类Chen-Qi混沌系统的固定时间自适应同步控制

类Chen-Qi四维混沌系统的渐近稳定控制的同步误差不能在有限时间内收敛到零,有限时间控制的同步误差收敛到零的状况与初值有关.因此,本文应用固定时间控制技术,设计了自适应控制器和参数估计律,试图使得驱动系统与同类型的参数未知的响应系统在固定时间内达到同步,完成了理论证明.应用数值仿真考察同步误差收敛到零的状况.选取不同参数值,不同状态初值,考察状态时程图、同步误差曲线等.结果表明:混沌运动时,固定时间内同步误差收敛到零的效果较好,与状态初值无关,收敛时间符合理论计算值;周期运动时,固定时间内前三个状态的同步误差收敛到零的效果较好,收敛时间符合理论计算值,但第四个状态的同步误差的收敛时间不符合理论计算值,其原因是系统存在的三次非线性项的不平衡、不匹配.

The Journey/DAO/TAO of Embodied Intelligence: From Large Models to Foundation Intelligence and Parallel Intelligence

THE tremendous impact of large models represented by ChatGPT[1]-[3]makes it necessary to con-sider the practical applications of such models[4].However,for an artificial intelligence(AI)to truly evolve,it needs to possess a physical“body”to transition from the virtual world to the real world and evolve through interaction with the real environments.In this context,“embodied intelligence”has sparked a new wave of research and technology,leading AI beyond the digital realm into a new paradigm that can actively act and perceive in a physical environment through tangible entities such as robots and automated devices[5].

A Framework Based on the DAO and NFT in Blockchain for Electronic Document Sharing

In the information age,electronic documents(e-documents)have become a popular alternative to paper documents due to their lower costs,higher dissemination rates,and ease of knowledge sharing.However,digital copyright infringements occur frequently due to the ease of copying,which not only infringes on the rights of creators but also weakens their creative enthusiasm.Therefore,it is crucial to establish an e-document sharing system that enforces copyright protection.However,the existing centralized system has outstanding vulnerabilities,and the plagiarism detection algorithm used cannot fully detect the context,semantics,style,and other factors of the text.Digital watermark technology is only used as a means of infringement tracing.This paper proposes a decentralized framework for e-document sharing based on decentralized autonomous organization(DAO)and non-fungible token(NFT)in blockchain.The use of blockchain as a distributed credit base resolves the vulnerabilities inherent in traditional centralized systems.The e-document evaluation and plagiarism detection mechanisms based on the DAO model effectively address challenges in comprehensive text information checks,thereby promoting the enhancement of e-document quality.The mechanism for protecting and circulating e-document copyrights using NFT technology ensures effective safeguarding of users’e-document copyrights and facilitates e-document sharing.Moreover,recognizing the security issues within the DAO governance mechanism,we introduce an innovative optimization solution.Through experimentation,we validate the enhanced security of the optimized governance mechanism,reducing manipulation risks by up to 51%.Additionally,by utilizing evolutionary game analysis to deduce the equilibrium strategies of the framework,we discovered that adjusting the reward and penalty parameters of the incentive mechanism motivates creators to generate superior quality and unique e-documents,while evaluators are more likely to engage in assessments.

The Essential Role of Zheng Qi in Promoting Health: From the Perspective of Chinese Medicine and Modern Medicine

