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Interannual variability of boreal summer intraseasonal oscillation over the northwestern Pacific influenced by the Pacific Meridional Mode
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作者 Haoyu Zhou Pang-Chi Hsu +1 位作者 Lin Chen Yitian Qian 《Atmospheric and Oceanic Science Letters》 2025年第1期6-11,共6页
During the boreal summer,intraseasonal oscillations exhibit significant interannual variations in intensity over two key regions:the central-western equatorial Pacific(5°S-5°N,150°E-150°W)and the s... During the boreal summer,intraseasonal oscillations exhibit significant interannual variations in intensity over two key regions:the central-western equatorial Pacific(5°S-5°N,150°E-150°W)and the subtropical Northwestern Pacific(10°-20°N,130°E-175°W).The former is well-documented and considered to be influenced by the ENSO,while the latter has received comparatively less attention and is likely influenced by the Pacific Meridional Mode(PMM),as suggested by partial correlation analysis results.To elucidate the physical processes responsible for the enhanced(weakened)intraseasonal convection over the subtropical northwestern Pacific during warm(cold)PMM years,the authors employed a moisture budget analysis.The findings reveal that during warm PMM years,there is an increase in summer-mean moisture over the subtropical northwestern Pacific.This increase interacts with intensified vertical motion perturbations in the region,leading to greater vertical moisture advection in the lower troposphere and consequently resulting in convective instability.Such a process is pivotal in amplifying intraseasonal convection anomalies.The observational findings were further verified by model experiments forced by PMM-like sea surface temperature patterns. 展开更多
关键词 Boreal summer intraseasonal oscillation Interannual variability Pacific Meridional mode Moisture budget analysis
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非小细胞肺癌患者血清CA211水平和NK细胞数与预后相关 被引量:1
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作者 丁飞 王洒 黄常新 《基础医学与临床》 2024年第2期180-184,共5页
目的 探究非小细胞肺癌(NSCLC)患者血清糖类抗原211(CA211)表达水平和自然杀伤(NK)细胞数与预后的相关性。方法 选取杭州师范大学附属医院2019年6月至2022年7月收治的132例NSCLC患者作为实验组,另选取同期收治的132例肺部良性病变患者... 目的 探究非小细胞肺癌(NSCLC)患者血清糖类抗原211(CA211)表达水平和自然杀伤(NK)细胞数与预后的相关性。方法 选取杭州师范大学附属医院2019年6月至2022年7月收治的132例NSCLC患者作为实验组,另选取同期收治的132例肺部良性病变患者作为对照组。从检验科收集数据分析NSCLC患者血清CA211表达水平和NK细胞数与患者预后关系以及影响NSCLC患者预后的相关因素。结果 实验组中性粒细胞/淋巴细胞值(NLR值)和血清CA211表达水平高于对照组(P<0.05),NK细胞数低于对照组(P<0.05);实验组血清CA211表达水平和NK细胞数呈负相关(r=-0.405,P<0.001);不同血清CA211表达水平和NK细胞数的患者淋巴结转移情况以及TNM分期存在显著性差异(P<0.05);CA211低表达者1年生存率高于CA211高表达者(P<0.05),NK细胞高水平者1年生存率高于NK细胞低水平者(P<0.05);淋巴结转移、TNM分期、CA211是影响NSCLC患者预后的危险因素(P<0.05),NK细胞是NSCLC患者预后的保护因素(P<0.05)。结论 NSCLC患者血清CA211表达水平及NK细胞数与临床病理特征及预后有密切联系。 展开更多
关键词 非小细胞肺癌 糖类抗原211 自然杀伤细胞 预后
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circFAT1调节miR-211-5p/CCND2轴对糖尿病心肌病大鼠心肌损伤的影响
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作者 谷君 许峥嵘 +3 位作者 史丽 任卫东 左丽娟 张秋子 《中国医科大学学报》 CAS 北大核心 2024年第6期516-524,共9页
