Relationship between longitudinal changes in lipid composition and ischemic stroke among hypertensive patients

BACKGROUND Dyslipidemia was strongly linked to stroke,however the relationship between dyslipidemia and its components and ischemic stroke remained unexplained.AIM To investigate the link between longitudinal changes in lipid profiles and dyslipidemia and ischemic stroke in a hypertensive population.METHODS Between 2013 and 2014,6094 hypertension individuals were included in this,and ischemic stroke cases were documented to the end of 2018.Longitudinal changes of lipid were stratified into four groups:(1)Normal was transformed into normal group;(2)Abnormal was transformed into normal group;(3)Normal was transformed into abnormal group;and(4)Abnormal was transformed into abnormal group.To examine the link between longitudinal changes in dyslipidemia along with its components and the risk of ischemic stroke,we utilized multivariate Cox proportional hazards models with hazard ratio(HR)and 95%CI.RESULTS The average age of the participants was 62.32 years±13.00 years,with 329 women making up 54.0%of the sample.Over the course of a mean follow-up of 4.8 years,143 ischemic strokes happened.When normal was transformed into normal group was used as a reference,after full adjustments,the HR for dyslipidemia and ischemic stroke among abnormal was transformed into normal group,normal was transformed into abnormal group and abnormal was transformed into abnormal Wei CC et al.Dyslipidemia changed and ischemic stroke WJCC https://www.wjgnet.com 2 February 6,2025 Volume 13 Issue 4 group were 1.089(95%CI:0.598-1.982;P=0.779),2.369(95%CI:1.424-3.941;P<0.001)and 1.448(95%CI:1.002-2.298;P=0.047)(P for trend was 0.233),respectively.CONCLUSION In individuals with hypertension,longitudinal shifts from normal to abnormal in dyslipidemia-particularly in total and low-density lipoprotein cholesterol-were significantly associated with the risk of ischemic stroke.

Macular microvascular and structural changes on optical coherence tomography angiography in atypical optic neuritis

BACKGROUND Atypical optic neuritis,consisting of neuromyelitis optica spectrum disorders(NMOSD)or myelin oligodendrocyte glycoprotein antibody disease(MOGAD),has a very similar presentation but different prognostic implications and longterm management strategies.Vascular and metabolic factors are being thought to play a role in such autoimmune neuro-inflammatory disorders,apart from the obvious immune mediated damage.With the advent of optical coherence tomography angiography(OCTA),it is easy to pick up on these subclinical macular microvascular and structural changes.AIM To study the macular microvascular and structural changes on OCTA in atypical optic neuritis.METHODS This observational cross-sectional study involved 8 NMOSD and 17 MOGAD patients,diagnosed serologically,as well as 10 healthy controls.Macular vascular density(MVD)and ganglion cell+inner plexiform layer thickness(GCIPL)were studied using OCTA.RESULTS There was a significant reduction in MVD in NMOSD and MOGAD affected as well as unaffected eyes when compared with healthy controls.NMOSD and MOGAD affected eyes had significant GCIPL thinning compared with healthy controls.NMOSD unaffected eyes did not show significant GCIPL thinning compared to healthy controls in contrast to MOGAD unaffected eyes.On comparing NMOSD with MOGAD,there was no significant difference in terms of MVD or GCIPL in the affected or unaffected eyes.CONCLUSION Although significant microvascular and structural changes are present on OCTA between atypical optic neuritis and normal patients,they could not help in differentiating between NMOSD and MOGAD cases.

Recent Progress in Studies on Land Cover Change and Its Regional Climatic Effects over China during Historical Times