The concept of Zheng Qi in traditional Chinese medicine (TCM) refers to the vital energy produced by the interaction of Yin and Yang forces in the body. Zheng Qi performs two main functions: Wei Qi (defensive Qi), which shields the body from external pathogens, and Ying Qi (nutritive Qi), which sustains the internal organs and enhances their functionality. In TCM, Chinese tonifying herbs can help restore the balance of Yin/Yang and Qi/Blood function in visceral organs (i.e., optimal physiological functions), thereby fostering the efficient production of Zheng Qi and enhancing health. To ensure the quality of Chinese herbal products, functional assays to measure Yin/Yang, Qi/Blood functions, and Zheng Qi production should be implemented. The efficacy of Yang and Qi herbs can be evaluated by their ability to increase mitochondrial ATP in cultured mouse cardiomyocytes, while Yin and Blood herbs are tested through their immunostimulatory effects on antigen-induced T/B cell proliferation in mouse splenocytes and the production of erythropoietin/nitric oxide in hepatocytes/vascular endothelial cells, respectively. Additionally, Zheng Qi’s effect can be gauged by examining natural killer cell activity and antigen-induced T/B cell proliferation in mice ex vivo. These assays act as biomarkers for assessing the quality and effectiveness of herbal health products within TCM theory.

TCM-HIN2Vec:A strategy for uncovering biological basis of heart qi deficiency pattern based on network embedding and transcriptomic experiment

Objective To elucidate the biological basis of the heart qi deficiency(HQD)pattern,an in-depth understanding of which is essential for improving clinical herbal therapy.Methods We predicted and characterized HQD pattern genes using the new strategy,TCM-HIN2Vec,which involves heterogeneous network embedding and transcriptomic experiments.First,a heterogeneous network of traditional Chinese medicine(TCM)patterns was constructed using public databases.Next,we predicted HQD pattern genes using a heterogeneous network-embedding algorithm.We then analyzed the functional characteristics of HQD pattern genes using gene enrichment analysis and examined gene expression levels using RNA-seq.Finally,we identified TCM herbs that demonstrated enriched interactions with HQD pattern genes via herbal enrichment analysis.Results Our TCM-HIN2Vec strategy revealed that candidate genes associated with HQD pattern were significantly enriched in energy metabolism,signal transduction pathways,and immune processes.Moreover,we found that these candidate genes were significantly differentially expressed in the transcriptional profile of mice model with heart failure with a qi deficiency pattern.Furthermore,herbal enrichment analysis identified TCM herbs that demonstrated enriched interactions with the top 10 candidate genes and could potentially serve as drug candidates for treating HQD.Conclusion Our results suggested that TCM-HIN2Vec is capable of not only accurately identifying HQD pattern genes,but also deciphering the basis of HQD pattern.Furthermore our finding indicated that TCM-HIN2Vec may be further expanded to develop other patterns,leading to a new approach aimed at elucidating general TCM patterns and developing precision medicine.

Exploring the therapeutic potential of Qi Teng Mai Ning recipe in ischemic stroke and vascular cognitive impairment

Background:This study aims to explore the therapeutic effects of the Qi Teng Mai Ning recipe on ischemic stroke and vascular cognitive impairment through its potential to modulate cellular autophagy,with a focus on identifying its active ingredients and their target proteins.Methods:The study began with the identification of active ingredients in the Qi Teng Mai Ning recipe.It proceeded to screen the gene expression omnibus database for ischemic stroke and vascular cognitive impairment-associated differentially expressed mRNAs and to identify cellular autophagy-related proteins via the Human Autophagy Database.These proteins were annotated with Gene Ontology and Kyoto Encyclopedia of Genes and Genomes functions and subjected to molecular docking with the recipe’s core active ingredients.In vitro cell experiments were conducted on hypoxic HT22 cells,involving CCK8 assay,lentiviral transfection to silence autophagy related 9B(ATG9B),immunofluorescence staining,and qPCR validation to investigate the effects of the recipe on autophagy.Results:The analysis identified 104 active ingredients targeting 408 proteins and forming a complex ingredient-target network.Intersecting 55 ischemic stroke-related and 909 vascular cognitive impairment-related differentially expressed mRNAs revealed 14 co-expressed mRNAs.Molecular docking showed quercetin,kaempferol,myrcene,and conferone as key ingredients targeting autophagy-related proteins.Cellular experiments indicated that the recipe significantly enhanced cell viability under hypoxic conditions,reduced apoptosis,and modulated the expression of autophagy-related factors,thereby decreasing apoptosis rates in HT22 cells.Conclusion:The Qi Teng Mai Ning recipe offers protective effects against ischemic stroke and vascular cognitive impairment by modulating autophagy-related proteins.Its efficacy highlights the potential of traditional Chinese medicine in treating these conditions,though further research is needed to fully understand its mechanisms and clinical applications.

