Ten-year observation of corneal densitometry and associated factors following small incision lenticule extraction

●AIM:To investigate the long-term changes of corneal densitometry(CD)and its contributing elements after small incision lenticule extraction(SMILE).●METHODS:Totally 31 eyes of 31 patients with mean spherical equivalent of-6.46±1.50 D and mean age 28.23±7.38y were enrolled.Full-scale examinations were conducted on all patients preoperatively and during followup.Visual acuity,manifest refraction,axial length,corneal thickness,corneal higher-order aberrations,and CD were evaluated.●RESULTS:All surgeries were completed successfully without complications or adverse events.Ten-year safety index was 1.17±0.20 and efficacy 1.04±0.28.CD value of 0–6 mm zones in central layer was statistically significantly lower 10y postoperatively,compared with preoperative values(0–2 mmΔ=-1.62,2–6 mmΔ=-1.24,P<0.01).There were no correlations between CD values and factors evaluated.●CONCLUSION:SMILE is a safe and efficient procedure for myopia on a long-term basis.CD values get lower 10y postoperatively,whose mechanism is to be further discussed.

Changes in posterior corneal elevation after small incision lenticule extraction for different myopic diopters

●AIM:To study the changes and effect factors of posterior corneal surface after small incision lenticule extraction(SMILE)with different myopic diopters.●METHODS:Ninety eyes of 90 patients who underwent SMILE were included in this retrospective study.Patients were allocated into three groups based on the preoperative spherical equivalent(SE):low myopia(SE≥-3.00 D),moderate myopia(-3.00 D>SE>-6.00 D)and high myopia(SE≤-6.00 D).Posterior corneal surfaces were measured by a Scheimpflug camera preoperatively and different postoperative times(1wk,1,3,6mo,and 1y).Posterior mean elevation(PME)at 25 predetermined points of 3 concentric circles(2-,4-,and 6-mm diameter)above the best fit sphere was analyzed.●RESULTS:All surgeries were completed uneventfully and no ectasia was found through the observation.The difference of myopia group was significant at the 2-mm ring at 1 and 3mo postoperatively(1mo:P=0.017;3mo:P=0.018).The effect of time onΔPME was statistically significant(2-mm ring:P=0.001;4-mm ring:P<0.001;6-mm ring:P<0.001).The effect of different corneal locations onΔPME was significant except 1wk postoperatively(1mo:P=0.000;3mo:P=0.000;6mo:P=0.001;1y:P=0.001).Posterior corneal stability was linearly correlated with SE,central corneal thickness,ablation depth,residual bed thickness,percent ablation depth and percent stromal bed thickness.●CONCLUSION:The posterior corneal surface changes dynamically after SMILE.No protrusion is observed on the posterior corneal surface in patients with different degrees of myopia within one year after surgery.SMILE has good stability,accuracy,safety and predictability.

Clinical observation of extraction-site incisional hernia after laparoscopic colorectal surgery

BACKGROUND Laparoscopic colorectal cancer surgery increases the risk of incisional hernia(IH)at the tumor extraction site.AIM To investigate the incidence of IH at extraction sites following laparoscopic colo-rectal cancer surgery and identify the risk factors for IH incidence.METHODS This study retrospectively analyzed the data of 1614 patients who underwent la-paroscopic radical colorectal cancer surgery with tumor extraction through the abdominal wall at our center between January 2017 and December 2022.Diffe-rences in the incidence of postoperative IH at different extraction sites and the risk factors for IH incidence were investigated.RESULTS Among the 1614 patients who underwent laparoscopic radical colorectal cancer surgery,303(18.8%),923(57.2%),171(10.6%),and 217(13.4%)tumors were ex-tracted through supraumbilical midline,infraumbilical midline,umbilical,and off-midline incisions.Of these,52 patients developed IH in the abdominal wall,with an incidence of 3.2%.The incidence of postoperative IH was significantly higher in the off-midline incision group(8.8%)than in the middle incision groups[the supraumbilical midline(2.6%),infraumbilical midline(2.2%),and umbilical incision(2.9%)groups](χ^(2)=24.985;P<0.05).Univariate analysis showed that IH occurrence was associated with age,obesity,sex,chronic cough,incision infection,and combined diabetes,anemia,and hypopro-teinemia(P<0.05).Similarly,multivariate analysis showed that off-midline incision,age,sex(female),obesity,incision infection,combined chronic cough,and hypoproteinemia were independent risk factors for IH at the site of laparoscopic colorectal cancer surgery(P<0.05).CONCLUSION The incidence of postoperative IH differs between extraction sites for laparoscopic colorectal cancer surgery.The infraumbilical midline incision is associated with a lower hernia rate and is thus a suitable tumor extraction site.