The recent progresses on the reconstruction of historical land cover and the studies on regional climatic effects to temperature, precipitation, and the East Asian Monsoon across China were reviewed. Findings show that the land cover in China has been significantly modified by human activities over the last several thousands years, mainly through cropland expansion and forest clearance. The cropland over traditional Chinese agricultural areas increased from 5.32×10^5 km^2 in the mid-17th century to 8.27×10^5 km^2 in the mid-20th century, while the forest area over the Chinese mainland had been reduced by 1.66×10^6 km^2 during the last 300 years. These changes of land cover have been detected as an important driving force of climate change by simulations of climatic effects based on various climate models （including RegCM3, RegCM2-NCC, RIEMS version1, MM5 version 2, and AGCM＋SSiB） with reconstructed historical land cover data or by contrasting current land cover to potential natural vegetation. The human-induced land cover changes over China have led to the enhancement of the East Asian winter monsoon, as well as cooling in winter and warming in summer approximately since 1700. However, the simulation results on annual mean temperature, precipitation, and the East Asian summer monsoon varied from model to model, which cannot be simply attributed to certain forcing so far, but undoubtedly, using different land cover datasets in various simulations played a key role. Thus, developing different regional scales with high time resolution more accurate gridded historical land cover datasets on is needed in the future.

Analyzing the Impact of Scene Transitions on Indoor Camera Localization through Scene Change Detection in Real-Time

Real-time indoor camera localization is a significant problem in indoor robot navigation and surveillance systems.The scene can change during the image sequence and plays a vital role in the localization performance of robotic applications in terms of accuracy and speed.This research proposed a real-time indoor camera localization system based on a recurrent neural network that detects scene change during the image sequence.An annotated image dataset trains the proposed system and predicts the camera pose in real-time.The system mainly improved the localization performance of indoor cameras by more accurately predicting the camera pose.It also recognizes the scene changes during the sequence and evaluates the effects of these changes.This system achieved high accuracy and real-time performance.The scene change detection process was performed using visual rhythm and the proposed recurrent deep architecture,which performed camera pose prediction and scene change impact evaluation.Overall,this study proposed a novel real-time localization system for indoor cameras that detects scene changes and shows how they affect localization performance.

Environmental Changes and Human Impacts on Landscapes near Medieval Steklyanukha-2 Fortress in Russia from Early Iron Age to Modern Times

The development of landscapes in one of the most populated river basins of the southern Russian Far East was studied using pollen and diatom data. The study sites were a multi-layered mountain fortress, Steklyanukha-2, and an Upper Holocene high floodplain sequence of the Steklyanukha River. Buried soil from the fluvial section acts as an environmental archive of the time in which people from the Yankovskaya archeological cultures settled in the river basin. The soil was formed under conditions of decreasing water supply in the valley and prolonged droughts. Findings of pollen Fagopyrum and Urtica signal economic activity in the Early Iron Age.Floodplain lake sediments accumulated from 1.6 to 0.5 kyr, when the valley was actively developed during the Middle Ages. There are signals of the development of secondary birch and oak forests. In the cultural layer of the fortress and lake sediments formed in the Middle Ages, Ambrosia and Xanthium pollens were found and are reliable evidence of agricultural activity in the valley. The pollens of plants typically seen in human-disturbed areas were also found. Indirect evidence of human activity includes non-pollen palynomorphs.The study of diatoms in a depression near a rampart confirmed the archaeologists' assumption that it was used as a water reserve. Pollen spectra from surface soils reflect agricultural activity in the river basin since the second half of the 19th century. The largest amount of pollen of alien and synanthropic plants and weeds, as well as spores of pathogenic fungi and fire indicators, were found here.

Tujia Costumes–Multicolored Attires that Record the Changes of the Times

The traditional clothes of the Tujia ethnic group boast a long history of transforming and progressing with the times.Throughout the transformation process,however,they have always held on to their ethnic characteristics and aesthetic beauty.Fundamentally Tujia traditional clothes are loose-fitting and comfortable,and are a significant physical embodiment of the Tujia culture.They combine simple elegance with glamorous beauty,exhibit quaint brilliance in simplicity,all the while recording the socio-cultural changes of the ethnic minority.