Pharmacological Investigation on the Qi-Invigorating Action of Schisandrin B: Effects on Mitochondrial ATP Generation in Multiple Tissues and Innate/Adaptive Immunity in Mice

Schisandrae Fructus, containing schisandrin B (Sch B) as its main active component, is recognized in traditional Chinese medicine (TCM) for its Qi-invigorating properties in the five visceral organs. Our laboratory has shown that the Qi-invigorating action of Chinese tonifying herbs is linked to increased mitochondrial ATP generation and an enhancement in mitochondrial glutathione redox status. To explore whether Sch B can exert Qi-invigorating actions across various tissues, we investigated the effects of Sch B treatment on mitochondrial ATP generation and glutathione redox status in multiple mouse tissues ex vivo. In line with TCM theory, which posits that Zheng Qi generation relies on the Qi function of the visceral organs, we also examined Sch B’s impact on natural killer cell activity and antigen-induced splenocyte proliferation, both serving as indirect measures of Zheng Qi. Our findings revealed that Sch B treatment consistently enhanced mitochondrial ATP generation and improved mitochondrial glutathione redox status in mouse tissues. This boost in mitochondrial function was associated with stimulated innate and adaptive immune responses, marked by increased natural killer cell activity and antigen-induced T/B cell proliferation, potentially through the increased generation of Zheng Qi.

Clinical Observation of the Hot and Humid Compress Therapy of Traditional Chinese Medicine in the Treatment of Qi Stagnation and Blood Stasis Type of Lumbar Disc Herniation

Background: Although a number of studies have reported that the hot and humid compress from traditional Chinese medicine (TCM) is effective in treating lumbar disc herniation (LDH) with qi stagnation and blood stasis, clinical evidence is limited. Objective: The purpose of this study is to provide high-quality evidence to support the effectiveness of the traditional Chinese hot and humid compress in the treatment of LDH with qi stagnation and blood stasis. Methods: From October 2021 to November 2023, 86 patients with LDH of qi stagnation and blood stasis type were recruited in our hospital and divided into a control (n = 43) and an observation group (n = 43) according to the random number table method. The control group was given routine clinical treatment, and the observation group was treated with the hot and humid compress therapy for two weeks. The visual analogue scale (VAS) score, Japanese Orthopaedic Association (JOA) score, TCM syndrome score, serum interleukin-6 (IL-6), serum interleukin-1β (IL-1β), and tumor necrosis factor-α (TNF-α) were observed and compared between the two groups before and after treatment, and the clinical efficacy of the two groups was evaluated. Results: After treatment, the VAS score, TCM symptom score, and serum IL-6, IL-1β, and TNF-α levels decreased in both groups (P P P P P Conclusions: The hot and humid compress of traditional Chinese medicine can effectively relieve pain, restore lumbar function, improve TCM syndromes, reduce the level of inflammatory factors, and have a curative effect in treating LDH.

Network pharmacology-based exploration of molecular mechanisms underlying therapeutic effects of Jianpi Huatan Quyu recipe on chronic heart failure with spleen Qi deficiency syndrome

