Zhuang medicine medicated thread moxibustion is a kind of external therapy with ethnic medicine characteristics that spreads in Guangxi Zhuang region.It has a wide range of clinical application and significant curativ...Zhuang medicine medicated thread moxibustion is a kind of external therapy with ethnic medicine characteristics that spreads in Guangxi Zhuang region.It has a wide range of clinical application and significant curative effect,and can be used to treat diseases such as internal medicine,surgery,dermatology,gynecology,pediatrics,and five sense organs.Through reviewing and combing the literature on the Zhuang medicine medicated thread moxibustion in recent years,this paper summarizes and prospects its clinical application,with a view to further explaining the basic principles and application rules of Zhuang medicine medicated thread moxibustion and digging its clinical value.展开更多
Objective:To explore the efficacy and safety of Zhuang medicine medicated thread moxibustion(ZMTM)on psoriasis vulgaris.Methods:A multicenter,randomized,parallel controlled clinical trial was designed.A total of 241 o...Objective:To explore the efficacy and safety of Zhuang medicine medicated thread moxibustion(ZMTM)on psoriasis vulgaris.Methods:A multicenter,randomized,parallel controlled clinical trial was designed.A total of 241 outpatients with psoriasis vulgaris were randomly divided into a control group(120 cases)and a treatment group(121 cases)using a central block randomization from June 2015 to May 2018.The control group was treated with Western medicines alone including pidotimod dispersible tablets,vitamin B compound tablets,and compound cod liver oil-zinc oxide ointment.The treatment group was treated with ZMTM every 2 days combined with Western medicines.The two groups received continuous intervention for 30 days.The primary outcome was Psoriasis Area and Severity Index(PASI),and the secondary outcomes included Itch Rating Scale,Dermatology Quality of Life Index(DLQI),Hamilton Anxiety Rating Scale(HAMA),as well as PASI response rate.Meanwhile,adverse events were evaluated during the whole clinical trial.Follow-up was carried out 30 days after treatment.Results:There were 5 cases of shedding in this trial.In intention-to-treat analysis,236 cases were included and each group contained 118 cases.On the 30th and 60th days,PASI scores of patients in each group were significantly lower than that at baseline(P<0.01)and the PASI score reduction of the treatment group was greater than that of the control group(P<0.01).Itch Rating Scale,DLQI,and HAMA scale were decreased in both groups after treatment,and the treatment group showed a better therapeutic effect(P<0.01).The response rates of PASI 50 and 75 were significantly higher than those in the control group[81.4%(96/118),43.2%(51/118)vs.41.5%(49/118),11.0%(13/118),respectively,P<0.05].During follow-up,the improvements in scores of PASI,Itch Rating Scale,DLQI,and HAMA of the treatment group were significantly greater than those of the control group(P<0.01).The response rates of PASI 50 and 75 in the treatment group were significantly higher than those in the control group,respectively(both P<0.05).No obvious adverse reaction was found in either group.Conclusion:ZMTM combined with Western medicines showed a better therapeutic effect in the treatment of psoriasis vulgaris without obvious adverse reaction.(Trial Registration No.ChiCTR-IOR-16008159)展开更多
目的:运用代谢组学方法研究刺血结合药线治疗大鼠急性痛风性关节炎的机制。方法:Wistar成年雄性大鼠30只,随机分为模型组、西药组、治疗组,每组10只,治疗结束后,收集3组大鼠血清样本,运用气相色谱仪与飞行时间质谱仪的联用(gas chromato...目的:运用代谢组学方法研究刺血结合药线治疗大鼠急性痛风性关节炎的机制。方法:Wistar成年雄性大鼠30只,随机分为模型组、西药组、治疗组,每组10只,治疗结束后,收集3组大鼠血清样本,运用气相色谱仪与飞行时间质谱仪的联用(gas chromatographytime-of-flight mass spectrometry,GC-TOF-MS)代谢组学技术分析大鼠血清代谢色谱,并进行主成分分析法(PCA)和正交偏最小二乘方-判别分析(OPLS-DA)。结果:治疗组大鼠步态较西药组大鼠好,其肿胀度也低;治疗组较模型组的代谢物能抗炎镇痛;治疗组较西药组的代谢物能促进代谢,降尿酸。结论:采用代谢组学的方法,较全面的反应了刺血结合药线治疗急性痛风性关节炎大鼠的代谢状态,其对血清代谢物影响明显。展开更多
基金"Zhuang medicine",a key discipline of traditional Chinese medicine in Guangxi(No.GZXK-Z-20-60),the project to improve the basic scientific research ability of young and middle-aged teachers in Guangxi universities(No.2020KY07023),and the scientific research project of Guangxi Zhuang Autonomous Region Administration of Traditional Chinese Medicine(No.GXZYZ20210456).
