As the population ages,the burden of age-related diseases becomes greater.Currently,over 55 million people suffer from dementia worldwide,with Alzheimer’s disease being the most common form.However,it is becoming cle...As the population ages,the burden of age-related diseases becomes greater.Currently,over 55 million people suffer from dementia worldwide,with Alzheimer’s disease being the most common form.However,it is becoming clearer that underlying vascular pathology such as cerebral small vessel disease(cSVD)may be a more detrimental cause for dementia(Cuadrado-Godia et al.,2018).It is estimated that 10%-30%of the elderly population and 35%-90%of all dementia patients exhibit signs of cSVD.The term cSVD refers to pathology affecting the small vessels of the brain,which can lead to lacunar cerebral infarcts,enlarged perivascular spaces,and cortical hemorrhages(Cuadrado-Godia et al.,2018).CSVD is often associated with cognitive decline,gait problems,and dementia(Cuadrado-Godia et al.,2018).展开更多
Coyotes (Canis latrans) are a relatively new predator to the southeastern United States, and may be negatively impacting white-tailed deer (Odocoileus virginianus;hereafter, deer) populations. Our objectives were to e...Coyotes (Canis latrans) are a relatively new predator to the southeastern United States, and may be negatively impacting white-tailed deer (Odocoileus virginianus;hereafter, deer) populations. Our objectives were to evaluate the impacts of coyotes on deer fawns by assessing deer fawn survival and cause-specific mortality, and gain an understanding of factors affecting fawn survival and coyote predation. We captured and radio collared 30 fawns in the Red Hills region of Florida and Georgia, USA (2012-2013). Fawns were monitored for 12 weeks for survival and cause-specific mortality, and we quantified habitat and environmental characteristics of birth sites. Predation (n = 19;95%) was the leading cause of fawn mortality (n = 20;67%), with coyote predation (n = 14;74%) being the most important type of predation. Survival rates for all fawns were greater (P = 0.048) where coyotes were removed compared to non-removal sites, with 50% and 25% of fawns surviving to 12 weeks on coyote-removal and non-removal sites, respectively. Survival rates of fawns ultimately predated by coyotes were greater (P = 0.096) on coyote-removal than non-removal sites, with 40% and 50% of fawns predated by coyotes within 12 weeks on coyote-removal and non-removal sites, respectively. Survival of all fawns and those predated by coyotes was lower when fawns were born at sites with greater hardwood basal area, total basal area, and canopy closure;and survival improved if born in or near hardwood, natural pine, and managed (planted) pine cover types. Increased canopy cover within 10 m of the birth site was selected by adult females for birth sites of all fawns and those that were predated by coyotes. Compared with fawns that lived, all dying fawns and those predated by coyotes had less shrub cover within 5 m and less grass cover at and within 10 m of the birth site. Coyote removal increased fawn daily survival rates, and habitat played a role in fawn survival.展开更多
In eastern North America, white-tailed deer(Odocoileus virginianus) can have profound influences on forest biodiversity and forest successional processes.Moderate to high deer populations in the central Appalachians h...In eastern North America, white-tailed deer(Odocoileus virginianus) can have profound influences on forest biodiversity and forest successional processes.Moderate to high deer populations in the central Appalachians have resulted in lower forest biodiversity.Legacy effects in some areas persist even following deer population reductions or declines. This has prompted managers to consider deer population management goals in light of policies designed to support conservation of biodiversity and forest regeneration while continuing to support ample recreational hunting opportunities. However,despite known relationships between herbivory intensity and biodiversity impact, little information exists on the predictability of herbivory intensity across the varied and spatially diverse habitat conditions of the central Appalachians. We examined the predictability of browsing rates across central Appalachian landscapes at four environmental scales: vegetative community characteristics, physical environment, habitat configuration, and local human and deer population demographics. In an information-theoretic approach, we found that a model fitting the number of stems browsed relative to local vegetation characteristics received most(62%) of the overall support of all tested models assessing herbivory impact. Our data suggest that deer herbivory responded most predictably to differences in vegetation quantity and type. No other spatial factors or demographic factors consistently affected browsing intensity. Because herbivory, vegetation communities, and productivity vary spatially, we suggest that effective broad-scale herbivory impact assessment should include spatially-balanced vegetation monitoring that accounts for regional differences in deer forage preference.Effective monitoring is necessary to avoid biodiversity impacts and deleterious changes in vegetation community composition that are difficult to reverse and/or may not be detected using traditional deer-density based management goals.展开更多
Minerals are critical in maintaining health and physiological function in wildlife. Geographic variation in soil and forage mineral concentration may predispose wildlife to mineral imbalances, where a common symptom i...Minerals are critical in maintaining health and physiological function in wildlife. Geographic variation in soil and forage mineral concentration may predispose wildlife to mineral imbalances, where a common symptom is restricted somatic growth. We investigated if mineral imbalances could explain localized differences in morphology of white-tailed deer (Odocoileus virginianus) occurring in geographically proximate sites with similar management, climate, and habitat. We collected serum samples and morphological measurements from free-ranging white-tailed deer captured during 2011-2019 from coastal and inland rangeland sites in South Texas, USA. We measured mineral concentrations in serum from captured deer at each location. Asymptotic deer body mass and antler size averaged 8% - 20% smaller for deer at the coastal compared to the inland site. The proportion of deer with deficient levels of serum copper was greater at the coastal site (66% versus 14%). Our results suggest regional mineral deficiencies in deer may limit antler and body development. Wildlife managers should be aware of all aspects of wildlife nutrition and the importance of considering nutrients beyond energy and protein.展开更多
White matter,a densely packed collection of myelinated axons,plays an essential part in neural networks.With high spatial resolution and deep penetration,multi-photon microscopy(MPM)is promising for white matter imagi...White matter,a densely packed collection of myelinated axons,plays an essential part in neural networks.With high spatial resolution and deep penetration,multi-photon microscopy(MPM)is promising for white matter imaging in animal models in vivo.The third harmonic generation(THG)signal can be generated from white matter,but the bottom part of the white matter layer generates weak THG due to its high scattering.Here,we demonstrate an in vivo labeling and imaging technology,capable of visualizing the white matter layer in the mouse brain,combining°uorescence labeling with MitoTracker Red and three-photon°uorescence(3PF)microscopy excited at the 1700 nm window.3PF signals are several times higher than THG signals,resulting in deeper imaging of the white matter layer with the former.Our results indicate that 3PF microscopy is a promising technology for white matter imaging in the deep brain in vivo.展开更多