目的探讨circFAT1对糖尿病心肌病(DCM)大鼠心肌损伤的影响及对miR-211-5p/细胞周期蛋白D2(CCND2)轴的调节机制。方法利用高糖高脂饲料联合链脲佐菌素建立DCM大鼠模型,并随机分为DCM组、circ-NC组、circFAT1组、circFAT1+激动剂-NC组和ci... 目的探讨circFAT1对糖尿病心肌病(DCM)大鼠心肌损伤的影响及对miR-211-5p/细胞周期蛋白D2(CCND2)轴的调节机制。方法利用高糖高脂饲料联合链脲佐菌素建立DCM大鼠模型,并随机分为DCM组、circ-NC组、circFAT1组、circFAT1+激动剂-NC组和circFAT1+miR-211-5p激动剂组,以喂食普通饲料的大鼠作为对照组,每组20只。实时PCR检测心肌组织中circFAT1、miR-211-5p、CCND2水平;Western blotting检测心肌组织CCND2蛋白表达;生化分析仪检测大鼠空腹血糖(FBG)、总胆固醇(TC)和甘油三酯(TG)水平;心脏超声检测大鼠心功能;HE和Masson染色观察心肌组织病理形态;TUNEL染色检测心肌细胞凋亡情况;ELISA法检测白细胞介素-1β(IL-1β)、白细胞介素-6(IL-6)和肿瘤坏死因子-α(TNF-α)水平;双荧光素酶报告基因实验验证circFAT1、miR-211-5p、CCND2之间的靶向关系。结果与对照组相比,DCM组circFAT1、CCND2 mRNA及蛋白表达,左心室射血分数(LVEF)、左心室缩短分数(LVFS)水平降低(P<0.05),FBG、TC、TG、左心室舒张末期直径(LVEDd)、左心室收缩末期直径(LVEDs)、胶原容积分数(CVF)、细胞凋亡率、IL-1β、IL-6、TNF-α水平均升高(P<0.05);与DCM组相比,circFAT1组circFAT1、CCND2 mRNA及蛋白表达,LVEF、LVFS水平升高(P<0.05),FBG、TC、TG、LVEDd、LVEDs、CVF、细胞凋亡率、IL-1β、IL-6、TNF-α水平降低(P<0.05);miR-211-5p激动剂逆转了circFAT1对DCM心肌损伤的缓解作用,且CCND2 mRNA及蛋白表达降低(P<0.05)。结论circFAT1通过调控miR-211-5p/CCND2轴减轻DCM大鼠心肌组织损伤。 展开更多
关键词 circFAT1 miR-211-5p 细胞周期蛋白D2 糖尿病心肌病 心肌损伤
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血清CYFRA211、CA153、AFP联合检测在卵巢癌诊断中的应用价值
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作者 李珊珊 《哈尔滨医药》 2024年第2期79-81,共3页
目的探究血清细胞角蛋白19血清片段211(CYFRA211)、糖类抗原153(CA153)、甲胎蛋白(AFP)联合检测在卵巢癌诊断中的应用价值。方法回顾性选取进行手术治疗的卵巢肿瘤85例患者的临床资料,按术后病理结果分为恶性肿瘤51例(Ⅰ期11例,Ⅱ期10例... 目的探究血清细胞角蛋白19血清片段211(CYFRA211)、糖类抗原153(CA153)、甲胎蛋白(AFP)联合检测在卵巢癌诊断中的应用价值。方法回顾性选取进行手术治疗的卵巢肿瘤85例患者的临床资料,按术后病理结果分为恶性肿瘤51例(Ⅰ期11例,Ⅱ期10例,Ⅲ期18例,Ⅳ期12例),设为恶性组,剩余34例均为良性肿瘤,设为良性组,并同期选取30例于本院妇科进行体检的女性,作为对照组,收集卵巢肿瘤患者术后及对照组相关实验室数据资料,比较三组研究对象、恶性肿瘤不同分期患者血清CYFRA211、CA153、AFP水平差异,并分析血清CYFRA211、CA153、AFP联合检测卵巢癌的诊断价值。结果三组血清CYFRA211、CA153、AFP水平比较,差异有统计学意义(P<0.05)。恶性组各血清学指标水平均明显高于良性组、对照组,良性组血清学指标水平明显高于对照组,差异均有统计学意义(P<0.05)。不同分期的恶性肿瘤患者血清CYFRA211、CA153、AFP水平比较,差异有统计学意义(P<0.05),且各指标水平随分期升高而升高;血清CYFRA211、CA153、AFP及联合检测诊断卵巢癌的灵敏度分别为82.35%、86.27%、94.11%、68.43%,特异度分别为70.59%、78.41%、94.11%、68.43%;其中AFP检测灵敏度最高,三项联合检测的特异度明显高于单项检测,差异均有统计学意义(P<0.05)。结论卵巢癌会导致患者血清CYFRA211、CA153、AFP水平明显升高,血清CYFRA211、CA153、AFP水平对于诊断卵巢癌具有一定诊断效能,且联合诊断特异度更好。 展开更多
关键词 卵巢癌 细胞角蛋白19血清片段211 糖类抗原153 甲胎蛋白 诊断效能
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211Z.1铝合金微观组织及力学性能研究
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作者 张中可 车云 +1 位作者 门三泉 李祥 《贵州科学》 2024年第4期93-96,共4页
主要对211Z.1铝合金材料进行了金属型铸造加工及力学性能测试。实验结果显示,制备出的铸造试棒表面光滑,无铸造缺陷。经过T5热处理工艺之后,其平均抗拉强度达到了349.8 MPa,断后延伸率为21.3%,布氏硬度100,展现出优良的力学性能。通过... 主要对211Z.1铝合金材料进行了金属型铸造加工及力学性能测试。实验结果显示,制备出的铸造试棒表面光滑,无铸造缺陷。经过T5热处理工艺之后,其平均抗拉强度达到了349.8 MPa,断后延伸率为21.3%,布氏硬度100,展现出优良的力学性能。通过光学显微镜(OM)、扫描电子显微镜(SEM)等技术手段,实施了对合金微观结构的深入分析,探索了微观组织对合金力学性能的影响,并揭示了其性能的内在联系。本研究结果为211Z.1铝合金在工程领域的应用以及未来材料设计方面提供了理论探索和实践指引。 展开更多
关键词 211Z.1铝合金 微观组织 力学性能
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用于^(211)At生产的高功率金属Bi靶热效应模拟
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作者 熊杰 窦国梁 +5 位作者 孙良亭 王洋 秦芝 任洁茹 赵永涛 赵红卫 《强激光与粒子束》 CAS CSCD 北大核心 2024年第9期88-93,共6页
为提高用于医用同位素^(211)At生产的金属Bi靶在高束流功率作用下的可靠性与使役寿命,对多种束流均匀化方法进行了模拟与对比,利用计算流体力学(CFD)方法模拟分析了在wobbler磁铁作用下强度为500 eμA的α束流轰击Bi靶产生的热效应,为... 为提高用于医用同位素^(211)At生产的金属Bi靶在高束流功率作用下的可靠性与使役寿命,对多种束流均匀化方法进行了模拟与对比,利用计算流体力学(CFD)方法模拟分析了在wobbler磁铁作用下强度为500 eμA的α束流轰击Bi靶产生的热效应,为靶系统的设计和寿命的延长提供了关键技术支撑。结果表明,通过扫描实现束流均匀化可大幅降低靶上的最大热功率密度;在靶前采用wobbler磁铁对束流进行周期性圆扫描可有效降低Bi靶的表面温度。当扫描频率为50 Hz时,Bi靶最高温度为189.8℃,低于其熔点(271.3℃),能够满足Bi靶在此高功率束流照射下安全运行的温度要求。 展开更多
关键词 Bi靶 α离子束 At-211 同位素生产 计算流体力学
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^(211)At干馏装置研制及分离工艺研究
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作者 覃贻琳 刘葳豪 +5 位作者 叶天真 杨远友 李飞泽 兰图 廖家莉 刘宁 《原子能科学技术》 EI CAS CSCD 北大核心 2024年第4期742-750,共9页
