful evidence are urgently demanding in China.

Tourism Competitiveness Evaluation and Spatio-temporal Characteristics of Chinese Border Counties

Under the current government strategy of building a Silk Road economic belt, tourism in Chinese border counties has becoming increasingly popular. Studying tourism competitiveness in Chinese border counties is of sizable theoretical and practical importance, as there are several notable factors involved. In this study, we constructed a tourism competitiveness evaluation model based on eight factors: natural environment, tourism resource, location and transportation, social environment, tourism service facility, border port, tourism industrial cluster and tourism market. We then analyzed the spatial characteristics of tourism competitiveness in border counties and identified five types of border counties: resource advantage type(RA), border-port advantage type(PA), location advantage type(LA), agglomeration advantage type(AA), and relative balance type(RB), and examined the correlation between tourism market competitiveness and interior competitiveness factors in the counties from 2006 to 2011. Results showed that tourism resource, location and transportation, and tourism service facility are the most important competition factors for RA border counties during the study period. Competition factors in PA counties transferred from tourism resource, social environment and tourism service facility to border port and tourism industrial cluster; competition factors in LA counties transferred from natural environment and tourism resource to tourism service facility and tourism industrial cluster and border port. Competition factors in AA counties transferred from tourism service facility to tourism resource. Tourism industrial cluster, tourism service facility and tourism resource proved to be important competition factors in RB counties. The findings of this study can be used to target tourism strategies according to different county types.