Objective:To explore the effect of the Xian Fang Huo Ming Yin(XFHM)for treating cutaneous infections and promoting wound healing in patients with perianal abscesses.Methods:Sixty-one patients with perianal abscesses w...Objective:To explore the effect of the Xian Fang Huo Ming Yin(XFHM)for treating cutaneous infections and promoting wound healing in patients with perianal abscesses.Methods:Sixty-one patients with perianal abscesses who were admitted to our hospital(Xinghua City People’s Hospital)from May 2022 to May 2023 were selected and randomly divided into two groups,a control group(30 cases)and a study group(31 cases).Both groups received surgical treatment.The control group received conventional treatment and warm water fumigation,sitz bath,and surgical dressing change after surgery,while the research group received XFHM based on the control group.XFHM was taken orally and replaced with warm water for fumigation and sitz bathing.Both groups received treatment for 4 weeks but discontinued sitz bathing after 2 weeks.Various clinical indicators between the two groups were compared.Results:The total clinical effective rate and wound recovery rate of the study group were higher than that of the control group.There were differences in the wound pain scores,surrounding tissue edema,and wound secretions at different time points.Both groups experienced wound pain.The scores of wound pain,surrounding tissue edema,and wound secretions of the study group were lower than those of the control group,7 and 14 days after surgery.The serum interleukin 6(IL-6),tumor necrosis factor-alpha(TNF-α)levels,and pH values of the study group were lower than those of the control group 10 days after surgery(P<0.05).Conclusion:The application of XFHM for treating cutaneous infections and promoting wound healing in patients with perianal abscesses improved the treatment outcome,alleviated clinical symptoms,and promoted healing.展开更多
Based on the contents and temperament of pastoral poetries written by TAO Yuan-ming,by centering on respecting the nature,indifference and optimism,and plainness and authenticity,the paper had analyzed aesthetic ideol...Based on the contents and temperament of pastoral poetries written by TAO Yuan-ming,by centering on respecting the nature,indifference and optimism,and plainness and authenticity,the paper had analyzed aesthetic ideologies contained in his poetries.On this basis,it had discussed the influence of aesthetic ideology of TAO Yuan-ming on the style of classical gardens in South China,which were quiet and natural,elegant and fresh,simple and plain,and far-reaching in artistic conception.By combining with cases,it pointed out that the poetic prose had been directly quoted as the names of gardens or scenic spots of classical gardens in South China,and showed that the aesthetic ideology of TAO Yuan-ming had set up a successful ideal model for cultural landscapes,producing far-reaching influence on the aesthetic state of mind of gardeners or owners of gardens,further instilling humanistic spirit into classical gardens in South China.展开更多
Only in the presence of sidelobe jamming (SLJ), can the conventional adaptive monopulse technique null the jamming effectively and maintain the monopulse angle estimation accuracy simultaneously. While mainlobe jamm...Only in the presence of sidelobe jamming (SLJ), can the conventional adaptive monopulse technique null the jamming effectively and maintain the monopulse angle estimation accuracy simultaneously. While mainlobe jamming (MLJ) exists, the mainlobe of adaptive pattern will subject to serious distortion, which results in a failure of detecting and tracking targets by monopulse technique. Therefore, a monopulse angle estimation algorithm based on combining sum-difference beam and auxiliary beam is presented. This algorithm utilizes both high gain difference beams and high gain auxiliary beams for cancelling the mainlobe jammer and multiple sidelobe jammers (SLJs) while keeping an adap- tive monopulse ratio. Theoretical analysis and simulation results indicate that the serious invalidation of monopulse technique in MLJ and SLJs scenarios is resolved well, which improves the monopulse angle accuracy greatly. Furthermore, the proposed algorithm is of simple implementation and low computational complexity.展开更多
