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Box-Behnken响应面法结合层次分析法优化萸仙茅炮制工艺
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作者 徐国伟 王巍 +3 位作者 刘思翰 洪艺丹 张立强 鞠成国 《中国中医药信息杂志》 CAS 2025年第1期134-139,共6页
目的优选萸仙茅炮制工艺。方法在单因素试验基础上,以料液比、炒制时间和炒制温度为影响因素,以仙茅苷、苔黑酚葡萄糖苷、苔黑酚龙胆二糖苷含量及外观性状的综合评分为评价指标,利用Box-Behnken响应面法结合层次分析法优化萸仙茅最佳炮... 目的优选萸仙茅炮制工艺。方法在单因素试验基础上,以料液比、炒制时间和炒制温度为影响因素,以仙茅苷、苔黑酚葡萄糖苷、苔黑酚龙胆二糖苷含量及外观性状的综合评分为评价指标,利用Box-Behnken响应面法结合层次分析法优化萸仙茅最佳炮制工艺,并进行工艺验证。结果萸仙茅最佳炮制工艺为:取生仙茅饮片,加入等量吴茱萸汁拌匀,置密闭容器内,闷润至药汁被完全吸尽,于130℃炒制6min,取出,60℃干燥。每100kg仙茅用吴茱萸10kg。吴茱萸汁制法:取吴茱萸10kg,加12倍量水浸泡60min,煎煮50min,提取3次,合并滤液,浓缩至100kg。结论本研究优化所得萸仙茅的炮制工艺可行、稳定。 展开更多
关键词 萸仙茅 box-Behnken响应面法 层次分析法 炮制工艺
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Black Box Modeling Method and Its Application in Refractories Techniques
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作者 WANG Jiezeng YUAN Lin YE Yahong LI Penghai WANG Juntao 《China's Refractories》 CAS 2012年第4期1-6,共6页
Concept of black box, condition of modeling and control methods were introduced. Taking high purity silica brick as an example, the silica brick featured with high purity, low porosity, low true density and high stren... Concept of black box, condition of modeling and control methods were introduced. Taking high purity silica brick as an example, the silica brick featured with high purity, low porosity, low true density and high strength was developed through problem analysis, test design, modeling and optimization. Using information technology to upgrade refractories industry was discussed. 展开更多
关键词 black box MODELING OPTIMIZATION TECHNIQUES REFRACTORIES
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Electric power generation technology of natural gas pressure reduction:Insights from black box-gray box hierarchical exergy analysis and evaluation method
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作者 Zhi-Dong Li Qing-Lin Cheng +4 位作者 You-Wang Chen Jiang-Dong Wei Li-Li Lv Hao Wu Yang Liu 《Petroleum Science》 SCIE CAS CSCD 2022年第1期329-338,共10页
Based on the“three box”exergy analysis model,a black box-gray box hierarchical exergy analysis and evaluation method is put forward in this paper,which is applied to evaluate the power generation technology of diffe... Based on the“three box”exergy analysis model,a black box-gray box hierarchical exergy analysis and evaluation method is put forward in this paper,which is applied to evaluate the power generation technology of differential pressure produced by natural gas expansion.By using the exergy analysis theory,the black box-gray box hierarchical exergy analysis models of three differential pressure power generation technologies are established respectively.Firstly,the“black box”analysis models of main energy consuming equipment are established,and then the“gray box”analysis model of the total system is established.Based on the calculation results of exergy analysis indexes,the weak energy consumption equipment in the whole power generation process is accurately located.Taking a gas field in southwest China as an example,the comprehensive energy consumption evaluation of the three power generation technologies is carried out,and the technology with the best energy consumption condition among the three technologies is determined.Finally,the rationalization improvement measures are put forward from improving the air tightness,replacing the deflector and reducing the flow loss. 展开更多
关键词 Expansion differential pressure power generation black box-gray box hierarchy Exergy analysis method Weak link of energy consumption
