Cohort study on the treatment of BRAF V600E mutant metastatic colorectal cancer with integrated Chinese and western medicine

BACKGROUND Patients with BRAF V600E mutant metastatic colorectal cancer(mCRC)have a low incidence rate,poor biological activity,suboptimal response to conventional treatments,and a poor prognosis.In the previous cohort study on mCRC conducted by our team,it was observed that integrated Chinese and Western medicine treatment could significantly prolong the overall survival(OS)of patients with colorectal cancer.Therefore,we further explored the survival benefits in the population with BRAF V600E mutant mCRC.AIM To evaluate the efficacy of integrated Chinese and Western medicine in the treatment of BRAF V600E mutant metastatic colorectal cancer.METHODS A cohort study was conducted on patients with BRAF V600E mutant metastatic colorectal cancer admitted to Xiyuan Hospital of China Academy of Chinese Medical Sciences and Traditional Chinese Medicine Hospital of Xinjiang Uygur Autonomous Region from January 2016 to December 2022.The patients were divided into two cohorts.RESULTS A total of 34 cases were included,with 23 in Chinese-Western medicine cohort(cohort A)and 11 in Western medicine cohort(cohort B).The median overall survival was 19.9 months in cohort A and 14.2 months in cohort B,with a statistically significant difference(P=0.038,hazard ratio=0.46).The 1-3-year survival rates were 95.65%(22/23),39.13%(9/23),and 26.09%(6/23)in cohort A,and 63.64%(7/11),18.18%(2/11),and 9.09%(1/11)in cohort B,respectively.Subgroup analysis showed statistically significant differences in median OS between the two cohorts in the right colon,liver metastasis,chemotherapy,and first-line treatment subgroups(P<0.05).CONCLUSION Integrated Chinese and Western medicine can prolong the survival and reduce the risk of death in patients with BRAF V600E mutant metastatic colorectal cancer,with more pronounced benefits observed in patients with right colon involvement,liver metastasis,combined chemotherapy,and first-line treatment.

Resilience-Oriented Load Restoration Method and Repair Strategies for Regional Integrated Electricity-Natural Gas System

The rising frequency of extreme disaster events seriously threatens the safe and secure operation of the regional integrated electricity-natural gas system(RIENGS).With the growing level of coupling between electric and natural gas systems,it is critical to enhance the load restoration capability of both systems.This paper proposes a coordinated optimization strategy for resilience-enhanced RIENGS load restoration and repair scheduling and transforms it into a mixed integer second-order cone programming(MISOCP)model.The proposed model considers the distribution network reconfiguration and the coordinated repair strategy between the two systems,minimizing the total system load loss cost and repair time.In addition,a bi-directional gas flow model is used to describe the natural gas system,which can provide the RIENGS with more flexibility for load restoration during natural gas system failure.Finally,the effectiveness of the proposed approach is verified by conducting case studies on the test systems RIENGS E13-G7 and RIENGS E123-G20.

Integrated process of large-scale and size-controlled SnO_2 nanoparticles by hydrothermal method

SnO2 nanoparticles with the average particle size of 5-30 nm were synthesized using SnCl4·5H2O as the precursor and NH3·H2O as the mineralizing agent by hydrothermal method.In the case of 1 kg/batch production,the effects of synthesis conditions including solution concentration,reaction temperature,pressure,time and pH value on the grain size,particle morphology and crystal structure of SnO2 were systematically studied.The particles were characterized by X-ray diffraction（XRD） and transmission electron microscopy（TEM）.The results show that,the particle size can be well controlled in the range of 5-30 nm by adjusting the processing parameters such as reaction temperature and time when the crystal structure and particle morphology remain unchanged.The previous reports,the unusual dependences of the grain size of SnO2 on reaction temperature and time were found.The mechanism for such abnormal grain growth behavior was tentatively elucidated.

Multi-attribute decision-making based on subjective and objective integrated eigenvector method

An integrated approach is proposed to investigate the fuzzy multi-attribute decision-making （MADM） problems, where subjective preferences are expressed by a pairwise comparison matrix on the relative weights of attributes and objective information is expressed by a decision matrix. An eigenvector method integrated the subjective fuzzy preference matrix and objective information is proposed. Two linear programming models based on subjective and objective information are introduced to assess the relative importance weights of attributes in an MADM problem. The simple additive weighting method is utilized to aggregate the decision information, and then all the alternatives are ranked. Finally, a numerical example is given to show the feasibility and effectiveness of the method. The result shows that it is easier than other methods of integrating subjective and objective information.