^(211)At是一种α核素,其半衰期为7.2 h,不仅适用于α靶向内放射治疗,也可替代长半衰期核素用于α辐解的研究。为解决现有^(211)At干馏工艺产额低、稳定性差的问题,本研究优化设计了^(211)At干馏生产工艺,集成了一套半自动化^(211)At干... ^(211)At是一种α核素,其半衰期为7.2 h,不仅适用于α靶向内放射治疗,也可替代长半衰期核素用于α辐解的研究。为解决现有^(211)At干馏工艺产额低、稳定性差的问题,本研究优化设计了^(211)At干馏生产工艺,集成了一套半自动化^(211)At干馏分离装置。采用碘干馏模拟实验确定了影响干馏分离的主要影响因素,改进得到了简便可行的^(211)At干馏分离工艺步骤。^(211)At干馏分离结果表明:当加速器α束流强度为20μA、能量为28.5 MeV时,轰击Bi靶4 h后,^(211)At的3次平均产额为17.87 mCi(6.61×10^(8) Bq),产品核纯度>99.9%,无Bi、Cu等杂质。^(211)At收率达98%以上,分离耗时45~60 min。本研究不仅为各类^(211)At应用工作的开展垫定了良好的基础,也可为后续^(211)At干馏自动化装置的研制提供参考。 展开更多
关键词 ^(211)At 干馏分离 工艺 碘模拟工艺 干馏装置
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磁共振弥散加权成像联合血清CYFRA211在直肠癌术前分期诊断中的应用价值 被引量:1
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作者 李晓成 孟宪平 费锋 《中国医药导报》 CAS 2024年第4期21-24,69,共5页
目的 分析磁共振弥散加权成像(MRI-DWI)联合血清CYFRA211在直肠癌术前分期诊断中的应用价值。方法 回顾性分析2020年1月至2023年4月东南大学医学院附属江阴医院收治的124例直肠癌患者的临床资料。以病理结果为金标准,分析MRI-DWI联合血... 目的 分析磁共振弥散加权成像(MRI-DWI)联合血清CYFRA211在直肠癌术前分期诊断中的应用价值。方法 回顾性分析2020年1月至2023年4月东南大学医学院附属江阴医院收治的124例直肠癌患者的临床资料。以病理结果为金标准,分析MRI-DWI联合血清CYFRA211对直肠癌术前T、N分期的诊断价值。结果 病理结果显示,124例直肠癌患者中,T_(1)期16例、T_(2)期14例、T_(3)期46例、T_(4)期48例;N_(0)期54例、N_(1)期40例、N_(2)期30例。T_(4)期患者血清CYFRA211高于T_(1)、T_(2)、T_(3)期,T_(3)期患者血清CYFRA211高于T_(1)、T_(2)期,T_(2)期患者血清CYFRA211高于T_(1)期(P<0.05)。N_(2)期患者血清CYFRA211高于N_(0)、N_(1)期,N_(1)期患者血清CYFRA211高于N_(0)期(P<0.05)。血清CYFRA211诊断直肠癌术前T_(1)、T_(2)、T_(3)、T_(4)、N_(0)、N_(1)、N_(2)期曲线下面积分别为0.756、0.744、0.805、0.897、0.791、0.813、0.821。MRI-DWI对术前T_(1)、T_(2)、T_(3)、T_(4)期的诊断一致性一般(Kappa=0.452、0.587、0.672、0.720,P<0.01);MRI-DWI联合血清CYFRA211对术前T_(1)、T_(2)、T_(3)、T_(4)期的诊断一致性较好(Kappa=0.768、0.785、0.827、0.839,P<0.01)。MRI-DWI对术前N_(0)、N_(1)、N_(2)期的诊断一致性一般(Kappa=0.473、0.598、0.682,P<0.01),MRI-DWI联合血清CYFRA211对术前N_(0)、N_(1)、N_(2)期的诊断一致性较好(Kappa=0.795、0.821、0.834,P<0.01)。结论 MRI-DWI联合血清CYFRA211在直肠癌术前T、N分期的诊断价值更高。 展开更多
关键词 磁共振弥散加权成像 CYFRA211 直肠癌 术前分期
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基于主客观环流分型的强降水数值预报MODE检验方法及其在2019年暖季东北地区的应用
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作者 齐铎 崔晓鹏 +4 位作者 陈力强 黄丽君 刘松涛 卜文惠 王承伟 《大气科学》 CSCD 北大核心 2024年第3期1113-1130,共18页
本文构建了基于主客观环流分型的强降水数值预报空间检验(MODE)方法框架,并利用该框架对欧洲中期天气预报中心全球模式(ECMWF)和中国气象局区域中尺度数值天气预报模式(CMA_MESO)的2019年暖季东北地区强降水预报进行检验。结果表明,201... 本文构建了基于主客观环流分型的强降水数值预报空间检验(MODE)方法框架,并利用该框架对欧洲中期天气预报中心全球模式(ECMWF)和中国气象局区域中尺度数值天气预报模式(CMA_MESO)的2019年暖季东北地区强降水预报进行检验。结果表明,2019年暖季东北地区54个强降水日的环流型可分为:西风槽型(15个)、副热带高压影响型(13个)、急流型(5个)、西部(12个)和东部冷涡型(9个)。其中,西风槽型和急流型以区域性强降水为主,模式对其强降水发生与否的预报能力强,TS评分较高;西部、东部冷涡型强降水的局地性强,模式对其强降水发生与否的预报能力差,TS评分低;副热带高压影响型也以区域性强降水为主,模式对其强降水发生与否的预报能力也比较强,但是对其强降水质心位置、强度、面积等属性预报偏差较大,TS评分也相对较低。另外,从两种模式预报性能对比看,CMA_MESO强降水强度和面积预报较实况普遍偏强,虽然其预报的TS评分一般高于ECMWF,但其对强降水预报的空报率也都比ECMWF大,对强降水的属性预报偏差一致性一般也低于ECMWF,其预报的可订正性整体上不及ECMWF。 展开更多
关键词 主客观融合环流分型 东北冷涡客观识别 强降水 数值预报 mode检验
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皮肤恶性黑色素瘤血清miR-211、miR-128水平及与疗效关系
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作者 刘月丽 朱林 +1 位作者 魏星 吴勇 《分子诊断与治疗杂志》 2024年第1期178-182,共5页
目的探究皮肤恶性黑色素瘤(CMM)血清miR-211、miR-128水平及与疗效关系。方法选取2021年7月至2022年6月期间河南中医药大学第三附属医院收治的120例CMM患者为CMM组,选取同期90例非肿瘤皮肤病患者为对照组,比较两组血清miR-211、miR-128... 目的探究皮肤恶性黑色素瘤(CMM)血清miR-211、miR-128水平及与疗效关系。方法选取2021年7月至2022年6月期间河南中医药大学第三附属医院收治的120例CMM患者为CMM组,选取同期90例非肿瘤皮肤病患者为对照组,比较两组血清miR-211、miR-128表达水平,分析血清miR-211、miR-128表达与CMM临床病理特征关系;3个月后,根据CMM组患者实体瘤疗效分为缓解组和未缓解组,分析血清miR-211、miR-128表达与患者疗效关系。结果CMM组血清miR-211、miR-128表达量低于对照组,差异有统计学意义(t=18.186、48.871,P均<0.05)。不同病理类型、分化程度、淋巴结转移、临床分期、Ki-67指数患者血清miR-211表达比较差异有统计学意义(F或t=13.209、3.044、5.601、7.996、3.748,P均<0.05),不同分化程度、淋巴结转移、临床分期患者血清miR-128表达比较差异有统计学意义(t=5.940、9.592、12.895,P均<0.05)。