In the novel White Deer Plain,Chen Zhongshi profoundly narrated the tragic fate of the survival of the image of Chinese women,revealed the social status,inner world and character characteristics of women in Chinese tr...In the novel White Deer Plain,Chen Zhongshi profoundly narrated the tragic fate of the survival of the image of Chinese women,revealed the social status,inner world and character characteristics of women in Chinese traditional culture,and explained the tragic root of the survival of Chinese women from the Chinese cultural level.About the description of the characters,Tian Xiao’e was deeper to touch the depths of human nature affection Aaron and reason of conflict,touched the moral self and human self in a culture of conflict,so that the survival of female tragic signs of the novel has a wider significance and general significance.In this article,the author takes Tian Xiao’e as the example,to analyze this typical characteristic from the angle of the female tragedy semiotics in multi-dimensional interpretation of the characters.It is not only has practical significance for gender ethics construction,also has the vital significance to our mind world and the cultural construction today.展开更多
The corpus of this research was selected from the novel White Deer Plain,focusing on the inter-characteristics of various sign text modalities(fiction,TV lines and TV series),involving the interaction between sign tex...The corpus of this research was selected from the novel White Deer Plain,focusing on the inter-characteristics of various sign text modalities(fiction,TV lines and TV series),involving the interaction between sign text interpreters such as authors,scriptwriters,directors,actors,censors,post-producers,audiences,etc.Sign manipulations were adopted in these processes.It can be said that these sign processes from linguistic signs to TV drama cross-media and multimedia composite signs are typical sign text.Therefore,the research about complexity of the sign process attracts authors’interest.There are relatively few studies on the analysis of Bai Jiaxuan and Lu Zilin in White Deer Plain from the perspective of semiotics.This paper will analyze the differences in the characterizing process between novels and TV series from the perspective of sign manipulations.展开更多
Studies from nearly 3 decades ago suggested that,in the central nervous system(CNS),myelination of axons by oligodendrocytes not only helps improve axonal conductivity but also stabilizes circuitry(Colello and Schwab,...Studies from nearly 3 decades ago suggested that,in the central nervous system(CNS),myelination of axons by oligodendrocytes not only helps improve axonal conductivity but also stabilizes circuitry(Colello and Schwab,1994).Over the years,myelin sheaths produced by oligodendrocytes have been found to contain multiple molecules that are inhibitory to axonal growth(e.g.,MAG,NogoA,OMgp,Semaphorins)(Yiu and He,2006;Silver et al.,2014).After white matter injury in the adult CNS,myelin debris from damaged axons and dead oligodendrocytes accumulates in the forming glial scar and exposes these myelin-associated axon growth-inhibitory molecules to the injured axonal stumps,thereby contributing to the inhibition of axonal regrowth.During development,CNS axons reach their postsynaptic targets and stop growing before oligodendrocytes appear and myelinate them(Foran and Peterson,1992;Dangata et al.,1996).Therefore,myelin-associated axon growth-inhibitory molecules interacting with already grown axons during myelination were thought to block axons from promiscuous sprouting and miswiring,thereby stabilizing neural circuitry in the CNS(Colello and Schwab,1994).展开更多
In this paper, the authors analyzed the correlation between the microbiological stability of white wines and the content of sulfur dioxide, which influences the main redox processes that take place in the technologica...In this paper, the authors analyzed the correlation between the microbiological stability of white wines and the content of sulfur dioxide, which influences the main redox processes that take place in the technological stages of the wine. The consecutive, parallel and spontaneous development of several redox processes and their impact on the quality, microbiological and crystalline stability of white wines were examined. The reduction of additive and subtractive technological interventions, of the amounts of adjuvants (sulphurous anhydride) is essential for the production of organic wines.展开更多
Humans have infected a wide range of animals with SARS-CoV-2 viruses1-5,but the establishment of a new natural animal reservoir has not been observed.Here,we document that free-ranging white-tailed deer(Odocoileus vir...Humans have infected a wide range of animals with SARS-CoV-2 viruses1-5,but the establishment of a new natural animal reservoir has not been observed.Here,we document that free-ranging white-tailed deer(Odocoileus virginianus)are highly susceptible to infection with SARS-CoV-2 virus,are exposed to a range of viral diversity from humans,and are capable of sustaining transmission in nature.SARS-CoV-2 virus was detected by rRT-PCR in more than one-third(129/360,35.8%)of nasal swabs obtained from Odocoileus virginianus in northeast Ohio(USA)during January-March 2021.Deer in 6 locations were infected with 3 SARS-CoV-2 lineages(B.1.2,B.1.582,B.1.596).The B.1.2 viruses,dominant in humans in Ohio at the time,infected deer in four locations.Probable deer-to-deer transmission of B.1.2,B.1.582,and B.1.596 viruses was observed,allowing the virus to acquire amino acid substitutions in the spike protein(including the receptor-binding domain)and ORF1 that are infrequently seen in humans.展开更多
●Multiple evanescent white dot syndrome(MEWDS)is a rare fundus disease,characterized by acute vision loss and visual field defects.Many previous studies have explained the possible pathogenesis and clinical features ...●Multiple evanescent white dot syndrome(MEWDS)is a rare fundus disease,characterized by acute vision loss and visual field defects.Many previous studies have explained the possible pathogenesis and clinical features of primary MEWDS.However,as the number of reported cases increases,secondary MEWDS occurs in other related retinal diseases and injuries,exhibiting some special characteristics.The associated retinal diseases include multifocal choroiditis/punctate inner choroidopathy(MFC/PIC),acute zonal occult outer retinopathy,best vitelliform macular dystrophy,pseudoxanthoma elasticum,and ocular toxoplasmosis.The related retinal injury is laser photocoagulation,surgery,and trauma.Although primary MEWDS often have a self-limiting course,secondary MEWDS may require treatment in some cases,according to the severity of concomitant diseases and complications.Notably,MEWDS secondary to MFC/PIC that is prone to forming choroidal neovascularization and focal choroidal excavation,needs positive treatment with corticosteroids.The possible underlying pathogenesis of secondary MEWDS is the exposure of choroidal antigen after the disruption of Bruch’s membrane.The MEWDS-related features in secondary MEWDS are still evanescent under most circumstances.Its prognosis and treatment depend on the severity of complications.Current studies propose that the etiology is associated with immune factors,including viral infection,inflammation in choroid and Bruch’s membrane,and antigen exposure caused by retinal and/or choroidal insults.More pathogenic studies should be conducted in the future.Accurate diagnosis for secondary MEWDS could benefit patients in aspects of management and prognosis.展开更多