Spatial interpolation method based on integrated RBF neural networks for estimating heavy metals in soil of a mountain region

A novel spatial interpolation method based on integrated radial basis function artificial neural networks （IRBFANNs） is proposed to provide accurate and stable predictions of heavy metals concentrations in soil at un- sampled sites in a mountain region. The IRBFANNs hybridize the advantages of the artificial neural networks and the neural networks integration approach. Three experimental projects under different sampling densities are carried out to study the performance of the proposed IRBFANNs-based interpolation method. This novel method is compared with six peer spatial interpolation methods based on the root mean square error and visual evaluation of the distribution maps of Mn elements. The experimental results show that the proposed method performs better in accuracy and stability. Moreover, the proposed method can provide more details in the spatial distribution maps than the compared interpolation methods in the cases of sparse sampling density.

Integrated interpretation of dual frequency induced polarization measurement based on wavelet analysis and metal factor methods

In mineral exploration, the apparent resistivity and apparent frequency （or apparent polarizability） parameters of induced polarization method are commonly utilized to describe the induced polarization anomaly. When the target geology structure is significantly complicated, these parameters would fail to reflect the nature of the anomaly source, and wrong conclusions may be obtained. A wavelet approach and a metal factor method were used to comprehensively interpret the induced polarization anomaly of complex geologic bodies in the Adi Bladia mine. Db5 wavelet basis was used to conduct two-scale decomposition and reconstruction, which effectively suppress the noise interference of greenschist facies regional metamorphism and magma intrusion, making energy concentrated and boundary problem unobservable. On the basis of that, the ore-induced anomaly was effectively extracted by the metal factor method.

Integrated identification method of rheological model of sandstone in Sanmenxia bauxite

Based on the uniaxial compression creep experiments conducted on bauxite sandstone obtained from Sanmenxia,typical creep experiment curves were obtained.From the characteristics of strain component of creep curves,the creep strain is composed of instantaneous elastic strain,ε（me）,instantaneous plastic strain,ε（mp）,viscoelastic strain,ε（ce）,and viscoplastic strain,ε（cp）.Based on the characteristics of instantaneous plastic strain,a new element of instantaneous plastic rheology was introduced,instantaneous plastic modulus was defined,and the modified Burgers model was established.Then identification of direct screening method in this model was completed.According to the mechanical properties of rheological elements,one- and three-dimensional creep equations in different stress levels were obtained.One-dimensional model parameters were identified by the method of least squares,and in the process of computation,Gauss-Newton iteration method was applied.Finally,by fitting the experimental curves,the correctness of direct method model was verified,then the examination of posterior exclusive method of the model was accomplished.The results showed that in the improved Burgers models,the rheological characteristics of sandstone are embodied properly,microscopic analysis of creep curves is also achieved,and the correctness of comprehensive identification method of rheological model is verified.

Integrated Surveillance Method of Mosquitoes and Mosquito-borne Diseases

Monitoring on vector-borne virus lays foundation for control of vector-borne disease, and a scientific and highly-efficient surveil ance method is of great signifi-cance for prevention and control ing of vector-borne diseases. The research sum-marized mosquito and mosquito-borne disease monitoring methods and proposed problems in the monitoring system, as wel as introducing new monitoring methods at home and abroad, providing references for improvements of integrated surveil-lance of mosquito or mosquito-borne viruses.