In the late Ming period,Xu Guangqi and other Catholic literati were actively involved with military affairs because of the invasion of the Manchu forces and the threat of uprisings.The story of how they imported Europ...In the late Ming period,Xu Guangqi and other Catholic literati were actively involved with military affairs because of the invasion of the Manchu forces and the threat of uprisings.The story of how they imported European cannons and gunners from Macao is now quite famous.However,the introduction of European fortifications,mainly the trace Italienne,in the same period is still relatively unknown.Xu Guangqi and his student Sun Yuanhua exerted considerable efforts in advocating European-style bastions.Xu not only received help from Jesuits,but also support from some Fujianese who were familiar with Intramuros,the Spanish walled city of Manila.In addition to Xu and Sun,Han Lin and Han Yun(also Xu’s students)prepared a Chinese treatise on European fortification architecture based on Italian sources and tried to put the knowledge into practice.Another relevant figure is Ma Weicheng,who allegedly directed the building of 32 angled bastions in three cities around 1640.Although a few recorded writings and practices of constructing European-style fortification appeared in the first half of the seventeenth century,soon afterwards the art of trace Italienne met its end prematurely in China.To a great extent,the swift collapse of the Ming dynasty eliminated the possibility of spreading the new defense technology.Throughout the eighteenth century,the Qing dynasty enjoyed long-term peace,and the warfare at the frontiers brought few threats to the city walls.There was thus little urgency to develop innovative defensive works and European fortification sunk into oblivion until the mid-nineteenth century.展开更多
Objective The effects of Shuang Dan Ming Mu capsule on expression of VEGF-a,VEGF-b,VEGF-c and the VEGF receptor,Flk-1,were examined in a diabetic retinopathy rats model.Methods Forty Sprague-Dawley(SD)rats were random...Objective The effects of Shuang Dan Ming Mu capsule on expression of VEGF-a,VEGF-b,VEGF-c and the VEGF receptor,Flk-1,were examined in a diabetic retinopathy rats model.Methods Forty Sprague-Dawley(SD)rats were randomized into Groups A(blank),B(model),C(Shuang Dan Ming Mu)and D(positive control)group,with each group containing10rats and20eyes.Rats from groups B,C and D were administered one dose of50mg/kg streptozotocin(STZ)by tail vein injection to establish a diabetic rat model.One week after model preparation,medication was continuously administered by gavage.After gavage for8weeks,the animals were sacrificed and retinal expression of VEGF-a,VEGF-b,VEGF-c and Flk-1was quantified by immunohistochemical analysis.Results At week8of drug administration after model preparation,the average protein expression grayscale values for VEGF-a,VEGF-b,VEGF-c and Flk-1in the rats model,Shuang Dan Ming Mu and positive control groups were all lower than those in the normal group,while the mean optical density values were higher than those in the normal group.When the model group was compared to the normal group,the difference was extremely significant(P<0.01).The mean grayscale values of VEGF-a,VEGF-b,VEGF-c and Flk-1in the Shuang Dan Ming Mu and positive control groups were all higher than those in the model group,while the mean optical density values were lower than those in the model group(P<0.05or0.01).Conclusion Shuang Dan Ming Mu capsule can significantly decrease the expression of VEGF-a,VEGF-b,VEGF-c and Flk-1in the retinas of diabetic model rats and exhibit some protective effects in their retinas.展开更多
An alpha-uniformized Markov chain is defined by the concept of equivalent infinitesimalgenerator for a semi-Markov decision process (SMDP) with both average- and discounted-criteria.According to the relations of their...An alpha-uniformized Markov chain is defined by the concept of equivalent infinitesimalgenerator for a semi-Markov decision process (SMDP) with both average- and discounted-criteria.According to the relations of their performance measures and performance potentials, the optimiza-tion of an SMDP can be realized by simulating the chain. For the critic model of neuro-dynamicprogramming (NDP), a neuro-policy iteration (NPI) algorithm is presented, and the performanceerror bound is shown as there are approximate error and improvement error in each iteration step.The obtained results may be extended to Markov systems, and have much applicability. Finally, anumerical example is provided.展开更多