A theory of very short-time price change:security price drivers in times of high-frequency trading

Academic research has identified several factors that affect price movements;however,the scenario changes abruptly in the case of very short time price changes(VSTPC).This topic is not specifically examined in the existing literature;nonetheless,the behavior of the market microstructure is quite different at the subsecond scale.Indeed,below a certain psychological time threshold,most factors typically influencing price changes cease to apply.This paper analyzes several parameters considered to affect price changes and identifies four of them as potentially influencing VSTPC.These factors are previous volatility,scarce liquidity,high quantity exchanged,and stop-loss(SL)orders(seldom mentioned in the literature).These four parameters are examined by means of a mathematical model,audit trail data analysis,Granger-causality testing,and agent-based model.The results of these four techniques converge to suggest a nonlinear combination of previous volatility,liquidity,and SL orders as the main causes of excess volatility.However,contrary to mainstream literature on trading time above a certain psychological threshold,the volumes exchanged are not integral agents for VSTPC.Currently,financial markets face many ultrafast orders,yet a coherent theory of price change at time scales incomprehensible by humans and only manageable by computers is still lacking.The theory presented in this paper attempts to fill this gap.The outcome of such a theory is important for purposes of market stability,crisis avoidance,investment planning,risk management,and high-frequency trading.

StarTimes Kenya Promotes Sino-Kenya Film and TV Art Exchanges

Kenya has large media markets and a complex media environment.Since it was put into operation in 2013,StarTimes Kenya has taken the responsibility of tellig China's stories well,making the nation's voices heard and presenting a true,multidimensional,and panoramic view of China".

Periodic Signature Change in Spacetimes of Embedding Class One

The idea of an oscillating Universe has remained a topic of interest even after the discovery of dark energy. This paper confirms this idea by means of another well-established theory in general relativity, the embedding of curved spacetimes in higher-dimensional flat spacetimes: an n-dimensional Riemannian space is said to be of embedding class m if m +n is the lowest dimension of the flat space in which the given space can be embedded;here . So a four-dimensional Riemannian space is of class two and can therefore be embedded in a six-dimensional flat space. A line element of class two can be reduced to a line element of class one by a suitable coordinate transformation. The extra dimension can be either spacelike or timelike, leading to accelerating and decelerating expansions, respectively. Accordingly, it is proposed in this paper that the free parameter occurring in the transformation be a periodic function of time. The result is a mathematical model that can be interpreted as a periodic change in the signature of the embedding space. This signature change may be the best model for an oscillating Universe and complements various models proposed in the literature.

Strengthening Exchanges and Cooperation in the Northeast Asia Region Follows the Trend of the Times——Sidelights of the 10^(th) Northeast Asia Youth Forum

The 10thNortheast Asia Youth Forum,with the theme of China-ROK-Japan Youth Employment Guidance,sponsored by Moral Re-Armament/Initiatives of Change(MRA/IC)-Korea was held in Seoul and Cheonan from August 12 to 17.Seventy five college students from 37 universities sent by China International Youth Exchange Center,Moral Re-Armament/Initiatives of Change(MRA/IC)-Korea and Japan Society attended the Forum.Lee Boksil,Vice-Minister of Ministry of

Changing the balance of the MTO reaction dual-cycle mechanism: Reactions over ZSM-5 with varying contact times

The methanol to olefins （MTO） reaction was performed over ZSM‐5 zeolite at 300℃ under various methanol weight hourly space velocity （WHSV） values. During these trials, the catalytic perfor‐mance was assessed, in addition to the formation and function of organic compounds retained in the zeolite. Analysis of reaction effluents and confined organics demonstrated a dual‐cycle reaction mechanism when employing ZSM‐5. The extent of the hydrogen transfer reaction, a secondary reac‐tion in the MTO process, varied as the catalyst‐methanol contact time was changed. In addition, 12C/13C‐methanol switch experiments indicated a relationship between the dual‐cycle mechanism and the extent of the hydrogen transfer reaction. Reactions employing a low methanol WHSV in conjunction with a long contact time favored the hydrogen transfer reaction to give alkene products and promoted the generation and accumulation of retained organic species, such as aromatics and methylcyclopentadienes, which enhance the aromatic cycle. When using higher WHSV values, the reduced contact times lessened the extent of the hydrogen transfer reaction and limited the genera‐tion of methylcyclopentadienes and aromatic species. This suppressed the aromatic cycle, such that the alkene cycle became the dominant route during the MTO reaction.

