With the continuous advancement of technology,the application of 3D printing technology in the field of dental medicine is becoming increasingly widespread.This article aims to explore the current applications and fut...With the continuous advancement of technology,the application of 3D printing technology in the field of dental medicine is becoming increasingly widespread.This article aims to explore the current applications and future potential of 3D printing technology in dental medicine and to analyze its benefits and challenges.It first introduces the current state of 3D printing technology in dental implants,crowns,bridges,orthodontics,and maxillofacial surgery.It then discusses the potential applications of 3D printing technology in oral tissue engineering,drug delivery systems,personalized dental prosthetics,and surgical planning.Finally,it analyzes the benefits of 3D printing technology in dental medicine,such as improving treatment accuracy and patient comfort,and shortening treatment times,while also highlighting the challenges faced,such as costs,material choices,and technical limitations.This article aims to provide a reference for professionals in the field of dental medicine and to promote the further application and development of 3D printing technology in this area.展开更多
In recent years,the government has issued a series of documents to promote the construction of digital campuses.This initiative serves to encourage the deep integration of information technology and intelligent techno...In recent years,the government has issued a series of documents to promote the construction of digital campuses.This initiative serves to encourage the deep integration of information technology and intelligent technology education and digital reform,the combination of virtual reality and campus management is the need for innovative thinking and economic and social development,and then better change our learning style and living environment.The construction of the digital campus is based on virtual reality technology,BIM,GIS,and three-dimensional modeling technology to provide an immersive platform for students,promote the integration of virtual reality technology and education,help teachers,students,and parents to understand all kinds of education information and resources,to achieve their interoperability.From the off-campus environment to the school teaching equipment,teachers to teaching quality certification,and learning,to extracurricular entertainment,opening ceremonies to graduation parties,to bring more efficient,convenient,and safe campus life for teachers,students,and staff in school,and break the traditional information restrictions.展开更多
Three-dimensional(3D)printing technology is increasingly used in experimental research of geotechnical engineering.Compared to other materials,3D layer-by-layer printing specimens are extremely similar to the inherent...Three-dimensional(3D)printing technology is increasingly used in experimental research of geotechnical engineering.Compared to other materials,3D layer-by-layer printing specimens are extremely similar to the inherent properties of natural layered rock masses.In this paper,soft-hard interbedded rock masses with different dip angles were prepared based on 3D printing(3DP)sand core technology.Uniaxial compression creep tests were conducted to investigate its anisotropic creep behavior based on digital imaging correlation(DIC)technology.The results show that the anisotropic creep behavior of the 3DP soft-hard interbedded rock mass is mainly affected by the dip angles of the weak interlayer when the stress is at low levels.As the stress level increases,the effect of creep stress on its creep anisotropy increases significantly,and the dip angle is no longer the main factor.The minimum value of the long-term strength and creep failure strength always appears in the weak interlayer within 30°–60°,which explains why the failure of the layered rock mass is controlled by the weak interlayer and generally emerges at 45°.The tests results are verified by comparing with theoretical and other published studies.The feasibility of the 3DP soft-hard interbedded rock mass provides broad prospects and application values for 3DP technology in future experimental research.展开更多