Background Chitinase is an enzyme that hydrolyzes chitin,a major component of the exoskeleton of insects,including plant pests like whiteflies.The present study aimed to investigate the expression of chemically synthe...Background Chitinase is an enzyme that hydrolyzes chitin,a major component of the exoskeleton of insects,including plant pests like whiteflies.The present study aimed to investigate the expression of chemically synthesized barley ch1 and chi2 genes in cotton(Gossypium hirsutum)through Agrobacterium-mediated transformation.Fifty-five putative transgenic cotton plants were obtained,out of which fifteen plants successfully survived and were shifted to the field.Using gene-specific primers,amplification of 447 bp and 401 bp fragments confirmed the presence of the ch1 and chi2 genes in five transgenic cotton plants of the T0 generation.These five plants were further evalu-ated for their mRNA expression levels.The T0 transgenic cotton plants with the highest mRNA expression level and better yield performance in field,were selected to raise their subsequent progenies.Results The T1 cotton plants showed the highest mRNA expression levels of 3.5-fold in P10(2)for the ch1 gene and 3.7-fold in P2(1)for the chi2 gene.Fluorescent in situ hybridization(FISH)confirmed a single copy number of ch1 and chi2(hemizygous)on chromosome no.6.Furthermore,the efficacy of transgenes on whitefly was evaluated through an insect bioassay,where after 96 h of infestation,mortality rates of whitefly were calculated to be 78%–80%in transgenic cotton plants.The number of eggs on transgenic cotton plants were calculated to be 0.1%–0.12 per plant compared with the non-transgenic plants where egg number was calculated to be 0.90–1.00 per plant.Conclusion Based on these findings,it can be concluded that the chemically synthesized barley chitinase genes(ch1 and chi2)have the potential to be effective against insects with chitin exoskeletons,including whiteflies.The transgenic cotton plants expressing these genes showed increased resistance to whiteflies,resulting in reduced egg numbers and higher mortality rates.展开更多
Ag-In-Ga-S(AIGS)quantum dots(QDs)have recently attracted great interests due to the outstanding optical properties and eco-friendly components,which are considered as an alternative replacement for toxic Pb-and Cd-bas...Ag-In-Ga-S(AIGS)quantum dots(QDs)have recently attracted great interests due to the outstanding optical properties and eco-friendly components,which are considered as an alternative replacement for toxic Pb-and Cd-based QDs.However,enormous attention has been paid to how to narrow their broadband spectra,ignoring the application advantages of the broadband emission.In this work,the AIGS QDs with controllable broad green-red dual-emission are first reported,which is achieved through adjusting the size distribution of QDs by controlling the nucleation and growth of AIGS crystals.Resultantly,the AIGS QDs exhibit broad dual-emission at green-and red-band evidenced by photoluminescence(PL)spectra,and the PL relative intensity and peak position can be finely adjusted.Furthermore,the dual-emission is the intrinsic characteristics from the difference in confinement effect of large particles and tiny particles confirmed by temperature-dependent PL spectra.Accordingly,the AIGS QDs(the size consists of 17 nm and 3.7 nm)with 530 nm and 630 nm emission could successfully be synthesized at 220°C.By combining the blue light-emitting diode(LED)chips and dual-emission AIGS QDs,the constructed white light-emitting devices(WLEDs)exhibit a continuous and broad spectrum like natural sunlight with the Commission Internationale de l’Eclairage(CIE)chromaticity coordinates of(0.33,0.31),a correlated color temperature(CCT)of 5425 K,color rendering index(CRI)of 90,and luminous efficacy of radiation(LER)of 129 lm/W,which indicates that the AIGS QDs have huge potential for lighting applications.展开更多
Tea’s popularity and flavor are influenced by factors like cultivation and processing methods and shaping techniques also have an impact on tea flavor.This study employed targeted metabolomics and chemometrics to inv...Tea’s popularity and flavor are influenced by factors like cultivation and processing methods and shaping techniques also have an impact on tea flavor.This study employed targeted metabolomics and chemometrics to investigate how shaping techniques affect the flavor of milk-flavored white tea(MFWT).The results showed that the tea cake sample with the shortest pressing time(Y90)has the highest amino acid content and milky aroma intensity.There were variations in amino acids,catechins,and soluble sugars among MFWT samples with different shaping techniques.The total contents of amino acids and catechins in tea cake sample(Y90)were significantly lower than those in the loose tea sample(SC)and bundle-like tea sample(SG),while the total sugar content was significantly higher than that in SC(P<0.05).Additionally,the content of volatiles presenting milky aroma(VIP&OAV>1)in Y90 remained lower relative to SC and SG(P<0.05),but the proportion was not different from that in SC and SG,minimally affecting the overall flavor.The short-time pressing method might be suitable for mass production of MFWT.These findings provide insights into improving the tightness of the appearance of MFWT with minimal impact on tea flavor.展开更多
Two magnetic monopole models (i.e., model (I, II)) are presented to discuss the energy resources problem based on magnetic monopole catalytic nuclear decay in massive white dwarfs. We find that the luminosities for mo...Two magnetic monopole models (i.e., model (I, II)) are presented to discuss the energy resources problem based on magnetic monopole catalytic nuclear decay in massive white dwarfs. We find that the luminosities for most of massive white dwarfs increase as the temperature increases. The luminosities of model (II) are agreed well with those of the observations at relativistic high temperature (e.g., T6=1,10), However, the luminosities of the observations can be five orders of magnitude larger than those of model (I).展开更多
Twenty-five typical massive white dwarfs(WDs)are selected and the proton decay reaction catalyzed by magnetic monopoles(MMs)for these WDs is discussed.A velocity-dependent correction factor strongly affects the cross-...Twenty-five typical massive white dwarfs(WDs)are selected and the proton decay reaction catalyzed by magnetic monopoles(MMs)for these WDs is discussed.A velocity-dependent correction factor strongly affects the cross-section.We find that a strong suppression controls the monopole catalysis of nucleon decay by the correction factor.The maximum number of MMs is captured and the luminosity can be 2.235×10^(21)and 1.7859×10^(32)erg s^(-1)(e.g.,for the O+Ne core mass WD J055631.17+130639.78).The luminosities of most massive WDs agree well with the observations at relatively low temperatures(e.g.,T_(6)=0.1),but can be three and two orders of magnitude higher than those of the observations for model(Ⅰ)and(Ⅱ)at relatively high temperatures(e.g.,T_(6)=10),respectively.The luminosities of model(Ⅰ)are about one order of magnitude higher than those of model(Ⅱ).Since we consider the effect of the number of MMs captured on the mass–radius relation and the suppression of the proton decay by the correction factor,the study by model(Ⅱ)may be an improved estimation.展开更多