Timing theory integrated nursing combined behavior change integrated theory of nursing on primiparous influence

BACKGROUND The comprehension and utilization of timing theory and behavior change can offer a more extensive and individualized provision of support and treatment alternatives for primipara.This has the potential to enhance the psychological well-being and overall quality of life for primipara,while also furnishing healthcare providers with efficacious interventions to tackle the psychological and physiological obstacles encountered during the stages of pregnancy and postpartum.AIM To explore the effect of timing theory combined with behavior change on selfefficacy,negative emotions and quality of life in patients with primipara.METHODS A total of 80 primipara cases were selected and admitted to our hospital between August 2020 and May 2022.These cases were divided into two groups,namely the observation group and the control group,with 40 cases in each group.The nursing interventions differed between the two groups,with the control group receiving routine nursing and the observation group receiving integrated nursing based on the timing theory and behavior change.The study aimed to compare the pre-and post-nursing scores of Chinese Perceived Stress Scale(CPSS),Edinburgh Postpartum Depression Scale(EPDS),Self-rating Anxiety Scale(SAS),breast milk knowledge,self-efficacy,and SF-36 quality of life in both groups.RESULTS After nursing,the CPSS,EPDS,and SAS scores of the two groups was significantly lower than that before nursing,and the CPSS,EPDS,and SAS scores of the observation group was significantly lower than that of the control group(P=0.002,P=0.011,and P=0.001 respectively).After nursing,the breastfeeding knowledge mastery,selfefficacy,and SF-36 quality of life scores was significantly higher than that before nursing,and the breastfeeding knowledge mastery(P=0.013),self-efficacy(P=0.008),and SF-36 quality of life(P=0.011)scores of the observation group was significantly higher than that of the control group.CONCLUSION The integration of timing theory and behavior change integrated theory has been found to be an effective approach in alleviating negative mood and stress experienced by primipara individuals,while also enhancing their selfefficacy and overall quality of life.This study focuses on the key concepts of timing theory,behavior change,primipara individuals,negative mood,and quality of life.

Recent advances in graphene-based phase change composites for thermal energy storage and management

Energy storage and conservation are receiving increased attention due to rising global energy demands.Therefore,the development of energy storage materials is crucial.Thermal energy storage(TES)systems based on phase change materials(PCMs)have increased in prominence over the past two decades,not only because of their outstanding heat storage capacities but also their superior thermal energy regulation capability.However,issues such as leakage and low thermal conductivity limit their applicability in a variety of settings.Carbon-based materials such as graphene and its derivatives can be utilized to surmount these obstacles.This study examines the recent advancements in graphene-based phase change composites(PCCs),where graphene-based nanostructures such as graphene,graphene oxide(GO),functionalized graphene/GO,and graphene aerogel(GA)are incorporated into PCMs to substantially enhance their shape stability and thermal conductivity that could be translated to better storage capacity,durability,and temperature response,thus boosting their attractiveness for TES systems.In addition,the applications of these graphene-based PCCs in various TES disciplines,such as energy conservation in buildings,solar utilization,and battery thermal management,are discussed and summarized.

Global Change in Agricultural Flash Drought over the 21st Century

Agricultural flash droughts are high-impact phenomena, characterized by rapid soil moisture dry down. The ensuing dry conditions can persist for weeks to months, with detrimental effects on natural ecosystems and crop cultivation. Increases in the frequency of these rare events in a future warmer climate would have significant societal impact. This study uses an ensemble of 10 Coupled Model Intercomparison Project(CMIP) models to investigate the projected change in agricultural flash drought during the 21st century. Comparison across geographical regions and climatic zones indicates that individual events are preceded by anomalously low relative humidity and precipitation, with long-term trends governed by changes in temperature, relative humidity, and soil moisture. As a result of these processes, the frequency of both upperlevel and root-zone flash drought is projected to more than double in the mid-and high latitudes over the 21st century, with hot spots developing in the temperate regions of Europe, and humid regions of South America, Europe, and southern Africa.

