DOG1(Delay of germination 1)蛋白是种子休眠的一种主要调控因子,可与ABA协同作用来延迟种子萌发。核心脱落酸(ABA)信号转导途径和DOG1途径在蛋白磷酸酶2C(PP2C)中汇聚。DOG1调控种子休眠需要PP2C,并通过与ABA过敏感萌发(AHG1/AHG3)结...DOG1(Delay of germination 1)蛋白是种子休眠的一种主要调控因子,可与ABA协同作用来延迟种子萌发。核心脱落酸(ABA)信号转导途径和DOG1途径在蛋白磷酸酶2C(PP2C)中汇聚。DOG1调控种子休眠需要PP2C,并通过与ABA过敏感萌发(AHG1/AHG3)结合来增强ABA的信号转导。DOG1抑制AHG1的作用来增加ABA的敏感性和诱导种子休眠。近年来,DOG1对种子休眠与萌发的调控研究取得了显著进展。本文对该领域的研究成果进行了综述,主要包括:DOG1对种子成熟、休眠与萌发的作用,DOG1表达的转录调控机制以及DOG1对种子休眠与萌发的调控及作用机制,最后提出了在本领域需要进一步研究的科学问题。展开更多
The aim of the present study was to compare the ixodicide efficacy of 1% permethrin applied as a shampoo-bath in single treatment and a combined formulation of 2% permethrin + 1% piperonyl butoxide applied as powder i...The aim of the present study was to compare the ixodicide efficacy of 1% permethrin applied as a shampoo-bath in single treatment and a combined formulation of 2% permethrin + 1% piperonyl butoxide applied as powder in a single treatment against Rhipicephalus sanguineus ticks, in naturally infested dogs. Eighteen adult cross-mixed dogs, harboring to at least 20 ticks/animal, were selected on pre-treatment live tick counts. On day 0, the dogs were then divided in 3 groups of 6 animals each, for treatment: Group 1 (G1) received 1% permethrin applied as shampoo-bath (approximately 10 ml/kg bw), according to label instructions. G2 was treated with 2% permethrin + 1% piperonyl butoxide applied as powder, and rubbed as massage on the body, as recommended by the producer. G3 served as a non-treated control. After the treatment, the dogs were checked out for live ticks counting on days 0, 1, 7, and 14. The ixodicide efficacy was assessed based on the percentage reductions of ticks on the days analyzed post-treatment, with respect to the untreated control. Results showed that permethrin alone removed ticks on 81%, 93.1% and 89.6% for days 1, 7 and 14, respectively. The combined formulation of 2% permethrin + 1% piperonyl butoxide exerted a better efficacy of 98.8, 97.7 and 97.0%, respectively. It is concluded that this combined formulation was highly effective at rapidly repelling and killing Riphicephalus sanguineus ticks on naturally infected dogs, showing a significant effect on days 1, 7 and 14 after tick exposure. The sustained high and quick level of efficacy of this combination may well interfere with the transmission of Riphicephalus sanguineus ticks. It is concluded that the sustained high level of efficacy of the permethrin + piperonyl butoxide combination may well exert an additive effect and could interfere with the transmission of Riphicephalus sanguineus ticks.展开更多
The cloud computing technology is utilized for achieving resource utilization of remotebased virtual computer to facilitate the consumers with rapid and accurate massive data services.It utilizes on-demand resource pr...The cloud computing technology is utilized for achieving resource utilization of remotebased virtual computer to facilitate the consumers with rapid and accurate massive data services.It utilizes on-demand resource provisioning,but the necessitated constraints of rapid turnaround time,minimal execution cost,high rate of resource utilization and limited makespan transforms the Load Balancing(LB)process-based Task Scheduling(TS)problem into an NP-hard optimization issue.In this paper,Hybrid Prairie Dog and Beluga Whale Optimization Algorithm(HPDBWOA)is propounded for precise mapping of tasks to virtual machines with the due objective of addressing the dynamic nature of cloud environment.This capability of HPDBWOA helps in decreasing the SLA violations and Makespan with optimal resource management.It is modelled as a scheduling strategy which utilizes the merits of PDOA and BWOA for attaining reactive decisions making with respect to the process of assigning the tasks to virtual resources by considering their priorities into account.It addresses the problem of pre-convergence with wellbalanced exploration and exploitation to attain necessitated Quality of Service(QoS)for minimizing the waiting time incurred during TS process.It further balanced exploration and exploitation rates for reducing the makespan during the task allocation with complete awareness of VM state.The results of the proposed HPDBWOA confirmed minimized energy utilization of 32.18% and reduced cost of 28.94% better than approaches used for investigation.The statistical investigation of the proposed HPDBWOA conducted using ANOVA confirmed its efficacy over the benchmarked systems in terms of throughput,system,and response time.展开更多