BACKGROUND Chronic heart failure is a complex clinical syndrome.The Chinese herbal compound preparation Jianpi Huatan Quyu recipe has been used to treat chronic heart failure;however,the underlying molecular mechanism is still not clear.AIM To identify the effective active ingredients of Jianpi Huatan Quyu recipe and explore its molecular mechanism in the treatment of chronic heart failure.METHODS The effective active ingredients of eight herbs composing Jianpi Huatan Quyu recipe were identified using the Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform.The target genes of chronic heart failure were searched in the Genecards database.The target proteins of active ingredients were mapped to chronic heart failure target genes to obtain the common drugdisease targets,which were then used to construct a key chemical componenttarget network using Cytoscape 3.7.2 software.The protein-protein interaction network was constructed using the String database.Gene Ontology and Kyoto Encyclopedia of Genes and Genomes enrichment analyses were performed through the Metascape database.Finally,our previously published relevant articles were searched to verify the results obtained via network pharmacology.RESULTS A total of 227 effective active ingredients for Jianpi Huatan Quyu recipe were identified,of which quercetin,kaempferol,7-methoxy-2-methyl isoflavone,formononetin,and isorhamnetin may be key active ingredients and involved in the therapeutic effects of TCM by acting on STAT3,MAPK3,AKT1,JUN,MAPK1,TP53,TNF,HSP90AA1,p65,MAPK8,MAPK14,IL6,EGFR,EDN1,FOS,and other proteins.The pathways identified by KEGG enrichment analysis include pathways in cancer,IL-17 signaling pathway,PI3K-Akt signaling pathway,HIF-1 signaling pathway,calcium signaling pathway,cAMP signaling pathway,NF-kappaB signaling pathway,AMPK signaling pathway,etc.Previous studies on Jianpi Huatan Quyu recipe suggested that this Chinese compound preparation can regulate the TNF-α,IL-6,MAPK,cAMP,and AMPK pathways to affect the mitochondrial structure of myocardial cells,oxidative stress,and energy metabolism,thus achieving the therapeutic effects on chronic heart failure.CONCLUSION The Chinese medicine compound preparation Jianpi Huatan Quyu recipe exerts therapeutic effects on chronic heart failure possibly by influencing the mitochondrial structure of cardiomyocytes,oxidative stress,energy metabolism,and other processes.Future studies are warranted to investigate the role of the IL-17 signaling pathway,PI3K-Akt signaling pathway,HIF-1 signaling pathway,and other pathways in mediating the therapeutic effects of Jianpi Huatan Quyu recipe on chronic heart failure.

Exploring the Effect of Qi Cross-Shaped Moxibustion on the Recovery of Gastrointestinal Function after Hip Fracture in the Elderly

Objective:To explore the effect of Qi cross-shaped moxibustion on the recovery of gastrointestinal function in elderly hip fracture patients after surgery.Methods:62 elderly hip fracture surgery patients were selected as the base analysis sample,enrolled in January 2023-May 2024,and divided into an observation group(n=31)and a control group(n=31)using the digital table random draw scheme.The patients in the control group underwent conventional dietary intervention,and the patients in the observation group underwent Qi cross-shaped moxibustion intervention,comparing the gastrointestinal function recovery time and quality of life scores(PAC-QOL)of patients with constipation between the two groups.Results:The gastrointestinal function recovery time of the observation group was lower than that of the control group(P<0.05);the PAC-QOL score of the observation group was lower than that of the control group after the intervention(P<0.05).Conclusion:Qi cross-shaped moxibustion can shorten the recovery time of gastrointestinal function and improve the quality of life of elderly hip fracture patients after surgery,and it has the value of promotion and application.

Observation on the Nursing Effect of Ginger Moxibustion on Gastrointestinal Symptoms in Patients with Heart Failure Due to Yang Qi Deficiency

Objective:To evaluate the nursing measures and effects of ginger moxibustion in the treatment of heart failure(yang qi deficiency type)with gastrointestinal symptoms.Methods:86 patients with heart failure(yang qi deficiency type)accompanied by gastrointestinal symptoms who were admitted to the hospital between January 2023 and January 2024 were selected and divided into 43 cases in each group by random number table grouping;Group I implemented integrated care,while Group II adopted conventional care.The indicators of care were compared between the two groups.Results:After the nursing care,the digestive symptom scores of Group I were lower than those of Group I,and the psychological scores were lower than those of Group II(P<0.05).Conclusion:Ginger moxibustion can improve gastrointestinal symptoms and enhance the psychological health of patients with heart failure(yang qi deficiency type)with gastrointestinal symptoms.