Time-lapse geophysical technology-based study on overburden strata changes induced by modern coal mining

To study the impact of modern coal mining on overlying strata and its water bearing conditions,integrated time-lapse geophysical prospecting integrating 3D seismic,electrical and ground penetrating radar method were used.Through observing and analyzing the geophysical data variations of all stages of pre-mining,mining and post-mining as well as post-mining deposition stable period,impacts of coal mining on stratigraphic structure and its water bearing were studied and modern coal mining induced stratigraphic change pattern was summarized.The research result shows that the stratigraphic structure and the water bearing of surface layer during modern coal mining have self-healing pattern with mining time;the self-healing capability of near-surface strata is relatively strong while the roof weak;water bearing selfhealing of near-surface strata is relatively high while the roof strata adjacent to mined coal beds low.Due to integrated time-lapse geophysical prospecting technology has extra time dimension which makes up the deficiency of static analysis of conventional geophysical methods,it can better highlight the dynamic changes of modern coal mining induced overburden strata and its water bearing conditions.

Shikimic acid accelerates phase change and flowering in Chinese jujube

The juvenile-to-adult phase change with first flowering as the indicator plays a crucial role in the lifecycle of fruit trees. However, the molecular mechanisms underlying phase change in fruit trees remain largely unknown. Shikimic acid (ShA) pathway is a main metabolic pathway closely related to the synthesis of hormones and many important secondary metabolites participating in plant phase change. So,whether ShA regulates phase change in plants is worth clarifying. Here, the distinct morphological characteristics and the underlying mechanisms of phase change in jujube (Ziziphus jujuba Mill.), an important fruit tree native to China with nutritious fruit and outstanding tolerance abiotic stresses, were clarified. A combined transcriptome and metabolome analysis found that ShA is positively involved in jujube(Yuhong’×Xing 16’) phase change. The genes in the upstream of ShA synthesis pathway (ZjDAHPS, ZjDHQS and ZjSDH), the contents of ShA and the downstream secondary metabolites like phenols were significantly upregulated in the phase change period. Further, the treatment of spraying exogenous ShA verified that ShA at a very low concentration (60 mg·L^(-1)) can substantially speed up the phase change and flowering of jujube and other tested plants including Arabidopsis, tomato and wheat. The exogenous ShA (60 mg·L^(-1)) treatment in jujube seedlings could increase the accumulation of endogenous ShA, enhance leaf photosynthesis and the synthesis of phenols especially flavonoids and phenolic acids, and promote the expression of genes (ZjCOs, ZjNFYs and ZjPHYs) involved in flowering pathway. Basing on above results, we put forward a propose for the underlying mechanism of ShA regulating phase change, and a hypothesis that ShA could be considered a phytohormone-like substance because it is endogenous, ubiquitous, movable and highly efficient at very low concentrations. This study highlights the critical role of ShA in plant phase change and its phytohormone-like properties.

Projected changes in extreme snowfall events over the Tibetan Plateau based on a set of RCM simulations

Extreme snowfall events over the Tibetan Plateau(TP)cause considerable damage to local society and natural ecosystems.In this study,the authors investigate the projected changes in such events over the TP and its surrounding areas based on an ensemble of a set of 21st century climate change projections using a regional climate model,RegCM4.The model is driven by five CMIP5 global climate models at a grid spacing of 25 km,under the RCP4.5 and RCP8.5 pathways.Four modified ETCCDI extreme indices-namely,SNOWTOT,S1mm,S10mm,and Sx5day-are employed to characterize the extreme snowfall events.RegCM4 generally reproduces the spatial distribution of the indices over the region,although with a tendency of overestimation.For the projected changes,a general decrease in SNOWTOT is found over most of the TP,with greater magnitude and better cross-simulation agreement over the eastern part.All the simulations project an overall decrease in S1mm,ranging from a 25%decrease in the west and to a 50%decrease in the east of the TP.Both S10mm and Sx5day are projected to decrease over the eastern part and increase over the central and western parts of the TP.Notably,S10mm shows a marked increase(more than double)with high cross-simulation agreement over the central TP.Significant increases in all four indices are found over the Tarim and Qaidam basins,and northwestern China north of the TP.The projected changes show topographic dependence over the TP in the latitudinal direction,and tend to decrease/increase in low-/high-altitude areas.