The quality upgrading and deashing of inferior coal by chemical method still faces great challenges.The dangers of strong acid,strong alkali,waste water and exhaust gas as well as high cost limit its industrial produc...The quality upgrading and deashing of inferior coal by chemical method still faces great challenges.The dangers of strong acid,strong alkali,waste water and exhaust gas as well as high cost limit its industrial production.This paper systematically investigates the ash reduction and desilicification of two typical inferior coal utilizing ammonium fluoride roasting method.Under the optimal conditions,for fat coal and gas coal,the deashing rates are 69.02%and 54.13%,and the desilicification rates are 92.64%and 90.27%,respectively.The molar dosage of ammonium fluoride remains consistent for both coals;however,the gas coal,characterized by a lower ash and silica content(less than half that of the fat coal),achieves optimum deashing effect at a reduced time and temperature.The majority of silicon in coal transforms into gaseous ammonium fluorosilicate,subsequently preparing nanoscale amorphous silica with a purity of 99.90%through ammonia precipitation.Most of the fluorine in deashed coal are assigned in inorganic minerals,suggesting the possibility of further fluorine and ash removal via flotation.This research provides a green and facile route to deash inferior coal and produce nano-scale white carbon black simultaneously.展开更多
Background:White matter lesion(WML)is common in aging brain and is associated with cognitive impairment and dementia.However,recent studies reported an association between patent foramen ovale(PFO)and WML in migraineu...Background:White matter lesion(WML)is common in aging brain and is associated with cognitive impairment and dementia.However,recent studies reported an association between patent foramen ovale(PFO)and WML in migraineurs,especially in young,middle-aged migraineurs.Our retrospective,case-control study aims to describe the clinical characteristics of WML in this population and to explore potential risk factors.Methods:226 patients with migraine and PFO were consecutively initially screened.Relevant factors were selected by the least absolute shrinkage and selection operator(LASSO)regression and multivariable logistic regression model.A Nomogram was employed to visualize the prediction model conveniently.The discrimination and calibration abilities were evaluated using the Receiver Operating Characteristic(ROC)curve,the Hosmer-Lemeshow test,and calibration curves.Results:One hundred and nineteen participants were ultimately enrolled in our study,with a median age of 36.9±12.7 years and 80.7%of females.Brain magnetic resonance imaging MRI showed 67(56.3%)patients had WML,whereas 52(43.7%)patients were categorized into the non-WML group.LASSO regression screened out potential variables and subsequent multivariate analysisfinally identified age,mean platelet volume,andfibri-nogen(FIB)as independent predictive factors of WML.The area under the ROC curve(AUC)was 0.807.Hos-mer-Lemeshow test and calibration curve verified a consistency between the predicted and actual probability.Conclusion:The predictive nomogram established and validated in our study may assist clinicians in screening WML among young middle-aged migraineurs with PFO and developing individualized preventive and treatment strategies.展开更多
Neutron resonance imaging(NRI)has recently emerged as an appealing technique for neutron radiography.Its complexity surpasses that of conventional transmission imaging,as it requires a high demand for both a neutron s...Neutron resonance imaging(NRI)has recently emerged as an appealing technique for neutron radiography.Its complexity surpasses that of conventional transmission imaging,as it requires a high demand for both a neutron source and detector.Consequently,the progression of NRI technology has been sluggish since its inception in the 1980s,particularly considering the limited studies analyzing the neutron energy range above keV.The white neutron source(Back-n)at the China Spallation Neutron Source(CSNS)provides favorable beam conditions for the development of the NRI technique over a wide neutron energy range from eV to MeV.Neutron-sensitive microchannel plates(MCP)have emerged as a cutting-edge tool in the field of neutron detection owing to their high temporal and spatial resolutions,high detection efficiency,and low noise.In this study,we report the development of a 10B-doped MCP detector,along with its associated electronics,data processing system,and NRI experiments at the Back-n.Individual heavy elements such as gold,silver,tungsten,and indium can be easily identified in the transmission images by their characteristic resonance peaks in the 1–100 eV energy range;the more difficult medium-weight elements such as iron,copper,and aluminum with resonance peaks in the 1–100 keV energy range can also be identified.In particular,results in the neutron energy range of dozens of keV(Aluminum)are reported here for the first time.展开更多
The similarities and differences in inherent mechanism and characteristic frequency between the onedimensional(1D)poroelastic model and the layered White model were investigated.This investigation was conducted under ...The similarities and differences in inherent mechanism and characteristic frequency between the onedimensional(1D)poroelastic model and the layered White model were investigated.This investigation was conducted under the assumption that the rock was homogenous and isotropic at the mesoscopic scale.For the inherent mechanism,both models resulted from quasi-static flow in a slow P-wave diffusion mode,and the differences between them originated from saturated fluids and boundary conditions.On the other hand,for the characteristic frequencies of the models,the characteristic frequency of the 1D poroelastic model was first modified because the elastic constant and formula for calculating it were misused and then compared to that of the layered White model.Both of them moved towards higher frequencies with increasing permeability and decreasing viscosity and diffusion length.The differences between them were due to the diffusion length.The diffusion length for the 1D poroelastic model was determined by the sample length,whereas that for the layered White model was determined by the length of the representative elementary volume(REV).Subsequently,a numerical example was presented to demonstrate the similarities and differences between the models.Finally,published experimental data were interpreted using the 1D poroelastic model combined with the Cole-Cole model.The prediction of the combined model was in good agreement with the experimental data,thereby validating the effectiveness of the 1D poroelastic model.Furthermore,the modified characteristic frequency in our study was much closer to the experimental data than the previous prediction,validating the effectiveness of our modification of the characteristic frequency of the 1D poroelastic model.The investigation provided insight into the internal relationship between wave-induced fluid flow(WIFF)models at macroscopic and mesoscopic scales and can aid in a better understanding of the elastic modulus dispersion and attenuation caused by the WIFF at different scales.展开更多
文摘As the population ages,the burden of age-related diseases becomes greater.Currently,over 55 million people suffer from dementia worldwide,with Alzheimer’s disease being the most common form.However,it is becoming clearer that underlying vascular pathology such as cerebral small vessel disease(cSVD)may be a more detrimental cause for dementia(Cuadrado-Godia et al.,2018).It is estimated that 10%-30%of the elderly population and 35%-90%of all dementia patients exhibit signs of cSVD.The term cSVD refers to pathology affecting the small vessels of the brain,which can lead to lacunar cerebral infarcts,enlarged perivascular spaces,and cortical hemorrhages(Cuadrado-Godia et al.,2018).CSVD is often associated with cognitive decline,gait problems,and dementia(Cuadrado-Godia et al.,2018).