缓解组与未缓解组病理类型、分化程度、有无淋巴结转移、临床分期、Ki-67指数水平、是否手术比较差异均有统计学意义(χ^(2)=8.062、19.171、7.333、14.436、5.025、4.309,P均<0.05);治疗后,缓解组血清miR-211、miR-128表达均高于未缓解组,差异有统计学意义(t=13.926、8.849,P均<0.05)。多因素Logistic回归分析显示,低分化(OR=2.275,95%CI:1.027~5.042)、淋巴结转移(OR=2.643,95%CI:1.243~5.622)、临床分期Ⅲ~Ⅳ期(OR=3.022,95%CI:1.348~6.777)、miR-211低表达(OR=2.208,95%CI:1.217~4.006)、miR-128低表达(OR=2.375,95%CI:1.086~5.192)是影响患者疗效的危险因素(P<0.05)。结论CMM患者血清miR-211、miR-128表达水平明显降低,两指标均与患者临床病理特征及疗效有关,具有一定参考价值。 展开更多
关键词 皮肤恶性黑色素瘤 微小RNA-211 微小RNA-128 临床病理特征
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miR-211-5p和miR-202-3p在抑郁症患者中的表达及其与患者病情程度和认知功能的关系
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作者 张果 赵方方 何丹丹 《成都医学院学报》 CAS 2024年第4期624-627,632,共5页
目的探究微小核糖核酸-211-5p(miR-211-5p)和微小核糖核酸-202-3p(miR-202-3p)在抑郁症患者中的表达及其与患者病情程度和认知功能的关系。方法选取2021年1月至2023年6月郑州大学第一附属医院精神科收治的92例确诊为抑郁症的患者为抑郁... 目的探究微小核糖核酸-211-5p(miR-211-5p)和微小核糖核酸-202-3p(miR-202-3p)在抑郁症患者中的表达及其与患者病情程度和认知功能的关系。方法选取2021年1月至2023年6月郑州大学第一附属医院精神科收治的92例确诊为抑郁症的患者为抑郁症组,同期选取本院体检健康(精神状态正常)的志愿者92例为对照组。根据抑郁自评量表(SDS)分为轻度抑郁组(SDS:53~62分)45例、中度抑郁组(SDS:63~72分)30例、重度抑郁组(SDS:73分及以上)17例。根据简易智力状态检查量表(MMSE)评分分为轻度认知功能障碍组(MMSE:21~26分)24例、中度认知功能障碍组(MMSE:10~20分)40例、重度认知功能障碍组(MMSE:1~9分)28例。实时荧光定量聚合酶链反应检测miR-211-5p和miR-202-3p水平。血清miR-211-5p、miR-202-3p水平对抑郁症的诊断价值采用ROC曲线进行分析。血清miR-211-5p、miR-202-3p水平与病情程度及认知功能的关系采用Spearman相关性分析。结果抑郁症患者血清miR-211-5p水平低于对照组,miR-202-3p水平高于对照组(P<0.05)。miR-211-5p、miR-202-3p联合诊断抑郁症的AUC高于miR-211-5p(Z=4.701,P<0.001)、miR-202-3p(Z=2.275,P=0.023)单独诊断的AUC。与轻度抑郁组相比,中度抑郁组和重度抑郁组miR-211-5p水平依次降低,与轻度抑郁组相比,中度抑郁组和重度抑郁组miR-202-3p水平依次升高。不同认知功能抑郁症患者血清miR-211-5p水平比较:重度认知功能障碍组<中度认知功能障碍组<轻度认知功能障碍组;miR-202-3p水平比较:重度认知功能障碍组>中度认知功能障碍组>轻度认知功能障碍组(P<0.05)。Spearman相关性分析显示,抑郁症患者血清miR-211-5p水平与病情程度及认知功能损害呈负相关,miR-202-3p水平与病情程度及认知功能损害呈正相关(P<0.05)。结论抑郁症患者血清miR-211-5p低表达,miR-202-3p高表达,二者与病情程度及认知功能有关,有成为抑郁症辅助诊断生物学指标的潜力。 展开更多
关键词 微小核糖核酸-211-5p 微小核糖核酸-202-3p 抑郁症 病情程度 认知功能
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一种基于粗糙熵的改进K-modes聚类算法
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作者 刘财辉 曾雄 谢德华 《南京理工大学学报》 CAS CSCD 北大核心 2024年第3期335-341,共7页
K-modes聚类算法被广泛应用于人工智能、数据挖掘等领域。传统的K-modes聚类算法有不错的聚类效果,但是存在迭代次数多、计算量大、容易受到冗余属性的干扰等问题,且仅采用简单的0-1匹配的方法来定义2个样本属性值之间的距离,没有充分... K-modes聚类算法被广泛应用于人工智能、数据挖掘等领域。传统的K-modes聚类算法有不错的聚类效果,但是存在迭代次数多、计算量大、容易受到冗余属性的干扰等问题,且仅采用简单的0-1匹配的方法来定义2个样本属性值之间的距离,没有充分考虑每个属性对聚类结果的影响。针对上述问题,该文将粗糙熵引入K-modes算法。首先利用粗糙集属性约简算法消除冗余属性,确定各属性的重要程度;然后利用粗糙熵确定每个属性的权重,从而定义新的类内距离。将该文所提算法与传统的K-modes聚类算法分别在4组公开数据集上进行对比试验。试验结果表明,该文所提算法聚类准确率比传统的K-modes聚类算法更高。 展开更多
关键词 聚类 K-modes算法 粗糙集 粗糙熵 属性约简 权重
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Phase-locked single-mode terahertz quantum cascade lasers array 被引量:1
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作者 Yunfei Xu Weijiang Li +9 位作者 Yu Ma Quanyong Lu Jinchuan Zhang Shenqiang Zhai Ning Zhuo Junqi Liu Shuman Liu Fengmin Cheng Lijun Wang Fengqi Liu 《Journal of Semiconductors》 EI CAS CSCD 2024年第6期87-91,共5页
