Long-term levodopa administration can lead to the development of levodopa-induced dyskinesia.Gamma oscillations are a widely recognized hallmark of abnormal neural electrical activity in levodopa-induced dyskinesia.Cu...Long-term levodopa administration can lead to the development of levodopa-induced dyskinesia.Gamma oscillations are a widely recognized hallmark of abnormal neural electrical activity in levodopa-induced dyskinesia.Currently,studies have reported increased oscillation power in cases of levodopa-induced dyskinesia.However,little is known about how the other electrophysiological parameters of gamma oscillations are altered in levodopa-induced dyskinesia.Furthermore,the role of the dopamine D3 receptor,which is implicated in levodopa-induced dyskinesia,in movement disorder-related changes in neural oscillations is unclear.We found that the cortico-striatal functional connectivity of beta oscillations was enhanced in a model of Parkinson’s disease.Furthermore,levodopa application enhanced cortical gamma oscillations in cortico-striatal projections and cortical gamma aperiodic components,as well as bidirectional primary motor cortex(M1)↔dorsolateral striatum gamma flow.Administration of PD128907(a selective dopamine D3 receptor agonist)induced dyskinesia and excessive gamma oscillations with a bidirectional M1↔dorsolateral striatum flow.However,administration of PG01037(a selective dopamine D3 receptor antagonist)attenuated dyskinesia,suppressed gamma oscillations and cortical gamma aperiodic components,and decreased gamma causality in the M1→dorsolateral striatum direction.These findings suggest that the dopamine D3 receptor plays a role in dyskinesia-related oscillatory activity,and that it has potential as a therapeutic target for levodopa-induced dyskinesia.展开更多
With the continuous advancement of technology,the application of 3D printing technology in the field of dental medicine is becoming increasingly widespread.This article aims to explore the current applications and fut...With the continuous advancement of technology,the application of 3D printing technology in the field of dental medicine is becoming increasingly widespread.This article aims to explore the current applications and future potential of 3D printing technology in dental medicine and to analyze its benefits and challenges.It first introduces the current state of 3D printing technology in dental implants,crowns,bridges,orthodontics,and maxillofacial surgery.It then discusses the potential applications of 3D printing technology in oral tissue engineering,drug delivery systems,personalized dental prosthetics,and surgical planning.Finally,it analyzes the benefits of 3D printing technology in dental medicine,such as improving treatment accuracy and patient comfort,and shortening treatment times,while also highlighting the challenges faced,such as costs,material choices,and technical limitations.This article aims to provide a reference for professionals in the field of dental medicine and to promote the further application and development of 3D printing technology in this area.展开更多
The different formats of codec stream carried in the radio access network and the core network make the double speech encoding/decoding necessary, which degrades the speech quality. Accordingly, codec negotiation tech...The different formats of codec stream carried in the radio access network and the core network make the double speech encoding/decoding necessary, which degrades the speech quality. Accordingly, codec negotiation technologies are necessary for unifying encoding/ decoding in the whole process. Transcoder Free Operation (TrFO), Tandem Free Operation (TFO), and network quality deciding technology are the leading codec negotiation technologies. The TrFO is a mechanism for optimum selection during the establishment of a call. It tries to establish connection between User Equipment (UE) without Transcoder (TC). Its successful fulfillment enables the efficient utilization of bandwidth. The TFO, a standby technology of TrFO, is the negotiation technology of an in-band codec. With it, the user codec stream is free from the compression and decompression by the voice codec, and the quality of voice can accordingly be improved. The network-quantity deciding technology adopts G.711 or G.729 flexibly according to the number of accessed calls. This allows the access of new calls while won’t increase the load of network too much.展开更多
This paper introduced the theory and approaches of building driving forcemodels revealing the changes in land utilization level by integrating RS, GPS, and GIS technologiesbased on the example of Yuanmou County of Yun...This paper introduced the theory and approaches of building driving forcemodels revealing the changes in land utilization level by integrating RS, GPS, and GIS technologiesbased on the example of Yuanmou County of Yunnan Province. We first created the land utilizationtype database, natural driving forces for land utilization database, and human driving forces forland utilization database. Then we obtained the dependent and the independent variables of changesin land utilization level by exploring various data. Lastly we screened major factors affectingchanges in land utilization level by using the powerful spatial correlation analysis and maincomponent analysis module of GIS and obtained a multivariable linear regression model of thechangesin land utilization level by using GIS spatial regression analysis module.展开更多
