Objective To investigate whether plasma big endothelin-1(ET-1) predicts ventricular arrythmias(VAs) and end-stage events in primary prevention implantable cardioverter-defibrillator(ICD) indication patigents. Methods ...Objective To investigate whether plasma big endothelin-1(ET-1) predicts ventricular arrythmias(VAs) and end-stage events in primary prevention implantable cardioverter-defibrillator(ICD) indication patigents. Methods In total, 207 patients fulfilling the inclusion criteria from Fuwai Hospital between January 2013 and December 2015 were retrospectively analyzed. The cohort was divided into three groups according to baseline plasma big ET-1 tertiles: tertile 1(< 0.38 pmol/L, n = 68), tertile 2(0.38–0.7 pmol/L, n = 69), and tertile 3(> 0.7 pmol/L, n = 70). The primary endpoints were VAs. The secondary endpoints were end-stage events comprising all-cause mortality and heart transplantation. Results During a mean follow-up period of 25.6 ± 13.9 months, 38(18.4%) VAs and 78(37.7%) end-stage events occurred. Big ET-1 was positively correlated with NYHA class(r = 0.165, P = 0.018), serum creatinine concentration(Scr;r = 0.147, P = 0.034), high-sensitivity C-reactive protein(hs-CRP;r = 0.217, P = 0.002), Lg NT-pro BNP(r = 0.463, P < 0.001), left ventricular end diastolic diameter(LVEDD;r = 0.234, P = 0.039) and negatively correlated with left ventricular ejection fraction(LVEF;r =-0.181, P = 0.032). Kaplan-Meier analysis showed that elevated big ET-1 was associated with increased risk of VAs and end-stage events(P < 0.05). In multivariate Cox regression models, big ET-1 was an independent risk factor for VAs(hazard ratio(HR) = 3.477, 95% confidence interval(CI): 1.352–8.940, P = 0.010, tertile 2 vs. tertile 1;HR = 4.112, 95% CI: 1.604–10.540, P = 0.003, tertile 3 vs. tertile 1) and end-stage events(HR = 2.804, 95% CI: 1.354–5.806, P = 0.005, tertile 2 vs. tertile 1;HR = 4.652, 95% CI: 2.288–9.459, P < 0.001, tertile 3 vs. tertile 1). Conclusions In primary prevention ICD indication patients, plasma big ET-1 levels can predict VAs and end-stage events and may facilitate ICD-implantation risk stratification.展开更多
This paper begins with an overview of quantum mechanics, and then recounts a relatively recent algebraic extension of the Boolean algebra of probabilistic events to “conditional events” (order pairs of events). The ...This paper begins with an overview of quantum mechanics, and then recounts a relatively recent algebraic extension of the Boolean algebra of probabilistic events to “conditional events” (order pairs of events). The main point is to show that a so-called “superposition” of two (or more) quantum events (usually with mutually inconsistent initial conditions) can be represented in this algebra of conditional events and assigned a consistent conditional probability. There is no need to imagine that a quantum particle can simultaneously straddle two inconsistent possibilities.展开更多
With the acceleration of the process of economic globalization and information synchronization, every major event is accompanied by the simultaneous renewal of the city. In the era of urban development, the launch of ...With the acceleration of the process of economic globalization and information synchronization, every major event is accompanied by the simultaneous renewal of the city. In the era of urban development, the launch of major events is also for the renewal and development of the city. 2016 Rio Summer Olympics and 2010 Shanghai World Expo are taken as the research objects. Through the analysis of urban renewal from the perspective of the role of big event catalyst, it is verified that the big event catalyst has a positive impact on urban renewal, transportation, industrial transformation and other aspects. Moreover, it tries to combine the theory of urban catalyst to analyze its inspiration for the Beijing Winter Olympic Games, hoping to play a catalytic role in accelerating the urban renewal and transformation of Beijing and the reorganization of urban structure.展开更多
基金supported by Natural Science Foundation of China(81470466)。
文摘Objective To investigate whether plasma big endothelin-1(ET-1) predicts ventricular arrythmias(VAs) and end-stage events in primary prevention implantable cardioverter-defibrillator(ICD) indication patigents. Methods In total, 207 patients fulfilling the inclusion criteria from Fuwai Hospital between January 2013 and December 2015 were retrospectively analyzed. The cohort was divided into three groups according to baseline plasma big ET-1 tertiles: tertile 1(< 0.38 pmol/L, n = 68), tertile 2(0.38–0.7 pmol/L, n = 69), and tertile 3(> 0.7 pmol/L, n = 70). The primary endpoints were VAs. The secondary endpoints were end-stage events comprising all-cause mortality and heart transplantation. Results During a mean follow-up period of 25.6 ± 13.9 months, 38(18.4%) VAs and 78(37.7%) end-stage events occurred. Big ET-1 was positively correlated with NYHA class(r = 0.165, P = 0.018), serum creatinine concentration(Scr;r = 0.147, P = 0.034), high-sensitivity C-reactive protein(hs-CRP;r = 0.217, P = 0.002), Lg NT-pro BNP(r = 0.463, P < 0.001), left ventricular end diastolic diameter(LVEDD;r = 0.234, P = 0.039) and negatively correlated with left ventricular ejection fraction(LVEF;r =-0.181, P = 0.032). Kaplan-Meier analysis showed that elevated big ET-1 was associated with increased risk of VAs and end-stage events(P < 0.05). In multivariate Cox regression models, big ET-1 was an independent risk factor for VAs(hazard ratio(HR) = 3.477, 95% confidence interval(CI): 1.352–8.940, P = 0.010, tertile 2 vs. tertile 1;HR = 4.112, 95% CI: 1.604–10.540, P = 0.003, tertile 3 vs. tertile 1) and end-stage events(HR = 2.804, 95% CI: 1.354–5.806, P = 0.005, tertile 2 vs. tertile 1;HR = 4.652, 95% CI: 2.288–9.459, P < 0.001, tertile 3 vs. tertile 1). Conclusions In primary prevention ICD indication patients, plasma big ET-1 levels can predict VAs and end-stage events and may facilitate ICD-implantation risk stratification.
文摘This paper begins with an overview of quantum mechanics, and then recounts a relatively recent algebraic extension of the Boolean algebra of probabilistic events to “conditional events” (order pairs of events). The main point is to show that a so-called “superposition” of two (or more) quantum events (usually with mutually inconsistent initial conditions) can be represented in this algebra of conditional events and assigned a consistent conditional probability. There is no need to imagine that a quantum particle can simultaneously straddle two inconsistent possibilities.
文摘With the acceleration of the process of economic globalization and information synchronization, every major event is accompanied by the simultaneous renewal of the city. In the era of urban development, the launch of major events is also for the renewal and development of the city. 2016 Rio Summer Olympics and 2010 Shanghai World Expo are taken as the research objects. Through the analysis of urban renewal from the perspective of the role of big event catalyst, it is verified that the big event catalyst has a positive impact on urban renewal, transportation, industrial transformation and other aspects. Moreover, it tries to combine the theory of urban catalyst to analyze its inspiration for the Beijing Winter Olympic Games, hoping to play a catalytic role in accelerating the urban renewal and transformation of Beijing and the reorganization of urban structure.