We demonstrated a scheme of phase-locked terahertz quantum cascade lasers(THz QCLs)array,with a single-mode pulse power of 108 mW at 13 K.The device utilizes a Talbot cavity to achieve phase locking among five ridge l... We demonstrated a scheme of phase-locked terahertz quantum cascade lasers(THz QCLs)array,with a single-mode pulse power of 108 mW at 13 K.The device utilizes a Talbot cavity to achieve phase locking among five ridge lasers with first-order buried distributed feedback(DFB)grating,resulting in nearly five times amplification of the single-mode power.Due to the optimum length of Talbot cavity depends on wavelength,the combination of Talbot cavity with the DFB grating leads to better power amplification than the combination with multimode Fabry-Perot(F-P)cavities.The Talbot cavity facet reflects light back to the ridge array direction and achieves self-imaging in the array,enabling phase-locked operation of ridges.We set the spacing between adjacent elements to be 220μm,much larger than the free-space wavelength,ensuring the operation of the fundamental supermode throughout the laser's dynamic range and obtaining a high-brightness far-field distribution.This scheme provides a new approach for enhancing the single-mode power of THz QCLs. 展开更多
关键词 quantum cascade lasers phase locking TERAHERTZ single mode
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211At标记的α核素靶向治疗
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作者 陈环宇 邓银倩 +3 位作者 张立 吴宇筠 兰晓莉 曹卫 《标记免疫分析与临床》 CAS 2024年第11期2145-2152,共8页
放射性核素靶向治疗在肿瘤治疗中潜力巨大,可向癌细胞提供高细胞毒性剂量的电离辐射且最大限度地减少对周围组织的损害。α核素相比β核素,射程更短、能量更聚焦,在破坏DNA双链彻底杀死细胞的同时具有较小的辐射问题。砹-211(Astatine-2... 放射性核素靶向治疗在肿瘤治疗中潜力巨大,可向癌细胞提供高细胞毒性剂量的电离辐射且最大限度地减少对周围组织的损害。α核素相比β核素,射程更短、能量更聚焦,在破坏DNA双链彻底杀死细胞的同时具有较小的辐射问题。砹-211(Astatine-211,At)因其原材料廉价易得、低子核素脱靶毒性、短半衰期等优势,成为α核素靶向治疗中最有前景的α发射体之一。目前已开发出多种类型的载体将211 At递送至靶细胞,包括单克隆抗体、小分子、多肽及纳米颗粒。本文综述了基于不同载体的211 At标记靶向药物的临床及临床前研究现状及进展。 展开更多
关键词 α核素靶向治疗 放射性核素药物 211 At
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Effects of spot size on the operation mode of Ga As photoconductive semiconductor switch employing extrinsic photoconductivity 被引量:1
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作者 韦金红 李嵩 +5 位作者 陈红 曾凡正 贾成林 付泽斌 葛行军 钱宝良 《Plasma Science and Technology》 SCIE EI CAS CSCD 2024年第5期91-99,共9页
To guide the illuminating design to improve the on-state performances of gallium arsenide(GaAs)photoconductive semiconductor switch(PCSS),the effect of spot size on the operation mode of GaAsPCSS based on a semi-insul... To guide the illuminating design to improve the on-state performances of gallium arsenide(GaAs)photoconductive semiconductor switch(PCSS),the effect of spot size on the operation mode of GaAsPCSS based on a semi-insulating wafer with a thickness of 1 mm,triggered by a 1064-nm extrinsic laser beam with the rectangular spot,has been investigated experimentally.It is found that the variation of the spot size in length and width can act on the different parts of the output waveform integrating the characteristics of the linear and nonlinear modes,and then significantly boosts the PCSS toward different operation modes.On this basis,a two-channel model containing the active and passive parts is introduced to interpret the relevant influencing mechanisms.Results indicate that the increased spot length can peak the amplitude of static domains in the active part to enhance the development of the nonlinear switching,while the extended spot width can change the distribution of photogenerated carriers on both parts to facilitate the linear switching and weaken the nonlinear switching,which have been proved by comparing the domain evolutions under different spot sizes. 展开更多
关键词 GaAs PCSS operation mode spot size on-state performances two-channel model domain evolution