After more than 30 years of scientific and social development, surveying and mapping technology by leaps and bounds, engineering surveying technology has undergone tremendous changes. In the process of protecting anci...After more than 30 years of scientific and social development, surveying and mapping technology by leaps and bounds, engineering surveying technology has undergone tremendous changes. In the process of protecting ancient buildings, it is necessary to obtain the precise dimensions of architectural details. In this study, the path of 3D laser scanning combined with BIM technology is explored. Taking the observation and protection of the ancestral hall of the Liu family as an example, this study aims to draw drawings that reflect the relevant information about the ancient buildings, the accurate three-dimensional model of ancient buildings is established with BIM technology, which provides new methods and ideas for the research and protection of ancient buildings. .展开更多
The informatization of higher vocational education is the future development trend,and it is also encouraged and promoted by the Ministry of Education.This article focuses on the road and bridge major,combined with th...The informatization of higher vocational education is the future development trend,and it is also encouraged and promoted by the Ministry of Education.This article focuses on the road and bridge major,combined with the author’s experience in introducing virtual simulation and three-dimensional(3D)animation technology into relevant course teaching in recent years,discusses the application of virtual simulation and 3D animation technology in higher vocational education and promotes classroom revolution,to obtain better teaching effect.展开更多
目的探讨NOTCH3基因第5外显子C260S位点突变导致的伴有皮层下梗死和白质脑病的常染色体显性遗传性脑动脉病(cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy,CADASIL)家系的临床和影像学...目的探讨NOTCH3基因第5外显子C260S位点突变导致的伴有皮层下梗死和白质脑病的常染色体显性遗传性脑动脉病(cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy,CADASIL)家系的临床和影像学特征。方法选取2021年12月首都医科大学附属北京同仁医院来自同一家庭的CADASIL患者,对所有患者进行NOTCH3基因测序,回顾性分析患者的临床表现和头颅影像学特征。复习既往文献报道的导致同一位置氨基酸改变的其他突变类型的临床及影像学特征。结果4名家庭成员中,包括先证者(46岁,女)及其两个姐姐(分别为48岁和50岁)和女儿(18岁)。先证者及其父亲、两个姐姐都有偏头痛病史,其中大姐有记忆力减退;先证者患有脑梗死及伴有视觉先兆的偏头痛;先证者女儿体健;先证者父亲因脑梗死去世。4名家庭成员均存在C260S位点的NOTCH3基因突变。既往文献无此位点突变的报道,先证者头颅MRI示右侧脑桥亚急性梗死,颞叶、脑室周围及脑干异常高信号改变,其大姐脑桥可见腔隙性梗死灶。结论NOTCH3基因第5外显子c.778T>A(p.C260S)的罕见突变导致的CADASIL发病时间早,早期会出现认知障碍。合并偏头痛的脑干梗死患者,需警惕CADASIL的可能。展开更多
光催化灭活是公认的控制病原微生物最具前景手段之一。本文以尿素和硫代巴比妥酸为起始原料,通过热聚合反应制备S掺杂g-C_(3)N_(4)(SCN),随后采用光还原法将Ag纳米粒负载于SCN表面获得新颖的可见光响应型Ag/SCN抗菌材料。对所制备纳米...光催化灭活是公认的控制病原微生物最具前景手段之一。本文以尿素和硫代巴比妥酸为起始原料,通过热聚合反应制备S掺杂g-C_(3)N_(4)(SCN),随后采用光还原法将Ag纳米粒负载于SCN表面获得新颖的可见光响应型Ag/SCN抗菌材料。对所制备纳米材料进行XRD、SEM、TEM、XPS及UV-Vis DRS表征,并深入探讨其在可见光下灭活大肠杆菌(E.coli)的性能和机制。结果表明,Ag纳米粒均匀且牢固地负载在SCN表面,纳米材料表现出显著增强的可见光响应能力。当负载量为6%时,Ag/SCN-6呈现出最佳的光催化灭菌活性,60 min内能够将6.2 lg CFU·mL^(-1)的E.coli全部灭活。自由基捕获实验结果表明,超氧自由基(·O-2)是灭活过程中最主要活性物种,它协同光生空穴(h+)和羟基自由基(·OH)主导了光催化抗菌的进程。展开更多
Proteolytic cleavage of tau by asparagine endopeptidase(AEP)creates tau-N368 fragments,which may drive the pathophysiology associated with synaptic dysfunction and memory deterioration in the brain of Alzheimer’s dis...Proteolytic cleavage of tau by asparagine endopeptidase(AEP)creates tau-N368 fragments,which may drive the pathophysiology associated with synaptic dysfunction and memory deterioration in the brain of Alzheimer’s disease patients.Nonetheless,the molecular mechanisms of truncated tau-induced cognitive deficits remain unclear.Evidence suggests that signal transduction and activator of transcription-3(STAT3)is associated with modulating synaptic plasticity,cell apoptosis,and cognitive function.Using luciferase reporter assays,electrophoretic mobility shift assays,western blotting,and immunofluorescence,we found that human tau-N368 accumulation inhibited STAT3 activity by suppressing STAT3 translocation into the nucleus.Overexpression of STAT3 improved tau-N368-induced synaptic deficits and reduced neuronal loss,thereby improving the cognitive deficits in tau-N368 mice.Moreover,in tau-N368 mice,activation of STAT3 increased N-methyl-D-aspartic acid receptor levels,decreased Bcl-2 levels,reversed synaptic damage and neuronal loss,and thereby alleviated cognitive deficits caused by tau-N368.Taken together,STAT3 plays a critical role in truncated tau-related neuropathological changes.This indicates a new mechanism behind the effect of tau-N368 on synapses and memory deficits.STAT3 can be used as a new molecular target to treat tau-N368-induced protein pathology.展开更多