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基于Box-Behnken设计-响应面法优化调肝活血稳压颗粒提取工艺及其质量标准的研究
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作者 李凡 张国松 +4 位作者 魏鑫华 贾超 夏明艳 李东勲 张文锍 《陕西中医药大学学报》 2025年第1期100-106,共7页
目的优化调肝活血稳压颗粒的提取工艺,并对其质量标准进行研究。方法本研究以浸膏得率及丹酚酸B的转移率的综合评分为指标,采用单因素考察结合Box-Behnken设计-响应面法优化调肝活血稳压颗粒的提取工艺,采用薄层色谱法对方中药材进行鉴... 目的优化调肝活血稳压颗粒的提取工艺,并对其质量标准进行研究。方法本研究以浸膏得率及丹酚酸B的转移率的综合评分为指标,采用单因素考察结合Box-Behnken设计-响应面法优化调肝活血稳压颗粒的提取工艺,采用薄层色谱法对方中药材进行鉴别。结果确定最终提取工艺为:第一次加入10倍量水煎煮90 min,第二次加入6倍量水煎煮60 min。测定方法结果准确可靠。薄层色谱法检测出天麻、栀子、丹参等三味中药的特征性斑点。结论优化后的提取工艺操作简单,提取效果良好,结果稳定可靠。 展开更多
关键词 调肝活血稳压颗粒 丹酚酸B 薄层色谱法 高效液相色谱法 box-Behnken设计-响应面法
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On the Effectiveness of the System Validation Based on the Black Box Testing Methodology
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作者 Dusica Marijan Nikola Teslic +1 位作者 Miodrag Temerinac Vukota Pekovic 《Journal of Electronic Science and Technology of China》 2009年第4期385-389,共5页
With the advancement of technology in recent years, effective fault diagnosis became a necessity to verify the performance and ensure the quality of complex systems. In this paper, an original verification methodology... With the advancement of technology in recent years, effective fault diagnosis became a necessity to verify the performance and ensure the quality of complex systems. In this paper, an original verification methodology for complex consumer electronic devices is presented. Verification of the system which consists of hardware (integrated circuit) and corresponding software within a flat panel TV set is in the focus. Proposed methodology provides reliable functional failure detection using the concept of black box testing. Further, the approach is fully automated, improving the reliability and speed of failure detection. The methodology effectiveness has been experimentally evaluated and the analysis results have been reported. 展开更多
关键词 Automated verification black box testiug system failure detection system fault diagnosis.
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Application of Elzaki Transform Method to Market Volatility Using the Black-Scholes Model
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作者 Henrietta Ify Ojarikre Ideh Rapheal Ebimene James Mamadu 《Journal of Applied Mathematics and Physics》 2024年第3期819-828,共10页
Black-Scholes Model (B-SM) simulates the dynamics of financial market and contains instruments such as options and puts which are major indices requiring solution. B-SM is known to estimate the correct prices of Europ... Black-Scholes Model (B-SM) simulates the dynamics of financial market and contains instruments such as options and puts which are major indices requiring solution. B-SM is known to estimate the correct prices of European Stock options and establish the theoretical foundation for Option pricing. Therefore, this paper evaluates the Black-Schole model in simulating the European call in a cash flow in the dependent drift and focuses on obtaining analytic and then approximate solution for the model. The work also examines Fokker Planck Equation (FPE) and extracts the link between FPE and B-SM for non equilibrium systems. The B-SM is then solved via the Elzaki transform method (ETM). The computational procedures were obtained using MAPLE 18 with the solution provided in the form of convergent series. 展开更多
关键词 Elzaki Transform method European Call black-Scholes Model Fokker-Planck Equation Market Volatility
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基于Box-Behnken设计-响应面法优化败毒止泻提取物制备工艺研究