Objective To analyze the effects of Dan Huang Ming Mu Recipe(DHMMR)(a pharmaceutical preparation from herbs and having the function of replenishing vital essence,removing heat,promoting blood circulation and excreting...Objective To analyze the effects of Dan Huang Ming Mu Recipe(DHMMR)(a pharmaceutical preparation from herbs and having the function of replenishing vital essence,removing heat,promoting blood circulation and excreting pathogenic water) on diabetic retinopathy(DR) after retinal laser photocoagulation through regulating the expression of vascular endothelial growth factor(VEGF) and pigment epithelium-derived factor(PEDF).Methods Forty male Brown Norway(BN) rats were randomly divided into blank group(group A,10 BN rats) and model group(30 BN rats).DR models were induced by 40 mg/kg streptozotocin(STZ) and the body weight and blood glucose of rats were monitored.After 12-week injection,fluorescein fundus angiography(FFA) and histopathological examination were detected to confirm the successful establishment of DR models.Subsequently,the right eyes of model group rats were conducted retinal laser photocoagulation with the left eyes having no retinal laser photocoagulation and rats of the model group were randomly divided into group B(the model control group),group C(the positive control group),and group D(the DHMMR group),with 10 rats in each group.Rats of the group A and the group B were given vehicle,and the group C were given calcium dobesilate suspension by gavage,and the group D were given DHMMR by gavage.After 4-week gavage,FFA was carried out to observe the fundus microvascular change.Then,the rats were sacrificed to do histopathological examinations and the serum levels of P-selectin,cAMP,cGMP,and the relative expression of the protein of VEGF and PEDF in retina were detected.Results After 12-week STZ injection,the blood glucose of the model group were pronouncedly higher than the blank group(P < 0.01).Fundus micro-hemangioma changes were observed in the rats of the model group through FFA,and the rats of the blank group did not see any changes.The pictures of HE staining showed that the retinal structure of the model group was more disordered than the blank group.After 4-week gavage,treatments with DHMMR showed dramatic reduction of serum levels of Pselectin,cAMP and cGMP compared with the group B(P < 0.01).FFA and histopathological examinations of DHMMR-treated rats revealed significantly suppression of retinal edema,fundus microvascular destruction and retinal destruction distinguishing from the group B.And the relative expression of VEGF protein of the group D and the group A was markedly lower than that of the group B(P < 0.01).The relative expression of PEDF protein of the group D and the group A was dramatically higher than that of the group B to the contrary(P < 0.01).Conclusions DHMMR demonstrates pronounced suppressive effects on the progression of DR after retinal laser photocoagulation,through down-regulating VEGF and upregulating PEDF.展开更多
Being based on preliminary study of Kunming famous temples during the Ming and Qing dynasties,field investigation was carried out about the framework of landscape,layout of waters,characteristic of structure and plant...Being based on preliminary study of Kunming famous temples during the Ming and Qing dynasties,field investigation was carried out about the framework of landscape,layout of waters,characteristic of structure and plant furnishing in Tanhua temple,Black Dragon Pool,Masijid of Shuncheng,Haiyuan temple and Golden Shrine which are famous temple garden in Kunming. A simple interpretation was drawn of artistic characteristics on temple garden in Kunming during the Ming and Qing dynasties via analytical investigation on many factors which influenced the development of garden of Dynasties of Ming and Qing. Then we have reviewed the elemental traits of temple garden built at that time,put forward some constructive suggestions on how to protect and develop those temple garden now still exist in Kunming.展开更多
This paper explored the background of the leisure boom among the literati in the late Ming Dynasty from the aspects of politics, economy, ideology and social environment, and elaborated the leisure styles of the liter...This paper explored the background of the leisure boom among the literati in the late Ming Dynasty from the aspects of politics, economy, ideology and social environment, and elaborated the leisure styles of the literati in terms of enjoying a sightseeing tour, sampling wine and tea, appreciating and collecting calligraphy and painting works, favoring theatergoing, indulging in dallying with prostitutes, practicing meditation, and building gardens, and analyzed the influence of their leisure styles on the painting and calligraphy art, drama, literary creation, garden construction and other aspects of the society at that time. It is hoped that this paper can provide a deep understanding of social politics, economy, ideology and culture in the late Ming Dynasty and a reference for the development of the current leisure tourism.展开更多
