金匮肾气丸辅治Ⅱ-Ⅲ期糖尿病肾病疗效观察

目的:观察金匮肾气丸辅治Ⅱ-Ⅲ期糖尿病肾病的临床疗效。方法:74例按照随机数字表法分为对照组与研究组各37例,两组均用达格列净和贝那普利治疗,研究组加用金匮肾气丸。结果:研究组总有效率与估算肾小球滤过率(eGFR)水平高于对照组(P<0.05),中医证候积分、血肌酐(SCR)、血尿素氮(BUN)、24h尿总量蛋白(TUP)和尿微量白蛋白/尿肌酐(UMA/UCR)以及空腹血糖(FBG)水平均低于对照组(P<0.05)。结论:金匮肾气丸辅治Ⅱ-Ⅲ期糖尿病肾病可提高疗效。

血清TAP、proGRP、cyfra21-1与Ⅲ~Ⅳ期NSCLC新辅助化疗疗效及预后的关系

目的探讨血清肿瘤异常蛋白(TAP)、胃泌素释放肽前体(proGRP)、细胞角蛋白19片段(cyfra21-1)与Ⅲ~Ⅳ期非小细胞肺癌(NSCLC)新辅助化疗(NCT)疗效及预后的关系。方法选取100例Ⅲ~Ⅳ期NSCLC患者为研究对象,所有患者均采用NCT治疗,根据疗效将患者分为有效组和无效组,比较不同疗效患者化疗前后TAP、proGRP、cyfra21-1水平,分析化疗后TAP、proGRP、cyfra21-1水平对NSCLC患者NCT疗效的评估价值。所有患者均随访1年,分析化疗后TAP、proGRP、cyfra21-1表达水平与预后的关系。结果化疗后,有效组TAP、proGRP、cyfra21-1水平低于无效组(P<0.05)。ROC曲线结果显示,TAP评估NSCLC患者NCT疗效的AUC和截点值分别为0.739、178.18μm 2,proGRP评估NSCLC患者NCT疗效的AUC和截点值分别为0.810、52.21 ng/L,cyfra21-1评估NSCLC患者NCT疗效的AUC和截点值分别为0.775、7.70μmol/L,联合评估NSCLC患者NCT疗效的AUC为0.913,高于单项诊断(P<0.05)。TAP、proGRP、cyfra21-1高表达患者的1年生存率均低于低表达患者(P<0.05)。结论TAP、proGRP、cyfra21-1联合评估Ⅲ~Ⅳ期NSCLC患者NCT疗效具有较高价值,且其均与NSCLC患者预后密切相关。

Three Stages of Mesozoic Bimodal Igneous Rocks and Their Tectonic Implications on the Continental Margin of Southeastern China

There are large-scale Mesozoic bimodal igneous rock associations on the continental margin of southeastern China. They aroused extensive attention in the 1980s because of their specific tectonic implications, and have been found frequently during recent geological surveys. This paper reviews the studies of regional Mesozoic bimodal rocks, and concludes that they can be subdivided into three stages, i.e., the Early Jurassic (209-170 Ma, the first (Ⅰ) stage), the Late Jurassic-early Early Cretaceous (154-121 Ma, the second (Ⅱ) stage), and the late Early Cretaceous-Late Cretaceous (115-85 Ma, the third (Ⅲ) stage). These three stages of bimodal rocks were formed in different tectonic settings, and are important indicators for regional Mesozoic tectonic evolution.

Prognostic and predictive significance of MSI in stages Ⅱ/Ⅲ colon cancer

In colon cancer,classic disease staging remains the key prognosis and treatment determinant.Although adjuvant chemotherapy has an established role in stageⅢcolon cancer patients,in stageⅡit is still a subject of controversy due to its restriction to a small subgroup of patients with high-risk histopathologic features.Patients with stageⅡtumors form a highly heterogeneous group,with five-year relative overall survival rates ranging from 87.5%(ⅡA)to 58.4%(ⅡC).Identifying those for whom adjuvant chemotherapy would be appropriate and necessary has been challenging,and prognostic markers which could serve in the selection of patients more likely to recur or benefit from adjuvant chemotherapy are eagerly needed.The stronger candidate in this category seems to be microsatellite instability(MSI).The recently reported European Society for Medical Oncology guidelines suggest that MSI should be evaluated in stageⅡcolorectal cancer patients in order to contribute in treatment decisionmaking regarding chemotherapy administration.Thehypothetical predictive role of MSI regarding its response to 5-fluorouracil-based adjuvant chemotherapy has proven a much more difficult issue to address.Almost every possible relation between MSI and chemotherapy outcome has been described in the adjuvant colon cancer setting in the international literature,and the matter is far from being settled.In this current report we critically evaluate the prognostic and predictive impact of MSI status in patients with stageⅡand stageⅢcolon cancer patients.