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作者 房思远 赵兵令 +2 位作者 郗艳菊 朱永明 李辰荃 《中兽医医药杂志》 2025年第1期73-79,共7页
为探索败毒止泻提取物的合理提取工艺,提高秦皮甲素和秦皮乙素总含量以及复方浸出物出膏率,选择影响试验指标的提取次数、提取时间、加水量等3个核心因素进行单因素试验,以最优单因素为影响因子,采用Box-Behnken中心组合设计建立数学模... 为探索败毒止泻提取物的合理提取工艺,提高秦皮甲素和秦皮乙素总含量以及复方浸出物出膏率,选择影响试验指标的提取次数、提取时间、加水量等3个核心因素进行单因素试验,以最优单因素为影响因子,采用Box-Behnken中心组合设计建立数学模型,考察相关参数对综合评分的影响程度。结果表明,败毒止泻提取物的最佳提取条件为提取3次,提取时间为1.5 h,加水量为12倍水;模型预测综合评分为96.932,验证值为96.757,理论值与验证值相对误差为0.18%。优化后的败毒止泻提取物标准工艺为中试生产转化以及临床使用的顺应性奠定了基础。 展开更多
关键词 败毒止泻提取物 box-Behnken响应面法 综合评分
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基于Cruise/BlackBox的电动汽车制动能量回收仿真 被引量:2
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作者 余楚礼 辛明华 《汽车工程师》 2016年第5期25-27,共3页
在使用AVL-Cruise进行整车仿真过程中,需要对制动能量回收策略进行研究。基于AVL-Cruise建立仿真平台,使用Cruise/Black Box引入控制代码,设定一个制动能量回收策略并使用Cruise/Black Box实现控制策略,使用AVL-Cruise联合Cruise/Black ... 在使用AVL-Cruise进行整车仿真过程中,需要对制动能量回收策略进行研究。基于AVL-Cruise建立仿真平台,使用Cruise/Black Box引入控制代码,设定一个制动能量回收策略并使用Cruise/Black Box实现控制策略,使用AVL-Cruise联合Cruise/Black Box接口组件对具体的工况进行仿真分析。结果表明,基于Cruise/Black Box的电动汽车制动能量回收仿真,能够完全真实地反映制动能量回收控制策略在电动汽车上的工作过程。 展开更多
关键词 电动汽车 Cruise/black box 制动能量回收
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SIMPLIFIED ANALYSIS METHOD FOR ULTIMATE LOAD CAPACITY OF WEB PLATES OF BOX GIRDERS
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作者 韩庆华 程万海 +1 位作者 尹越 刘锡良 《Transactions of Tianjin University》 EI CAS 2000年第1期32-35,共4页
The prosperous post buckling load capacity of web plates of box girders can be used.In this article,the post buckling behaviour of web plates of box girders under different loading conditions is theoretically analyz... The prosperous post buckling load capacity of web plates of box girders can be used.In this article,the post buckling behaviour of web plates of box girders under different loading conditions is theoretically analyzed and on the basis of domestic and overseas design codes of steel structures,the corresponding simplified analysis methods are put forward for the engineering design or code revision.It is proved that the simplified methods are safe,efficient and practicable through the comparison between several results. 展开更多
关键词 post buckling behaviour ultimate load capacity simplified analysis method web plates of box girders
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基于Box-Behnken设计-响应面法优化酒黄精炮制工艺
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作者 罗诚 蔡文菲 +4 位作者 张阿凤 汪晨怡 代安琳 胡菊 万军 《安徽医药》 CAS 2024年第10期1930-1934,I0001,共6页
目的采用Box-Behnken设计-响应面法(Box-Behnken design-response surface method,BBD-RSM)对黄精炮制工艺进行优化,筛选最佳工艺参数。方法研究于2023年1—5月开展。以黄精外观性状、醇浸出物、多糖含量等为评价指标,基于单因素试验进... 目的采用Box-Behnken设计-响应面法(Box-Behnken design-response surface method,BBD-RSM)对黄精炮制工艺进行优化,筛选最佳工艺参数。方法研究于2023年1—5月开展。以黄精外观性状、醇浸出物、多糖含量等为评价指标,基于单因素试验进行响应面综合实验,运用BBD-RSM,探索黄精饮片润制时间、蒸制时间、焖制时间等对其品质的影响,优选炮制工艺参数及炮制设备。结果通过拟合模型,外观性状评分、醇浸出物含量、黄精多糖含量预测值分别为72.31分、64.86%、12.96%,优选黄精最佳酒制工艺为润制时间1.5 h、蒸制时间5.5 h、焖制时间1.0 h;蒸制设备拟选用回转式蒸药机,干燥设备拟选用敞开式烘干箱。结论所优选酒黄精炮制工艺合理、可行,为酒黄精炮制生产工艺及设备选型提供了依据。 展开更多
关键词 黄精 酒制工艺 box-BEHNKEN设计 响应面法 炮制设备
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基于Box-Behnken响应面法优化方便藜麦粥制备工艺
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作者 郑守晶 黄思梅 +2 位作者 岳文杰 黄子建 郑明锋 《武夷科学》 2024年第1期73-80,共8页
以复水率、复水时间和感官品质为指标,通过单因素试验优选方便藜麦粥的最佳浸泡温度、料水比和蒸煮时间;利用Box-Behnken响应面法优化其制备工艺,并采用加权法计算综合得分。结果表明,最佳制备工艺为浸泡温度41℃,料水比1∶9,蒸煮时间23... 以复水率、复水时间和感官品质为指标,通过单因素试验优选方便藜麦粥的最佳浸泡温度、料水比和蒸煮时间;利用Box-Behnken响应面法优化其制备工艺,并采用加权法计算综合得分。结果表明,最佳制备工艺为浸泡温度41℃,料水比1∶9,蒸煮时间23 min。经验证试验,其综合得分为96.08,与理论预测值(96.43)的相对偏差为0.35%(<5.0%)。优化的方便藜麦粥制备工艺为其开发应用提供重要支撑。 展开更多
