An In-depth Interpretation of the Universal Declaration of Human Rights With the Common Values of Humanity As the Research Paradigm

Interpreting the Universal Declaration of Human Rights from political,juridical and philosophical perspectives is es-sential for promoting the guiding principles of the Declaration,build-ing consensus on human rights,and advancing human rights practice in the new historical context.To conduct an academic,systematic in-terpretation of the Declaration that conforms to the trends of the times and answers the fundamental questions of the world,it is necessary to find a new research paradigm.The common values of humanity,namely peace,development,equity,justice,democracy and freedom,put forward by Xi Jinping,general secretary of the Communist Party of China(CPC)Central Committee,provide the most explanatory and penetrating scientific paradigm for reaching the issue.This paper an-alyzes and reflects on the views,value foundation and principled(con-tractual)consensus of human rights in the Declaration,and narrates and foresees the far-reaching significance of the three global initia-tives(namely,the Global Development Initiative,the Global Security Initiative,and the Global Civilization Initiative)with the common val-ues of humanity as the soul in advancing the modernization of global human rights governance and building a new form of human rights civilization.

Commentary on:“Human neural stem cell-derived artificial organelles to improve oxidative phosphorylation”

Mitochondrial function is fundamental to neuroregeneration,particularly in neurons,where high energy demands are essential for repair and recovery(Patrón and Zinsmaier,2016;Beckervordersandforth et al.,2017;Iwata et al.,2023).Mitochondrial dysfunction,characterized by an imbalance in ATP levels and excessive production of mitochondrial reactive oxygen species,is a key factor that impedes neural regeneration in neurodegenerative diseases and after neuronal injury(Han et al.,2016,2020;Zheng et al.,2016;Zong et al.,2024).

Human endogenous retrovirus type-W and multiple sclerosis–related smoldering neuroinflammation

Introduction to human endogenous retrovirus type-W(HERV-W): Genomic inheritance from the past includes retroviral sequences that have been stably incorporated into our genomes and account for up to 8% of human DNA.

Treatment of spinal cord injury with biomaterials and stem cell therapy in non-human primates and humans

Spinal cord injury results in the loss of sensory,motor,and autonomic functions,which almost always produces permanent physical disability.Thus,in the search for more effective treatments than those already applied for years,which are not entirely efficient,researches have been able to demonstrate the potential of biological strategies using biomaterials to tissue manufacturing through bioengineering and stem cell therapy as a neuroregenerative approach,seeking to promote neuronal recovery after spinal cord injury.Each of these strategies has been developed and meticulously evaluated in several animal models with the aim of analyzing the potential of interventions for neuronal repair and,consequently,boosting functional recovery.Although the majority of experimental research has been conducted in rodents,there is increasing recognition of the importance,and need,of evaluating the safety and efficacy of these interventions in non-human primates before moving to clinical trials involving therapies potentially promising in humans.This article is a literature review from databases(PubMed,Science Direct,Elsevier,Scielo,Redalyc,Cochrane,and NCBI)from 10 years ago to date,using keywords(spinal cord injury,cell therapy,non-human primates,humans,and bioengineering in spinal cord injury).From 110 retrieved articles,after two selection rounds based on inclusion and exclusion criteria,21 articles were analyzed.Thus,this review arises from the need to recognize the experimental therapeutic advances applied in non-human primates and even humans,aimed at deepening these strategies and identifying the advantages and influence of the results on extrapolation for clinical applicability in humans.

Effects of P301L-TAU on post-translational modifications of microtubules in human iPSC-derived cortical neurons and TAU transgenic mice

TAU is a microtubule-associated protein that promotes microtubule assembly and stability in the axon.TAU is missorted and aggregated in an array of diseases known as tauopathies.Microtubules are essential for neuronal function and regulated via a complex set of post-translational modifications,changes of which affect microtubule stability and dynamics,microtubule interaction with other proteins and cellular structures,and mediate recruitment of microtubule-severing enzymes.As impairment of microtubule dynamics causes neuronal dysfunction,we hypothesize cognitive impairment in human disease to be impacted by impairment of microtubule dynamics.We therefore aimed to study the effects of a disease-causing mutation of TAU(P301L)on the levels and localization of microtubule post-translational modifications indicative of microtubule stability and dynamics,to assess whether P301L-TAU causes stability-changing modifications to microtubules.To investigate TAU localization,phosphorylation,and effects on tubulin post-translational modifications,we expressed wild-type or P301L-TAU in human MAPT-KO induced pluripotent stem cell-derived neurons(i Neurons)and studied TAU in neurons in the hippocampus of mice transgenic for human P301L-TAU(p R5 mice).Human neurons expressing the longest TAU isoform(2N4R)with the P301L mutation showed increased TAU phosphorylation at the AT8,but not the p-Ser-262 epitope,and increased polyglutamylation and acetylation of microtubules compared with endogenous TAU-expressing neurons.P301L-TAU showed pronounced somatodendritic presence,but also successful axonal enrichment and a similar axodendritic distribution comparable to exogenously expressed 2N4R-wildtype-TAU.P301L-TAU-expressing hippocampal neurons in transgenic mice showed prominent missorting and tauopathy-typical AT8-phosphorylation of TAU and increased polyglutamylation,but reduced acetylation,of microtubules compared with non-transgenic littermates.In sum,P301L-TAU results in changes in microtubule PTMs,suggestive of impairment of microtubule stability.This is accompanied by missorting and aggregation of TAU in mice but not in i Neurons.Microtubule PTMs/impairment may be of key importance in tauopathies.