New Maikhanellid Shells and Siphogonuchitid Spicule Bundles from the Cambrian Fortunian Stage of South China

Maikhanellids are a distinct group of Cambrian Fortunian small shelly fossils by the capshaped profiles and scaly shell ornamentation.According to the individual shell shape and ornamentation feature types of 50 maikhanellids fossils which were collected from Xixiang botia,we confirmed the family Maikhanellidae content of six genera,which are Maikhanella,Ramenta,Purella,Ramentoides,Yunnannopleura and Mediata.Unlike the halkieriid animals whose shells and spicules are articulated on different body parts,maikhanellids were presumably yielded by siphogonuchitid spicules penetrating the intermediate matrix（the ＂spicule shell＂ hypothesis）,and this is the reason that some researchers treated maikhanellids and co-occurring siphogonuchitids as synonyms.The affinities of Maikhanellids and siphogonuchitids remain debatable.Here,we report three dimensionally phosphatized maikhanellid shells and siphogonuchitid spicule bundles from the Cambrian Fortunian small shell faunas of South China.They differ from all the previously reported maikhanellids and siphogonuchitids,and may represent new types.The intact and smooth surface underneath the partially preserved scales of the shells challenges the ＂spicule-shell＂ hypothesis.The present siphogonuchitid spicules differ from the maikhanellid scales in size,morphology,and.arrangement pattern,thus the spicules might not be derived from the shells.Whether the shells and spicule bundles were articulated on different body parts of the same animals remains unknown.

Macroscopic appearance of TypeⅣand giant Type Ⅲ is a high risk for a poor prognosis in pathological stage Ⅱ/Ⅲ advanced gastric cancer with postoperative adjuvant chemotherapy

AIM To evaluate whether a high risk macroscopic appearance(Type Ⅳ and giant Type Ⅲ) is associated with a dismal prognosis after curative surgery, because its prognostic relevance remains elusive in pathological stage Ⅱ/Ⅲ(p Stage Ⅱ/Ⅲ) gastric cancer.METHODS One hundred and seventy-two advanced gastric cancer(defined as pT2 or beyond) patients with p Stage Ⅱ/Ⅲ who underwent curative surgery plus adjuvant S1 chemotherapy were evaluated, and the prognostic relevance of a high-risk macroscopic appearance was examined. RESULTS Advanced gastric cancers with a high-risk macroscopic appearance were retrospectively identified by preoperative recorded images. A high-risk macroscopic appearance showed a significantly worse relapse free survival(RFS)(35.7%) and overall survival(OS)(34%) than an average risk appearance(P = 0.0003 and P < 0.0001, respectively). A high-risk macroscopic appearance was significantly associated with the 13^(th) Japanese Gastric Cancer Association(JGCA) pT(P = 0.01), but not with the 13^(th) JGCA pN. On univariate analysis for RFS and OS, prognostic factors included 13^(th) JGCA p Stage(P < 0.0001)and other clinicopathological factors including macroscopic appearance. A multivariate Cox proportional hazards model for univariate prognostic factors identified highrisk macroscopic appearance(P = 0.036, HR = 2.29 for RFS and P = 0.021, HR = 2.74 for OS) as an independent prognostic indicator. CONCLUSION A high-risk macroscopic appearance was associated with a poor prognosis, and it could be a prognostic factor independent of 13^(th) JGCA stage in p Stage Ⅱ/Ⅲ advanced gastric cancer.