Climate change drives flooding risk increases in the Yellow River Basin

The Yellow River Basin(YRB)has experienced severe floods and continuous riverbed elevation throughout history.Global climate change has been suggested to be driving a worldwide increase in flooding risk.However,owing to insufficient evidence,the quantitative correlation between flooding and climate change remains illdefined.We present a long time series of maximum flood discharge in the YRB dating back to 1843 compiled from historical documents and instrument measurements.Variations in yearly maximum flood discharge show distinct periods:a dramatic decreasing period from 1843 to 1950,and an oscillating gentle decreasing from 1950 to 2021,with the latter period also showing increasing more extreme floods.A Mann-Kendall test analysis suggests that the latter period can be further split into two distinct sub-periods:an oscillating gentle decreasing period from 1950 to 2000,and a clear recent increasing period from 2000 to 2021.We further predict that climate change will cause an ongoing remarkable increase in future flooding risk and an∼44.4 billion US dollars loss of floods in the YRB in 2100.

Self‑Assembly of Binderless MXene Aerogel for Multiple‑Scenario and Responsive Phase Change Composites with Ultrahigh Thermal Energy Storage Density and Exceptional Electromagnetic Interference Shielding

The severe dependence of traditional phase change materials(PCMs)on the temperature-response and lattice deficiencies in versatility cannot satisfy demand for using such materials in complex application scenarios.Here,we introduced metal ions to induce the self-assembly of MXene nanosheets and achieve their ordered arrangement by combining suction filtration and rapid freezing.Subsequently,a series of MXene/K^(+)/paraffin wax(PW)phase change composites(PCCs)were obtained via vacuum impregnation in molten PW.The prepared MXene-based PCCs showed versatile applications from macroscale technologies,successfully transforming solar,electric,and magnetic energy into thermal energy stored as latent heat in the PCCs.Moreover,due to the absence of binder in the MXene-based aerogel,MK3@PW exhibits a prime solar-thermal conversion efficiency(98.4%).Notably,MK3@PW can further convert the collected heat energy into electric energy through thermoelectric equipment and realize favorable solar-thermal-electric conversion(producing 206 mV of voltage with light radiation intensity of 200 mw cm^(−2)).An excellent Joule heat performance(reaching 105℃with an input voltage of 2.5 V)and responsive magnetic-thermal conversion behavior(a charging time of 11.8 s can achieve a thermal insulation effect of 285 s)for contactless thermotherapy were also demonstrated by the MK3@PW.Specifically,as a result of the ordered arrangement of MXene nanosheet self-assembly induced by potassium ions,MK3@PW PCC exhibits a higher electromagnetic shielding efficiency value(57.7 dB)than pure MXene aerogel/PW PCC(29.8 dB)with the same MXene mass.This work presents an opportunity for the multi-scene response and practical application of PCMs that satisfy demand of next-generation multifunctional PCCs.

A study on the simulation of carbon and water fluxes of Dangxiong alpine meadow and its response to climate change

The alpine meadow ecosystem accounts for 27%of the total area of the Tibetan Plateau and is also one of the most important vegetation types.The Dangxiong alpine meadow ecosystem,located in the south-central part of the Tibetan Plateau,is a typical example.To understand the carbon and water fluxes,water use efficiency(WUE),and their responses to future climate change for the alpine meadow ecosystem in the Dangxiong area,two parameter estimation methods,the Model-independent Parameter Estimation(PEST)and the Dynamic Dimensions Search(DDS),were used to optimize the Biome-BGC model.Then,the gross primary productivity(GPP)and evapotranspiration(ET)were simulated.The results show that the DDS parameter calibration method has a better performance.The annual GPP and ET show an increasing trend,while the WUE shows a decreasing trend.Meanwhile,ET and GPP reach their peaks in July and August,respectively,and WUE shows a“dual-peak”pattern,reaching peaks in May and November.Furthermore,according to the simulation results for the next nearly 100 years,the ensemble average GPP and ET exhibit a significant increasing trend,and the growth rate under the SSP5–8.5 scenario is greater than that under the SSP2–4.5 scenario.WUE shows an increasing trend under the SSP2–4.5 scenario and a significant increasing trend under the SSP5–8.5 scenario.This study has important scientific significance for carbon and water cycle prediction and vegetation ecological protection on the Tibetan Plateau.