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UAV-assisted data collection for wireless sensor networks with dynamic working modes 被引量:1
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作者 Jie Chen Jianhua Tang 《Digital Communications and Networks》 SCIE CSCD 2024年第3期805-812,共8页
Wireless Sensor Network(WSN)is a cornerstone of Internet of Things(IoT)and has rich application scenarios.In this work,we consider a heterogeneous WSN whose sensor nodes have a diversity in their Residual Energy(RE).I... Wireless Sensor Network(WSN)is a cornerstone of Internet of Things(IoT)and has rich application scenarios.In this work,we consider a heterogeneous WSN whose sensor nodes have a diversity in their Residual Energy(RE).In this work,to protect the sensor nodes with low RE,we investigate dynamic working modes for sensor nodes which are determined by their RE and an introduced energy threshold.Besides,we employ an Unmanned Aerial Vehicle(UAV)to collect the stored data from the heterogeneous WSN.We aim to jointly optimize the cluster head selection,energy threshold and sensor nodes’working mode to minimize the weighted sum of energy con-sumption from the WSN and UAV,subject to the data collection rate constraint.To this end,we propose an efficient search method to search for an optimal energy threshold,and develop a penalty-based successive convex approximation algorithm to select the cluster heads.Then we present a low-complexity iterative approach to solve the joint optimization problem and discuss the implementation procedure.Numerical results justify that our proposed approach is able to reduce the energy consumption of the sensor nodes with low RE significantly and also saves energy for the whole WSN. 展开更多
关键词 Unmanned aerial vehicle Wireless sensor networks Cluster heads Dynamic working modes
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Adaptive Trajectory Tracking Control for Nonholonomic Wheeled Mobile Robots:A Barrier Function Sliding Mode Approach 被引量:1
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作者 Yunjun Zheng Jinchuan Zheng +3 位作者 Ke Shao Han Zhao Hao Xie Hai Wang 《IEEE/CAA Journal of Automatica Sinica》 SCIE EI CSCD 2024年第4期1007-1021,共15页
The trajectory tracking control performance of nonholonomic wheeled mobile robots(NWMRs)is subject to nonholonomic constraints,system uncertainties,and external disturbances.This paper proposes a barrier function-base... The trajectory tracking control performance of nonholonomic wheeled mobile robots(NWMRs)is subject to nonholonomic constraints,system uncertainties,and external disturbances.This paper proposes a barrier function-based adaptive sliding mode control(BFASMC)method to provide high-precision,fast-response performance and robustness for NWMRs.Compared with the conventional adaptive sliding mode control,the proposed control strategy can guarantee that the sliding mode variables converge to a predefined neighborhood of origin with a predefined reaching time independent of the prior knowledge of the uncertainties and disturbances bounds.Another advantage of the proposed algorithm is that the control gains can be adaptively adjusted to follow the disturbances amplitudes thanks to the barrier function.The benefit is that the overestimation of control gain can be eliminated,resulting in chattering reduction.Moreover,a modified barrier function-like control gain is employed to prevent the input saturation problem due to the physical limit of the actuator.The stability analysis and comparative experiments demonstrate that the proposed BFASMC can ensure the prespecified convergence performance of the NWMR system output variables and strong robustness against uncertainties/disturbances. 展开更多