Endoscopic radial incision and cutting method for adult congenital duodenal webs:A case report

BACKGROUND Congenital duodenal webs are rare in adults and can lead to various symptoms such as nausea,vomiting,and postprandial fullness.The treatment for this disease is mostly surgical.Endoscopic treatment techniques have been developed and attempted for this disease.Endoscopic radial incision and cutting(RIC)techniques are reportedly very effective in benign anastomotic stricture.This case report highlights the effectiveness and safety of endoscopic RIC as a minimally invasive treatment for adult congenital duodenal webs.CASE SUMMARY A 23-year-old female patient with indigestion was referred to a tertiary hospital.The patient complained of postprandial fullness in the epigastric region.Previous physical examinations or blood tests indicated no abnormalities.Computed tomography revealed an eccentric broad-based delayed-enhancing mass-like lesion in the second portion of the duodenum.Endoscopy showed an enlarged gastric cavity and a significantly dilated duodenal bulb;a very small hole was observed in the distal part of the second portion,and scope passage was not possible.Gastrografin upper gastrointestinal series was performed,revealing an intraduodenal barium contrast-filled sac with a curvilinear narrow radiolucent rim,a typical"windsock"sign.Endoscopic RIC was performed on the duodenal web.The patient recovered uneventfully.Follow-up endoscopy showed a patent duodenal lumen without any residual stenosis.The patient reported complete resolution of symptoms at the 18-month follow-up.CONCLUSION Endoscopic RIC may be an effective treatment for congenital duodenal webs in adults.

Micro-power negative pressure wound technique reduces risk of incision infection following loop ileostomy closure

BACKGROUND Prophylactic loop ileostomy is an effective way to reduce the clinical severity of anastomotic leakage following radical resection of rectal cancer.Incisional surgical site infection(SSI)is a common complication after ileostomy closure.AIM To evaluate the efficacy and safety of the micro-power negative pressure wound technique(MPNPWT)in preventing incisional SSI.METHODS This was a prospective,randomized controlled clinical trial conducted at a single center.A total of 101 consecutive patients who underwent ileostomy closure after rectal cancer surgery with a prophylactic ileostomy were enrolled from January 2019 to December 2021.Patients were randomly allocated into an MPNPWT group and a control group.The MPNPWT group underwent intermittent suturing of the surgical incision with 2-0 Prolene and was covered with a micro-power negative pressure dressing.The surgical outcomes were compared between the MPNPWT(n=50)and control(n=51)groups.Risk factors for incisional SSI were identified using logistic regression.RESULTS There were no differences in baseline characteristics between the MPNPWT(n=50)and control groups(n=51).The incisional SSI rate was significantly higher in the control group than in the MPNPWT group(15.7%vs 2.0%,P=0.031).However,MPNPWT did not affect other surgical outcomes,including intra-abdominal complications,operative time,and blood loss.Postoperative hospital stay length and hospitalization costs did not differ significantly between the two groups(P=0.069 and 0.843,respectively).None of the patients experienced adverse effects of MPNPWT,including skin allergy,dermatitis,and pain.MPNPWT also helped heal the infected incision.Our study indicated that MPNPWT was an independent protective factor[odds ratio(OR)=0.005,P=0.025)]and diabetes was a risk factor(OR=26.575,P=0.029)for incisional SSI.CONCLUSION MPNPWT is an effective and safe way to prevent incisional SSI after loop ileostomy closure.

