Accurate automatic segmentation of gliomas in various sub-regions,including peritumoral edema,necrotic core,and enhancing and non-enhancing tumor core from 3D multimodal MRI images,is challenging because of its highly...Accurate automatic segmentation of gliomas in various sub-regions,including peritumoral edema,necrotic core,and enhancing and non-enhancing tumor core from 3D multimodal MRI images,is challenging because of its highly heterogeneous appearance and shape.Deep convolution neural networks(CNNs)have recently improved glioma segmentation performance.However,extensive down-sampling such as pooling or stridden convolution in CNNs significantly decreases the initial image resolution,resulting in the loss of accurate spatial and object parts information,especially information on the small sub-region tumors,affecting segmentation performance.Hence,this paper proposes a novel multi-level parallel network comprising three different level parallel subnetworks to fully use low-level,mid-level,and high-level information and improve the performance of brain tumor segmentation.We also introduce the Combo loss function to address input class imbalance and false positives and negatives imbalance in deep learning.The proposed method is trained and validated on the BraTS 2020 training and validation dataset.On the validation dataset,ourmethod achieved a mean Dice score of 0.907,0.830,and 0.787 for the whole tumor,tumor core,and enhancing tumor core,respectively.Compared with state-of-the-art methods,the multi-level parallel network has achieved competitive results on the validation dataset.展开更多
The dwell time and spin polarization(SP)of electrons tunneling through a parallel doubleδ-magnetic-barrier nanostructure in the presence of a bias voltage is studied theoretically in this work.This nanostructure can ...The dwell time and spin polarization(SP)of electrons tunneling through a parallel doubleδ-magnetic-barrier nanostructure in the presence of a bias voltage is studied theoretically in this work.This nanostructure can be constructed by patterning two asymmetric ferromagnetic stripes on the top and bottom of InAs/AlxIn1-xAs heterostructure,respectively.An evident SP effect remains after a bias voltage is applied to the nanostructure.Moreover,both magnitude and sign of spin-polarized dwell time can be manipulated by properly changing the bias voltage,which may result in an electrically-tunable temporal spin splitter for spintronics device applications.展开更多
In order to study the work-ability and establish the optimum hot formation processing parameters for industrial 1060 pure aluminum, the compressive deformation behavior of pure aluminum was investigated at temperature...In order to study the work-ability and establish the optimum hot formation processing parameters for industrial 1060 pure aluminum, the compressive deformation behavior of pure aluminum was investigated at temperatures of 523?823 K and strain rates of 0.005?10 s?1 on a Gleeble?1500 thermo-simulation machine. The influence rule of processing parameters (strain, strain rate and temperature) on flow stress of pure aluminum was investigated. Nine analysis factors consisting of material parameters and according weights were optimized. Then, the constitutive equations of multilevel series rules, multilevel parallel rules and multilevel series ¶llel rules were established. The correlation coefficients (R) are 0.992, 0.988 and 0.990, respectively, and the average absolute relative errors (AAREs) are 6.77%, 8.70% and 7.63%, respectively, which proves that the constitutive equations of multilevel series rules can predict the flow stress of pure aluminum with good correlation and precision.展开更多
An improved recursive doubling algorithm for solving linear recurrence R <n,1>is given,whose parallel time complexity is (τ++τ.) logn when n processors are available,achieving the lower bound in array processo...An improved recursive doubling algorithm for solving linear recurrence R <n,1>is given,whose parallel time complexity is (τ++τ.) logn when n processors are available,achieving the lower bound in array processor type computation.展开更多
In the actual complex environment,the recognition accuracy of crop leaf disease is often not high.Inspired by the brain parallel interaction mechanism,a two-stream parallel interactive convolutional neural network(TSP...In the actual complex environment,the recognition accuracy of crop leaf disease is often not high.Inspired by the brain parallel interaction mechanism,a two-stream parallel interactive convolutional neural network(TSPI-CNN)is proposed to improve the recognition accuracy.TSPI-CNN includes a two-stream parallel network(TSP-Net)and a parallel interactive network(PI-Net).TSP-Net simulates the ventral and dorsal stream.PI-Net simulates the interaction between two pathways in the process of human brain visual information transmission.A large number of experiments shows that the proposed TSPI-CNN performs well on MK-D2,PlantVillage,Apple-3 leaf,and Cassava leaf datasets.Furthermore,the effect of numbers of interactions on the recognition performance of TSPI-CNN is discussed.The experimental results show that as the number of interactions increases,the recognition accuracy of the network also increases.Finally,the network is visualized to show the working mechanism of the network and provide enlightenment for future research.展开更多