Domestic cats and dogs are carnivores that have evolved differentially in the nutrition and metabolism of amino acids.This article highlights both proteinogenic and nonproteinogenic amino acids.Dogs inadequately synth...Domestic cats and dogs are carnivores that have evolved differentially in the nutrition and metabolism of amino acids.This article highlights both proteinogenic and nonproteinogenic amino acids.Dogs inadequately synthesize citrulline(the precursor of arginine)from glutamine,glutamate,and proline in the small intestine.Although most breeds of dogs have potential for adequately converting cysteine into taurine in the liver,a small proportion(1.3%-2.5%)of the Newfoundland dogs fed commercially available balanced diets exhibit a deficiency of taurine possibly due to gene mutations.Certain breeds of dogs(e.g.,golden retrievers)are more prone to taurine deficiency possibly due to lower hepatic activities of cysteine dioxygenase and cysteine sulfinate decarboxylase.De novo synthesis of arginine and taurine is very limited in cats.Thus,concentrations of both taurine and arginine in feline milk are the greatest among domestic mammals.Compared with dogs,cats have greater endogenous nitrogen losses and higher dietary requirements for many amino acids(e.g.,arginine,taurine,cysteine,and tyrosine),and are less sensitive to amino acid imbalances and antagonisms.Throughout adulthood,cats and dogs may lose 34%and 21%of their lean body mass,respectively.Adequate intakes of high-quality protein(i.e.,32%and 40%animal protein in diets of aging dogs and cats,respectively;dry matter basis)are recommended to alleviate aging-associated reductions in the mass and function of skeletal muscles and bones.Pet-food grade animal-sourced foodstuffs are excellent sources of both proteinogenic amino acids and taurine for cats and dogs,and can help to optimize their growth,development,and health.展开更多
Background: Quality of life (QoL) is a term used to evaluate general well-being, and it is defined as ‘the degree to which an individual enjoys his or her life. Within the realm of medicine, the evaluation of QoL fre...Background: Quality of life (QoL) is a term used to evaluate general well-being, and it is defined as ‘the degree to which an individual enjoys his or her life. Within the realm of medicine, the evaluation of QoL frequently involves examining how disease exerts a detrimental impact, diminishing the enjoyment and fulfilment experienced by the individual. Dermatological diseases have been found to exert a substantial negative influence on the QoL of dogs and their owners due to nuisance and stress related to the disease but also due to the caregiver burden. In the management of bacterial skin infections, topical therapy is commonly administered alongside systemic antibiotics. Nonetheless, the protracted duration of treatment and difficulties in ensuring owner compliance can introduce a significant caregiver burden, potentially exacerbating the challenges associated with these conditions. Purpose: This study aimed to evaluate the impact on the quality of life (QoL) of dogs with dermatologic diseases after fluorescent light energy (FLE) treatment. Methods: The study was an open, prospective, multicentric clinical trial that included dogs with various dermatological conditions. The dogs received FLE treatment once weekly until the clinical resolution was achieved. Owners completed a validated questionnaire to assess the QoL of their dogs before and after therapy. Results: Thirty-five dogs with deep pyoderma, interdigital furunculosis, pyotraumatic dermatitis, wounds and perianal fistulas were included. All dogs received two sessions of fluorescent light energy once a week. Median treatment duration was 9 weeks for perianal fistula, 7 weeks for interdigital furunculosis, 5 weeks for deep pyoderma, 3 weeks for wounds and 1.5 weeks for pyotraumatic dermatitis. Complete remission was noted in 86% of dogs, and 14% showed an improvement but partial remission. The majority of owners reported a positive impact on their dogs’ QoL after therapy, and 74% of the dogs showed at least a 50% reduction in QoL scores. Conclusion: Fluorescent light energy has been shown to exert beneficial effects on the healing of dermatological diseases and the quality of life (QoL) in dogs and their owners, whether used as a standalone treatment or in combination with standard care therapies. Additionally, it was well-tolerated by the dogs. This study emphasizes the significance of considering both the owner’s and dog’s QoL when evaluating the therapeutic efficacy of dermatological treatments.展开更多