The Black-winged Monarch(Monarcha frater)inhabits low-mid elevation forests across New Guinea and far northeastern Australia.Of its four recognized subspecies,M.f.canescens is migratory,breeding in tropical north-east...The Black-winged Monarch(Monarcha frater)inhabits low-mid elevation forests across New Guinea and far northeastern Australia.Of its four recognized subspecies,M.f.canescens is migratory,breeding in tropical north-eastern Australia from approximately November–March.The non-breeding range of M.f.canescens,apart from some individuals overwintering in Australia,has been unknown for>100 years.Data from 194 New Guinean and Australian specimens and a literature review have not solved this mystery;the narrow latitudinal range of the intratropical migration may inhibit use of GPS loggers in resolving the migration route.Field work in central and western parts of southern New Guinea is needed.Specimen data,however,revealed an essentially overlooked population in north-western New Guinea east of the Bird's Head Peninsula phenotypically indistinguishable from nominate M.f.frater of that Peninsula.Future genomic analysis of the complex will be largely done from toepad skin because frozen tissue samples for DNA analysis exist only of four individuals of what we suggest should be elevated to species rank as M.periophthalmicus.We discuss how genomic analysis might distinguish among alternative taxonomic hypotheses of one,two or three species.We suggest English names for what we consider to be three diagnosable taxa worth recognizing at species rank in this group:Arfak Monarch corresponding to M.frater(Bird's Head Peninsula and the“new”population of north-western New Guinea);Pearly Monarch for M.canescens(Australia and still unknown non-breeding range),and Masked Monarch for M.periophthalmicus(including kunupi,elsewhere in New Guinea).展开更多
Taking a section of the Ming Dynasty Outer City Wall from Xianhe Gate to Qilin Gate for example, this paper proposed the landscape design from the perspective of experience tourism, highlighted the wal, and took the b...Taking a section of the Ming Dynasty Outer City Wall from Xianhe Gate to Qilin Gate for example, this paper proposed the landscape design from the perspective of experience tourism, highlighted the wal, and took the beautiful environment and rich history and cultures of the Ming Dynasty Outer City Wall as the essential experience elements, to build cultural recreational corridors with the theme of "experiencing the Ming Dynasty culture", so that visitors will get unforgettable experience, tourism quality, popularity of the Ming Dynasty Outer City Wall as well as its cultural and educational significance will be further promoted.展开更多
Starting from the Tianping Mountain theme painting in Suzhou in the Ming Dynasty, we explore how did the painters and literati in this period shape the image of the Tianping Mountain through their works, thereby refle...Starting from the Tianping Mountain theme painting in Suzhou in the Ming Dynasty, we explore how did the painters and literati in this period shape the image of the Tianping Mountain through their works, thereby reflecting their understanding on many landscapes on the Tianping Mountain. By exploring a series of paintings and poems, we try to analyze the characteristics and cultural connotation of landscape paintings of the Tianping Mountain in the Ming Dynasty, which is conducive to improving position of the Tianping Mountain natural and humanistic landscape in Suzhou.展开更多
Phyto-groups on 5 remained city wall sections of the Ming Dynasty in Nanjing City was investigated through on-the-spot survey,99 species of 93 genera,60 families were found,and species of Asteraceae and Poaceae accoun...Phyto-groups on 5 remained city wall sections of the Ming Dynasty in Nanjing City was investigated through on-the-spot survey,99 species of 93 genera,60 families were found,and species of Asteraceae and Poaceae accounted for the largest ratio.Plants on the city wall are characterized by strong drought resistance and precocity,their seeds can grow out of the wall cracks,and roots secrete acidoid and obtain nutrients from wall bricks.Plants on different wall sections are different,and human interventions influence phyto-groups on the city wall greatly.On this basis,it was concluded that plants had negative influence on city wall,especially plant roots destroyed the wall seriously.Corresponding researches were carried out and prevention suggestions proposed to provide scientific support for the protection of ancient city walls in Nanjing City.展开更多