文摘Coyotes (Canis latrans) are a relatively new predator to the southeastern United States, and may be negatively impacting white-tailed deer (Odocoileus virginianus;hereafter, deer) populations. Our objectives were to evaluate the impacts of coyotes on deer fawns by assessing deer fawn survival and cause-specific mortality, and gain an understanding of factors affecting fawn survival and coyote predation. We captured and radio collared 30 fawns in the Red Hills region of Florida and Georgia, USA (2012-2013). Fawns were monitored for 12 weeks for survival and cause-specific mortality, and we quantified habitat and environmental characteristics of birth sites. Predation (n = 19;95%) was the leading cause of fawn mortality (n = 20;67%), with coyote predation (n = 14;74%) being the most important type of predation. Survival rates for all fawns were greater (P = 0.048) where coyotes were removed compared to non-removal sites, with 50% and 25% of fawns surviving to 12 weeks on coyote-removal and non-removal sites, respectively. Survival rates of fawns ultimately predated by coyotes were greater (P = 0.096) on coyote-removal than non-removal sites, with 40% and 50% of fawns predated by coyotes within 12 weeks on coyote-removal and non-removal sites, respectively. Survival of all fawns and those predated by coyotes was lower when fawns were born at sites with greater hardwood basal area, total basal area, and canopy closure;and survival improved if born in or near hardwood, natural pine, and managed (planted) pine cover types. Increased canopy cover within 10 m of the birth site was selected by adult females for birth sites of all fawns and those that were predated by coyotes. Compared with fawns that lived, all dying fawns and those predated by coyotes had less shrub cover within 5 m and less grass cover at and within 10 m of the birth site. Coyote removal increased fawn daily survival rates, and habitat played a role in fawn survival.
基金financially supported by the Wildlife and Sport Fish Restoration Program,Project WE99,Contract 2012-13694 to Virginia Tech
文摘In eastern North America, white-tailed deer(Odocoileus virginianus) can have profound influences on forest biodiversity and forest successional processes.Moderate to high deer populations in the central Appalachians have resulted in lower forest biodiversity.Legacy effects in some areas persist even following deer population reductions or declines. This has prompted managers to consider deer population management goals in light of policies designed to support conservation of biodiversity and forest regeneration while continuing to support ample recreational hunting opportunities. However,despite known relationships between herbivory intensity and biodiversity impact, little information exists on the predictability of herbivory intensity across the varied and spatially diverse habitat conditions of the central Appalachians. We examined the predictability of browsing rates across central Appalachian landscapes at four environmental scales: vegetative community characteristics, physical environment, habitat configuration, and local human and deer population demographics. In an information-theoretic approach, we found that a model fitting the number of stems browsed relative to local vegetation characteristics received most(62%) of the overall support of all tested models assessing herbivory impact. Our data suggest that deer herbivory responded most predictably to differences in vegetation quantity and type. No other spatial factors or demographic factors consistently affected browsing intensity. Because herbivory, vegetation communities, and productivity vary spatially, we suggest that effective broad-scale herbivory impact assessment should include spatially-balanced vegetation monitoring that accounts for regional differences in deer forage preference.Effective monitoring is necessary to avoid biodiversity impacts and deleterious changes in vegetation community composition that are difficult to reverse and/or may not be detected using traditional deer-density based management goals.
文摘Minerals are critical in maintaining health and physiological function in wildlife. Geographic variation in soil and forage mineral concentration may predispose wildlife to mineral imbalances, where a common symptom is restricted somatic growth. We investigated if mineral imbalances could explain localized differences in morphology of white-tailed deer (Odocoileus virginianus) occurring in geographically proximate sites with similar management, climate, and habitat. We collected serum samples and morphological measurements from free-ranging white-tailed deer captured during 2011-2019 from coastal and inland rangeland sites in South Texas, USA. We measured mineral concentrations in serum from captured deer at each location. Asymptotic deer body mass and antler size averaged 8% - 20% smaller for deer at the coastal compared to the inland site. The proportion of deer with deficient levels of serum copper was greater at the coastal site (66% versus 14%). Our results suggest regional mineral deficiencies in deer may limit antler and body development. Wildlife managers should be aware of all aspects of wildlife nutrition and the importance of considering nutrients beyond energy and protein.
基金funded by the National Natural Science Foundation of China(62075135,61975126)Shenzhen Key Laboratory of Photonics and Biophotonics(ZDSYS20210623092006020).