Background: Separation-related disorders are prevalent in dogs and can result in problem behaviours such as inappropriate elimination, destructive behaviour, and distress vocalizations which occur when an owner is abs...Background: Separation-related disorders are prevalent in dogs and can result in problem behaviours such as inappropriate elimination, destructive behaviour, and distress vocalizations which occur when an owner is absent or perceived as absent. Numerous natural products are marketed for managing anxiety in dogs;however, few, if any, of these products have documented evidence of efficacy in veterinary behaviour. Purpose: This open, multicentric clinical trial aimed to assess the efficacy of a new supplement containing alpha-casozepine and fish muscle hydrolysate on the separation-related problem in dogs and the impact on the quality of life of dogs and their pet owners. Material and Methods: Fifty-one dogs with clinical signs compatible with separation-related problems were included. The dogs were treated with a complementary feed (Zylkene Plus, Vetoquinol, France) for 30 days. Separation-related behaviour assessment (SRP), emotional disorders assessment (EDED) and the quality of life (QoL) of the pets and their pet owner were assessed at baseline and the end of the study by the veterinarians. In addition, owners were asked to rate their dog’s SRP weekly after enrolment using the same questionnaire that the veterinarian used at the beginning of the study. Results: There was a statistically significant improvement in the SRP, EDED, and QoL scores (P Conclusion: The results of this study support the hypothesis that the combination of alpha-casozepine and fish muscle hydrolysate is a promising and effective option to reduce the frequency and severity of separation-related behaviour in dogs and improve the quality of dogs and their owners.展开更多
In this study,it is aimed to examine the knowledge level of reading stray dogs’behavior and the correct approach.Understanding the aggression of dogs and understanding their behavior is very important for stray dogs ...In this study,it is aimed to examine the knowledge level of reading stray dogs’behavior and the correct approach.Understanding the aggression of dogs and understanding their behavior is very important for stray dogs and dog owners in social life.Questionnaires prepared online were shared with 279 people of different ages and genders working in different fields in 50 provinces located in different regions,and the feedback obtained by answering voluntarily was taken into consideration.As a result of the study,when a dangerous-looking dog is encountered,it is necessary to stay as calm as possible and start to walk away slowly,without losing sight of the dog,with short steps,and without running under any circumstances.But without turning your back,because turning your back on the dog is a sign of weakness and an invitation to attack.While 36%left unanswered the question of what should be done at the time of the dog attack,20.1%replied by saying that they would stand calmly and shout and scare,and 20.9%would shout and stop.The results of the survey show that there are inaccuracies and deficiencies in both the body language of the dogs and the way they approach the dog.The participants answered the frequency of encountering stray animals by saying 75.9%daily.A safe approach to dogs or knowing the suitable approaches to calm a dangerous dog is very important in eliminating the dangers.These results show that there is a need for correct,informative activities on dog behavior and the right approach.展开更多
Ian McEwan’s Black Dogs reflects the anxiety and panic after the Second World War vividly with charming words.Based on Ian McEwan’s Black Dogs,many scholars have explored and acquired great achievements in trauma wr...Ian McEwan’s Black Dogs reflects the anxiety and panic after the Second World War vividly with charming words.Based on Ian McEwan’s Black Dogs,many scholars have explored and acquired great achievements in trauma writing and historical writing.Through analyzing the similarities of the heroine’s long-term neglected inner needs and the cruelly killed creatures in nature,this paper finds there is an intimate connection between female and nature in Black Dogs.However,instead of being in a constant state of repression,female and nature will fight back.To sum up,this paper attempts to make an ecofeminism interpretation of Ian McEwan’s Black Dogs.A conclusion may be reached that June’s spiritual awakening resonates with enhancement of nature’s power.展开更多