文摘Objective:To explore the effect of the Xian Fang Huo Ming Yin(XFHM)for treating cutaneous infections and promoting wound healing in patients with perianal abscesses.Methods:Sixty-one patients with perianal abscesses who were admitted to our hospital(Xinghua City People’s Hospital)from May 2022 to May 2023 were selected and randomly divided into two groups,a control group(30 cases)and a study group(31 cases).Both groups received surgical treatment.The control group received conventional treatment and warm water fumigation,sitz bath,and surgical dressing change after surgery,while the research group received XFHM based on the control group.XFHM was taken orally and replaced with warm water for fumigation and sitz bathing.Both groups received treatment for 4 weeks but discontinued sitz bathing after 2 weeks.Various clinical indicators between the two groups were compared.Results:The total clinical effective rate and wound recovery rate of the study group were higher than that of the control group.There were differences in the wound pain scores,surrounding tissue edema,and wound secretions at different time points.Both groups experienced wound pain.The scores of wound pain,surrounding tissue edema,and wound secretions of the study group were lower than those of the control group,7 and 14 days after surgery.The serum interleukin 6(IL-6),tumor necrosis factor-alpha(TNF-α)levels,and pH values of the study group were lower than those of the control group 10 days after surgery(P<0.05).Conclusion:The application of XFHM for treating cutaneous infections and promoting wound healing in patients with perianal abscesses improved the treatment outcome,alleviated clinical symptoms,and promoted healing.
基金Supported by Fund for Scientific Research of Nanjing University of Finance and Economics (B2010017)~~
文摘Based on the contents and temperament of pastoral poetries written by TAO Yuan-ming,by centering on respecting the nature,indifference and optimism,and plainness and authenticity,the paper had analyzed aesthetic ideologies contained in his poetries.On this basis,it had discussed the influence of aesthetic ideology of TAO Yuan-ming on the style of classical gardens in South China,which were quiet and natural,elegant and fresh,simple and plain,and far-reaching in artistic conception.By combining with cases,it pointed out that the poetic prose had been directly quoted as the names of gardens or scenic spots of classical gardens in South China,and showed that the aesthetic ideology of TAO Yuan-ming had set up a successful ideal model for cultural landscapes,producing far-reaching influence on the aesthetic state of mind of gardeners or owners of gardens,further instilling humanistic spirit into classical gardens in South China.
基金supported by the National Natural Science Foundation of China(60925005)
文摘Only in the presence of sidelobe jamming (SLJ), can the conventional adaptive monopulse technique null the jamming effectively and maintain the monopulse angle estimation accuracy simultaneously. While mainlobe jamming (MLJ) exists, the mainlobe of adaptive pattern will subject to serious distortion, which results in a failure of detecting and tracking targets by monopulse technique. Therefore, a monopulse angle estimation algorithm based on combining sum-difference beam and auxiliary beam is presented. This algorithm utilizes both high gain difference beams and high gain auxiliary beams for cancelling the mainlobe jammer and multiple sidelobe jammers (SLJs) while keeping an adap- tive monopulse ratio. Theoretical analysis and simulation results indicate that the serious invalidation of monopulse technique in MLJ and SLJs scenarios is resolved well, which improves the monopulse angle accuracy greatly. Furthermore, the proposed algorithm is of simple implementation and low computational complexity.
文摘In the late Ming period,Xu Guangqi and other Catholic literati were actively involved with military affairs because of the invasion of the Manchu forces and the threat of uprisings.The story of how they imported European cannons and gunners from Macao is now quite famous.However,the introduction of European fortifications,mainly the trace Italienne,in the same period is still relatively unknown.Xu Guangqi and his student Sun Yuanhua exerted considerable efforts in advocating European-style bastions.Xu not only received help from Jesuits,but also support from some Fujianese who were familiar with Intramuros,the Spanish walled city of Manila.In addition to Xu and Sun,Han Lin and Han Yun(also Xu’s students)prepared a Chinese treatise on European fortification architecture based on Italian sources and tried to put the knowledge into practice.Another relevant figure is Ma Weicheng,who allegedly directed the building of 32 angled bastions in three cities around 1640.Although a few recorded writings and practices of constructing European-style fortification appeared in the first half of the seventeenth century,soon afterwards the art of trace Italienne met its end prematurely in China.To a great extent,the swift collapse of the Ming dynasty eliminated the possibility of spreading the new defense technology.Throughout the eighteenth century,the Qing dynasty enjoyed long-term peace,and the warfare at the frontiers brought few threats to the city walls.There was thus little urgency to develop innovative defensive works and European fortification sunk into oblivion until the mid-nineteenth century.