A stable implicit nodal integration-based particle finite element method(N-PFEM)for modelling saturated soil dynamics

In this study,we present a novel nodal integration-based particle finite element method(N-PFEM)designed for the dynamic analysis of saturated soils.Our approach incorporates the nodal integration technique into a generalised Hellinger-Reissner(HR)variational principle,creating an implicit PFEM formulation.To mitigate the volumetric locking issue in low-order elements,we employ a node-based strain smoothing technique.By discretising field variables at the centre of smoothing cells,we achieve nodal integration over cells,eliminating the need for sophisticated mapping operations after re-meshing in the PFEM.We express the discretised governing equations as a min-max optimisation problem,which is further reformulated as a standard second-order cone programming(SOCP)problem.Stresses,pore water pressure,and displacements are simultaneously determined using the advanced primal-dual interior point method.Consequently,our numerical model offers improved accuracy for stresses and pore water pressure compared to the displacement-based PFEM formulation.Numerical experiments demonstrate that the N-PFEM efficiently captures both transient and long-term hydro-mechanical behaviour of saturated soils with high accuracy,obviating the need for stabilisation or regularisation techniques commonly employed in other nodal integration-based PFEM approaches.This work holds significant implications for the development of robust and accurate numerical tools for studying saturated soil dynamics.

3D‑Printed Carbon‑Based Conformal Electromagnetic Interference Shielding Module for Integrated Electronics

Electromagnetic interference shielding(EMI SE)modules are the core com-ponent of modern electronics.However,the tra-ditional metal-based SE modules always take up indispensable three-dimensional space inside electronics,posing a major obstacle to the integra-tion of electronics.The innovation of integrating 3D-printed conformal shielding(c-SE)modules with packaging materials onto core electronics offers infinite possibilities to satisfy ideal SE func-tion without occupying additional space.Herein,the 3D printable carbon-based inks with various proportions of graphene and carbon nanotube nanoparticles are well-formulated by manipulating their rheological peculiarity.Accordingly,the free-constructed architectures with arbitrarily-customized structure and multifunctionality are created via 3D printing.In particular,the SE performance of 3D-printed frame is up to 61.4 dB,simultaneously accompanied with an ultralight architecture of 0.076 g cm^(-3) and a superhigh specific shielding of 802.4 dB cm3 g^(-1).Moreover,as a proof-of-concept,the 3D-printed c-SE module is in situ integrated into core electronics,successfully replacing the traditional metal-based module to afford multiple functions for electromagnetic compatibility and thermal dissipa-tion.Thus,this scientific innovation completely makes up the blank for assembling carbon-based c-SE modules and sheds a brilliant light on developing the next generation of high-performance shielding materials with arbitrarily-customized structure for integrated electronics.

An integrated method of selecting environmental covariates for predictive soil depth mapping

Environmental covariates are the basis of predictive soil mapping.Their selection determines the performance of soil mapping to a great extent,especially in cases where the number of soil samples is limited but soil spatial heterogeneity is high.In this study,we proposed an integrated method to select environmental covariates for predictive soil depth mapping.First,candidate variables that may influence the development of soil depth were selected based on pedogenetic knowledge.Second,three conventional methods(Pearson correlation analysis(PsCA),generalized additive models(GAMs),and Random Forest(RF))were used to generate optimal combinations of environmental covariates.Finally,three optimal combinations were integrated to produce a final combination based on the importance and occurrence frequency of each environmental covariate.We tested this method for soil depth mapping in the upper reaches of the Heihe River Basin in Northwest China.A total of 129 soil sampling sites were collected using a representative sampling strategy,and RF and support vector machine(SVM)models were used to map soil depth.The results showed that compared to the set of environmental covariates selected by the three conventional selection methods,the set of environmental covariates selected by the proposed method achieved higher mapping accuracy.The combination from the proposed method obtained a root mean square error(RMSE)of 11.88 cm,which was 2.25–7.64 cm lower than the other methods,and an R^2 value of 0.76,which was 0.08–0.26 higher than the other methods.The results suggest that our method can be used as an alternative to the conventional methods for soil depth mapping and may also be effective for mapping other soil properties.