What is the number one favourite pet in the UK?If you think the answer is“dogs”-you are wrong.There are 8.6 million cats and 8.3 million dogs in Britain according to recent figures.But experts predict that there wil...What is the number one favourite pet in the UK?If you think the answer is“dogs”-you are wrong.There are 8.6 million cats and 8.3 million dogs in Britain according to recent figures.But experts predict that there will be more dogs than cats next year as dogs become more and more popular.展开更多
文摘DOG1(Delay of germination 1)蛋白是种子休眠的一种主要调控因子,可与ABA协同作用来延迟种子萌发。核心脱落酸(ABA)信号转导途径和DOG1途径在蛋白磷酸酶2C(PP2C)中汇聚。DOG1调控种子休眠需要PP2C,并通过与ABA过敏感萌发(AHG1/AHG3)结合来增强ABA的信号转导。DOG1抑制AHG1的作用来增加ABA的敏感性和诱导种子休眠。近年来,DOG1对种子休眠与萌发的调控研究取得了显著进展。本文对该领域的研究成果进行了综述,主要包括:DOG1对种子成熟、休眠与萌发的作用,DOG1表达的转录调控机制以及DOG1对种子休眠与萌发的调控及作用机制,最后提出了在本领域需要进一步研究的科学问题。
文摘The aim of the present study was to compare the ixodicide efficacy of 1% permethrin applied as a shampoo-bath in single treatment and a combined formulation of 2% permethrin + 1% piperonyl butoxide applied as powder in a single treatment against Rhipicephalus sanguineus ticks, in naturally infested dogs. Eighteen adult cross-mixed dogs, harboring to at least 20 ticks/animal, were selected on pre-treatment live tick counts. On day 0, the dogs were then divided in 3 groups of 6 animals each, for treatment: Group 1 (G1) received 1% permethrin applied as shampoo-bath (approximately 10 ml/kg bw), according to label instructions. G2 was treated with 2% permethrin + 1% piperonyl butoxide applied as powder, and rubbed as massage on the body, as recommended by the producer. G3 served as a non-treated control. After the treatment, the dogs were checked out for live ticks counting on days 0, 1, 7, and 14. The ixodicide efficacy was assessed based on the percentage reductions of ticks on the days analyzed post-treatment, with respect to the untreated control. Results showed that permethrin alone removed ticks on 81%, 93.1% and 89.6% for days 1, 7 and 14, respectively. The combined formulation of 2% permethrin + 1% piperonyl butoxide exerted a better efficacy of 98.8, 97.7 and 97.0%, respectively. It is concluded that this combined formulation was highly effective at rapidly repelling and killing Riphicephalus sanguineus ticks on naturally infected dogs, showing a significant effect on days 1, 7 and 14 after tick exposure. The sustained high and quick level of efficacy of this combination may well interfere with the transmission of Riphicephalus sanguineus ticks. It is concluded that the sustained high level of efficacy of the permethrin + piperonyl butoxide combination may well exert an additive effect and could interfere with the transmission of Riphicephalus sanguineus ticks.
文摘The cloud computing technology is utilized for achieving resource utilization of remotebased virtual computer to facilitate the consumers with rapid and accurate massive data services.It utilizes on-demand resource provisioning,but the necessitated constraints of rapid turnaround time,minimal execution cost,high rate of resource utilization and limited makespan transforms the Load Balancing(LB)process-based Task Scheduling(TS)problem into an NP-hard optimization issue.In this paper,Hybrid Prairie Dog and Beluga Whale Optimization Algorithm(HPDBWOA)is propounded for precise mapping of tasks to virtual machines with the due objective of addressing the dynamic nature of cloud environment.This capability of HPDBWOA helps in decreasing the SLA violations and Makespan with optimal resource management.It is modelled as a scheduling strategy which utilizes the merits of PDOA and BWOA for attaining reactive decisions making with respect to the process of assigning the tasks to virtual resources by considering their priorities into account.It addresses the problem of pre-convergence with wellbalanced exploration and exploitation to attain necessitated Quality of Service(QoS)for minimizing the waiting time incurred during TS process.It further balanced exploration and exploitation rates for reducing the makespan during the task allocation with complete awareness of VM state.The results of the proposed HPDBWOA confirmed minimized energy utilization of 32.18% and reduced cost of 28.94% better than approaches used for investigation.The statistical investigation of the proposed HPDBWOA conducted using ANOVA confirmed its efficacy over the benchmarked systems in terms of throughput,system,and response time.