文摘White matter,a densely packed collection of myelinated axons,plays an essential part in neural networks.With high spatial resolution and deep penetration,multi-photon microscopy(MPM)is promising for white matter imaging in animal models in vivo.The third harmonic generation(THG)signal can be generated from white matter,but the bottom part of the white matter layer generates weak THG due to its high scattering.Here,we demonstrate an in vivo labeling and imaging technology,capable of visualizing the white matter layer in the mouse brain,combining°uorescence labeling with MitoTracker Red and three-photon°uorescence(3PF)microscopy excited at the 1700 nm window.3PF signals are several times higher than THG signals,resulting in deeper imaging of the white matter layer with the former.Our results indicate that 3PF microscopy is a promising technology for white matter imaging in the deep brain in vivo.
文摘In the novel White Deer Plain,Chen Zhongshi profoundly narrated the tragic fate of the survival of the image of Chinese women,revealed the social status,inner world and character characteristics of women in Chinese traditional culture,and explained the tragic root of the survival of Chinese women from the Chinese cultural level.About the description of the characters,Tian Xiao’e was deeper to touch the depths of human nature affection Aaron and reason of conflict,touched the moral self and human self in a culture of conflict,so that the survival of female tragic signs of the novel has a wider significance and general significance.In this article,the author takes Tian Xiao’e as the example,to analyze this typical characteristic from the angle of the female tragedy semiotics in multi-dimensional interpretation of the characters.It is not only has practical significance for gender ethics construction,also has the vital significance to our mind world and the cultural construction today.
文摘The corpus of this research was selected from the novel White Deer Plain,focusing on the inter-characteristics of various sign text modalities(fiction,TV lines and TV series),involving the interaction between sign text interpreters such as authors,scriptwriters,directors,actors,censors,post-producers,audiences,etc.Sign manipulations were adopted in these processes.It can be said that these sign processes from linguistic signs to TV drama cross-media and multimedia composite signs are typical sign text.Therefore,the research about complexity of the sign process attracts authors’interest.There are relatively few studies on the analysis of Bai Jiaxuan and Lu Zilin in White Deer Plain from the perspective of semiotics.This paper will analyze the differences in the characterizing process between novels and TV series from the perspective of sign manipulations.
基金supported by grants from The University of Connecticut School of Medicine (StartUp Fund)the National Institutes of Health (NIH)(Grant R01-EY029 739)+1 种基金the Connecticut Institute for the Brain and Cognitive Sciences (Research Seed Grant)the BrightFocus Foundation (Grant G2017204)(all to EFT)
文摘Studies from nearly 3 decades ago suggested that,in the central nervous system(CNS),myelination of axons by oligodendrocytes not only helps improve axonal conductivity but also stabilizes circuitry(Colello and Schwab,1994).Over the years,myelin sheaths produced by oligodendrocytes have been found to contain multiple molecules that are inhibitory to axonal growth(e.g.,MAG,NogoA,OMgp,Semaphorins)(Yiu and He,2006;Silver et al.,2014).After white matter injury in the adult CNS,myelin debris from damaged axons and dead oligodendrocytes accumulates in the forming glial scar and exposes these myelin-associated axon growth-inhibitory molecules to the injured axonal stumps,thereby contributing to the inhibition of axonal regrowth.During development,CNS axons reach their postsynaptic targets and stop growing before oligodendrocytes appear and myelinate them(Foran and Peterson,1992;Dangata et al.,1996).Therefore,myelin-associated axon growth-inhibitory molecules interacting with already grown axons during myelination were thought to block axons from promiscuous sprouting and miswiring,thereby stabilizing neural circuitry in the CNS(Colello and Schwab,1994).
文摘In this paper, the authors analyzed the correlation between the microbiological stability of white wines and the content of sulfur dioxide, which influences the main redox processes that take place in the technological stages of the wine. The consecutive, parallel and spontaneous development of several redox processes and their impact on the quality, microbiological and crystalline stability of white wines were examined. The reduction of additive and subtractive technological interventions, of the amounts of adjuvants (sulphurous anhydride) is essential for the production of organic wines.
文摘Humans have infected a wide range of animals with SARS-CoV-2 viruses1-5,but the establishment of a new natural animal reservoir has not been observed.Here,we document that free-ranging white-tailed deer(Odocoileus virginianus)are highly susceptible to infection with SARS-CoV-2 virus,are exposed to a range of viral diversity from humans,and are capable of sustaining transmission in nature.SARS-CoV-2 virus was detected by rRT-PCR in more than one-third(129/360,35.8%)of nasal swabs obtained from Odocoileus virginianus in northeast Ohio(USA)during January-March 2021.Deer in 6 locations were infected with 3 SARS-CoV-2 lineages(B.1.2,B.1.582,B.1.596).The B.1.2 viruses,dominant in humans in Ohio at the time,infected deer in four locations.Probable deer-to-deer transmission of B.1.2,B.1.582,and B.1.596 viruses was observed,allowing the virus to acquire amino acid substitutions in the spike protein(including the receptor-binding domain)and ORF1 that are infrequently seen in humans.
基金Supported by the National Natural Science Foundation of China(No.82171073No.82101147).
文摘●Multiple evanescent white dot syndrome(MEWDS)is a rare fundus disease,characterized by acute vision loss and visual field defects.Many previous studies have explained the possible pathogenesis and clinical features of primary MEWDS.However,as the number of reported cases increases,secondary MEWDS occurs in other related retinal diseases and injuries,exhibiting some special characteristics.The associated retinal diseases include multifocal choroiditis/punctate inner choroidopathy(MFC/PIC),acute zonal occult outer retinopathy,best vitelliform macular dystrophy,pseudoxanthoma elasticum,and ocular toxoplasmosis.The related retinal injury is laser photocoagulation,surgery,and trauma.Although primary MEWDS often have a self-limiting course,secondary MEWDS may require treatment in some cases,according to the severity of concomitant diseases and complications.Notably,MEWDS secondary to MFC/PIC that is prone to forming choroidal neovascularization and focal choroidal excavation,needs positive treatment with corticosteroids.The possible underlying pathogenesis of secondary MEWDS is the exposure of choroidal antigen after the disruption of Bruch’s membrane.The MEWDS-related features in secondary MEWDS are still evanescent under most circumstances.Its prognosis and treatment depend on the severity of complications.Current studies propose that the etiology is associated with immune factors,including viral infection,inflammation in choroid and Bruch’s membrane,and antigen exposure caused by retinal and/or choroidal insults.More pathogenic studies should be conducted in the future.Accurate diagnosis for secondary MEWDS could benefit patients in aspects of management and prognosis.