关键词 藜麦 方便粥 box-Behnken响应面法 制备工艺
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Analysis of Data on Xanthan Fermentation in Stationary Phase Using Black Box and Metabolic Network Models 被引量:2
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作者 马红武 赵学明 唐寅杰 《Chinese Journal of Chemical Engineering》 SCIE EI CAS CSCD 1999年第4期321-325,共5页
The xanthan fermentation data in the stationary phase was analyzed using the black box and the metabolic network models. The data consistency is checked through the elemental balance in the black box model. In the met... The xanthan fermentation data in the stationary phase was analyzed using the black box and the metabolic network models. The data consistency is checked through the elemental balance in the black box model. In the metabolic network model, the metabolic flux distribution in the cell is calculated using the metabolic flux analysis method, then the maintenance coefficients is calculated. 展开更多
关键词 xanthan fermentation black box model metabolic flux analysis maintenance coefficients
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多指标综合评分法结合Box-Behnken响应面法优选栀子茯苓压片糖果的提取工艺
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作者 邓刚 梁可文 蒋婳影 《化工科技》 CAS 2024年第3期40-45,共6页
以提取液中栀子苷含量及干膏率作为考察指标,在单因素试验基础上采用直接回流提取法、多指标综合评分法结合Box-Behnken响应面法考察了乙醇浓度、提取时间和料液比3个因素对提取工艺的影响。结果表明,制剂的最佳提取工艺为乙醇浓度75%,... 以提取液中栀子苷含量及干膏率作为考察指标,在单因素试验基础上采用直接回流提取法、多指标综合评分法结合Box-Behnken响应面法考察了乙醇浓度、提取时间和料液比3个因素对提取工艺的影响。结果表明,制剂的最佳提取工艺为乙醇浓度75%,提取时间120 min,料液比17倍,栀子苷平均含量为3.17%,平均干膏率为11.33%,综合评分平均值为98.30(n=3,RSD=0.18%)。该工艺合理可行,有效成分提取率高,适合大规模生产。 展开更多
关键词 栀子茯苓压片糖果 多指标综合评分法 box-Behnken响应面法 提取工艺
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Propagation methods for black locust (Robinia pseudoacacia L.) improvement in Hungary 被引量:1
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作者 Károly Redei Zoltán Osváth-Bujtás Ildikó Balla 《Journal of Forestry Research》 SCIE CAS CSCD 2001年第4期215-219,276,共6页
Black locust (Robinia pseudoacacia L.) is one of the most important stand-forming tree species in Hungary and its importance is increasing in many countries. Black locust plants are commonly produced by two methods, b... Black locust (Robinia pseudoacacia L.) is one of the most important stand-forming tree species in Hungary and its importance is increasing in many countries. Black locust plants are commonly produced by two methods, by seed and by root cuttings. Tissue culture propagation can be considered as a relatively new method. Growing trees from seed is a relatively sim-ple method for reliably producing seedlings on a large scale under a variety of circumstances. Mechanization of the method is easy and the production cost is relatively low. Propagation from root cuttings and tissue culture are valuable for reproduction of superior individuals or varieties. By applying these methods, superior traits of the selected trees can be preserved in the clones. Recent experiments demonstrated that micropropagated trees could be successfully transplanted into soil, hardened and grown in the field. 展开更多
关键词 Robinia pseudoacacia L. black locust Propagation method IMPROVEMENT
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Technology of black coloring for stainless steel by electrochemical method 被引量:1
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作者 何新快 陈白珍 +3 位作者 李小东 胡更生 吴璐烨 田文增 《Journal of Central South University of Technology》 EI 2006年第2期135-140,共6页