文摘With the continuous advancement of technology,the application of 3D printing technology in the field of dental medicine is becoming increasingly widespread.This article aims to explore the current applications and future potential of 3D printing technology in dental medicine and to analyze its benefits and challenges.It first introduces the current state of 3D printing technology in dental implants,crowns,bridges,orthodontics,and maxillofacial surgery.It then discusses the potential applications of 3D printing technology in oral tissue engineering,drug delivery systems,personalized dental prosthetics,and surgical planning.Finally,it analyzes the benefits of 3D printing technology in dental medicine,such as improving treatment accuracy and patient comfort,and shortening treatment times,while also highlighting the challenges faced,such as costs,material choices,and technical limitations.This article aims to provide a reference for professionals in the field of dental medicine and to promote the further application and development of 3D printing technology in this area.
文摘In recent years,the government has issued a series of documents to promote the construction of digital campuses.This initiative serves to encourage the deep integration of information technology and intelligent technology education and digital reform,the combination of virtual reality and campus management is the need for innovative thinking and economic and social development,and then better change our learning style and living environment.The construction of the digital campus is based on virtual reality technology,BIM,GIS,and three-dimensional modeling technology to provide an immersive platform for students,promote the integration of virtual reality technology and education,help teachers,students,and parents to understand all kinds of education information and resources,to achieve their interoperability.From the off-campus environment to the school teaching equipment,teachers to teaching quality certification,and learning,to extracurricular entertainment,opening ceremonies to graduation parties,to bring more efficient,convenient,and safe campus life for teachers,students,and staff in school,and break the traditional information restrictions.
基金the support of the National Natural Science Foundation of China(Grant Nos.42207199,52179113,42272333)Zhejiang Postdoctoral Scientific Research Project(Grant Nos.ZJ2022155,ZJ2022156)。
文摘Three-dimensional(3D)printing technology is increasingly used in experimental research of geotechnical engineering.Compared to other materials,3D layer-by-layer printing specimens are extremely similar to the inherent properties of natural layered rock masses.In this paper,soft-hard interbedded rock masses with different dip angles were prepared based on 3D printing(3DP)sand core technology.Uniaxial compression creep tests were conducted to investigate its anisotropic creep behavior based on digital imaging correlation(DIC)technology.The results show that the anisotropic creep behavior of the 3DP soft-hard interbedded rock mass is mainly affected by the dip angles of the weak interlayer when the stress is at low levels.As the stress level increases,the effect of creep stress on its creep anisotropy increases significantly,and the dip angle is no longer the main factor.The minimum value of the long-term strength and creep failure strength always appears in the weak interlayer within 30°–60°,which explains why the failure of the layered rock mass is controlled by the weak interlayer and generally emerges at 45°.The tests results are verified by comparing with theoretical and other published studies.The feasibility of the 3DP soft-hard interbedded rock mass provides broad prospects and application values for 3DP technology in future experimental research.
文摘After more than 30 years of scientific and social development, surveying and mapping technology by leaps and bounds, engineering surveying technology has undergone tremendous changes. In the process of protecting ancient buildings, it is necessary to obtain the precise dimensions of architectural details. In this study, the path of 3D laser scanning combined with BIM technology is explored. Taking the observation and protection of the ancestral hall of the Liu family as an example, this study aims to draw drawings that reflect the relevant information about the ancient buildings, the accurate three-dimensional model of ancient buildings is established with BIM technology, which provides new methods and ideas for the research and protection of ancient buildings. .
