Coalbed methane(CBM)drilling and completion technologies(DCTs)are signifcant basis for achieving efcient CBM exploration and exploitation.Characteristics of CBM reservoirs vary in diferent regions around the world,the...Coalbed methane(CBM)drilling and completion technologies(DCTs)are signifcant basis for achieving efcient CBM exploration and exploitation.Characteristics of CBM reservoirs vary in diferent regions around the world,thereby,it is crucial to develop,select and apply the optimum DCTs for each diferent CBM reservoir.This paper frstly reviews the development history of CBM DCTs throughout worldwide and clarifes its overall development tendency.Secondly,diferent well types and its characteristics of CBM exploitation are summarized,and main application scopes of these well types are also discussed.Then,the key technologies of CBM drilling(directional drilling tools,measurement while drilling,geo-steering drilling,magnetic guidance drilling,underbalanced drilling and drilling fuids),and the key technologies of CBM completion(open-hole,cavity and under-ream completion,cased-hole completion,screen pipe completion and horizontal well completion)are summarized and analyzed,it is found that safe,economic and efcient development of CBM is inseparable from the support of advanced technologies.Finally,based on the current status of CBM development,the achievements,existing challenges and future prospects are summarized and discussed from the perspective of CBM DCTs.展开更多
Objective:To investigate the anti-diabetic effect of the root extract of Annona muricata(AME)in streptozotocin-nicotinamide-induced type 2 diabetic(T2DM)mice.Methods:After 4 weeks of high-fat diet,ICR mice were given ...Objective:To investigate the anti-diabetic effect of the root extract of Annona muricata(AME)in streptozotocin-nicotinamide-induced type 2 diabetic(T2DM)mice.Methods:After 4 weeks of high-fat diet,ICR mice were given 1 g/kg nicotine and 120 mg/kg streptozotocin(STZ)orally to construct a T2DM model.The T2DM mice were randomly divided into five groups:model group,200 mg/kg metformin group and 50,100,200 mg/kg AME groups.Drugs were oral administered continuously for 4 weeks.Fasting blood glucose and body weight were measured weekly.Oral glucose tolerance test(OGTT)and detection of serum glycated hemoglobin(HbA1c)level were performed one week before the end of the experiment.At the end of drug administration,serum total cholesterol(TG),triglycerides(TC),low-density lipoprotein levels(LDL-C)and insulin levels were tested by lipid detection kits;homeostasis model assessment-estimated insulin resistance(HOMA-IR)and HOMA-βindexes were calculated.Liver and kidney tissues were weighed to calculate organ indices and pathological tests were performed.Western blot was performed in the liver to detect adenosine monophosphate-activated protein kinase(AMPK),acetyl coenzyme A carboxylase(ACC),glucose-6-phosphate carboxylase(G6Pase),and phosphoenolpyruvate carboxykinase(PCK1)protein expression.Results:with 200 mg/kg AME significantly reduced fasting blood glucose,HbA1c,TG and LDL-C levels,protected liver and kindey in diabetic mice,decreased the area under the OGTT curve,inhibited ACC and G6Pase protein expressions,and activated AMPK protein expression.Conclusion:AME showed good therapeutic activity against T2DM,and the mechanism may be related to the activation of AMPK and inhibition of ACC and G6Pase proteins.展开更多
Recently,continuous breakthroughs have been made about deep gold prospecting in the Jiaodong gold province area of China.Approximately 5000 t of cumulative gold resources have been explored in Jiaodong,which has thus ...Recently,continuous breakthroughs have been made about deep gold prospecting in the Jiaodong gold province area of China.Approximately 5000 t of cumulative gold resources have been explored in Jiaodong,which has thus become an internationally noteworthy gold ore cluster.The gold exploration depth has been increased to about 2000 m from the previous<1000 m.To further explore the mineralization potential of the Jiaodong area at a depth of about 3000 m,the Shandong Institute of Geological Sciences has drilled an exploratory drillhole named“Deep drillhole ZK01”to a depth of 3266 m.Hence,as reported herein,the mineralization characteristics of the Jiaojia metallogenic belt have been successfully documented.ZK01 is,to date,the deepest borehole with an gold intersect in China,and constitutes a significant advance in deep gold prospecting in China.The findings of this study further indicate that the depth interval of 2000 m to 4000 m below the ground surface in the Wuyi Village area incorporates 912 t of inferred gold resources,while the depth interval of 2000 m to 4000 m below the surface across the Jiaodong area possesses about 4000 t of inferred