基金funding support from the National Natural Science Foundation General Program (No. 814737370)Hunan Province Graduate Student Research Innovation Program (No. CX2016B377 and No. CX2017B432)+4 种基金Traditional Chinese Medicine Prevention and Treatment of Facial Feature Disease Hunan Province Key Laboratory Construction Program (No. 2017TP1018)Changsha City Science and Technology Program (No. kc1704005)Central Finance Supported Local High School Construction ProjectState Administration of Traditional Chinese Medicine Ophthalmology Key Discipline Construction ProjectHunan Province Traditional Chinese Medicine Facial Feature Key Discipline Construction Project
文摘Objective The effects of Shuang Dan Ming Mu capsule on expression of VEGF-a,VEGF-b,VEGF-c and the VEGF receptor,Flk-1,were examined in a diabetic retinopathy rats model.Methods Forty Sprague-Dawley(SD)rats were randomized into Groups A(blank),B(model),C(Shuang Dan Ming Mu)and D(positive control)group,with each group containing10rats and20eyes.Rats from groups B,C and D were administered one dose of50mg/kg streptozotocin(STZ)by tail vein injection to establish a diabetic rat model.One week after model preparation,medication was continuously administered by gavage.After gavage for8weeks,the animals were sacrificed and retinal expression of VEGF-a,VEGF-b,VEGF-c and Flk-1was quantified by immunohistochemical analysis.Results At week8of drug administration after model preparation,the average protein expression grayscale values for VEGF-a,VEGF-b,VEGF-c and Flk-1in the rats model,Shuang Dan Ming Mu and positive control groups were all lower than those in the normal group,while the mean optical density values were higher than those in the normal group.When the model group was compared to the normal group,the difference was extremely significant(P<0.01).The mean grayscale values of VEGF-a,VEGF-b,VEGF-c and Flk-1in the Shuang Dan Ming Mu and positive control groups were all higher than those in the model group,while the mean optical density values were lower than those in the model group(P<0.05or0.01).Conclusion Shuang Dan Ming Mu capsule can significantly decrease the expression of VEGF-a,VEGF-b,VEGF-c and Flk-1in the retinas of diabetic model rats and exhibit some protective effects in their retinas.
文摘An alpha-uniformized Markov chain is defined by the concept of equivalent infinitesimalgenerator for a semi-Markov decision process (SMDP) with both average- and discounted-criteria.According to the relations of their performance measures and performance potentials, the optimiza-tion of an SMDP can be realized by simulating the chain. For the critic model of neuro-dynamicprogramming (NDP), a neuro-policy iteration (NPI) algorithm is presented, and the performanceerror bound is shown as there are approximate error and improvement error in each iteration step.The obtained results may be extended to Markov systems, and have much applicability. Finally, anumerical example is provided.