Based on the latest research findings of 3GPP on network sharing, this paper introduces 4 solutions to WCDMA 3G network sharing: site sharing, common network sharing, geographically split network sharing, and radio ac...Based on the latest research findings of 3GPP on network sharing, this paper introduces 4 solutions to WCDMA 3G network sharing: site sharing, common network sharing, geographically split network sharing, and radio access network sharing. It also analyzes the key network sharing technologies, including the lu-Flex function in Release 5, the UTRAN sharing mechanism in the connected mode in Release 5 and the mechanism of network sharing support enhancement in Release 6.展开更多
The paper introduces two typical 3G services:the mobile multimedia short message service and the streaming media service. The former is considered as a strong driving force to promote the development of 3G services an...The paper introduces two typical 3G services:the mobile multimedia short message service and the streaming media service. The former is considered as a strong driving force to promote the development of 3G services and applications.The latter is regarded as a typical service on future 3G networks.As supporting technologies of 3G services,open service architecture and open mobile architecture are also discussed.展开更多
It is wise for fixed operators to make use of broadband wireless access technologies,such as IEEE802.16d,to develop mobile access based on their existing fixed broadband IP networks.Mobile operators have to evolve the...It is wise for fixed operators to make use of broadband wireless access technologies,such as IEEE802.16d,to develop mobile access based on their existing fixed broadband IP networks.Mobile operators have to evolve their networks from 2G to 3G for making full use of their current resources. However,the AII-IP core network will be a general trend since broadband wireless access adopts the connectionless statistical packet multiplexing technology.Based on the introduction of IEEE802.16d,High Speed Downlink Packet Access (HSDPA) and CDMA2000 1x EV-DV technologies,this paper discusses the development trend of broadband wireless access technologies, and concludes that 3G's packet access technologies are the same as IEEE802.16d/e,and AII-IP is the goal.It emphasizes that Chinese TD-SCDMA should develop toward connectionless statistical packet multiplexing as early as possible.展开更多
The application of virtual reality technology has become more and more influential in garden design. Quest3D as a significant software to realize the virtual reality technology is utilized in this study to make a gard...The application of virtual reality technology has become more and more influential in garden design. Quest3D as a significant software to realize the virtual reality technology is utilized in this study to make a garden roaming demonstration system with the gardening design of a classical courtyard as an example. Besides, the advantages and disadvantages of applying Quest3D technology in garden landscape design are elaborated from the perspective of the selection of Quest3D technology, basic procedures for the selection and establishment of software and hardware.展开更多
目的探讨NOTCH3基因第5外显子C260S位点突变导致的伴有皮层下梗死和白质脑病的常染色体显性遗传性脑动脉病(cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy,CADASIL)家系的临床和影像学...目的探讨NOTCH3基因第5外显子C260S位点突变导致的伴有皮层下梗死和白质脑病的常染色体显性遗传性脑动脉病(cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy,CADASIL)家系的临床和影像学特征。方法选取2021年12月首都医科大学附属北京同仁医院来自同一家庭的CADASIL患者,对所有患者进行NOTCH3基因测序,回顾性分析患者的临床表现和头颅影像学特征。复习既往文献报道的导致同一位置氨基酸改变的其他突变类型的临床及影像学特征。结果4名家庭成员中,包括先证者(46岁,女)及其两个姐姐(分别为48岁和50岁)和女儿(18岁)。先证者及其父亲、两个姐姐都有偏头痛病史,其中大姐有记忆力减退;先证者患有脑梗死及伴有视觉先兆的偏头痛;先证者女儿体健;先证者父亲因脑梗死去世。4名家庭成员均存在C260S位点的NOTCH3基因突变。既往文献无此位点突变的报道,先证者头颅MRI示右侧脑桥亚急性梗死,颞叶、脑室周围及脑干异常高信号改变,其大姐脑桥可见腔隙性梗死灶。结论NOTCH3基因第5外显子c.778T>A(p.C260S)的罕见突变导致的CADASIL发病时间早,早期会出现认知障碍。合并偏头痛的脑干梗死患者,需警惕CADASIL的可能。展开更多
In order to study the successive deposition and solidification processes of uniform alloy droplets during the drop-on-demand three dimensional（3D） printing method,based on the volume of fluid（VOF） method,a 3D nume...In order to study the successive deposition and solidification processes of uniform alloy droplets during the drop-on-demand three dimensional（3D） printing method,based on the volume of fluid（VOF） method,a 3D numerical model was employed.In this model,the 7075 alloy with larger temperature range for phase change was used.The simulation results show that the successive deposition and solidification processes of uniform 7075 alloy droplets can be well characterized by this model.Simulated droplets shapes agree well with SEM images under the same condition.The effects of deposition and solidification of droplets result in vertical and L-shaped ridges on the surface of droplets,and tips of dendrites appear near the overlap of droplets due to rapid solidification.展开更多
基金supported by the National Natural Science Foundation of China,No.82071254(to WZ).