A study on the treatment of chloasma with moxibustion based on the theory of“Yang transforming Qi,and Yin shaping”

Background:“Yang Transforming Qi and Yin shaping”comes from“Plain Question Yin and Yang should be like the theory”.Chinese medicine believes that the imbalance of yin and yang is the cause of human diseases.One of the strengths of TCM in treating diseases is holistic regulation.The theory of“Yang transforming Qi,and Yin shaping”implies a strong holistic view.Chloasma,one of the common skin diseases,seriously affects the physical and mental health of patients due to its unclear etiology,difficult treatment and easy recurrence.The occurrence and development of chloasma are closely related to internal organs.This paper is based on the theory of internal meridian,“Yang transforming Qi,and Yin shaping”which attaches importance to the concept of“Yang Qi”,from a new understanding of the pathogenesis etiology of chloasma.Methods:The author believes that the incidence of the disease is the deficiency of Yang Qi,which can’t promote the movement of Qi and blood to nourish the face,resulting in tangible material condensation,so proposes that this disease needs to be promoted by Yang transforming Qi and warm to dissipate.Moxibustion belongs to the fire,and its warming effect can dissipate the tangible evil.Results:Combined with clinical practice and the theory of internal meridian,the author elaborated that moxibustion is one of the effective methods for treating chloasma,which provides a new way of thinking for the treatment of chloasma.Conclusion:“Yang Transforming Qi and Yin shaping”can be used to guide the treatment of chloasma.

Integration of 1H-NMR-Based Metabolomics Approach with Traditional Chinese Pulse Diagnosis to Evaluate the Qi-Enhancing Activity of Herbal Tea

Human metabolism is intricately linked to an individual’s health status. Regardless of living habits, it will be reflected in the metabolic characteristics of urine. The utilization of the 1H NMR-based metabolomics method has enabled examine the metabolomic changes in urine under various physiology conditions, providing valuable insights into metabolites. In this particular study, volunteers were divided into two groups based on the strength of their spleen pulses, using the pulse diagnosis method employed in traditional Chinese medicine. Subsequently, their urine samples were analyzed, revealing notable variances in urea, creatinine, citric acid, succinic acid, trimethylamine-N-oxide (TMAO), alanine, hippuric acid, and glycine between the two groups. Interestingly, individuals with weak spleen pulses showed significant improvements after consuming herbal tea. Furthermore, we conducted LC-MS analysis on herbal tea and performed adenosine triphosphate (ATP) activity tests on the C2C12 mouse skeletal muscle cell line. The results indicated that within a reasonable concentration range, exposure to herbal tea led to an increase in the mitochondrial ATP production capacity of C2C12 cells. These findings shed light on the relationship between traditional Chinese medicine pulse diagnosis and urine metabolites, highlighting their potential as non-invasive and straightforward health assessment indicators. They can aid in the preliminary determination of necessary dietary and lifestyle changes to enhance overall bodily health.

扶阳罐治疗尿毒症维持性血液透析患者不安腿综合征的效果及对PSQI评分的影响

目的探析尿毒症维持性血液透析患者不安腿综合征采用扶阳罐治疗的效果。方法选取2021年7月—2023年12月在本院住院并进行规律维持性血液透析的尿毒症患者60例为研究对象,并将患者随机分为试验组(n=30)和对照组(n=30)。其中,对照组采取常规治疗,试验组加用扶阳罐治疗,比较两组治疗效果、临床症状积分、RLS评分、PSQI评分。结果试验组治疗有效率高于对照组,组间差异有统计学意义(P<0.05)。干预前,两组临床症状积分比较差异无统计学意义(P>0.05);干预后,试验组临床症状积分(下肢酸胀、下肢麻木、下肢灼烧感、下肢蚁行感、下肢瘙痒、下肢刺痛)低于对照组,组间差异有统计学意义(P<0.05)。干预后,试验组RLS评分、PSQI评分低于对照组,组间差异有统计学意义(P<0.05)。结论扶阳罐治疗尿毒症维持性血液透析患者不安腿综合征的效果明显,其临床症状显著缓解,患者的睡眠质量提升,临床上可借鉴及推广。