Major pulmonary disorders may occur after brain injuries as ventilator-associated pneumonia, acute respiratory distress syndrome or neurogenic pulmonary edema. They are key points for the management of brain-injured p...Major pulmonary disorders may occur after brain injuries as ventilator-associated pneumonia, acute respiratory distress syndrome or neurogenic pulmonary edema. They are key points for the management of brain-injured patients because respiratory failure and mechanical ventilation seem to be a risk factor for increased mortality, poor neurological outcome and longer intensive care unit or hospital length of stay. Brain and lung strongly interact via complex pathways from the brain to the lung but also from the lung to the brain. Several hypotheses have been proposed with a particular interest for the recently described "double hit" model. Ventilator setting in brain-injured patients with lung injuries has been poorly studied and intensivists are often fearful to use some parts of protective ventilation in patients with brain injury. This review aims to describe the epidemiology and pathophysiology of lung injuries in brain-injured patients, but also the impact of different modalities of mechanical ventilation on the brain in the context of acute brain injury.展开更多
By introducing the functional theory into the calculation of electric double layer (EDL) interaction, the interaction energies of two parallel plates were calculated respectively at low, moderate, and high potential...By introducing the functional theory into the calculation of electric double layer (EDL) interaction, the interaction energies of two parallel plates were calculated respectively at low, moderate, and high potentials. Compared with the results of two existing methods, Debye-Hückel and Langmuir methods, which are applicable just to the critical potentials and perform poorly in the intermediate potential, the functional approach not only has much simpler expression of the EDL interaction energy, but also performs well in the entire range of potentials.展开更多
BACKGROUND Transjugular intrahepatic portosystemic shunts(TIPS) can alleviate complications of portal hypertension such as ascites and variceal bleeding by decreasing the portosystemic gradient.In limited clinical sit...BACKGROUND Transjugular intrahepatic portosystemic shunts(TIPS) can alleviate complications of portal hypertension such as ascites and variceal bleeding by decreasing the portosystemic gradient.In limited clinical situations,parallel TIPS may be only solution to alleviate either variceal bleeding or ascites secondary to portal hypertension when the primary TIPS fails to do so.Data specifically addressing the use of this partially polytetrafluoroethylene covered nitinol stent(Viatorr~?) is largely lacking despite Viatorr~? being the current gold standard for modern TIPS placement.CASE SUMMARY All three patients had portal hypertension and already had a primary Viatorr~?TIPS placed previously.All patients have undergone failed endoscopy to manage acute variceal bleeding before referral for a parallel stent(PS).PS were placed in patients presenting with recurrent variceal bleeding despite existence of a widely patent primary TIPS.Primary stent patency was verified with either Doppler ultrasound or intra-procedural TIPS stent venography.Doppler ultrasound follow-up imaging demonstrated complete patency of both primary and parallel TIPS.All three patients did well on clinical follow-up of up to six months and no major complications were recorded.A review of existing literature on the role of PS in the management of portal hypertension complications is discussed.There are three case reports of use of primary and PS Viatorr~? stents placement,only one of which is in a patient with gastrointestinal variceal bleeding despite a patent primary Viatorr~? TIPS.CONCLUSION Viatorr~? PS placement in the management of variceal hemorrhage is feasible with promising short term patency and clinical follow-up data.展开更多
Numerous studies have confirmed that oligodendrocyte transcription factor 1 (Olig-1) is vital for myelin repair. However, the effects of hypoxia and ischemia on Olig-1 expression remain unknown. In this study, Olig-...Numerous studies have confirmed that oligodendrocyte transcription factor 1 (Olig-1) is vital for myelin repair. However, the effects of hypoxia and ischemia on Olig-1 expression remain unknown. In this study, Olig-1 mRNA and protein expressions were analyzed by in situ hybridization and immunohistochemistry, to determine the expression profile of Olig-1 in rat brain slices exposed to hypoxia and ischemia. Brains were obtained from 2-day-old Sprague-Dawley rats, and sections were randomly assigned to control and hypoxia/ischemia groups. Hematoxylin-eosin staining revealed karyorrhexis and karyopyknosis in cells from the hypoxia/ischemia group. Under electron microscopy, mitochondria swelling and neuropil edema were observed in the hypoxiaJischemia group. Olig-1 mRNA and protein expressions were increased at 1 day after hypoxia and ischemia treatment. These results suggest that in situ hybridization and immunohistochemistry could be used simultaneously to detect mRNA and protein expression in brain slices.展开更多
基金supported by the Sichuan Science and Technology Program (No.2019YJ0356).