Comparative study of functional optical zone:small incision lenticule extraction versus femtosecond laser assisted excimer laser keratomileusis

AIM:To investigate the size of functional optical zone(FOZ)after small incision lenticule extraction(SMILE)versus femtosecond laser assisted excimer laser keratomileusis(FS-LASIK)for myopia correction and potential associated factors for FOZ.METHODS:A total of 133 patients who received corneal refractive surgery in our hospital between November 2018 and July 2021 were retrospectively enrolled.There were 63 patients(123 eyes)in SMILE group and 70patients(139 eyes)in FS-LASIK group.The size of FOZ was measured using Pentacam 3-dementional anterior segment analyzer before and 3mo after surgery,so as to analyze postoperative achieved functional optical zone(AFOZ)and its contributing parameters.RESULTS:When planned functional optical zone(PFOZ)was 6.5 mm for both groups,AFOZ was 1.45±0.27 and 1.67±0.25 mm smaller than preoperative FOZ in SMILE group and FS-LASIK group 3mo after surgery.AFOZ in SMILE group was significantly larger than that in FS-LASIK group(P<0.001).Variation of FOZ was negatively correlated with preoperative spherical equivalent(SE)and positively correlated with variation of mean keratometry value(△Km),variation of spherical aberration(△SA),and variation of Q-value(△Q,all P<0.001)in both groups.Multiple variable linear regression equations were△FOZ=1.354-0.1×pre-SE+0.336×△Q+1.462×△SA in SMILE group and△FOZ=1.512+0.137×△Q+0.468×△SA in FS-LASIK group.CONCLUSION:AFOZ is significantly smaller than preoperative FOZ in both SMILE and FS-LASIK groups.With the same PFOZ,larger AFOZ is achieved in SMILE group than in FS-LASIK group.

Analysis of Ultrasonic Emulsification Surgery and Small Incision Cataract Extracapsular Extraction Surgery for Cataract Clinical Treatment Level Improvement

Objective:To analyze the efficacy of ultrasonic emulsification and small incision cataract extracapsular extraction in cataract patients.Methods:96 cataract patients admitted from May 2021 to May 2023 were selected and randomly grouped into group A(ultrasonic emulsification)and group B(small-incision extracapsular cataract extraction),with 48 cases each.Results:At 1 week,1-month,and 3 months post-operation,the visual acuity of group A was higher and the astigmatism value was lower than that of group B(P<0.05);at 12h,24h,and 48h post-operation,the intraocular pressure of group A was higher than that of group B(P<0.05);the thickness of macular area of group A was lower than that of group B at 1 week and 1-month post-operation(P<0.05).Conclusion:Ultrasonic emulsification in cataract patients was slightly better than small incision cataract extracapsular extraction in correcting astigmatism,improving visual acuity,and regulating macular thickness.However,due to the high energy of ultrasonic emulsification,the risk of complications such as high postoperative intraocular pressure was higher.Small-incision extracapsular cataract extraction has better application value in economically disadvantaged areas.