关键词 Adaptive sliding mode barrier function nonholonomic wheeled mobile robot(NWMR) trajectory tracking control
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Real-Time 4-Mode MDM Transmission Using Commercial 400G OTN Transceivers and All-Fiber Mode Multiplexers 被引量:1
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作者 REN Fang LI Yidan +2 位作者 YE Bing LIU Jianguo CHEN Weizhang 《ZTE Communications》 2024年第1期106-110,共5页
Weakly-coupled mode division multiplexing(MDM)technique is considered a promising candidate to enhance the capacity of an optical transmission system,in which mode multiplexers/demultiplexers(MMUX/MDEMUX)with low inse... Weakly-coupled mode division multiplexing(MDM)technique is considered a promising candidate to enhance the capacity of an optical transmission system,in which mode multiplexers/demultiplexers(MMUX/MDEMUX)with low insertion loss and modal crosstalk are the key components.In this paper,a low-modal-crosstalk 4-mode MMUX/MDEMUX for the weakly-coupled triple-ring-core few-mode fiber(TRC-FMF)is designed and fabricated with side-polishing processing.The measurement results show that a pair of MMUX/MDEMUX and 25 km weakly-coupled TRC-FMF MDM link achieve low modal crosstalk of lower than−17.5 dB and insertion loss of lower than 11.56 dB for all the four modes.Based on the TRC-FMF and all-fiber MMUX/MDEMUX,an experiment for 25 km real-time 4-mode 3-λwavelength division multiplexing(WDM)-MDM transmission is conducted using commercial 400G optical transport network(OTN)transceivers.The experimental results prove weakly-coupled MDM techniques facilitate a smooth upgrade of the optical transmission system. 展开更多
关键词 optical fiber couplers mode(de)multiplexers mode division multiplexing transmission
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Damage constitutive model of lunar soil simulant geopolymer under impact loading 被引量:2
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作者 Hanyan Wang Qinyong Ma Qianyun Wu 《Journal of Rock Mechanics and Geotechnical Engineering》 SCIE CSCD 2024年第3期1059-1071,共13页
Lunar base construction is a crucial component of the lunar exploration program,and considering the dynamic characteristics of lunar soil is important for moon construction.Therefore,investigating the dynamic properti... Lunar base construction is a crucial component of the lunar exploration program,and considering the dynamic characteristics of lunar soil is important for moon construction.Therefore,investigating the dynamic properties of lunar soil by establishing a constitutive relationship is critical for providing a theoretical basis for its damage evolution.In this paper,a split Hopkinson pressure bar(SHPB)device was used to perform three sets of impact tests under different pressures on a lunar soil simulant geopolymer(LSSG)with sodium silicate(Na_(2)SiO_(3))contents of 1%,3%,5%and 7%.The dynamic stressestrain curves,failure modes,and energy variation rules of LSSG