New Small Shelly Fossils(Acanthocassis and Xinlispina Gen.Nov.) from the Fortunian Stage(Early Cambrian) in Southern China

We describe new material of three-dimensionally phosphatized small shelly fossils Acanthocassis and Xinlispina gen.nov.from the Fortunian Stage（early Cambrian） of southern Shaanxi and northern Sichuan Provinces.The new materials allow description of the delicate morphology of these skeletons, and also their skeletogenesis.Acanthocassis and Xinlispina have comparable morphological features： a main branch and radially arranged sub-branches.They differ from each other in many details, e.g., the presence of a single central branch only in Xinlispina, and the presence of small nodes only in Acanthocassis.Acanthocassis cannot be a naked anthopolyp or hydropolyp because of the more-or-less stiffened cuticle and the absence of a mouth.Acanthocassisand Xinlispina differ from coeval sponge spicules and chancelloriid sclerites and rosettes of crossed pedicellariae of echinoderms, and might be cuticular ornaments of animals of unclear affinities.They occur in the first small shelly fossil assemblage zone, and could be adopted as auxiliary fossils for biostratigraphic correlation in southern China.

A New Species of Septuconularia(Hexangulaconulariidae,Cnidaria)from Cambrian Stage 2,South China

Hexangulaconulariids,an extinct family of medusozoan small shelly fossils(SSFs),were a conspicuous component of early Cambrian,shallow marine platform communities in South China.Described herein is Septuconularia crassiformis sp.nov.from Bed 5 of the Yanjiahe Formation(Cambrian Stage 2)in the Three Gorges area of Hubei Province.The new species differs from the type and only other known species,S.yanjiaheensis,in the shape of the abapical portion and in the degree of curvature of the adapertural margin.The anatomy of the apical portion of the new species is unknown.The diagnosis of the genus Septuconularia is emended and the spatio-temporal distribution of hexangulaconulariids in South China is summarized.Finally,S.yanjiaheensis,with its slit-like aperture and very narrow transverse cross-section,may have been better adapted to the shallow platform environment than the broader S.crassiformis,which appears to have been less common than the type species.

Post-Neogene Structural Evolution: An Important Geological Stage in the Formation of Gas Reservoirs in China

Tectonic movements since the Neogene have been the major developmental and evolutional stages of the latest global crustal deformation and orogenic movements. China is located in a triangular area bounded by the Indian landmass, the West Siberian landmass and the Pacific Plate, characterized by relatively active tectonic movements since the Neogene, and in this region, natural gas would have been very easy to dissipate, or difficult to preserve. Therefore, the characteristics of post-Neogene tectonic movements offer important geological factors in researching the formation and preservation of gas reservoirs in China. Summarizing the reservoiring history of gas fields in China, although there are some differences between various basins, they are all affected by the tectonic movements since the Neogene. These movements have certainly caused destruction to the reservoiring and distribution of natural gas in China, which has resulted in a certain dissipation of natural gas in some basins. As a whole, however, they have mainly promoted the reservoiring and accumulation of natural gas: (1) a series of China-type foreland basins have been formed between basins and ridges in western China, which provide favorable conditions for the formation of large and medium gas fields, as well as controlling the finalization of gas reservoirs in the basins; (2) rows and belts of anticlines have been formed in the Sichuan Basin in central China, which have been the major stages of the formation and finalization of gas reservoirs in that basin; the integral and quick rising and lifting, and a further west-dipping in the Ordos Basin have resulted in a further accumulation of natural gas in gas fields from Jingbian to Uxin; (3) in eastern China, the Bohai movement in the late Pliocene has provided favorable geological conditions for lately-formed gas reservoirs in the Bohai Sea area mainly composed of the Bozhong depression; and it also resulted in secondary hydrocarbon generation and formation of secondary gas reservoirs in other basins, as well as the formation of many carbon dioxide gas fields of inorganic origin; (4) in the offshore area, it promoted not only the formation of gas reservoirs of organic origin, but also the formation of inorganic origin non-hydrocarbon gas reservoirs, as well as the organic and inorganic natural gas of mixed origin, which resulted in the relatively complicated characteristics of gas reservoirs in the area. In short, tectonic movements activated since the Neogene resulted in a reservoiring model mainly characterized by late and superlate hydrocarbon generation and accumulation. These events provide an important geological stage that should not be neglected when studying the formation of gas reservoirs in China.