正常胎儿脐静脉血流量Z评分模型的构建及其对小于胎龄儿围生期不良结局的预测价值

目的构建正常胎儿脐静脉血流量(Quv)Z评分模型,并探讨该模型对小于胎龄儿(SGA)围生期不良结局的预测价值。方法(1)纳入862例18~40周正常胎儿建立模型。以腹部超声测量的腹内段Quv作为因变量,孕周为自变量,采用回归分析获得Quv均数及标准差的最佳拟合方程后,根据公式[Z评分=(实际Quv测值-拟合Quv均值)/拟合Quv标准差]建立正常胎儿Quv Z评分模型。(2)另纳入53例正常胎儿(正常组)和109例SGA,并根据围生期有无不良结局将SGA分为不良结局组(n=50)、无不良结局组(n=59)。利用所建立的模型获得3组的胎儿Quv Z评分。通过绘制受试者工作特征曲线分析正常胎儿Quv Z评分预测SGA围生期不良结局的效能。结果(1)正常胎儿的Quv与孕周呈正相关(P<0.05),Quv的均数及标准差相对孕周的最佳拟合方程均为线性方程。根据公式获得正常胎儿Quv Z评分模型:Z评分=(Quv+346.069-20.754×孕周)(/-51.320+4.075×孕周)。正常组胎儿Quv的Z评分呈正态分布,且不随孕周而改变。(2)不良结局组、无不良结局组、正常组的胎儿Quv Z评分依次增加(P<0.05)。(3)正常胎儿Quv Z评分预测SGA围生期不良结局的曲线下面积为0.843,基于最佳截断值-2.06的预测敏感度、特异度、阳性预测值、阴性预测值分别为74.0%、86.4%、82.2%、76.4%。结论所建立的正常胎儿Quv Z评分模型可消除孕周的影响,具有较好的临床适用性。正常胎儿Quv Z评分是预测SGA围生期不良结局较敏感的指标。

Z型异质结Cu_(2)O/Bi_(2)MoO_(6)的构建及光催化降解性能

通过水热法制备出一系列Z型异质结Cu_(2)O/Bi_(2)MoO_(6)新型光催化剂。采用扫描电子显微镜、粉末X射线衍射、红外光谱、紫外可见吸收光谱等表征手段研究了催化剂的形貌、结构性质和光电化学性质,并以四环素(TC)为降解目标污染物,进一步探究了其催化效率。实验结果表明,Cu_(2)O的加入提高了复合催化剂的光催化性能,其中20%Cu_(2)O/Bi_(2)MoO_(6)复合催化剂(Cu_(2)O和Bi_(2)MoO_(6)的质量比为20%)降解效果最好,100 min内可降解95%的TC。Cu_(2)O与Bi_(2)MoO_(6)之间的协同作用使其可以吸收更多的可见光,所构建的Z型异质结改变了电子转移途径,提高了电子与空穴的分离效率,光催化活性显著提高。通过自由基捕获实验和能带结构,分析了Z型异质结Cu_(2)O/Bi_(2)MoO_(6)复合催化剂光催化降解TC可能的机理。