under different pressures were obtained.The equation was modified based on the ZWT viscoelastic constitutive model and was combined with the damage variable.The damage element obeys the Weibull distribution and the constitutive equation that can describe the mechanical properties of LSSG under dynamic loading was obtained.The results demonstrate that the dynamic compressive strength of LSSG has a marked strain-rate strengthening effect.Na_(2)SiO_(3) has both strengthening and deterioration effects on the dynamic compressive strength of LSSG.As Na_(2)SiO_(3) grows,the dynamic compressive strength of LSSG first increases and then decreases.At a fixed air pressure,5%Na_(2)SiO_(3) had the largest dynamic compressive strength,the largest incident energy,the smallest absorbed energy,and the lightest damage.The ZWT equation was modified according to the stress response properties of LSSG and the range of the SHPB strain rate to obtain the constitutive equation of the LSSG,and the model’s correctness was confirmed. 展开更多
关键词 Lunar soil simulant geopolymer(LSSG) Split hopkinson pressure bar(SHPB)test Constitutive model Energy analysis Failure mode
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Control method based on DRFNN sliding mode for multifunctional flexible multistate switch 被引量:1
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作者 Jianghua Liao Wei Gao +1 位作者 Yan Yang Gengjie Yang 《Global Energy Interconnection》 EI CSCD 2024年第2期190-205,共16页
To address the low accuracy and stability when applying classical control theory in distribution networks with distributed generation,a control method involving flexible multistate switches(FMSs)is proposed in this st... To address the low accuracy and stability when applying classical control theory in distribution networks with distributed generation,a control method involving flexible multistate switches(FMSs)is proposed in this study.This approach is based on an improved double-loop recursive fuzzy neural network(DRFNN)sliding mode,which is intended to stably achieve multiterminal power interaction and adaptive arc suppression for single-phase ground faults.First,an improved DRFNN sliding mode control(SMC)method is proposed to overcome the chattering and transient overshoot inherent in the classical SMC and reduce the reliance on a precise mathematical model of the control system.To improve the robustness of the system,an adaptive parameter-adjustment strategy for the DRFNN is designed,where its dynamic mapping capabilities are leveraged to improve the transient compensation control.Additionally,a quasi-continuous second-order sliding mode controller with a calculus-driven sliding mode surface is developed to improve the current monitoring accuracy and enhance the system stability.The stability of the proposed method and the convergence of the network parameters are verified using the Lyapunov theorem.A simulation model of the three-port FMS with its control system is constructed in MATLAB/Simulink.The simulation result confirms the feasibility and effectiveness of the proposed control strategy based on a comparative analysis. 展开更多
关键词 Distribution networks Flexible multistate switch Grounding fault arc suppression Double-loop recursive fuzzy neural network Quasi-continuous second-order sliding mode
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