脓毒症预后不良患者血清I-FABP、DAO、D-Lac水平变化及其危险因素探讨

目的 探讨脓毒症预后不良患者血清肠型脂肪酸结合蛋白(I-FABP)、二胺氧化酶(DAO)、D-乳酸(D-Lac)水平变化及其危险因素。方法 收集2017年7月至2020年3月秦皇岛市第一医院收治的454例脓毒症患者临床资料,根据患者预后情况将其分为预后良好组(273例)和预后不良组(181例),统计脓毒症患者预后不良发生现状及其单因素,采用多因素Logistic回归分析脓毒症患者预后不良的危险因素。结果 454例脓毒症患者预后不良共181例,预后不良发生率为39.87%。单因素分析结果显示,预后不良组与预后良好组年龄、平均动脉压(MAP)、急性生理与慢性健康状况评分Ⅱ(APACHEⅡ)评分、感染相关器官功能衰竭(SOFA)评分、外周血白细胞(WBC)、中性粒细胞(NEU)、血清C反应蛋白(CRP)、降钙素原(PCT)、尿素氮(BUN)、血肌酐(Scr)、总胆红素(TBil)、前白蛋白(PAB)、I-FABP、DAO、D-Lac、D-二聚体(D-d)水平及凝血酶原时间(PT)、活化部分凝血酶原时间(APTT)、国际标准化比值(INR)比较,差异具有统计学意义(P<0.05)。多因素Logistic回归分析结果显示,年龄较大、MAP较低、APACHEⅡ评分较高、SOFA评分较高、外周血NEU、血清CRP、PCT、BUN、Scr、DAO、D-Lac、D-d、I-FABP水平较高、PT、APTT较长均为脓毒症患者预后不良的独立危险因素(P<0.05)。结论 脓毒症患者预后不良发生率较高,同时其危险因素与患者年龄、MAP、APACHEⅡ、SOFA评分、外周血NEU、血清CRP、PCT、BUN、Scr、DAO、D-Lac、D-d、I-FABP水平、PT、APT有关。

去中心化理念对传统组织法的冲击与再造——以“去中心化自治组织”(DAO)为中心的考察

传统组织法以单一的中心化假设为指引的模式,已经难以满足当下投资者的经济民主化诉求,在去中心化理念的冲击下,其适应性存疑。传统组织法应当适度接纳去中心化理念,而“去中心化自治组织”(DAO)由于具备商业上的可行性以及与传统法的可兼容性,是去中心化组织法研究的理想样本。将去中心化理念融入组织法,需要着重解决中心化节点权责配置错位问题,构建实控成员减轻信义义务框架以完善信义体系。还应进一步完善作为组织法支撑的通证监管框架,逐步实现“从通证化证券到证券通证”的设想。当然,也不应排除缔造“中心化—去中心化”二元组织法架构的可能性。

What Does ChatGPT Say:The DAO from Algorithmic Intelligence to Linguistic Intelligence

THE well-known ancient Chinese philosopher Lao Tzu(老子)or Laozi(6th~4th century BC during the Spring and Autumn period)started his classic Tao Teh Ching《道德经》or Dao De Jing(see Fig.1)with six Chinese characters:"道(Dao)可(Ke)道(Dao)非(Fei)常(Chang)道(Dao)",which has been traditionally interpreted as“道可道,非常道”or"The Dao that can be spoken is not the eternal Dao".