基金This work was supported by Texas A&M AgriLife Research(H-8200).
文摘Domestic cats and dogs are carnivores that have evolved differentially in the nutrition and metabolism of amino acids.This article highlights both proteinogenic and nonproteinogenic amino acids.Dogs inadequately synthesize citrulline(the precursor of arginine)from glutamine,glutamate,and proline in the small intestine.Although most breeds of dogs have potential for adequately converting cysteine into taurine in the liver,a small proportion(1.3%-2.5%)of the Newfoundland dogs fed commercially available balanced diets exhibit a deficiency of taurine possibly due to gene mutations.Certain breeds of dogs(e.g.,golden retrievers)are more prone to taurine deficiency possibly due to lower hepatic activities of cysteine dioxygenase and cysteine sulfinate decarboxylase.De novo synthesis of arginine and taurine is very limited in cats.Thus,concentrations of both taurine and arginine in feline milk are the greatest among domestic mammals.Compared with dogs,cats have greater endogenous nitrogen losses and higher dietary requirements for many amino acids(e.g.,arginine,taurine,cysteine,and tyrosine),and are less sensitive to amino acid imbalances and antagonisms.Throughout adulthood,cats and dogs may lose 34%and 21%of their lean body mass,respectively.Adequate intakes of high-quality protein(i.e.,32%and 40%animal protein in diets of aging dogs and cats,respectively;dry matter basis)are recommended to alleviate aging-associated reductions in the mass and function of skeletal muscles and bones.Pet-food grade animal-sourced foodstuffs are excellent sources of both proteinogenic amino acids and taurine for cats and dogs,and can help to optimize their growth,development,and health.
文摘Background: Quality of life (QoL) is a term used to evaluate general well-being, and it is defined as ‘the degree to which an individual enjoys his or her life. Within the realm of medicine, the evaluation of QoL frequently involves examining how disease exerts a detrimental impact, diminishing the enjoyment and fulfilment experienced by the individual. Dermatological diseases have been found to exert a substantial negative influence on the QoL of dogs and their owners due to nuisance and stress related to the disease but also due to the caregiver burden. In the management of bacterial skin infections, topical therapy is commonly administered alongside systemic antibiotics. Nonetheless, the protracted duration of treatment and difficulties in ensuring owner compliance can introduce a significant caregiver burden, potentially exacerbating the challenges associated with these conditions. Purpose: This study aimed to evaluate the impact on the quality of life (QoL) of dogs with dermatologic diseases after fluorescent light energy (FLE) treatment. Methods: The study was an open, prospective, multicentric clinical trial that included dogs with various dermatological conditions. The dogs received FLE treatment once weekly until the clinical resolution was achieved. Owners completed a validated questionnaire to assess the QoL of their dogs before and after therapy. Results: Thirty-five dogs with deep pyoderma, interdigital furunculosis, pyotraumatic dermatitis, wounds and perianal fistulas were included. All dogs received two sessions of fluorescent light energy once a week. Median treatment duration was 9 weeks for perianal fistula, 7 weeks for interdigital furunculosis, 5 weeks for deep pyoderma, 3 weeks for wounds and 1.5 weeks for pyotraumatic dermatitis. Complete remission was noted in 86% of dogs, and 14% showed an improvement but partial remission. The majority of owners reported a positive impact on their dogs’ QoL after therapy, and 74% of the dogs showed at least a 50% reduction in QoL scores. Conclusion: Fluorescent light energy has been shown to exert beneficial effects on the healing of dermatological diseases and the quality of life (QoL) in dogs and their owners, whether used as a standalone treatment or in combination with standard care therapies. Additionally, it was well-tolerated by the dogs. This study emphasizes the significance of considering both the owner’s and dog’s QoL when evaluating the therapeutic efficacy of dermatological treatments.
