Objective:To explore the mechanism of Xingshen Zhiyi Recipe(XSZYF)in the treatment of Nocturnal Enuresis(NE)based on network pharmacology.Methods:TCMSP,DrugBank databases,PubMed and CNKI were used to obtain the active...Objective:To explore the mechanism of Xingshen Zhiyi Recipe(XSZYF)in the treatment of Nocturnal Enuresis(NE)based on network pharmacology.Methods:TCMSP,DrugBank databases,PubMed and CNKI were used to obtain the active ingredients and corresponding targets of XSZYF.NE targets were obtained from GeneCard and OMIM databases.Cytoscape software was used to construct a drug-disease-target network model.The analysis was performed.The protein interaction network(PPI)was constructed using the STRING database.The gene ontology functional annotation(GO)and the Tokyo Genomic Encyclopedia(KEGG)pathway enrichment analysis were performed on key targets using the DAVID online tool.Surflex docking software was used for the analysis.Docking of key active ingredients and key targets to verify the results of network analysis.Results:199 gene targets of XSZYF were obtained,and 2486 gene targets of NE.Network analysis results showed that the key targets of XSZYF for treating NE include CHRM3,CHRM2,ADRB3,etc.Involved in regulating neuroactive ligand-receptor interactions,calcium signaling pathways,etc.Conclusion:This study revealed the material basis and action mechanism of XSZYF in treating NE from the perspective of network pharmacology.展开更多
Zhiyi Tongzhi Recipe(治疫通治方) in Traditional Chinese Medicine plays an important role in the history of anti-epidemic. When an epidemic is widespread, formulating accurate prescriptions will play a key role in cont...Zhiyi Tongzhi Recipe(治疫通治方) in Traditional Chinese Medicine plays an important role in the history of anti-epidemic. When an epidemic is widespread, formulating accurate prescriptions will play a key role in controlling the spread of the epidemic, improving clinical symptoms, preventing the spread of the disease, and promoting prognosis and recovery. This paper performed an objective analysis of the historical role played by Zhiyi Tongzhi Recipe in the history of infectious diseases in China, and summed up the experience and lessons of the application of Zhiyi Tongzhi Recipe. Meanwhile, this paper conducted a theoretical discussion on how to ensure the efficacy of Zhiyi Tongzhi Recipe, with a view to provide useful enlightenment for the better application of Zhiyi Tongzhi Recipe to fight against epidemics in the future.展开更多
As an annual calendar event, China’s International Man-made Fiber Conference sets out, as always as it started over 20 years ago, to provide an international platform at its 13th International Conference for technica...As an annual calendar event, China’s International Man-made Fiber Conference sets out, as always as it started over 20 years ago, to provide an international platform at its 13th International Conference for technical exchange and cooperation in an effort to direct Chinese MMF’s future roadmap. Mr. Zheng Zhiyi, President of China Chemical Fiber Association (CCFA), will roll out a technological tracking back into the past, and technological forecast back into the future, showing his determination in encouraging science and technology to play a contributive major role in beefing up the chemical fiber industry in China.展开更多
基金Shandong province development plan of TCM science and technology(No.2019-0972)
文摘Objective:To explore the mechanism of Xingshen Zhiyi Recipe(XSZYF)in the treatment of Nocturnal Enuresis(NE)based on network pharmacology.Methods:TCMSP,DrugBank databases,PubMed and CNKI were used to obtain the active ingredients and corresponding targets of XSZYF.NE targets were obtained from GeneCard and OMIM databases.Cytoscape software was used to construct a drug-disease-target network model.The analysis was performed.The protein interaction network(PPI)was constructed using the STRING database.The gene ontology functional annotation(GO)and the Tokyo Genomic Encyclopedia(KEGG)pathway enrichment analysis were performed on key targets using the DAVID online tool.Surflex docking software was used for the analysis.Docking of key active ingredients and key targets to verify the results of network analysis.Results:199 gene targets of XSZYF were obtained,and 2486 gene targets of NE.Network analysis results showed that the key targets of XSZYF for treating NE include CHRM3,CHRM2,ADRB3,etc.Involved in regulating neuroactive ligand-receptor interactions,calcium signaling pathways,etc.Conclusion:This study revealed the material basis and action mechanism of XSZYF in treating NE from the perspective of network pharmacology.
基金Research Project of Independent Topic Selection of Fundamental Scientific Research Business Expenses of China Academy of Chinese Medical Sciences (YZ-202001):Cognitive Research on Chinese Medicine Theory of COVID-19。
文摘Zhiyi Tongzhi Recipe(治疫通治方) in Traditional Chinese Medicine plays an important role in the history of anti-epidemic. When an epidemic is widespread, formulating accurate prescriptions will play a key role in controlling the spread of the epidemic, improving clinical symptoms, preventing the spread of the disease, and promoting prognosis and recovery. This paper performed an objective analysis of the historical role played by Zhiyi Tongzhi Recipe in the history of infectious diseases in China, and summed up the experience and lessons of the application of Zhiyi Tongzhi Recipe. Meanwhile, this paper conducted a theoretical discussion on how to ensure the efficacy of Zhiyi Tongzhi Recipe, with a view to provide useful enlightenment for the better application of Zhiyi Tongzhi Recipe to fight against epidemics in the future.
文摘As an annual calendar event, China’s International Man-made Fiber Conference sets out, as always as it started over 20 years ago, to provide an international platform at its 13th International Conference for technical exchange and cooperation in an effort to direct Chinese MMF’s future roadmap. Mr. Zheng Zhiyi, President of China Chemical Fiber Association (CCFA), will roll out a technological tracking back into the past, and technological forecast back into the future, showing his determination in encouraging science and technology to play a contributive major role in beefing up the chemical fiber industry in China.