探讨瓜蒌大黄汤对重症肺炎肺热腑实证患者血SP-A、DAO、炎症因子影响及临床疗效

目的 基于“肺与大肠相表里”理论,探索以宣肺通腑法为指导,在瓜蒌大黄汤干预下,对肺表面活性蛋白A(SP-A)、二胺氧化酶(DAO)及炎症因子等影响,揭示瓜蒌大黄汤治疗重症肺炎的作用机制及疗效。方法 筛选诊断为重症肺炎,中医辨证为肺热腑实证患者62例,随机分为试验组和对照组,每组各31例,两组又依据肺炎病情严重程度分为中高危亚组、极高危亚组。对照组给予常规西医治疗,试验组在对照组基础上加用瓜蒌大黄汤灌肠,观察并记录治疗前及治疗第7、14天两组患者血SP-A、DAO、胃动素(MTL)、肿瘤坏死因子-α(TNF-α)、白介素-6(IL-6)、白细胞(WBC)、中性粒细胞比率(NEUT%)水平及中医证候评分、急性生理与慢性健康评分(APACHE Ⅱ评分)、临床肺部感染评分(CPIS评分)、急性胃肠损伤评分(AGI评分)、临床疗效、28 d病死率、机械通气时间、ICU住院天数。结果 中高危亚组中,治疗第14天时试验组SP-A、DAO、WBC、NEUT%、TNF-α、IL-6指标水平明显低于对照组,治疗第7、14天时试验组MTL指标水平均明显高于对照组,P<0.05;治疗第7、14天时试验组AGI评分、CPIS评分均明显低于对照组,治疗第14天时试验组APACHE Ⅱ评分明显低于对照组,P<0.05。极高危亚组中,试验组与对照组以上指标比较差异无统计学意义,P>0.05。中高危亚组中,治疗第7、14天时试验组便秘评分明显低于对照组,治疗第14天时试验组喘息、腹胀评分明显低于对照组,P<0.05。极高危亚组中,治疗第14天时试验组便秘评分明显低于对照组,P<0.05。中高危亚组中,试验组显效率明显高于对照组,机械通气时间明显低于对照组,P<0.05;中高危亚组和极高危亚组中,试验组与对照组ICU住院天数、28 d病死率比较差异均无统计学意义,P>0.05。结论 重症肺炎肺热腑实证患者给予瓜蒌大黄汤灌肠能明显改善胃肠道症状,能改善中高危重症肺炎患者呼吸困难等临床症状,促进肺、肠黏膜屏障修复,减轻炎症反应,缩短呼吸机的上机时间,但不能改变预后。

An Exploration of the Original Meaning and Connotation of Daoyin from “Movement” and “Essential Qi”

Now,daoyin has developed into a complete set of conventional movement patterns,such as Baduanjin,Yijinjing,and Wuqinxi.However,the original meaning and the connotation of daoyin is ignored by people gradually,which will hinder the development of daoyin and make the specific application difficult.In this article,we will explore the basic composition of the daoyin–“movement”and its intrinsic basis–“essential qi”to think about the original meaning and connotation of daoyin.

DAO to HANOI via DeSci: AI Paradigm Shifts from AlphaGo to ChatGPT

From AlphaGo to ChatGPT,the field of AI has launched a series of remarkable achievements in recent years.Analyzing,comparing,and summarizing these achievements at the paradigm level is important for future AI innovation,but has not received sufficient attention.In this paper,we give an overview and perspective on machine learning paradigms.First,we propose a paradigm taxonomy with three levels and seven dimensions from a knowledge perspective.Accordingly,we give an overview on three basic and twelve extended learning paradigms,such as Ensemble Learning,Transfer Learning,etc.,with figures in unified style.We further analyze three advanced paradigms,i.e.,AlphaGo,AlphaFold and ChatGPT.Second,to enable more efficient and effective scientific discovery,we propose to build a new ecosystem that drives AI paradigm shifts through the decentralized science(DeSci)movement based on decentralized autonomous organization(DAO).To this end,we design the Hanoi framework,which integrates human factors,parallel intelligence based on a combination of artificial systems and the natural world,and the DAO to inspire AI innovations.