文摘Long-term levodopa administration can lead to the development of levodopa-induced dyskinesia.Gamma oscillations are a widely recognized hallmark of abnormal neural electrical activity in levodopa-induced dyskinesia.Currently,studies have reported increased oscillation power in cases of levodopa-induced dyskinesia.However,little is known about how the other electrophysiological parameters of gamma oscillations are altered in levodopa-induced dyskinesia.Furthermore,the role of the dopamine D3 receptor,which is implicated in levodopa-induced dyskinesia,in movement disorder-related changes in neural oscillations is unclear.We found that the cortico-striatal functional connectivity of beta oscillations was enhanced in a model of Parkinson’s disease.Furthermore,levodopa application enhanced cortical gamma oscillations in cortico-striatal projections and cortical gamma aperiodic components,as well as bidirectional primary motor cortex(M1)↔dorsolateral striatum gamma flow.Administration of PD128907(a selective dopamine D3 receptor agonist)induced dyskinesia and excessive gamma oscillations with a bidirectional M1↔dorsolateral striatum flow.However,administration of PG01037(a selective dopamine D3 receptor antagonist)attenuated dyskinesia,suppressed gamma oscillations and cortical gamma aperiodic components,and decreased gamma causality in the M1→dorsolateral striatum direction.These findings suggest that the dopamine D3 receptor plays a role in dyskinesia-related oscillatory activity,and that it has potential as a therapeutic target for levodopa-induced dyskinesia.
文摘With the continuous advancement of technology,the application of 3D printing technology in the field of dental medicine is becoming increasingly widespread.This article aims to explore the current applications and future potential of 3D printing technology in dental medicine and to analyze its benefits and challenges.It first introduces the current state of 3D printing technology in dental implants,crowns,bridges,orthodontics,and maxillofacial surgery.It then discusses the potential applications of 3D printing technology in oral tissue engineering,drug delivery systems,personalized dental prosthetics,and surgical planning.Finally,it analyzes the benefits of 3D printing technology in dental medicine,such as improving treatment accuracy and patient comfort,and shortening treatment times,while also highlighting the challenges faced,such as costs,material choices,and technical limitations.This article aims to provide a reference for professionals in the field of dental medicine and to promote the further application and development of 3D printing technology in this area.
文摘The different formats of codec stream carried in the radio access network and the core network make the double speech encoding/decoding necessary, which degrades the speech quality. Accordingly, codec negotiation technologies are necessary for unifying encoding/ decoding in the whole process. Transcoder Free Operation (TrFO), Tandem Free Operation (TFO), and network quality deciding technology are the leading codec negotiation technologies. The TrFO is a mechanism for optimum selection during the establishment of a call. It tries to establish connection between User Equipment (UE) without Transcoder (TC). Its successful fulfillment enables the efficient utilization of bandwidth. The TFO, a standby technology of TrFO, is the negotiation technology of an in-band codec. With it, the user codec stream is free from the compression and decompression by the voice codec, and the quality of voice can accordingly be improved. The network-quantity deciding technology adopts G.711 or G.729 flexibly according to the number of accessed calls. This allows the access of new calls while won’t increase the load of network too much.
文摘This paper introduced the theory and approaches of building driving forcemodels revealing the changes in land utilization level by integrating RS, GPS, and GIS technologiesbased on the example of Yuanmou County of Yunnan Province. We first created the land utilizationtype database, natural driving forces for land utilization database, and human driving forces forland utilization database. Then we obtained the dependent and the independent variables of changesin land utilization level by exploring various data. Lastly we screened major factors affectingchanges in land utilization level by using the powerful spatial correlation analysis and maincomponent analysis module of GIS and obtained a multivariable linear regression model of thechangesin land utilization level by using GIS spatial regression analysis module.