VEGETATION AND ENVIRONMENT OF EASTERN CHINA IN THE COLD STAGES OF THE QUATERNARY

In the cold stages of the Quaternary,steppe vegetation was dominant over eastern China as a consequence of long-term aridity.Steppe,forest-steppe and tundra might span conterminously from southern Europe to East Asia.In the South China floral region,subtropical coniferous forests extended widely over plains and hills.Many taxa of hydrophilic and/or thermophilic plants have survived in sanctuaries.The impact of cold climate in the Quaternary might be limited in severity and extent in eastern China.

Stage Ⅲ should be subclassified into Stage ⅢA and ⅢB in the American Joint Committee on Cancer(8^(th) Edition) staging system for pancreatic cancer

AIM To ascertain the prognostic role of the T4 and N2 category in stage Ⅲ pancreatic cancer according to the 8 th edition of the American Joint Committee on Cancer(AJCC) classification.METHODS Patients were collected from the Surveillance Epidemiology and End Results(SEER) database(2004-2013) and were divided into three groups: T(1-3)N2, T4 N(0-1), and T4 N2. Overall survival(OS) and disease-specific survival(DSS) of patients were evaluated by the Kaplan-Meier method. RESULTS For the first time, we found a significant difference in OS and DSS between T(1-3)N2/T4 N(0-1) and T4 N2 butnot between T(1-3)N2 and T4 N(0-1). A higher grading correlated with a worse prognosis in the T(1-3)N2 and T4 N2 groups.CONCLUSION Patients with stage T4 N2 had a worse prognosis than those with stage T(1-3)N2/T4 N(0-1) in the 8 th edition AJCC staging system for pancreatic cancer. We recommend that stage Ⅲ should be subclassified into stage ⅢA [T(1-3)N2/T4 N(0-1)] and stage ⅢB(T4 N2).

The Characteristics of the Stage of Ideology of Chinese Meteorological Film since the Founding of New China

Since the founding of the New China in 1949,with the gradual development of the history and the constant change of the realistic situation,China's national ideology has also undergone profound changes.As an important type of film,meteorological film plays an important role in the history of Chinese film.From the founding of New China to the end of 1970 s,Chinese meteorological films showed a strong atmosphere of class struggle and political propaganda style in ideology.From the beginning of 1980 s to the end of 1990 s,Chinese meteorological films showed new ideas in ideology and the characteristics of coexistence and spread of new viewpoints.Since the 21 stcentury,Chinese meteorological films have integrated into globalization ideologically and stuck nationalization.

Discussion on the Regional Division of the Development Stage of China's Wind Power

This paper constructs the index system of the regional division of the development stage of China's wind power resources,including the index of energy,the index of wind energy endowments and other indices.Based on principal component analysis and layered clustering analysis of these indices,and combined with the conceptual function of the development and utilization stage of the wind power,this paper divides the development and utilization stage of the wind power into four stages taking province as the basic yardstick:optimization growth stage,the rapid growth stage,the slow growth stage and the initial growth stage.In addition,this paper briefly discusses the basic strategy that should be adopted in each development stage of wind power resources.

Studies on the Morphological Characters of South China Double Cropping Super Rice at the Active Tillering Stage

The morphological characters of the newly released super hybrid rice in South China, Yueza 122, Fengyou 428, Peiza 67, and super conventional varieties, Guangchao 3, Shengtai 1 at the active tillering stage in both early and late crops were investigated. Using the analysis of variance and other statistic methods, the ideal morphological characteristics of South China double cropping super-rice at the active tillering stage were determined. They are 55-60 cm in the early crop and 60-76 cm in the late crop for the ideal plant height, about 15 tillers in the early crop and 14-19 tillers in the late crop for the ideal tiller number per plant, 40-44 cm in the early crop and 42-60 cm in the late crop for the ideal length of the first leaf under the top leaf, 1.2-1.4 cm in the early crop and 1.2-1.3cm in the late crop for the ideal width of the first leaf under the top leaf, 39- 44 cm in the early crop and 37-43 cm in the late crop for the ideal length of the second leaf under the top leaf, 1.1-1.4 cm in the early crop and about 1.1 cm in the late crop for the ideal width of the second leaf under the top leaf, 22-58o in the early crop and 4- 12o in the late crop for the ideal top leaf angle at the active tillering stage. Based on these results, a new concept of “dynamic plant type structure” for South China double cropping super rice breeding was suggested.