基金2021 Chongqing Energy Vocational College Science and Technology Department Teaching Reform Project"Discussion and Practice of Teaching Reform of"Bridge and Culvert Engineering Construction Technology"Based on Road and Bridge Simulation Software"(202106)。
文摘The informatization of higher vocational education is the future development trend,and it is also encouraged and promoted by the Ministry of Education.This article focuses on the road and bridge major,combined with the author’s experience in introducing virtual simulation and three-dimensional(3D)animation technology into relevant course teaching in recent years,discusses the application of virtual simulation and 3D animation technology in higher vocational education and promotes classroom revolution,to obtain better teaching effect.
文摘目的探讨NOTCH3基因第5外显子C260S位点突变导致的伴有皮层下梗死和白质脑病的常染色体显性遗传性脑动脉病(cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy,CADASIL)家系的临床和影像学特征。方法选取2021年12月首都医科大学附属北京同仁医院来自同一家庭的CADASIL患者,对所有患者进行NOTCH3基因测序,回顾性分析患者的临床表现和头颅影像学特征。复习既往文献报道的导致同一位置氨基酸改变的其他突变类型的临床及影像学特征。结果4名家庭成员中,包括先证者(46岁,女)及其两个姐姐(分别为48岁和50岁)和女儿(18岁)。先证者及其父亲、两个姐姐都有偏头痛病史,其中大姐有记忆力减退;先证者患有脑梗死及伴有视觉先兆的偏头痛;先证者女儿体健;先证者父亲因脑梗死去世。4名家庭成员均存在C260S位点的NOTCH3基因突变。既往文献无此位点突变的报道,先证者头颅MRI示右侧脑桥亚急性梗死,颞叶、脑室周围及脑干异常高信号改变,其大姐脑桥可见腔隙性梗死灶。结论NOTCH3基因第5外显子c.778T>A(p.C260S)的罕见突变导致的CADASIL发病时间早,早期会出现认知障碍。合并偏头痛的脑干梗死患者,需警惕CADASIL的可能。
文摘光催化灭活是公认的控制病原微生物最具前景手段之一。本文以尿素和硫代巴比妥酸为起始原料,通过热聚合反应制备S掺杂g-C_(3)N_(4)(SCN),随后采用光还原法将Ag纳米粒负载于SCN表面获得新颖的可见光响应型Ag/SCN抗菌材料。对所制备纳米材料进行XRD、SEM、TEM、XPS及UV-Vis DRS表征,并深入探讨其在可见光下灭活大肠杆菌(E.coli)的性能和机制。结果表明,Ag纳米粒均匀且牢固地负载在SCN表面,纳米材料表现出显著增强的可见光响应能力。当负载量为6%时,Ag/SCN-6呈现出最佳的光催化灭菌活性,60 min内能够将6.2 lg CFU·mL^(-1)的E.coli全部灭活。自由基捕获实验结果表明,超氧自由基(·O-2)是灭活过程中最主要活性物种,它协同光生空穴(h+)和羟基自由基(·OH)主导了光催化抗菌的进程。
基金supported in parts by the National Natural Science Foundation of China,Nos.82101501(to QF),and 82201589(to XH)。
文摘Proteolytic cleavage of tau by asparagine endopeptidase(AEP)creates tau-N368 fragments,which may drive the pathophysiology associated with synaptic dysfunction and memory deterioration in the brain of Alzheimer’s disease patients.Nonetheless,the molecular mechanisms of truncated tau-induced cognitive deficits remain unclear.Evidence suggests that signal transduction and activator of transcription-3(STAT3)is associated with modulating synaptic plasticity,cell apoptosis,and cognitive function.Using luciferase reporter assays,electrophoretic mobility shift assays,western blotting,and immunofluorescence,we found that human tau-N368 accumulation inhibited STAT3 activity by suppressing STAT3 translocation into the nucleus.Overexpression of STAT3 improved tau-N368-induced synaptic deficits and reduced neuronal loss,thereby improving the cognitive deficits in tau-N368 mice.Moreover,in tau-N368 mice,activation of STAT3 increased N-methyl-D-aspartic acid receptor levels,decreased Bcl-2 levels,reversed synaptic damage and neuronal loss,and thereby alleviated cognitive deficits caused by tau-N368.Taken together,STAT3 plays a critical role in truncated tau-related neuropathological changes.This indicates a new mechanism behind the effect of tau-N368 on synapses and memory deficits.STAT3 can be used as a new molecular target to treat tau-N368-induced protein pathology.
