AIM To compare the therapeutic effect of the herbal medicine Zhishi Xiaopiwan with that of Cisapride in the treatment of functional dyspepsia (FD). METHODS Fifty one FD patients were randomized into Herbal...AIM To compare the therapeutic effect of the herbal medicine Zhishi Xiaopiwan with that of Cisapride in the treatment of functional dyspepsia (FD). METHODS Fifty one FD patients were randomized into Herbal group ( n =27) and Cisapride group ( n =24). Two groups were given a four week treatment of Zhishi Xiaopiwan 100ml , tid, a.c. and Cisapride 5mg , tid, a.c. respectively. Patients′ symptoms were assessed and 39 patients′ (22 of Herbal group and 17 of Cisapride group) gastric liquid emptying times were measured with ultrasonography before and after the treatment. RESULTS The therapeutic effective rates of Herbal group and Cisapride group were 81 49% and 87 50% ( P >0 05). The half gastric emptying time (GET 50 ) and gastric emptying time (GET) of healthy controls and FD patients were 36 12min±10 22min vs 52 95min±13 49min and 87 07min±21 11min vs 120 74min±23 08min ( P <0 001). The GET 50 and GET of Herbal group before and after the treatment were 51 63min±13 15min vs 45 62min±10 82min and 117 34min±23 29min vs 103 26min±22 19min ( P <0 01). The results of Cisapride group were 54 66min±14 14min vs 40 95min±11 29min and 125 12min±24 47min vs 95 49min±22 31min ( P <0 01). The differences in values (median) of GET 50 and GET for Herbal group and Cisapride group before and after treatment were 5 75min vs 17 18min and 13 22min vs 33 54min ( P <0 05). CONCLUSION Delayed gastric emptying is one of the pathogenesis of FD. Both Zhishi Xiaopi pills and Cisapride can effectively alleviate the symptoms of FD and accelerate gastric liquid emptying. The effect of Zhishi Xiaopiwan on enhancing gastric motility is comparable with but less than that of Cisapride .展开更多
文摘AIM To compare the therapeutic effect of the herbal medicine Zhishi Xiaopiwan with that of Cisapride in the treatment of functional dyspepsia (FD). METHODS Fifty one FD patients were randomized into Herbal group ( n =27) and Cisapride group ( n =24). Two groups were given a four week treatment of Zhishi Xiaopiwan 100ml , tid, a.c. and Cisapride 5mg , tid, a.c. respectively. Patients′ symptoms were assessed and 39 patients′ (22 of Herbal group and 17 of Cisapride group) gastric liquid emptying times were measured with ultrasonography before and after the treatment. RESULTS The therapeutic effective rates of Herbal group and Cisapride group were 81 49% and 87 50% ( P >0 05). The half gastric emptying time (GET 50 ) and gastric emptying time (GET) of healthy controls and FD patients were 36 12min±10 22min vs 52 95min±13 49min and 87 07min±21 11min vs 120 74min±23 08min ( P <0 001). The GET 50 and GET of Herbal group before and after the treatment were 51 63min±13 15min vs 45 62min±10 82min and 117 34min±23 29min vs 103 26min±22 19min ( P <0 01). The results of Cisapride group were 54 66min±14 14min vs 40 95min±11 29min and 125 12min±24 47min vs 95 49min±22 31min ( P <0 01). The differences in values (median) of GET 50 and GET for Herbal group and Cisapride group before and after treatment were 5 75min vs 17 18min and 13 22min vs 33 54min ( P <0 05). CONCLUSION Delayed gastric emptying is one of the pathogenesis of FD. Both Zhishi Xiaopi pills and Cisapride can effectively alleviate the symptoms of FD and accelerate gastric liquid emptying. The effect of Zhishi Xiaopiwan on enhancing gastric motility is comparable with but less than that of Cisapride .