Spatial transcriptomics combined with single-nucleus RNA sequencing reveals glial cell heterogeneity in the human spinal cord

Glial cells play crucial roles in regulating physiological and pathological functions,including sensation,the response to infection and acute injury,and chronic neurodegenerative disorders.Glial cells include astrocytes,microglia,and oligodendrocytes in the central nervous system,and satellite glial cells and Schwann cells in the peripheral nervous system.Despite the greater understanding of glial cell types and functional heterogeneity achieved through single-cell and single-nucleus RNA sequencing in animal models,few studies have investigated the transcriptomic profiles of glial cells in the human spinal cord.Here,we used high-throughput single-nucleus RNA sequencing and spatial transcriptomics to map the cellular and molecular heterogeneity of astrocytes,microglia,and oligodendrocytes in the human spinal cord.To explore the conservation and divergence across species,we compared these findings with those from mice.In the human spinal cord,astrocytes,microglia,and oligodendrocytes were each divided into six distinct transcriptomic subclusters.In the mouse spinal cord,astrocytes,microglia,and oligodendrocytes were divided into five,four,and five distinct transcriptomic subclusters,respectively.The comparative results revealed substantial heterogeneity in all glial cell types between humans and mice.Additionally,we detected sex differences in gene expression in human spinal cord glial cells.Specifically,in all astrocyte subtypes,the levels of NEAT1 and CHI3L1 were higher in males than in females,whereas the levels of CST3 were lower in males than in females.In all microglial subtypes,all differentially expressed genes were located on the sex chromosomes.In addition to sex-specific gene differences,the levels of MT-ND4,MT2A,MT-ATP6,MT-CO3,MT-ND2,MT-ND3,and MT-CO_(2) in all spinal cord oligodendrocyte subtypes were higher in females than in males.Collectively,the present dataset extensively characterizes glial cell heterogeneity and offers a valuable resource for exploring the cellular basis of spinal cordrelated illnesses,including chronic pain,amyotrophic lateral sclerosis,and multiple sclerosis.

Expression of Humanity in Highway Landscape Design

Creation of human landscape is the important component of highway landscape design,which has incomparable advantage in the aspects of transmitting cultural atmosphere and expressing regional features.It can not only beautify highway environment,but also serve for traffic function.It is another effective approach to ensure traffic safety.The paper has analyzed existing problems and insufficiencies of modern highway human construction,and discussed the means and methods of expression of historical humanized landscape in highway landscape design.The paper has considered that during design of highway human landscape,it should fully explore historical and humanized background along the highway,extract cultural spirit,enrich cultural connotation,and oppose coarse and fictitious design on the basis of respecting culture and history.

The Sacrifice on the Altar-An Analysis of the Conflict between Montanelli's Humanity and Divinity in The Gadfly

Montanelli suffered from the fierce conflict between humanity and divinity in his pursuit of religious belief.As a sacrifice on the altar of God,Montanelli's tragedy reflects the influence of the religion upon his behaviors,his internal spirit and his tragic destiny in the end.Furthermore,it manifests the cruelty and darkness of the religious rule and the distortion of the humankind in his age.

The Call of Humanity in The Call of the Wild

Jack London is one of the greatest American novelists. Many of his works are very popular among readers all over the world. This paper firstly gives a brief introduction of Jack London and The Call of the Wild. Then it analyzes the theme and main Characters of this novel. At last the implied meaning is discussed.

Reflections on Humanity from the Modern Vampirism

Vampirism is a very popular theme in modern novels, movies or other forms of literature genres. This paper tries to explore the development of vampirism literatures and by doing so makes some deep reflections on humanity from the modern vampirism.

Insensibility of Humanity is the Root of Emily's Tragedy--A Brief Analysis on a Rose for Emily

In William Faulkner's A Rose for Emily,we can read his attitude to Southern traditional civilization and patriarchal social system.William Faulkner revealed that the root of women's tragic fate was the brutality and cruelty of Southern tradition,and opened out corrupting and perverting of Southern aristocrat according drawing many vivid characters.This thesis analyzes these insensible figures to fulminate against the inhuman society tradition in South America at that time.

Humanity factors and more: A little heads up for medical students and future doctors

Exactly how can we become a successful doctor in the future? It has been widely accepted that chasing perfection in our field of expertise alone is not enough. Here in China, doctors have the liability to do more. Chinese doctors are relatively more prone to confronting difficult situations in a more complex manner. Therefore, the humanity factor in medical practice is discussed, and some essential communication skills are suggested for medical practitioners, with heartfelt anticipation for a better medical environment as well as a more pleasant Doctor-Patient relationship.