gold resources.The Jiaojia Fault Belt tends to gently dip downward,having dip angles of about 25°and about 20°at vertical depths of 2000 m and 2850 m,respectively.The deep part of the Jiaojia metallogenic belt differs from the shallow and moderately deep parts about fracturing,alteration,mineralization,and tectonic type.The deep zones can generally be categorized from inside outward as cataclastic granite,granitic cataclasite,weakly beresitized granitic cataclasite,beresitized cataclasite,and gouge.These zones exhibit a gradual transitional relation or occur alternately and repeatedly.The mineralization degree of the pyritized cataclastic granite-type ore in the deep part of the Jiaojia metallogenic belt is closely related to the degree of pyrite vein development;that is,the higher the pyrite content,the wider the veins and the higher the gold grade.Compared to the shallow gold ores,the deep-seated gold ores have higher fineness and contain joseite,tetradymite,and native bismuth,suggesting that the deep gold mineralization temperature is higher and that mantle-sourced material may have contributed to this mineralization.ZK01 has also revealed that the deep-seated ore bodies in the Jiaojia metallogenic belt are principally situated above the main fracture plane(gouge)and hosted within the Linglong Granite,contradicting previous findings indicating that the moderately shallow gold ore bodies are usually hosted in the contact zone between the Linglong Granite and Jiaodong Group or meta-gabbro.These new discoveries are particularly significant because they can help correct mineralization prospecting models,determine favorable positions for deep prospecting,and improve metallogenic prediction and resource potential evaluation.展开更多
The grain-filling processes at different grain positions of curved-panicle type Longjing 29 and semi-erect-panicle type Longjing 31, two major rice （Oryza sativa L.） cultivars in Heilongjiang Province, were simulate...The grain-filling processes at different grain positions of curved-panicle type Longjing 29 and semi-erect-panicle type Longjing 31, two major rice （Oryza sativa L.） cultivars in Heilongjiang Province, were simulated by Richards growth eq-uation, so as to determine the reason of great differences in head rice rate of different rice cul- tivar among different years and to improve the processing quality of different rice cul- tivar through cultivation regulation measures. The results showed that the yield of Longjing 29 was slightly higher than that of Longjing 31, but the head rice rate of Longjing 29 was significantly lower than that of Longjing 31. More grains on sec- ondary rachis branch resulted in lower plumpness, lower seed-setting rate and lower milled rice rate of Longjing 29. The grain-filling rates at the six grain positions of Longjing 31 reached the peaks simultaneously, so the synchronous grain filling char- acteristic of Longjing 31 was more obvious. The grain-filling rate on the primary rachis branch of Longjing 31 was higher, and it reached the peak in the middle peri- od. Although the grain-filling rate on the secondary rachis branch of Longjing 31 was lower, it early reached the peak. In addition, the middle and late filling period of Longjing 31 was longer, resulting in plump and compact grains on the secondary rachis branch of Longjing 31. After the grain-filling rate on the primary rachis branch was decreased, the grain-filling rate on the secondary rachis branch of Longjing 29 started to be increased greatly, characterized by asynchronous grain filling. In the early grain filling stage, the grains on the upper, middle and basal secondary rachis branch were all significantly suppressed by those on the primary rachis branch of Longjing 29. The initial growth potential and maximum filling rate of grains on the secondary rachis branch of Longjing 29 were all lower. The grain-filling rate on the secondary rachis branch of Longjing 29 late reached the peak. Even worse, the mid- dle and late filling period of Longjing 29 was shorter. Therefore, the grains of Longjing 29 had poor plumpness. Synchronous grain filling led to small difference in grain quality within the same panicle, and this was also the reason for stable head rice rate of Longjing 31 among different years. In contrast, asynchronous grain filling led to great difference in grain quality within the same panicle of Longjing 29. In addi- tion, low temperature often occurred during the fast filling of grains on the secondary rachis branch of Longjing 29. Thus, the head rice rate of Longjing 29 was decreased.展开更多
基金supported by the Youth Scientific and Technological Innovation Team Foundation of Southwest Petroleum University(2019CXTD09)the Program of Introducing Talents of Discipline to Chinese Universities(111 Plan)(D18016).