基金the funding support from the Provincial Natural Science Foundation General Program(No.2015JJ2109)Hunan Province Graduate Student Research Innovation Program(No.CX2018B473)+7 种基金Hunan Traditional Chinese Medicine Scientific Research Program(NO.201463 and NO.2017141)Key Scientific Research Project of Hunan Administration of Traditional Chinese Medicine(NO.201917)University-level Scientific Research Projects of Hunan University of Chinese Medicine(NO.2017029 and NO.2018XJJJ31)The Domestic Firstclass Discipline Construction Project of Chinese Medicine of Hunan University of Chinese MedicineCentral Finance Supported Local High School Construction ProjectState Administration of Traditional Chinese Medicine Ophthalmology Key Discipline Construction ProjectHunan Province Traditional Chinese Medicine Facial Feature Key Discipline Construction ProjectHunan Engineering Technology Research Center for the Prevention and Treatment of Otorhinolaryngologic Diseases and Protection of Visual Function with Chinese Medicine,Hunan Provincial Key Laboratory for the Prevention and Treatment of Ophthalmology and Otolaryngology Diseases with Traditional Chinese Medicine
文摘Objective To analyze the effects of Dan Huang Ming Mu Recipe(DHMMR)(a pharmaceutical preparation from herbs and having the function of replenishing vital essence,removing heat,promoting blood circulation and excreting pathogenic water) on diabetic retinopathy(DR) after retinal laser photocoagulation through regulating the expression of vascular endothelial growth factor(VEGF) and pigment epithelium-derived factor(PEDF).Methods Forty male Brown Norway(BN) rats were randomly divided into blank group(group A,10 BN rats) and model group(30 BN rats).DR models were induced by 40 mg/kg streptozotocin(STZ) and the body weight and blood glucose of rats were monitored.After 12-week injection,fluorescein fundus angiography(FFA) and histopathological examination were detected to confirm the successful establishment of DR models.Subsequently,the right eyes of model group rats were conducted retinal laser photocoagulation with the left eyes having no retinal laser photocoagulation and rats of the model group were randomly divided into group B(the model control group),group C(the positive control group),and group D(the DHMMR group),with 10 rats in each group.Rats of the group A and the group B were given vehicle,and the group C were given calcium dobesilate suspension by gavage,and the group D were given DHMMR by gavage.After 4-week gavage,FFA was carried out to observe the fundus microvascular change.Then,the rats were sacrificed to do histopathological examinations and the serum levels of P-selectin,cAMP,cGMP,and the relative expression of the protein of VEGF and PEDF in retina were detected.Results After 12-week STZ injection,the blood glucose of the model group were pronouncedly higher than the blank group(P < 0.01).Fundus micro-hemangioma changes were observed in the rats of the model group through FFA,and the rats of the blank group did not see any changes.The pictures of HE staining showed that the retinal structure of the model group was more disordered than the blank group.After 4-week gavage,treatments with DHMMR showed dramatic reduction of serum levels of Pselectin,cAMP and cGMP compared with the group B(P < 0.01).FFA and histopathological examinations of DHMMR-treated rats revealed significantly suppression of retinal edema,fundus microvascular destruction and retinal destruction distinguishing from the group B.And the relative expression of VEGF protein of the group D and the group A was markedly lower than that of the group B(P < 0.01).The relative expression of PEDF protein of the group D and the group A was dramatically higher than that of the group B to the contrary(P < 0.01).Conclusions DHMMR demonstrates pronounced suppressive effects on the progression of DR after retinal laser photocoagulation,through down-regulating VEGF and upregulating PEDF.
文摘Being based on preliminary study of Kunming famous temples during the Ming and Qing dynasties,field investigation was carried out about the framework of landscape,layout of waters,characteristic of structure and plant furnishing in Tanhua temple,Black Dragon Pool,Masijid of Shuncheng,Haiyuan temple and Golden Shrine which are famous temple garden in Kunming. A simple interpretation was drawn of artistic characteristics on temple garden in Kunming during the Ming and Qing dynasties via analytical investigation on many factors which influenced the development of garden of Dynasties of Ming and Qing. Then we have reviewed the elemental traits of temple garden built at that time,put forward some constructive suggestions on how to protect and develop those temple garden now still exist in Kunming.
文摘This paper explored the background of the leisure boom among the literati in the late Ming Dynasty from the aspects of politics, economy, ideology and social environment, and elaborated the leisure styles of the literati in terms of enjoying a sightseeing tour, sampling wine and tea, appreciating and collecting calligraphy and painting works, favoring theatergoing, indulging in dallying with prostitutes, practicing meditation, and building gardens, and analyzed the influence of their leisure styles on the painting and calligraphy art, drama, literary creation, garden construction and other aspects of the society at that time. It is hoped that this paper can provide a deep understanding of social politics, economy, ideology and culture in the late Ming Dynasty and a reference for the development of the current leisure tourism.