文摘Accurate automatic segmentation of gliomas in various sub-regions,including peritumoral edema,necrotic core,and enhancing and non-enhancing tumor core from 3D multimodal MRI images,is challenging because of its highly heterogeneous appearance and shape.Deep convolution neural networks(CNNs)have recently improved glioma segmentation performance.However,extensive down-sampling such as pooling or stridden convolution in CNNs significantly decreases the initial image resolution,resulting in the loss of accurate spatial and object parts information,especially information on the small sub-region tumors,affecting segmentation performance.Hence,this paper proposes a novel multi-level parallel network comprising three different level parallel subnetworks to fully use low-level,mid-level,and high-level information and improve the performance of brain tumor segmentation.We also introduce the Combo loss function to address input class imbalance and false positives and negatives imbalance in deep learning.The proposed method is trained and validated on the BraTS 2020 training and validation dataset.On the validation dataset,ourmethod achieved a mean Dice score of 0.907,0.830,and 0.787 for the whole tumor,tumor core,and enhancing tumor core,respectively.Compared with state-of-the-art methods,the multi-level parallel network has achieved competitive results on the validation dataset.
基金the National Natural Science Foundation of China(Grant No.11864009).
文摘The dwell time and spin polarization(SP)of electrons tunneling through a parallel doubleδ-magnetic-barrier nanostructure in the presence of a bias voltage is studied theoretically in this work.This nanostructure can be constructed by patterning two asymmetric ferromagnetic stripes on the top and bottom of InAs/AlxIn1-xAs heterostructure,respectively.An evident SP effect remains after a bias voltage is applied to the nanostructure.Moreover,both magnitude and sign of spin-polarized dwell time can be manipulated by properly changing the bias voltage,which may result in an electrically-tunable temporal spin splitter for spintronics device applications.
基金Project(51275414)supported by the National Natural Science Foundation of ChinaProject(2015JM5204)supported by the Natural Science Foundation of Shaanxi Province,China+1 种基金Project(Z2015064)supported by the Graduate Starting Seed Fund of the Northwestern Polytechnical University,ChinaProject(130-QP-2015)supported by the Research Fund of the State Key Laboratory of Solidification Processing(NWPU),China
文摘In order to study the work-ability and establish the optimum hot formation processing parameters for industrial 1060 pure aluminum, the compressive deformation behavior of pure aluminum was investigated at temperatures of 523?823 K and strain rates of 0.005?10 s?1 on a Gleeble?1500 thermo-simulation machine. The influence rule of processing parameters (strain, strain rate and temperature) on flow stress of pure aluminum was investigated. Nine analysis factors consisting of material parameters and according weights were optimized. Then, the constitutive equations of multilevel series rules, multilevel parallel rules and multilevel series ¶llel rules were established. The correlation coefficients (R) are 0.992, 0.988 and 0.990, respectively, and the average absolute relative errors (AAREs) are 6.77%, 8.70% and 7.63%, respectively, which proves that the constitutive equations of multilevel series rules can predict the flow stress of pure aluminum with good correlation and precision.
文摘An improved recursive doubling algorithm for solving linear recurrence R <n,1>is given,whose parallel time complexity is (τ++τ.) logn when n processors are available,achieving the lower bound in array processor type computation.
基金National Natural Science Foundation of China(Nos.61806051 and 61903078)Fundamental Research Funds for the Central Universities,China(Nos.2232021A-10 and 2232021D-32)Natural Science Foundation of Shanghai,China(No.20ZR1400400)。
文摘In the actual complex environment,the recognition accuracy of crop leaf disease is often not high.Inspired by the brain parallel interaction mechanism,a two-stream parallel interactive convolutional neural network(TSPI-CNN)is proposed to improve the recognition accuracy.TSPI-CNN includes a two-stream parallel network(TSP-Net)and a parallel interactive network(PI-Net).TSP-Net simulates the ventral and dorsal stream.PI-Net simulates the interaction between two pathways in the process of human brain visual information transmission.A large number of experiments shows that the proposed TSPI-CNN performs well on MK-D2,PlantVillage,Apple-3 leaf,and Cassava leaf datasets.Furthermore,the effect of numbers of interactions on the recognition performance of TSPI-CNN is discussed.The experimental results show that as the number of interactions increases,the recognition accuracy of the network also increases.Finally,the network is visualized to show the working mechanism of the network and provide enlightenment for future research.