Review the Nature and the Humanity in King Lear

Tragedy is the art that purifies the mind.Through richly-drawn impressive characters,King Lear illustrates the sameness of human nature and manifest the common outlook on humanity in Chinese and western culture.King Lear should be studied from the perspectives of dialectics of nature and history of social development.Through manifestation of nature and human beings,King Lear proves to be deeply touching for being earthshaking,society-changing and mind-purifying.The artistic value of this tragedy lies in that the truth,the good and the beauty against the fake,the bad and the ugly.All these contributes to its extraordinary standing in aesthetics,philosophy,anthropology,sociology and psychology.

A Study on Kant’s Views on Humanity in His Aesthetics

A key to understand Immanuel Kant's philosophy is his views on humanity,and the cornerstone of Kant’s philosophy is the idea that“beauty is a symbol of morality”.From the perspective of his views on humanity,we can have a deep understanding of Kant*s analysis of beauty and the sublime and his aesthetics.The focus of Kant's aesthetics is the realization of human freedom and the sublime,and this is of special humanistic feature.

Philosophical Implications of “A Community of Shared Future for Humanity”

A new concept contributing to global governance in the era of globalization,“A Community of Shared Future for Humanity(CSFH)”boasts rich philosophical implications and values connotations despite insufficient research toward it in academia.This study seeks to analyze the philosophical significance of CSFH and concludes that it is a new practice of Marxist“Anthropological Philosophy”,a reserved development of“One Unified World under the Heaven”and“Supreme Harmony Consummated by Coordination of Varied Interests”in traditional Chinese philosophy and a dimensional transcendence over the western“self-reliant”national state system.

Xi Jinping’s Analysis of “A Common Future for Humanity”:Its Relation to Marx’s Das Kapital

President Xi Jinping’s analysis of “a common future for humanity” is one of the most important and original features of China’s foreign policy and of “Xi Jinping’s Thought on Socialism with Chinese Characteristics for a New Era”.This concept is comprehensible not only in classical Chinese but in Western philosophical thought.Therefore,it is a creative development of Marxism whose accurate relation to economic reality,provides an exceptionally firm basis for China’s foreign policy and that of other countries.

Marx's Theory of Humanity and Nature

Marx's theory of humanity and nature is an indispensable part of Marx's theory of social development. The history of the development of human society is essentially a natural historical process. Human must start from certain natural premises and start from a combination of certain natural premises and human practices. This is the objective process and inevitable law of the development of human society. Grasping and understanding the scientific connotation of Marx's theory of humanity and nature has very important guiding significance for the development of human society.

Analysis of Space Design of a Campus Square from the Perspective of Humanity:A Case Study of Sanjiacun Square in Xiamen University

The behavior styles of students which are the main service groups of Sanjiacun Square in Xiamen University were surveyed and analyzed firstly from the aspects of their perception,use and assessment of the square space,and then strategies to design the square space in the campus from the perspective of humanity were summarized to provide scientific references for the design of a square space in an university campus.

Humanβ-defensin-1 affects the mammalian target of rapamycin pathway and autophagy in colon cancer cells through long noncoding RNA TCONS_00014506

BACKGROUND Colorectal cancer has a low 5-year survival rate and high mortality.Humanβ-defensin-1(hBD-1)may play an integral function in the innate immune system,contributing to the recognition and destruction of cancer cells.Long non-coding RNAs(lncRNAs)are involved in the process of cell differentiation and growth.AIM To investigate the effect of hBD-1 on the mammalian target of rapamycin(mTOR)pathway and autophagy in human colon cancer SW620 cells.METHODS CCK8 assay was utilized for the detection of cell proliferation and determination of the optimal drug concentration.Colony formation assay was employed to assess the effect of hBD-1 on SW620 cell proliferation.Bioinformatics was used to screen potentially biologically significant lncRNAs related to the mTOR pathway.Additionally,p-mTOR(Ser2448),Beclin1,and LC3II/I expression levels in SW620 cells were assessed through Western blot analysis.RESULTS hBD-1 inhibited the proliferative ability of SW620 cells,as evidenced by the reduction in the colony formation capacity of SW620 cells upon exposure to hBD-1.hBD-1 decreased the expression of p-mTOR(Ser2448)protein and increased the expression of Beclin1 and LC3II/I protein.Furthermore,bioinformatics analysis identified seven lncRNAs(2 upregulated and 5 downregulated)related to the mTOR pathway.The lncRNA TCONS_00014506 was ultimately selected.Following the inhibition of the lncRNA TCONS_00014506,exposure to hBD-1 inhibited p-mTOR(Ser2448)and promoted Beclin1 and LC3II/I protein expression.CONCLUSION hBD-1 inhibits the mTOR pathway and promotes autophagy by upregulating the expression of the lncRNA TCONS_00014506 in SW620 cells.

A Journey Revealing the Evil Side of Humanity

This paper discusses the dark side of humanity exposed in Heart of Darkness. It analyses how Marlow finds the evil and deceitful nature of human beings during the journey into Africa.