文摘Coalbed methane(CBM)drilling and completion technologies(DCTs)are signifcant basis for achieving efcient CBM exploration and exploitation.Characteristics of CBM reservoirs vary in diferent regions around the world,thereby,it is crucial to develop,select and apply the optimum DCTs for each diferent CBM reservoir.This paper frstly reviews the development history of CBM DCTs throughout worldwide and clarifes its overall development tendency.Secondly,diferent well types and its characteristics of CBM exploitation are summarized,and main application scopes of these well types are also discussed.Then,the key technologies of CBM drilling(directional drilling tools,measurement while drilling,geo-steering drilling,magnetic guidance drilling,underbalanced drilling and drilling fuids),and the key technologies of CBM completion(open-hole,cavity and under-ream completion,cased-hole completion,screen pipe completion and horizontal well completion)are summarized and analyzed,it is found that safe,economic and efcient development of CBM is inseparable from the support of advanced technologies.Finally,based on the current status of CBM development,the achievements,existing challenges and future prospects are summarized and discussed from the perspective of CBM DCTs.
基金National Natural Science Foundation of China(No.81460591)Hainan Medical University Training Fund(HY2018-09)。
文摘Objective:To investigate the anti-diabetic effect of the root extract of Annona muricata(AME)in streptozotocin-nicotinamide-induced type 2 diabetic(T2DM)mice.Methods:After 4 weeks of high-fat diet,ICR mice were given 1 g/kg nicotine and 120 mg/kg streptozotocin(STZ)orally to construct a T2DM model.The T2DM mice were randomly divided into five groups:model group,200 mg/kg metformin group and 50,100,200 mg/kg AME groups.Drugs were oral administered continuously for 4 weeks.Fasting blood glucose and body weight were measured weekly.Oral glucose tolerance test(OGTT)and detection of serum glycated hemoglobin(HbA1c)level were performed one week before the end of the experiment.At the end of drug administration,serum total cholesterol(TG),triglycerides(TC),low-density lipoprotein levels(LDL-C)and insulin levels were tested by lipid detection kits;homeostasis model assessment-estimated insulin resistance(HOMA-IR)and HOMA-βindexes were calculated.Liver and kidney tissues were weighed to calculate organ indices and pathological tests were performed.Western blot was performed in the liver to detect adenosine monophosphate-activated protein kinase(AMPK),acetyl coenzyme A carboxylase(ACC),glucose-6-phosphate carboxylase(G6Pase),and phosphoenolpyruvate carboxykinase(PCK1)protein expression.Results:with 200 mg/kg AME significantly reduced fasting blood glucose,HbA1c,TG and LDL-C levels,protected liver and kindey in diabetic mice,decreased the area under the OGTT curve,inhibited ACC and G6Pase protein expressions,and activated AMPK protein expression.Conclusion:AME showed good therapeutic activity against T2DM,and the mechanism may be related to the activation of AMPK and inhibition of ACC and G6Pase proteins.
基金by the National Natural Science Foundation of China(41772076,41672084,41372086,41503038)the National Key Research and Development Program of China(2016YFC0600105-04,2016YFC0600606)+1 种基金the Key Research and Development Program of Shandong Province(2017CXGC1601,2017CXGC1602,2017CXGC1603),the Special Fund for“Taishan Scholars”Project of Shandong Province.