文摘Major pulmonary disorders may occur after brain injuries as ventilator-associated pneumonia, acute respiratory distress syndrome or neurogenic pulmonary edema. They are key points for the management of brain-injured patients because respiratory failure and mechanical ventilation seem to be a risk factor for increased mortality, poor neurological outcome and longer intensive care unit or hospital length of stay. Brain and lung strongly interact via complex pathways from the brain to the lung but also from the lung to the brain. Several hypotheses have been proposed with a particular interest for the recently described "double hit" model. Ventilator setting in brain-injured patients with lung injuries has been poorly studied and intensivists are often fearful to use some parts of protective ventilation in patients with brain injury. This review aims to describe the epidemiology and pathophysiology of lung injuries in brain-injured patients, but also the impact of different modalities of mechanical ventilation on the brain in the context of acute brain injury.
基金This work was supported by the National Natural Science Foundation of China (No.20676051 and No.20573048) and the Important Construction Project (category A) of Shanghai Jiao Tong University (No.AE150085).
文摘By introducing the functional theory into the calculation of electric double layer (EDL) interaction, the interaction energies of two parallel plates were calculated respectively at low, moderate, and high potentials. Compared with the results of two existing methods, Debye-Hückel and Langmuir methods, which are applicable just to the critical potentials and perform poorly in the intermediate potential, the functional approach not only has much simpler expression of the EDL interaction energy, but also performs well in the entire range of potentials.
文摘BACKGROUND Transjugular intrahepatic portosystemic shunts(TIPS) can alleviate complications of portal hypertension such as ascites and variceal bleeding by decreasing the portosystemic gradient.In limited clinical situations,parallel TIPS may be only solution to alleviate either variceal bleeding or ascites secondary to portal hypertension when the primary TIPS fails to do so.Data specifically addressing the use of this partially polytetrafluoroethylene covered nitinol stent(Viatorr~?) is largely lacking despite Viatorr~? being the current gold standard for modern TIPS placement.CASE SUMMARY All three patients had portal hypertension and already had a primary Viatorr~?TIPS placed previously.All patients have undergone failed endoscopy to manage acute variceal bleeding before referral for a parallel stent(PS).PS were placed in patients presenting with recurrent variceal bleeding despite existence of a widely patent primary TIPS.Primary stent patency was verified with either Doppler ultrasound or intra-procedural TIPS stent venography.Doppler ultrasound follow-up imaging demonstrated complete patency of both primary and parallel TIPS.All three patients did well on clinical follow-up of up to six months and no major complications were recorded.A review of existing literature on the role of PS in the management of portal hypertension complications is discussed.There are three case reports of use of primary and PS Viatorr~? stents placement,only one of which is in a patient with gastrointestinal variceal bleeding despite a patent primary Viatorr~? TIPS.CONCLUSION Viatorr~? PS placement in the management of variceal hemorrhage is feasible with promising short term patency and clinical follow-up data.
基金the National Natural Science Foundation of China, No. 30872778the Natural Science Foundation of Beijing City, No. 7072023Clinical Basic Corporation Foundation of Capital Medi-cal University, No. 2006jl18
文摘Numerous studies have confirmed that oligodendrocyte transcription factor 1 (Olig-1) is vital for myelin repair. However, the effects of hypoxia and ischemia on Olig-1 expression remain unknown. In this study, Olig-1 mRNA and protein expressions were analyzed by in situ hybridization and immunohistochemistry, to determine the expression profile of Olig-1 in rat brain slices exposed to hypoxia and ischemia. Brains were obtained from 2-day-old Sprague-Dawley rats, and sections were randomly assigned to control and hypoxia/ischemia groups. Hematoxylin-eosin staining revealed karyorrhexis and karyopyknosis in cells from the hypoxia/ischemia group. Under electron microscopy, mitochondria swelling and neuropil edema were observed in the hypoxiaJischemia group. Olig-1 mRNA and protein expressions were increased at 1 day after hypoxia and ischemia treatment. These results suggest that in situ hybridization and immunohistochemistry could be used simultaneously to detect mRNA and protein expression in brain slices.