Equivalent Method of Integrated Power Generation System of Wind, Photovoltaic and Energy Storage in Power Flow Calculation and Transient Simulation

针对工程实际开展风光储联合发电系统在潮流计算和机电暂态仿真中的等值方法研究，旨在为大容量风光储联合发电系统的并网仿真分析奠定基础。将潮流计算的等值分为单元机组和集电系统2部分来研究。单元机组等值采用根据不同控制模式选取不同节点类型的方法，针对集电系统等值提出基于损耗不变原则的方法。等值模型和详细模型的算例结果表明，潮流计算等值方法具有较好的精度。在机电暂态仿真动态等值中，基于实际工程计算的最严重工况分析原则，提出运行在满出力点的单机“倍乘”等值模型，为工程计算中的风光储联合发电系统动态等值提供了一种解决方案。

Landslide susceptibility mapping using an integrated model of information value method and logistic regression in the Bailongjiang watershed,Gansu Province,China

Bailongjiang watershed in southern Gansu province, China, is one of the most landslide-prone regions in China, characterized by very high frequency of landslide occurrence. In order to predict the landslide occurrence, a comprehensive map of landslide susceptibility is required which may be significantly helpful in reducing loss of property and human life. In this study, an integrated model of information value method and logistic regression is proposed by using their merits at maximum and overcoming their weaknesses, which may enhance precision and accuracy of landslide susceptibility assessment. A detailed and reliable landslide inventory with 1587 landslides was prepared and randomly divided into two groups,(i) training dataset and(ii) testing dataset. Eight distinct landslide conditioning factors including lithology, slope gradient, aspect, elevation, distance to drainages,distance to faults, distance to roads and vegetation coverage were selected for landslide susceptibility mapping. The produced landslide susceptibility maps were validated by the success rate and prediction rate curves. The validation results show that the success rate and the prediction rate of the integrated model are 81.7 % and 84.6 %, respectively, which indicate that the proposed integrated method is reliable to produce an accurate landslide susceptibility map and the results may be used for landslides management and mitigation.

Optimal synthesis of heat-integrated distillation configurations using the two-column superstructure

In the realm of the synthesis of heat-integrated distillation configurations,the conventional approach for exploring more heat integration possibilities typically entails the splitting of a single column into a twocolumn configuration.However,this approach frequently necessitates tedious enumeration procedures,resulting in a considerable computational burden.To surmount this formidable challenge,the present study introduces an innovative remedy:The proposition of a superstructure that encompasses both single-column and multiple two-column configurations.Additionally,a simultaneous optimization algorithm is applied to optimize both the process parameters and heat integration structures of the twocolumn configurations.The effectiveness of this approach is demonstrated through a case study focusing on industrial organosilicon separation.The results underscore that the superstructure methodology not only substantially mitigates computational time compared to exhaustive enumeration but also furnishes solutions that exhibit comparable performance.

Analysis of the integrated test and evaluation methods of tidal current energy generating devices in the offshore testing site

Actual sea condition testing and inspection and evaluation method research are carried out for tidal energy devices to provide scientific and effective technical support for the ocean high-tech achievement transformation and marine renewable energy development. By analyzing three core indicators, including the power output characteristics of the tidal current device, the generating capacity, energy conversion efficiency, proposed the test contents and evaluation methods of indicators are proposed in this paper; and based on the research of wind farms, power quality testing and assessment methods of offshore tidal energy device are proposed; given the security access to the test contents of tidal current energy device, tidal current energy device running conditions in the testing ground are comprehensively assessed.

Pixelated non-volatile programmable photonic integrated circuits with 20-level intermediate states

Multi-level programmable photonic integrated circuits(PICs)and optical metasurfaces have gained widespread attention in many fields,such as neuromorphic photonics,opticalcommunications,and quantum information.In this paper,we propose pixelated programmable Si_(3)N_(4)PICs with record-high 20-level intermediate states at 785 nm wavelength.Such flexibility in phase or amplitude modulation is achieved by a programmable Sb_(2)S_(3)matrix,the footprint of whose elements can be as small as 1.2μm,limited only by the optical diffraction limit of anin-house developed pulsed laser writing system.We believe our work lays the foundation for laser-writing ultra-high-level(20 levels and even more)programmable photonic systems and metasurfaces based on phase change materials,which could catalyze diverse applications such as programmable neuromorphic photonics,biosensing,optical computing,photonic quantum computing,and reconfigurable metasurfaces.