Z型异质结Ag_(2)S/AgVO_(3)可见光催化转化低浓度瓦斯制甲醇性能研究

因缺乏合理有效的利用途径,大量低浓度瓦斯(C_(CH_(4))<30%)被直接排放,研究开发低浓度瓦斯高值转化利用方法和技术对保障煤矿安全生产与减缓温室效应具有重要意义,也是实现我国“双碳”战略目标必不可缺少的部分。以低浓度瓦斯为碳源制取液体燃料甲醇被认为是其理想的利用途径之一,以清洁太阳能为驱动力的光催化技术可在室温常压下活化转化甲烷,为低浓度瓦斯低碳利用提供新途径。首先采用水热法制备AgVO_(3),以硫代乙酰胺为硫源,通过阴离子交换策略在AgVO_(3)表面原位复合Ag_(2)S,构筑出Ag_(2)S/AgVO_(3)异质结,改变硫代乙酰胺的用量可调控Ag_(2)S复合比例。利用XRD、SEM、TEM和紫外可见漫反射光谱等对复合催化剂的微观结构进行表征分析,以体积比为1∶12的甲烷/空气混合物模拟低浓度瓦斯,系统研究了Ag_(2)S复合比例、氧化剂用量、光照强度等对甲烷转化、甲醇产生及其选择性的影响规律,借助瞬态光电流响应谱和电子顺磁共振谱(EPR)探究了Z型异质结构Ag_(2)S/AgVO_(3)对增强模拟瓦斯转化性能的内在机理。研究结果表明:所制AgVO_(3)呈纤维状形貌,其晶相结构为单斜相,原位复合的Ag_(2)S呈纳米颗粒形态,其平均粒径为60 nm,且Ag_(2)S颗粒均匀分布于AgVO_(3)纤维表面。与单一AgVO_(3)和Ag_(2)S相比,复合材料Ag_(2)S/AgVO_(3)具有更强的光吸收性能,AgVO_(3)的带隙能、价带与导带电势分别为2.08 eV、2.21 V和0.13 V,Ag_(2)S的带隙能、价带与导带电势分别为0.91 eV、0.34 V和−0.57 V。与AgVO_(3)相比,复合催化剂Ag_(2)S/AgVO_(3)具有显著增强的瓦斯转化性能,可见光照射1 h最优催化剂20%Ag_(2)S/AgVO_(3)的甲烷转化和甲醇产生量为3.10 mmol/g和2.45 mmol/g,分别为单一AgVO_(3)的1.72倍与2.63倍,且其甲醇选择性高达78.9%;6次循环试验结果表明:Ag_(2)S/AgVO_(3)具有优异的催化稳定性。能带结构分析与EPR测试结果表明:Ag_(2)S/AgVO_(3)异质结遵循Z型电荷迁移机制,这不仅增强了光生电荷的空间分离,同时使其具有较强的氧化/还原能力,显著提升低浓度瓦斯定向转化制取甲醇的催化性能,为低浓度瓦斯低碳高效利用提供新思路。

数字智能时代“Z世代”的工作自主性

数字智能技术正在推动人们工作方式的变革,青年群体尤其是作为网络原住民的“Z世代”正身处这场影响颇深的变革之中。随着新产业的兴起与新劳动的产生,青年群体在生产中获得了以创意设计自主性、规划安排自主性、技术运用自主性等为特征的工作自主性,这在很大程度上推进了生产效率的提升。深受优绩主义影响的“Z世代”青年文化、数字智能技术的广泛掌握与熟练运用、企业劳动管理模式的革新与迭代这三个因素成为青年群体获取工作自主性的重要条件与动力。然而,数字智能时代的工作自主性并不意味着管理的缺失,而意味着管理方式的转变。我们需要为青年劳动群体的自主性成长提供支持,警惕其陷入自主性异化的困境。可以从法律层面入手,本着推动劳动者成长目的来发展完善劳动法律法规;从社会层面入手,着力消除各类显性和隐性的歧视;以及从企业组织层面入手,理顺组织内部的工作协调,减少权力霸凌,打造包容、善意的职场文化。总之,帮助与支持青年群体的自主成长不仅是青年自身的要求,更是全社会共同的目标。

Z世代的新质生产力特质与评价研究——基于“能力-意愿”的代际比较

加快形成新质生产力是我国经济发展战略重要组成部分,高质量人力资本是重要的新质生产力。Z世代逐渐成为劳动力市场主体,以要素和协作两种形式创造新质生产力。本文以马克思劳动价值论为基础构建以劳动为变量的生产力跨期模型,根据经济学、社会学相关理论和“三新”经济统计数据有关内容,构建劳动“能力-意愿”评价指标体系,并从2021年中国社会状况综合调查(CSS)结果中提取劳动相关指标数据,将其代入生产力跨期模型比较不同世代群体的新质生产力水平。结果显示:在能力维度方面,Z世代群体具有更多高等学历受教育程度经历、更多参加专业领域内职业技能培训、更高频次使用互联网进行商务和工作、更高比例从事专业技术和新兴产业工作等高质量人力资本特征,以要素形式创造更多的新质生产力,并通过“七普”数据、教育信息化发展实践现状和信息产业就业情况等证据给予证实;在参与创造新质生产力意愿方面,Z世代群体表现出较高的社会服务参与热情,但对人与人关系的信任水平偏低,这可能会降低劳动的协作生产力。最后,从能力和意愿两方面给出Z世代群体创造更多新质生产力的建议。