Effect of TCM Combined with Chemotherapy on Immune Function and Quality of Life of Patients with Non-small Cell Lung Cancer inStage Ⅲ-Ⅳ

Objective: To observe and compare the effect of traditional Chinese medicine (TCM) combined with chemotherapy (CT) on immune function and quality of life (QOL)of patients with non-small cell lung cancer (NSCLC) in stage Ⅲ-Ⅳ. Methods: One hundred cases with stage Ⅲ-Ⅳ NSCLC were randomly divided into two groups. The treated group (n=50) received CT combined with TCM, and the control group received CT alone. The percentage of T lymphocyte subset in peripheral blood and the change of natural killer (NK) cell count were observed after treatment. The QOL and tolerance of CT were also compared between the two groups after treatment. Results: In the treated group, CD3 cell count, CD4 cell count, CD4/ CDg ratio and NK cell activity were higher than those in control group, while CD8 cell count in the treated group was lower than that in the control group (P<0.05), and QOL and tolerance of CT in the treated group were also better (P<0.05). Conclusion: TCM combined with CT could raise the patients' ability in tolerating CT in stage Ⅲ-ⅣNSCLC.

Measurement and Analysis of Agricultural Production Efficiency in Taiwan of China Based on Three-stage DEA Model

Agricultural production efficiency in Taiwan of China in 2015 is studied by using three-stage DEA model. The results show that total output value of agriculture,forestry,animal husbandry and fishery is taken as output index,while employees of agriculture,forestry,animal husbandry and fishery,number of tractors,investment in dry land and paddy field are taken as input indexes,which meets " isotropic" condition assumption of model application. Natural disaster,number of workers in agricultural production and marketing class,expenditure on farmland water conservancy are not favorable for the promotion of agricultural production efficiency,while multiple cropping index is favorable for promoting agricultural production efficiency. Three-stage DEA model effectively eliminates the influences of environmental and random factors on agricultural production efficiency. After environmental and random factors are eliminated,comprehensive technical efficiency in Taiwan of China declines because of the decline of pure technical efficiency. Each county and city of Taiwan could be divided into different types according to pure technical efficiency and scale efficiency,and it can have some emphasis in improving agricultural production efficiency according to their own efficiency characteristics.

Late Quaternary fluvial terrace formation in the Luan River drainage basin,north China and its possible linkages with climate change and tectonic activation

The Luan River is the most important water system in north-eastern Hebei Province,China and is located in the transitional zone of the Eastern Yan Mountains,North China Plain and Songliao Plain.The well-developed river terraces of its tributary,the Yixun River,provide excellent information for studying neotectonics and climate change.There are seven terraces in the lower reaches of the Yixun River,numbered T7-T1.The optically stimulated luminescence dating results of 23 samples show that terraces T7-T2 formed at 111.36±5.83 ka,78.20±4.45 ka,65.29±4.15 ka,56.44±3.07 ka,40.08±2.66 ka,and 13.14±0.76 ka,respectively.A comparison with the oxygen isotope curves of deep-sea sediments reveals that the sediment formation of each terrace corresponded to cold periods of marine isotope stages MIS 4 and MIS 2 and the relatively cold periods of MIS 5e,MIS 3,and MIS 1.Since the Late Pleistocene,the incision rate of the Yixun River has ranged from 0.371-1.740 mm/a.During the formation of T7-T6,T5-T4,T4-T3,and T3-T2,the incision rate was low.However,in the two stages during which T6-T5 and T2-T1 formed(13.14±0.76 ka to 0.58±0.08 ka and 10.79±0.64 ka to 0.16±0.01 ka),these rates reached 1.554 mm/a and 1.592-1.740 mm/a,respectively.At approximately 30 ka,the activity of the Langying Fault increased,leading to footwall uplift.The river gathered in the north of Langying to form the ancient Erdaowan Lake,which resulted in the drying of the river in the lower reaches of the Yixun River during the last glacial maximum without forming river deposits.In the Early Holocene,headward erosion in the lower reaches of the Yixun River was enhanced,which resulted in the disappearance of the lake,and incised meandering formed due to increased neotectonism.Based on the analyses of river incision and the formation of ancient lakes and incised meandering,it was inferred that there have been three periods of strong tectonism in the river basin since the Late Pleistocene.