文摘Background Chitinase is an enzyme that hydrolyzes chitin,a major component of the exoskeleton of insects,including plant pests like whiteflies.The present study aimed to investigate the expression of chemically synthesized barley ch1 and chi2 genes in cotton(Gossypium hirsutum)through Agrobacterium-mediated transformation.Fifty-five putative transgenic cotton plants were obtained,out of which fifteen plants successfully survived and were shifted to the field.Using gene-specific primers,amplification of 447 bp and 401 bp fragments confirmed the presence of the ch1 and chi2 genes in five transgenic cotton plants of the T0 generation.These five plants were further evalu-ated for their mRNA expression levels.The T0 transgenic cotton plants with the highest mRNA expression level and better yield performance in field,were selected to raise their subsequent progenies.Results The T1 cotton plants showed the highest mRNA expression levels of 3.5-fold in P10(2)for the ch1 gene and 3.7-fold in P2(1)for the chi2 gene.Fluorescent in situ hybridization(FISH)confirmed a single copy number of ch1 and chi2(hemizygous)on chromosome no.6.Furthermore,the efficacy of transgenes on whitefly was evaluated through an insect bioassay,where after 96 h of infestation,mortality rates of whitefly were calculated to be 78%–80%in transgenic cotton plants.The number of eggs on transgenic cotton plants were calculated to be 0.1%–0.12 per plant compared with the non-transgenic plants where egg number was calculated to be 0.90–1.00 per plant.Conclusion Based on these findings,it can be concluded that the chemically synthesized barley chitinase genes(ch1 and chi2)have the potential to be effective against insects with chitin exoskeletons,including whiteflies.The transgenic cotton plants expressing these genes showed increased resistance to whiteflies,resulting in reduced egg numbers and higher mortality rates.
基金supported by National Natural Science Foundation of China(Grant Nos.52272166,22205214,and 12204427).
文摘Ag-In-Ga-S(AIGS)quantum dots(QDs)have recently attracted great interests due to the outstanding optical properties and eco-friendly components,which are considered as an alternative replacement for toxic Pb-and Cd-based QDs.However,enormous attention has been paid to how to narrow their broadband spectra,ignoring the application advantages of the broadband emission.In this work,the AIGS QDs with controllable broad green-red dual-emission are first reported,which is achieved through adjusting the size distribution of QDs by controlling the nucleation and growth of AIGS crystals.Resultantly,the AIGS QDs exhibit broad dual-emission at green-and red-band evidenced by photoluminescence(PL)spectra,and the PL relative intensity and peak position can be finely adjusted.Furthermore,the dual-emission is the intrinsic characteristics from the difference in confinement effect of large particles and tiny particles confirmed by temperature-dependent PL spectra.Accordingly,the AIGS QDs(the size consists of 17 nm and 3.7 nm)with 530 nm and 630 nm emission could successfully be synthesized at 220°C.By combining the blue light-emitting diode(LED)chips and dual-emission AIGS QDs,the constructed white light-emitting devices(WLEDs)exhibit a continuous and broad spectrum like natural sunlight with the Commission Internationale de l’Eclairage(CIE)chromaticity coordinates of(0.33,0.31),a correlated color temperature(CCT)of 5425 K,color rendering index(CRI)of 90,and luminous efficacy of radiation(LER)of 129 lm/W,which indicates that the AIGS QDs have huge potential for lighting applications.
基金support from the National Key Research and Development Program of China(2022YFD2101101)the Modern Agricultural(Tea)Industry Technology System of Fujian Province,China([2021]No.90)+2 种基金the Guiding Project of Science and Technology Department in Fujian Province,China(2022N0031)the Special Fund Program for Science and Technology Innovation of Fujian Agriculture and Forestry University,China(KFB23203)the Special Fund for Science and Technology Innovation of Fujian Zhang Tianfu Tea Development Foundation,China(FJZTF01)。
文摘Tea’s popularity and flavor are influenced by factors like cultivation and processing methods and shaping techniques also have an impact on tea flavor.This study employed targeted metabolomics and chemometrics to investigate how shaping techniques affect the flavor of milk-flavored white tea(MFWT).The results showed that the tea cake sample with the shortest pressing time(Y90)has the highest amino acid content and milky aroma intensity.There were variations in amino acids,catechins,and soluble sugars among MFWT samples with different shaping techniques.The total contents of amino acids and catechins in tea cake sample(Y90)were significantly lower than those in the loose tea sample(SC)and bundle-like tea sample(SG),while the total sugar content was significantly higher than that in SC(P<0.05).Additionally,the content of volatiles presenting milky aroma(VIP&OAV>1)in Y90 remained lower relative to SC and SG(P<0.05),but the proportion was not different from that in SC and SG,minimally affecting the overall flavor.The short-time pressing method might be suitable for mass production of MFWT.These findings provide insights into improving the tightness of the appearance of MFWT with minimal impact on tea flavor.
文摘Two magnetic monopole models (i.e., model (I, II)) are presented to discuss the energy resources problem based on magnetic monopole catalytic nuclear decay in massive white dwarfs. We find that the luminosities for most of massive white dwarfs increase as the temperature increases. The luminosities of model (II) are agreed well with those of the observations at relativistic high temperature (e.g., T6=1,10), However, the luminosities of the observations can be five orders of magnitude larger than those of model (I).
基金supported in part by the National Natural Science Foundation of China(NSFC,grant Nos.11965010 and 11565020)the foundation for high-level talents program of Hainan basic and applied basic research program(natural science)under grant 2019RC239+3 种基金the Natural Science Foundation of Hainan Province under grants 118MS071 and 114012the Counterpart Foundation of Sanya under grants 2016PT43 and 2019PT76the Special Foundation of Science and Technology Cooperation for Advanced Academy and Regional of Sanya under grant 2016YD28the Scientific Research Starting Foundation for 515 Talented Project of Hainan Tropical Ocean University under grant RHDRC201701。
文摘Twenty-five typical massive white dwarfs(WDs)are selected and the proton decay reaction catalyzed by magnetic monopoles(MMs)for these WDs is discussed.A velocity-dependent correction factor strongly affects the cross-section.We find that a strong suppression controls the monopole catalysis of nucleon decay by the correction factor.The maximum number of MMs is captured and the luminosity can be 2.235×10^(21)and 1.7859×10^(32)erg s^(-1)(e.g.,for the O+Ne core mass WD J055631.17+130639.78).The luminosities of most massive WDs agree well with the observations at relatively low temperatures(e.g.,T_(6)=0.1),but can be three and two orders of magnitude higher than those of the observations for model(Ⅰ)and(Ⅱ)at relatively high temperatures(e.g.,T_(6)=10),respectively.The luminosities of model(Ⅰ)are about one order of magnitude higher than those of model(Ⅱ).Since we consider the effect of the number of MMs captured on the mass–radius relation and the suppression of the proton decay by the correction factor,the study by model(Ⅱ)may be an improved estimation.