The technology of black coloring for stainless steel by electrochemical method was studied. The optimum bath compositions and operating conditions were obtained as follows: 4050g/L K2Cr2O7 , 1520g/L MnSO4, 1520g/L (... The technology of black coloring for stainless steel by electrochemical method was studied. The optimum bath compositions and operating conditions were obtained as follows: 4050g/L K2Cr2O7 , 1520g/L MnSO4, 1520g/L (NH4)2SO4, 2040g/L H3BO3, 2030 g/L additive A, 2 g/L (NH4)6Mo7O 24 ; time 920 min; temperature 1530℃; potential 3V and current density 12mA/cm 2 . The effects of the compositions of the bath on the quality of black colored film were discussed. The influences of passivation process on the black coloring velocity and performances of black colored film layer were investigated. The results show that the passivation process can improve the corrosion resistance and the stability to bear color-change; (NH4)2SO4 can control the black coloring velocity and prolong black coloring bath life remarkably; and additive A can improve the evenness and compactness of black colored film layer. The results of scanning electron microscopy and energy dispersive spectra show that the microstructure is of cylindrical lump, the filling process can decrease the crackles, and the main elements of black colored film are Fe, Cr, Mn and Ni. 展开更多
关键词 stainless steel electrochemical method black coloring corrosion resistance
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Reliable Space Pursuing for Reliability-based Design Optimization with Black-box Performance Functions 被引量:2
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作者 SHAN Songqing WANG G Gary 《Chinese Journal of Mechanical Engineering》 SCIE EI CAS CSCD 2009年第1期27-35,共9页
Reliability-based design optimization (RBDO) is intrinsically a double-loop procedure since it involves an overall optimization and an iterative reliability assessment at each search point. Due to the double-loop pr... Reliability-based design optimization (RBDO) is intrinsically a double-loop procedure since it involves an overall optimization and an iterative reliability assessment at each search point. Due to the double-loop procedure, the computational expense of RBDO is normally very high. Current RBDO research focuses on problems with explicitly expressed performance functions and readily available gradients. This paper addresses a more challenging type of RBDO problem in which the performance functions are computation intensive. These computation intensive functions are often considered as a "black-box" and their gradients are not available or not reliable. On the basis of the reliable design space (RDS) concept proposed earlier by the authors, this paper proposes a Reliable Space Pursuing (RSP) approach, in which RDS is first identified and then gradually refined while optimization is performed. It fundamentally avoids the nested optimization and probabilistic assessment loop. Three well known RBDO problems from the literature are used for testing and demonstrating the effectiveness of the proposed RSP method. 展开更多
关键词 Reliability based design optimization black-box function reliable design space
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Application of ″Black Box″ to fault diagnosis of rotating machine 被引量:1
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作者 张金祥 徐敏强 +2 位作者 黄文虎 张佳莺 张国斌 《Journal of Harbin Institute of Technology(New Series)》 EI CAS 2001年第1期83-86,共4页
Presents the navigation based on reinforcement learning and an algorithm, and disscusses the combination of the neural network with Q learning.