文摘Zhuang medicine medicated thread moxibustion is a kind of external therapy with ethnic medicine characteristics that spreads in Guangxi Zhuang region.It has a wide range of clinical application and significant curative effect,and can be used to treat diseases such as internal medicine,surgery,dermatology,gynecology,pediatrics,and five sense organs.Through reviewing and combing the literature on the Zhuang medicine medicated thread moxibustion in recent years,this paper summarizes and prospects its clinical application,with a view to further explaining the basic principles and application rules of Zhuang medicine medicated thread moxibustion and digging its clinical value.
基金Supported by the Scientific Research Special Fund of Traditional Chinese Medicine Industry(No.201507006)。
文摘Objective:To explore the efficacy and safety of Zhuang medicine medicated thread moxibustion(ZMTM)on psoriasis vulgaris.Methods:A multicenter,randomized,parallel controlled clinical trial was designed.A total of 241 outpatients with psoriasis vulgaris were randomly divided into a control group(120 cases)and a treatment group(121 cases)using a central block randomization from June 2015 to May 2018.The control group was treated with Western medicines alone including pidotimod dispersible tablets,vitamin B compound tablets,and compound cod liver oil-zinc oxide ointment.The treatment group was treated with ZMTM every 2 days combined with Western medicines.The two groups received continuous intervention for 30 days.The primary outcome was Psoriasis Area and Severity Index(PASI),and the secondary outcomes included Itch Rating Scale,Dermatology Quality of Life Index(DLQI),Hamilton Anxiety Rating Scale(HAMA),as well as PASI response rate.Meanwhile,adverse events were evaluated during the whole clinical trial.Follow-up was carried out 30 days after treatment.Results:There were 5 cases of shedding in this trial.In intention-to-treat analysis,236 cases were included and each group contained 118 cases.On the 30th and 60th days,PASI scores of patients in each group were significantly lower than that at baseline(P<0.01)and the PASI score reduction of the treatment group was greater than that of the control group(P<0.01).Itch Rating Scale,DLQI,and HAMA scale were decreased in both groups after treatment,and the treatment group showed a better therapeutic effect(P<0.01).The response rates of PASI 50 and 75 were significantly higher than those in the control group[81.4%(96/118),43.2%(51/118)vs.41.5%(49/118),11.0%(13/118),respectively,P<0.05].During follow-up,the improvements in scores of PASI,Itch Rating Scale,DLQI,and HAMA of the treatment group were significantly greater than those of the control group(P<0.01).The response rates of PASI 50 and 75 in the treatment group were significantly higher than those in the control group,respectively(both P<0.05).No obvious adverse reaction was found in either group.Conclusion:ZMTM combined with Western medicines showed a better therapeutic effect in the treatment of psoriasis vulgaris without obvious adverse reaction.(Trial Registration No.ChiCTR-IOR-16008159)
文摘目的:运用代谢组学方法研究刺血结合药线治疗大鼠急性痛风性关节炎的机制。方法:Wistar成年雄性大鼠30只,随机分为模型组、西药组、治疗组,每组10只,治疗结束后,收集3组大鼠血清样本,运用气相色谱仪与飞行时间质谱仪的联用(gas chromatographytime-of-flight mass spectrometry,GC-TOF-MS)代谢组学技术分析大鼠血清代谢色谱,并进行主成分分析法(PCA)和正交偏最小二乘方-判别分析(OPLS-DA)。结果:治疗组大鼠步态较西药组大鼠好,其肿胀度也低;治疗组较模型组的代谢物能抗炎镇痛;治疗组较西药组的代谢物能促进代谢,降尿酸。结论:采用代谢组学的方法,较全面的反应了刺血结合药线治疗急性痛风性关节炎大鼠的代谢状态,其对血清代谢物影响明显。