文摘Recently,continuous breakthroughs have been made about deep gold prospecting in the Jiaodong gold province area of China.Approximately 5000 t of cumulative gold resources have been explored in Jiaodong,which has thus become an internationally noteworthy gold ore cluster.The gold exploration depth has been increased to about 2000 m from the previous<1000 m.To further explore the mineralization potential of the Jiaodong area at a depth of about 3000 m,the Shandong Institute of Geological Sciences has drilled an exploratory drillhole named“Deep drillhole ZK01”to a depth of 3266 m.Hence,as reported herein,the mineralization characteristics of the Jiaojia metallogenic belt have been successfully documented.ZK01 is,to date,the deepest borehole with an gold intersect in China,and constitutes a significant advance in deep gold prospecting in China.The findings of this study further indicate that the depth interval of 2000 m to 4000 m below the ground surface in the Wuyi Village area incorporates 912 t of inferred gold resources,while the depth interval of 2000 m to 4000 m below the surface across the Jiaodong area possesses about 4000 t of inferred gold resources.The Jiaojia Fault Belt tends to gently dip downward,having dip angles of about 25°and about 20°at vertical depths of 2000 m and 2850 m,respectively.The deep part of the Jiaojia metallogenic belt differs from the shallow and moderately deep parts about fracturing,alteration,mineralization,and tectonic type.The deep zones can generally be categorized from inside outward as cataclastic granite,granitic cataclasite,weakly beresitized granitic cataclasite,beresitized cataclasite,and gouge.These zones exhibit a gradual transitional relation or occur alternately and repeatedly.The mineralization degree of the pyritized cataclastic granite-type ore in the deep part of the Jiaojia metallogenic belt is closely related to the degree of pyrite vein development;that is,the higher the pyrite content,the wider the veins and the higher the gold grade.Compared to the shallow gold ores,the deep-seated gold ores have higher fineness and contain joseite,tetradymite,and native bismuth,suggesting that the deep gold mineralization temperature is higher and that mantle-sourced material may have contributed to this mineralization.ZK01 has also revealed that the deep-seated ore bodies in the Jiaojia metallogenic belt are principally situated above the main fracture plane(gouge)and hosted within the Linglong Granite,contradicting previous findings indicating that the moderately shallow gold ore bodies are usually hosted in the contact zone between the Linglong Granite and Jiaodong Group or meta-gabbro.These new discoveries are particularly significant because they can help correct mineralization prospecting models,determine favorable positions for deep prospecting,and improve metallogenic prediction and resource potential evaluation.
基金Supported by National Key Technology Research and Development Program(2012BAD04B01-02)Science Foundation of Heilongjiang Province for Outstanding Young Scientists(JG05-22)+2 种基金Key Science and Technology Program of Heilongjiang Province(GA09B102-3)Youth Foundation for Agricultural Science and Technology Innovation in Heilongjiang Province in 2012Heilongjiang Postdoctoral Sustentation Fund(LBH-Z10038)~~
文摘The grain-filling processes at different grain positions of curved-panicle type Longjing 29 and semi-erect-panicle type Longjing 31, two major rice （Oryza sativa L.） cultivars in Heilongjiang Province, were simulated by Richards growth eq-uation, so as to determine the reason of great differences in head rice rate of different rice cul- tivar among different years and to improve the processing quality of different rice cul- tivar through cultivation regulation measures. The results showed that the yield of Longjing 29 was slightly higher than that of Longjing 31, but the head rice rate of Longjing 29 was significantly lower than that of Longjing 31. More grains on sec- ondary rachis branch resulted in lower plumpness, lower seed-setting rate and lower milled rice rate of Longjing 29. The grain-filling rates at the six grain positions of Longjing 31 reached the peaks simultaneously, so the synchronous grain filling char- acteristic of Longjing 31 was more obvious. The grain-filling rate on the primary rachis branch of Longjing 31 was higher, and it reached the peak in the middle peri- od. Although the grain-filling rate on the secondary rachis branch of Longjing 31 was lower, it early reached the peak. In addition, the middle and late filling period of Longjing 31 was longer, resulting in plump and compact grains on the secondary rachis branch of Longjing 31. After the grain-filling rate on the primary rachis branch was decreased, the grain-filling rate on the secondary rachis branch of Longjing 29 started to be increased greatly, characterized by asynchronous grain filling. In the early grain filling stage, the grains on the upper, middle and basal secondary rachis branch were all significantly suppressed by those on the primary rachis branch of Longjing 29. The initial growth potential and maximum filling rate of grains on the secondary rachis branch of Longjing 29 were all lower. The grain-filling rate on the secondary rachis branch of Longjing 29 late reached the peak. Even worse, the mid- dle and late filling period of Longjing 29 was shorter. Therefore, the grains of Longjing 29 had poor plumpness. Synchronous grain filling led to small difference in grain quality within the same panicle, and this was also the reason for stable head rice rate of Longjing 31 among different years. In contrast, asynchronous grain filling led to great difference in grain quality within the same panicle of Longjing 29. In addi- tion, low temperature often occurred during the fast filling of grains on the secondary rachis branch of Longjing 29. Thus, the head rice rate of Longjing 29 was decreased.