文摘Background: Separation-related disorders are prevalent in dogs and can result in problem behaviours such as inappropriate elimination, destructive behaviour, and distress vocalizations which occur when an owner is absent or perceived as absent. Numerous natural products are marketed for managing anxiety in dogs;however, few, if any, of these products have documented evidence of efficacy in veterinary behaviour. Purpose: This open, multicentric clinical trial aimed to assess the efficacy of a new supplement containing alpha-casozepine and fish muscle hydrolysate on the separation-related problem in dogs and the impact on the quality of life of dogs and their pet owners. Material and Methods: Fifty-one dogs with clinical signs compatible with separation-related problems were included. The dogs were treated with a complementary feed (Zylkene Plus, Vetoquinol, France) for 30 days. Separation-related behaviour assessment (SRP), emotional disorders assessment (EDED) and the quality of life (QoL) of the pets and their pet owner were assessed at baseline and the end of the study by the veterinarians. In addition, owners were asked to rate their dog’s SRP weekly after enrolment using the same questionnaire that the veterinarian used at the beginning of the study. Results: There was a statistically significant improvement in the SRP, EDED, and QoL scores (P Conclusion: The results of this study support the hypothesis that the combination of alpha-casozepine and fish muscle hydrolysate is a promising and effective option to reduce the frequency and severity of separation-related behaviour in dogs and improve the quality of dogs and their owners.
文摘In this study,it is aimed to examine the knowledge level of reading stray dogs’behavior and the correct approach.Understanding the aggression of dogs and understanding their behavior is very important for stray dogs and dog owners in social life.Questionnaires prepared online were shared with 279 people of different ages and genders working in different fields in 50 provinces located in different regions,and the feedback obtained by answering voluntarily was taken into consideration.As a result of the study,when a dangerous-looking dog is encountered,it is necessary to stay as calm as possible and start to walk away slowly,without losing sight of the dog,with short steps,and without running under any circumstances.But without turning your back,because turning your back on the dog is a sign of weakness and an invitation to attack.While 36%left unanswered the question of what should be done at the time of the dog attack,20.1%replied by saying that they would stand calmly and shout and scare,and 20.9%would shout and stop.The results of the survey show that there are inaccuracies and deficiencies in both the body language of the dogs and the way they approach the dog.The participants answered the frequency of encountering stray animals by saying 75.9%daily.A safe approach to dogs or knowing the suitable approaches to calm a dangerous dog is very important in eliminating the dangers.These results show that there is a need for correct,informative activities on dog behavior and the right approach.
文摘Ian McEwan’s Black Dogs reflects the anxiety and panic after the Second World War vividly with charming words.Based on Ian McEwan’s Black Dogs,many scholars have explored and acquired great achievements in trauma writing and historical writing.Through analyzing the similarities of the heroine’s long-term neglected inner needs and the cruelly killed creatures in nature,this paper finds there is an intimate connection between female and nature in Black Dogs.However,instead of being in a constant state of repression,female and nature will fight back.To sum up,this paper attempts to make an ecofeminism interpretation of Ian McEwan’s Black Dogs.A conclusion may be reached that June’s spiritual awakening resonates with enhancement of nature’s power.
基金Supported jointly by the Internal Medicine Research Program of Tianjin Seismological Bureau (Zd202108 and Zd202204)the Seismological Science and Technology Spark Program (XH20003Y)+3 种基金the Three Combination Program of Monitoring,Forecasting and Scientific Research of China Seismological Bureau (3JH-202201040)the Scientific Research and Development Program of Hebei University of Economics and Trade (2021ZD06)the Higher Education Teaching Reform Research and Practice Program of Hebei Province (2021GJJG175)the Teaching Research Program of Hebei University of Economics and Trade (2021JYQ05)。
文摘What is the number one favourite pet in the UK?If you think the answer is“dogs”-you are wrong.There are 8.6 million cats and 8.3 million dogs in Britain according to recent figures.But experts predict that there will be more dogs than cats next year as dogs become more and more popular.