关键词 reinforcement learning neural network robot navigation
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Box-Behnken响应面法优化羟基红花黄色素A纳米粒处方工艺及体外释放评价 被引量:1
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作者 肖奕菲 杜利新 +3 位作者 魏起东 陆慧玲 郭志华 李雅 《中药新药与临床药理》 CAS CSCD 北大核心 2024年第1期122-131,共10页
目的优化羟基红花黄色素A(hydroxysafflor yellow A,HSYA)纳米粒制备工艺,并对其进行体外释放评价。方法以乳酸-羟基乙酸共聚物[poly(lactic-co-glycolicacid),PLGA]为载体,利用改良的复乳法制备HSYA纳米粒,通过Plackett-Burman设计实... 目的优化羟基红花黄色素A(hydroxysafflor yellow A,HSYA)纳米粒制备工艺,并对其进行体外释放评价。方法以乳酸-羟基乙酸共聚物[poly(lactic-co-glycolicacid),PLGA]为载体,利用改良的复乳法制备HSYA纳米粒,通过Plackett-Burman设计实验联用Box-Behnken响应面法优选最佳制备工艺;利用粒径测定仪、TEM扫描电镜仪、傅里叶红外光谱(FT-IR)仪、X-射线粉末衍射(XRD)仪对纳米粒进行表征;并对其进行4℃储藏稳定性、生理介质中稳定性、冻干保护剂及体外释放率考察。结果优选出纳米粒最佳工艺处方为:pH为6.95,投药量为2.8 mg,载体用量为18.2 mg;在此条件下制备出的纳米粒粒径为(176.4±1.29)nm,多分散系数(Polydiseperse Index,PDI)为(0.152±0.014),Zeta电位为(-17.6±0.46)mV,包封率为(78.5±0.49)%,载药量为(7.3±0.07)%,纳米粒形态圆整,分散性好;在4℃储存环境下、不同生理介质中稳定性良好,最佳冻干保护剂为1%葡萄糖;纳米粒48 h体外释放率为85%。结论该优化方法合理可靠,所得纳米粒稳定性良好,具有一定的缓释作用,体外释放符合一级动力学模型。 展开更多
关键词 羟基红花黄色素A PLGA纳米粒 Plackett-Burman设计实验 box-Behnken响应面法 体外释放
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Box-Behnken响应面法结合BP神经网络优化黑胡椒脐贴处方研究 被引量:2
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作者 程索婷 黄莉 +3 位作者 邹纯才 鄢海燕 任佩 王紫彤 《安徽中医药大学学报》 CAS 2024年第3期93-99,共7页
目的采用Box-Behnken响应面法结合BP神经网络优化黑胡椒脐贴处方。方法在前期预试验的基础上,以载药量、促渗剂用量、聚乙二醇(polyethylene glycol,PEG)6000与微粉硅胶的比例为影响因素,进行单因素试验。结合体外透皮试验,利用高效液... 目的采用Box-Behnken响应面法结合BP神经网络优化黑胡椒脐贴处方。方法在前期预试验的基础上,以载药量、促渗剂用量、聚乙二醇(polyethylene glycol,PEG)6000与微粉硅胶的比例为影响因素,进行单因素试验。结合体外透皮试验,利用高效液相色谱法测定胡椒碱的含量,对胡椒碱峰面积、指纹图谱的总峰面积和脐贴的成型性、剥离残留度和基质填充情况赋以权重,所得结果为综合评价指标。在单因素试验的基础上利用Box-Behnken响应面法结合BP神经网络优化脐贴处方。结果黑胡椒脐贴的最佳处方为载药量7%、氮酮4.5%、PEG6000与微粉硅胶的质量比为43∶1。结论黑胡椒脐贴的处方合理,可为后续贴剂的药效学研究提供基础。 展开更多
关键词 黑胡椒 脐贴 box-Behnken响应面法 BP神经网络
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Powell's optimal identification of material constants of thin-walled box girders based on Fibonacci series search method
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作者 张剑 叶见曙 周储伟 《Applied Mathematics and Mechanics(English Edition)》 SCIE EI 2011年第1期97-106,共10页
A dynamic Bayesian error function of material constants of the structure is developed for thin-walled curve box girders. Combined with the automatic search scheme with an optimal step length for the one-dimensional Fi... A dynamic Bayesian error function of material constants of the structure is developed for thin-walled curve box girders. Combined with the automatic search scheme with an optimal step length for the one-dimensional Fibonacci series, Powell's optimization theory is used to perform the stochastic identification of material constants of the thin-walled curve box. Then, the steps in the parameter identification are presented. Powell's identification procedure for material constants of the thin-walled curve box is compiled, in which the mechanical analysis of the thin-walled curve box is completed based on the finite curve strip element (FCSE) method. Some classical examples show that Powell's identification is numerically stable and convergent, indicating that the present method and the compiled procedure are correct and reliable. During the parameter iterative processes, Powell's theory is irrelevant with the calculation of the FCSE partial differentiation, which proves the high computation efficiency of the studied methods. The stochastic performances of the system parameters and responses axe simultaneously considered in the dynamic Bayesian error function. The one-dimensional optimization problem of the optimal step length is solved by adopting the Fibonacci series search method without the need of determining the region, in which the optimized step length lies. 展开更多
关键词 Powell's theory thin-walled curve box material constant Fibonacci seriessearch method finite curve strip element theory
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