文摘The Black-winged Monarch(Monarcha frater)inhabits low-mid elevation forests across New Guinea and far northeastern Australia.Of its four recognized subspecies,M.f.canescens is migratory,breeding in tropical north-eastern Australia from approximately November–March.The non-breeding range of M.f.canescens,apart from some individuals overwintering in Australia,has been unknown for>100 years.Data from 194 New Guinean and Australian specimens and a literature review have not solved this mystery;the narrow latitudinal range of the intratropical migration may inhibit use of GPS loggers in resolving the migration route.Field work in central and western parts of southern New Guinea is needed.Specimen data,however,revealed an essentially overlooked population in north-western New Guinea east of the Bird's Head Peninsula phenotypically indistinguishable from nominate M.f.frater of that Peninsula.Future genomic analysis of the complex will be largely done from toepad skin because frozen tissue samples for DNA analysis exist only of four individuals of what we suggest should be elevated to species rank as M.periophthalmicus.We discuss how genomic analysis might distinguish among alternative taxonomic hypotheses of one,two or three species.We suggest English names for what we consider to be three diagnosable taxa worth recognizing at species rank in this group:Arfak Monarch corresponding to M.frater(Bird's Head Peninsula and the“new”population of north-western New Guinea);Pearly Monarch for M.canescens(Australia and still unknown non-breeding range),and Masked Monarch for M.periophthalmicus(including kunupi,elsewhere in New Guinea).
基金Sponsored by Youth Program of National Natural Science Foundation of China(41601131)Youth Program of Humanistic and Social Science Research,Ministry of Education(15YJC790092)Nanjing Scientific and Technological Innovation Team Program“Tourism Geography(Wel ness Tourism)”
文摘Taking a section of the Ming Dynasty Outer City Wall from Xianhe Gate to Qilin Gate for example, this paper proposed the landscape design from the perspective of experience tourism, highlighted the wal, and took the beautiful environment and rich history and cultures of the Ming Dynasty Outer City Wall as the essential experience elements, to build cultural recreational corridors with the theme of "experiencing the Ming Dynasty culture", so that visitors will get unforgettable experience, tourism quality, popularity of the Ming Dynasty Outer City Wall as well as its cultural and educational significance will be further promoted.
基金Sponsored by the General Project of Humanity and Social Science in Colleges and Universities of Jiangxi Province(YS18126)the Jiangxi Postgraduate Innovation Fund Project in 2018(YC2018-S149)
文摘Starting from the Tianping Mountain theme painting in Suzhou in the Ming Dynasty, we explore how did the painters and literati in this period shape the image of the Tianping Mountain through their works, thereby reflecting their understanding on many landscapes on the Tianping Mountain. By exploring a series of paintings and poems, we try to analyze the characteristics and cultural connotation of landscape paintings of the Tianping Mountain in the Ming Dynasty, which is conducive to improving position of the Tianping Mountain natural and humanistic landscape in Suzhou.
基金Supported by Program of National Natural Science Foundation of China(NSFC J0730641)Phase-III Innovative Undergraduate Cultivation Program of "985 Project" of Nanjing University
文摘Phyto-groups on 5 remained city wall sections of the Ming Dynasty in Nanjing City was investigated through on-the-spot survey,99 species of 93 genera,60 families were found,and species of Asteraceae and Poaceae accounted for the largest ratio.Plants on the city wall are characterized by strong drought resistance and precocity,their seeds can grow out of the wall cracks,and roots secrete acidoid and obtain nutrients from wall bricks.Plants on different wall sections are different,and human interventions influence phyto-groups on the city wall greatly.On this basis,it was concluded that plants had negative influence on city wall,especially plant roots destroyed the wall seriously.Corresponding researches were carried out and prevention suggestions proposed to provide scientific support for the protection of ancient city walls in Nanjing City.