文摘Based on the latest research findings of 3GPP on network sharing, this paper introduces 4 solutions to WCDMA 3G network sharing: site sharing, common network sharing, geographically split network sharing, and radio access network sharing. It also analyzes the key network sharing technologies, including the lu-Flex function in Release 5, the UTRAN sharing mechanism in the connected mode in Release 5 and the mechanism of network sharing support enhancement in Release 6.
文摘The paper introduces two typical 3G services:the mobile multimedia short message service and the streaming media service. The former is considered as a strong driving force to promote the development of 3G services and applications.The latter is regarded as a typical service on future 3G networks.As supporting technologies of 3G services,open service architecture and open mobile architecture are also discussed.
文摘It is wise for fixed operators to make use of broadband wireless access technologies,such as IEEE802.16d,to develop mobile access based on their existing fixed broadband IP networks.Mobile operators have to evolve their networks from 2G to 3G for making full use of their current resources. However,the AII-IP core network will be a general trend since broadband wireless access adopts the connectionless statistical packet multiplexing technology.Based on the introduction of IEEE802.16d,High Speed Downlink Packet Access (HSDPA) and CDMA2000 1x EV-DV technologies,this paper discusses the development trend of broadband wireless access technologies, and concludes that 3G's packet access technologies are the same as IEEE802.16d/e,and AII-IP is the goal.It emphasizes that Chinese TD-SCDMA should develop toward connectionless statistical packet multiplexing as early as possible.
文摘The application of virtual reality technology has become more and more influential in garden design. Quest3D as a significant software to realize the virtual reality technology is utilized in this study to make a garden roaming demonstration system with the gardening design of a classical courtyard as an example. Besides, the advantages and disadvantages of applying Quest3D technology in garden landscape design are elaborated from the perspective of the selection of Quest3D technology, basic procedures for the selection and establishment of software and hardware.
文摘目的探讨NOTCH3基因第5外显子C260S位点突变导致的伴有皮层下梗死和白质脑病的常染色体显性遗传性脑动脉病(cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy,CADASIL)家系的临床和影像学特征。方法选取2021年12月首都医科大学附属北京同仁医院来自同一家庭的CADASIL患者,对所有患者进行NOTCH3基因测序,回顾性分析患者的临床表现和头颅影像学特征。复习既往文献报道的导致同一位置氨基酸改变的其他突变类型的临床及影像学特征。结果4名家庭成员中,包括先证者(46岁,女)及其两个姐姐(分别为48岁和50岁)和女儿(18岁)。先证者及其父亲、两个姐姐都有偏头痛病史,其中大姐有记忆力减退;先证者患有脑梗死及伴有视觉先兆的偏头痛;先证者女儿体健;先证者父亲因脑梗死去世。4名家庭成员均存在C260S位点的NOTCH3基因突变。既往文献无此位点突变的报道,先证者头颅MRI示右侧脑桥亚急性梗死,颞叶、脑室周围及脑干异常高信号改变,其大姐脑桥可见腔隙性梗死灶。结论NOTCH3基因第5外显子c.778T>A(p.C260S)的罕见突变导致的CADASIL发病时间早,早期会出现认知障碍。合并偏头痛的脑干梗死患者,需警惕CADASIL的可能。
基金Projects (51005186,51221001) supported by the National Natural Science Foundation of ChinaProject (85-TZ-2013) supported by the Research Fund of the State Key Laboratory of Solidification Processing(NWPU),ChinaProject (20126102110022) supported by the Doctoral Fund of Ministry of Education of China
文摘In order to study the successive deposition and solidification processes of uniform alloy droplets during the drop-on-demand three dimensional（3D） printing method,based on the volume of fluid（VOF） method,a 3D numerical model was employed.In this model,the 7075 alloy with larger temperature range for phase change was used.The simulation results show that the successive deposition and solidification processes of uniform 7075 alloy droplets can be well characterized by this model.Simulated droplets shapes agree well with SEM images under the same condition.The effects of deposition and solidification of droplets result in vertical and L-shaped ridges on the surface of droplets,and tips of dendrites appear near the overlap of droplets due to rapid solidification.