冠状动脉Z值等四联指标模型对黏膜皮肤淋巴结综合征的辅助诊断价值

目的探讨冠状动脉Z值联合发热时间、白细胞介素-6(IL-6)、C反应蛋白(CRP)四联指标模型对黏膜皮肤淋巴结综合征(又称“川崎病”)的辅助诊断价值。方法选取2017年1月至2022年12月厦门大学附属中山医院儿科收治的怀疑为川崎病的患儿165例,以临床诊断标准作为金标准最终确诊的83例为病例组(包括不完全川崎病),排除川崎病诊断的82例为对照组。收集患儿的临床资料和冠脉Z值,采用多因素logistic回归分析发病的独立危险因素,构建川崎病四联指标模型。绘制受试者工作特征曲线(ROC曲线),计算曲线下面积(AUC),用约登指数确定最佳诊断阔值。用Kappa值评价四联指标模型与临床诊断标准的一致性。结果冠脉Z值、发热时间、IL-6、CRP是川崎病的独立危险因素,最佳诊断阀值分别为:冠脉Z值1.5,发热时间5.5d,IL-631pg/mL,CRP42mg/L。基于独立危险因素构建的四联指标模型AUC为0.960,Kappa值为0.867,诊断价值高于各独立危险因素,与临床诊断标准具有较好的一致性。结论冠脉Z值联合发热时间、IL-6、CRP构建的四联指标模型能有效地辅助临床诊断并减少漏诊,为提高KD诊断效率提供参考依据。

LD端面抽运Z型腔的Nd∶GdVO_(4)激光器稳定性研究

为了提升半导体激光二极管端面抽运Z型腔固体激光器的稳定性,以Nd∶GdVO_(4)固体激光器为例,采用数值模拟的方法,在考虑晶体热透镜效应的情况下,研究了Z型谐振腔的臂长、镜片曲率半径等参数对高斯光束的影响,得到了晶体热透镜焦距随抽运光功率变化的关系曲线、谐振腔稳定性随热透镜焦距变化的关系曲线、以及高斯光束束腰半径随谐振腔分臂长和镜片曲率半径变化的关系曲线,并绘制了高斯光束的轮廓曲线。结果表明,适当选取Z型腔的分臂参数可在晶体主平面和后端镜处获得较小的束腰尺寸。本研究结果可对Z型固体激光器谐振腔的搭建提供理论参考及依据。

基于价值观的气候传播:中国Z世代价值观念与气候叙事探究

随着“双碳”目标的提出,中国正式迈入“双碳”时代,Z世代因其特殊的世代坐标,是决定未来“双碳”目标顺利实现与否的关键群体。文章以中国Z世代公众为研究对象,提出以价值观念作为气候传播中叙事设计的主要依据。研究中招募54名中国Z世代志愿者,共计开展12次焦点小组访谈,探讨他们的价值观念和气候态度,随后邀请他们进行叙事语料测试,语料的不同段落和表述暗含了对应的价值观念假设。通过对焦点小组和语料测试的质性材料分析,发现Z世代群体普遍体现出自我提升和“躺平”期待的并存、强烈的国族认同感以及平等主义倾向,同时既自我关注又有较低的自我效能感。文章尝试建立起价值取向与气候认知和态度之间的可靠关联,并总结了Z世代价值偏向对气候叙事实践的启示。

一种新型准Z源高增益DC-DC升压变换器

针对传统准Z源阻抗网络DC-DC升压变换器存在电压增益低和元件电压应力高的问题,提出一种新型准Z源高增益DC-DC升压变换器(HSQZSC)。首先,分析HSQZSC变换器两种模态工作原理,并对其进行稳态分析和参数设计。其次,与现已提出的Z源变换器进行性能对比,表明HSQZSC变换器具有高电压增益和元件电压应力低的优势。然后,对其建立状态空间模型进行小信号分析、稳定性分析和控制器的设计。最后,搭建100 W实物样机,实验结果验证了HSQZSC变换器的可行性与有效性。