Unresectable stage Ⅲ non-small-cell lung cancer: Have we made any progress?

Lung cancer is responsible for the most cancer deaths worldwide with an incidence that is still rising. One third of patients have unresectable stage ⅢA or stage ⅢB disease. The standard of care for locally advanceddisease in patients with good performance status consists of combined modality therapy in particular concurrent chemoradiotherapy. But despite a lot of efforts done in the past, local control and survival of patients with unresectable stage Ⅲ non-small-cell lung cancer(NSCLC) remains poor. Improving outcomes for patients with unresectable stage Ⅲ NSCLC has therefore been an area of ongoing research. Research has focused on improving systemic therapy, improving radiation therapy or adding a maintenance therapy to consolidate the initial therapy. Also implementation of newer targeted therapies and immunotherapy has been investigated as well as the option of prophylactic cranial irradiation. This article reviews the latest literature on improving local control and preventing distant metastases. It seems that we have reached a plateau with conventional chemotherapy. Radiotherapy dose escalation did not improve outcome although increasing radiation dose-intensity with new radiotherapy techniques and the use of newer agents, e.g., immunotherapy might be promising. In the future well-designed clinical trials are necessary to prove those promising results.

Differential tectonic evolution and formation mechanism of three subsags in Wenchang Sag of Pearl River Mouth Basin,South China Sea

Notable differences in the structural characteristics and evolution of three adjacent sub-sags,i.e.,the Wenchang sub-sags A,B,and C,on the downthrown side of the Zhu IlI South Fault in the Wenchang Sag,are significant as they affect the formation and distribution of the oil and gas in these three sub-sags.However,the differences in their tectonic evolutions and formation mechanisms have not yet been adequately explained.In this paper,stress analysis,equilibrium profiles,and paleogeomorphic restora-tion,are used to investigate the dynamic settings,formation mechanisms,and influencing factors of the structural deformation related to the formation of the Wenchang Sag based on interpretation of seismic data.The results of the stress analysis suggest clockwise deflection of the regional tensile stress direction from a WNW-ESE trend during the Early Paleocene to NW-SE and NNW-SSE trends during the Eocene,to a nearly N-S trend during the Oligocene,and finally to a NNE-SSW trend during the Miocene.This clockwise rotation of the regional tensile stress direction led to the formation of a dextral strike-slip stress component parallel to the NE-trending Zhu I South Fault.This strike-slip stress component formed a releasing bend in sub-sag A,and may be associated with the continuous subsidence of a thick sedimentary layer in sub-sag A.It also created a restraining bend in sub-sag B,which underwent multiple structural inversions during its extension and subsidence and has a relatively s mall sedimentary thick-ness.The double restraining bend in sub-sag C is considered to have been strongly uplifted and eroded in response to this strike-slip stress component.Four obvious structural inversions in sub-sag B are iden-tified in this paper.These structural inversions correspond to the last four regional tectonic movements.This interpretation suggests that the formation of the structural inversions was likely related to the strong tensile stress and the small intersection angle between the direction of the regional tensile stress and the pre-existing boundary fault.The rotation of the tensile stress direction was responsible for the strike-slip movement on the pre-existing boundary fault and the formation of the releasing bend and restraining bend,which controlled the structural evolutions of the sub-sags.This reasonably explains the differential tectonic evolution of these three sub-sags in the Wenchang Sag,and provides a crucial idea forstructuralanalysisof similarbasins.

“Malaysia Has Certainly Benefited from China’s Prominence on the World Stage”——Exclusive Interview with See Chee Kong Leonard, Business Minister of Embassy of Malaysia in PRC

Relations between China and Malaysia have been developing steadily.Recently,See Chee Kong Leonard,Business Minister of Embassy of Malaysia in PRC,accepted an interview with Chinas Foreign Tradey and talked about the 45 years of economic and trade cooperation and achievements of the two countries.