文摘The quality upgrading and deashing of inferior coal by chemical method still faces great challenges.The dangers of strong acid,strong alkali,waste water and exhaust gas as well as high cost limit its industrial production.This paper systematically investigates the ash reduction and desilicification of two typical inferior coal utilizing ammonium fluoride roasting method.Under the optimal conditions,for fat coal and gas coal,the deashing rates are 69.02%and 54.13%,and the desilicification rates are 92.64%and 90.27%,respectively.The molar dosage of ammonium fluoride remains consistent for both coals;however,the gas coal,characterized by a lower ash and silica content(less than half that of the fat coal),achieves optimum deashing effect at a reduced time and temperature.The majority of silicon in coal transforms into gaseous ammonium fluorosilicate,subsequently preparing nanoscale amorphous silica with a purity of 99.90%through ammonia precipitation.Most of the fluorine in deashed coal are assigned in inorganic minerals,suggesting the possibility of further fluorine and ash removal via flotation.This research provides a green and facile route to deash inferior coal and produce nano-scale white carbon black simultaneously.
文摘Background:White matter lesion(WML)is common in aging brain and is associated with cognitive impairment and dementia.However,recent studies reported an association between patent foramen ovale(PFO)and WML in migraineurs,especially in young,middle-aged migraineurs.Our retrospective,case-control study aims to describe the clinical characteristics of WML in this population and to explore potential risk factors.Methods:226 patients with migraine and PFO were consecutively initially screened.Relevant factors were selected by the least absolute shrinkage and selection operator(LASSO)regression and multivariable logistic regression model.A Nomogram was employed to visualize the prediction model conveniently.The discrimination and calibration abilities were evaluated using the Receiver Operating Characteristic(ROC)curve,the Hosmer-Lemeshow test,and calibration curves.Results:One hundred and nineteen participants were ultimately enrolled in our study,with a median age of 36.9±12.7 years and 80.7%of females.Brain magnetic resonance imaging MRI showed 67(56.3%)patients had WML,whereas 52(43.7%)patients were categorized into the non-WML group.LASSO regression screened out potential variables and subsequent multivariate analysisfinally identified age,mean platelet volume,andfibri-nogen(FIB)as independent predictive factors of WML.The area under the ROC curve(AUC)was 0.807.Hos-mer-Lemeshow test and calibration curve verified a consistency between the predicted and actual probability.Conclusion:The predictive nomogram established and validated in our study may assist clinicians in screening WML among young middle-aged migraineurs with PFO and developing individualized preventive and treatment strategies.
基金supported by the National Natural Science Foundation of China(No.12035017)the Guangdong Basic and Applied Basic Research Foundation(No.2023A1515030074)。
文摘Neutron resonance imaging(NRI)has recently emerged as an appealing technique for neutron radiography.Its complexity surpasses that of conventional transmission imaging,as it requires a high demand for both a neutron source and detector.Consequently,the progression of NRI technology has been sluggish since its inception in the 1980s,particularly considering the limited studies analyzing the neutron energy range above keV.The white neutron source(Back-n)at the China Spallation Neutron Source(CSNS)provides favorable beam conditions for the development of the NRI technique over a wide neutron energy range from eV to MeV.Neutron-sensitive microchannel plates(MCP)have emerged as a cutting-edge tool in the field of neutron detection owing to their high temporal and spatial resolutions,high detection efficiency,and low noise.In this study,we report the development of a 10B-doped MCP detector,along with its associated electronics,data processing system,and NRI experiments at the Back-n.Individual heavy elements such as gold,silver,tungsten,and indium can be easily identified in the transmission images by their characteristic resonance peaks in the 1–100 eV energy range;the more difficult medium-weight elements such as iron,copper,and aluminum with resonance peaks in the 1–100 keV energy range can also be identified.In particular,results in the neutron energy range of dozens of keV(Aluminum)are reported here for the first time.
基金supported by the National Natural Science Foundation of China (42030810,42104115)。
文摘The similarities and differences in inherent mechanism and characteristic frequency between the onedimensional(1D)poroelastic model and the layered White model were investigated.This investigation was conducted under the assumption that the rock was homogenous and isotropic at the mesoscopic scale.For the inherent mechanism,both models resulted from quasi-static flow in a slow P-wave diffusion mode,and the differences between them originated from saturated fluids and boundary conditions.On the other hand,for the characteristic frequencies of the models,the characteristic frequency of the 1D poroelastic model was first modified because the elastic constant and formula for calculating it were misused and then compared to that of the layered White model.Both of them moved towards higher frequencies with increasing permeability and decreasing viscosity and diffusion length.The differences between them were due to the diffusion length.The diffusion length for the 1D poroelastic model was determined by the sample length,whereas that for the layered White model was determined by the length of the representative elementary volume(REV).Subsequently,a numerical example was presented to demonstrate the similarities and differences between the models.Finally,published experimental data were interpreted using the 1D poroelastic model combined with the Cole-Cole model.The prediction of the combined model was in good agreement with the experimental data,thereby validating the effectiveness of the 1D poroelastic model.Furthermore,the modified characteristic frequency in our study was much closer to the experimental data than the previous prediction,validating the effectiveness of our modification of the characteristic frequency of the 1D poroelastic model.The investigation provided insight into the internal relationship between wave-induced fluid flow(WIFF)models at macroscopic and mesoscopic scales and can aid in a better understanding of the elastic modulus dispersion and attenuation caused by the WIFF at different scales.