High-chromium vanadium-titanium magnetite all-pellet integrated burden optimization and softening-melting behavior based on flux pellets

High-chromium vanadium-titanium magnetite(HVTM)is a crucial polymetallic-associated resource to be developed.The allpellet operation is a blast furnace trend that aims to reduce carbon dioxide emissions in the future.By referencing the production data of vanadium-titanium magnetite blast furnaces,this study explored the softening-melting behavior of high-chromium vanadium-titanium magnetite and obtained the optimal integrated burden based on flux pellets.The results show that the burden with a composition of 70wt%flux pellets and 30wt%acid pellets exhibits the best softening-melting properties.In comparison to that of the single burden,the softening-melting characteristic temperature of this burden composition was higher.The melting interval first increased from 307 to 362℃and then decreased to 282℃.The maximum pressure drop(ΔPmax)decreased from 26.76 to 19.01 kPa.The permeability index(S)dropped from 4643.5 to 2446.8 kPa·℃.The softening-melting properties of the integrated burden were apparently improved.The acid pellets played a role in withstanding load during the softening process.The flux pellets in the integrated burden exhibited a higher slag melting point,which increased the melting temperature during the melting process.The slag homogeneity and the TiC produced by over-reduction led to the gas permeability deterioration of the single burden.The segregation of the flux and acid pellets in the HVTM proportion and basicity mainly led to the better softening-melting properties of the integrated burden.

Measurement of mouse liver glutathione S-transferase activity by the integrated method

Objective: The integrated method was investigated to measure Vm/Km of mouse liver glutathione S-transfer-ase (GST) activity on GSH and 7-Cl-4-nitrobenzofurazozan. Methods: Presetting concentration of one substrate twenty-fold above the other's and taking maximum product absorbance Am as parameter while Km as constant, Vm/Km was obtained by nonlinear fitting of GST reaction curve to the integrated Michaelis-Menten equation In [Am/(Am -Ai)] + Ai/ ( ξ× Km ) = ( Vm/Km )×ti (1). Results: Vm/Km for GST showed slight dependence on initial substrate concentration and data range, but it was resistant to background absorbance, error in reaction origin and small deviation in presetting Km. Vm/Km was proportional to the amount of GST with upper limit higher than that by initial rate. There was close correlation between Vm/Km and initial rate of the same GST. Consistent results were obtained by this integrated method and classical initial rate method for the measurement of mouse liver GST. Conclusion: With the concentration of one substrate twenty-fold above the other's, this integrated method was reliable to measure the activity of enzyme on two substrates , and substrate concentration of the lower one close to its apparent Km was able to be used.

Benefit allocation model of distributed photovoltaic power generation vehicle shed and energy storage charging pile based on integrated weighting-Shapley method

In this study,to develop a benefit-allocation model,in-depth analysis of a distributed photovoltaic-powergeneration carport and energy-storage charging-pile project was performed;the model was developed using Shapley integrated-empowerment benefit-distribution method.First,through literature survey and expert interview to identify the risk factors at various stages of the project,a dynamic risk-factor indicator system is developed.Second,to obtain a more meaningful risk-calculation result,the subjective and objective weights are combined,the weights of the risk factors at each stage are determined by the expert scoring method and entropy weight method,and the interest distribution model based on multi-dimensional risk factors is established.Finally,an example is used to verify the rationality of the method for the benefit distribution of the charging-pile project.The results of the example indicate that the limitations of the Shapley method can be reasonably avoided,and the applicability of the model for the benefit distribution of the charging-pile project is verified.

A coupled Legendre-Laguerre polynomial method with analytical integration for the Rayleigh waves in a quasicrystal layered half-space with an imperfect interface

The Laguerre polynomial method has been successfully used to investigate the dynamic responses of a half-space.However,it fails to obtain the correct stress at the interfaces in a layered half-space,especially when there are significant differences in material properties.Therefore,a coupled Legendre-Laguerre polynomial method with analytical integration is proposed.The Rayleigh waves in a one-dimensional(1D)hexagonal quasicrystal(QC)layered half-space with an imperfect interface are investigated.The correctness is validated by comparison with available results.Its computation efficiency is analyzed.The dispersion curves of the phase velocity,displacement distributions,and stress distributions are illustrated.The effects of the phonon-phason coupling and imperfect interface coefficients on the wave characteristics are investigated.Some novel findings reveal that the proposed method is highly efficient for addressing the Rayleigh waves in a QC layered half-space.It can save over 99%of the computation time.This method can be expanded to investigate waves in various layered half-spaces,including earth-layered media and surface acoustic wave(SAW)devices.