微细金属Z-pin对复合材料开孔板压缩性能的影响

通过开孔板压缩试验和建立的参数化多尺度有限元模型,获得微细(φ0.11 mm)金属Z-pin植入体积分数和排布方式对开孔板压缩力学性能和失效行为的影响规律.采用离散实体单元代表Z-pin,选用3D Hashin失效准则判断面内起始损伤,可以有效地模拟结构失效过程中扭结现象的不稳定扩展.结果表明,所有加Z-pin开孔板的压缩强度均低于无Z-pin试样.随着Z-pin植入体积分数的增加,Z-pin与层合板之间的桥联作用增强,加Z-pin开孔层合板压缩强度增加,开孔周围分层损伤区域受到抑制,损伤区域面积最高减小了67%.在相同的体积分数下,Z-pin排布变化对开孔板压缩强度没有显著影响.加Z-pin开孔板有限元模型的模拟结果与试验结果之间的最大相对误差为8.6%.

红色旅游对Z世代文化自信的影响机制研究

Z世代成为红色旅游消费的主力军,彰显了年轻人对红色文化的热爱。基于积极情绪拓展—建构理论,以红色情感为中介变量,采用偏最小二乘法结构方程模型分析红色旅游体验对Z世代文化自信的影响机制。研究结果显示:构建的红色旅游文化自信影响模型具有较强的解释力,各研究假设均成立。红色旅游体验通过红色情感对Z世代文化自信产生积极影响,其中,革命文化感知对文化自信的影响最显著。由此提出,以科技赋能、文创助力为双翼,加强情感体验,让红色资源“活起来”、红色文化“潮起来”,推动红色旅游高质量发展,增强Z世代文化自信。

可持续发展意识对Z世代服装可持续消费行为影响研究

服装可持续消费作为一种全新的可持续生活和消费方式被年轻消费群体接受。研究基于环境、社会和经济的可持续发展意识对理性行为理论(TRA)进行延伸,分析Z世代的可持续发展意识,以及可持续发展意识对Z世代服装可持续消费意愿的影响。利用结构方程模型,以Z世代为研究对象,对375份网络问卷调研数据进行实证分析。结果表明,Z世代的可持续发展意识较高,可持续发展意识对服装可持续消费意愿起到积极作用,且服装可持续消费态度和主观规范能更好地推动可持续发展意识较高的Z世代提高服装可持续消费意愿,中介作用显著。政府需从环境、社会和经济三方面全面加强可持续发展宣传,增强消费者可持续发展意识,从而促进服装可持续消费行为。

探讨姜黄素通过NF-κB对鼻咽癌CNE-2Z细胞的生长抑制作用、诱导凋亡作用及其机制研究

目的:探讨姜黄素通过NF-κB对鼻咽癌CNE-2Z细胞增殖的影响。方法:MTT法测定姜黄素对鼻咽癌CNE-2Z细胞增殖的影响,采用流式细胞仪测定姜黄素不同浓度下的CNE-2Z细胞凋亡情况,Western Blot测定NF-κB蛋白的表达。结果:姜黄素能影响CNE-2Z细胞的NF-κB蛋白表达,使NF-κB蛋白表达水平降低,说明姜黄素对CNE-2Z的增殖和转移有一定的影响。姜黄素对CNE-2Z的作用效果受作用时间和浓度影响,其对CNE-2Z细胞24 h的IC50数值为(43.514~45.435)μmol/L,48 h的IC50数值为(8.366~13.11)μmol/L,72 h的IC50数值为(5.658~8.469)μmol/L。结论:姜黄素能够通过NF-κB蛋白的表达,来抑制鼻咽癌CNE-2Z细胞增殖与侵袭。姜黄素浓度越高,作用时间越长,CNE-2Z细胞增殖抑制效果越好。