Colorectal cancer(CRC)is a very heterogeneous disease that is caused by the interaction of genetic and environmental factors.CRC develops through a gradual accumulation of genetic and epigenetic changes,leading to the...Colorectal cancer(CRC)is a very heterogeneous disease that is caused by the interaction of genetic and environmental factors.CRC develops through a gradual accumulation of genetic and epigenetic changes,leading to the transformation of normal colonic mucosa into invasive cancer.CRC is one of the most prevalent and incident cancers worldwide,as well as one of the most deadly.Approximately 1235108 people are diagnosed annually with CRC,and 609051 die from CRC annually.The World Health Organization estimates an increase of77%in the number of newly diagnosed cases of CRCand an increase of 80%in deaths from CRC by 2030.The incidence of CRC can benefit from different strategies depending on its stage:health promotion through health education campaigns(when the disease is not yet present),the implementation of screening programs(for detection of the disease in its early stages),and the development of nearly personalized treatments according to both patient characteristics(age,sex)and the cancer itself(gene expression).Although there are different strategies for screening and although the number of such strategies is increasing due to the potential of emerging technologies in molecular marker application,not all strategies meet the criteria required for screening tests in population programs;the three most accepted tests are the fecal occult blood test(FOBT),colonoscopy and sigmoidoscopy.FOBT is the most used method for CRC screening worldwide and is also the primary choice in most population-based screening programs in Europe.Due to its non-invasive nature and low cost,it is one of the most accepted techniques by population.CRC is a very heterogeneous disease,and with a few exceptions(APC,p53,KRAS),most of the genes involved in CRC are observed in a small percentage of cases.The design of genetic and epigenetic marker panels that are able to provide maximum coverage in the diagnosis of colorectal neoplasia seems a reasonable strategy.In recent years,the use of DNA,RNA and protein markers in different biological samples has been explored as strategies for CRC diagnosis.Although there is not yet sufficient evidence to recommend the analysis of biomarkers such as DNA,RNA or proteins in the blood or stool,it is likely that given the quick progression of technology tools in molecular biology,increasingly sensitive and less expensive,these tools will gradually be employed in clinical practice and will likely be developed in mass.展开更多
Numerous Quaternary deposits are existed in the mountainous areas of Southwest China,especially in the transition zone between the QinghaiTibet Plateau and the Sichuan Basin,where strong tectonic movements and frequen...Numerous Quaternary deposits are existed in the mountainous areas of Southwest China,especially in the transition zone between the QinghaiTibet Plateau and the Sichuan Basin,where strong tectonic movements and frequent climatic changes increase the potential landslides.The possible deformation and failure process of potential landslides and their impacts on the surrounding environment are important research topics.Field investigation and monitoring indicate that the Qingliu landslide in Xiameng town,Li County,Sichuan Province,China has been continuously deforming since August 2020.The deformation zone has a maximum deformation depth of approximately 18.9m,a total area of 54,628 m2,and a volume of 34.0×104 m3,which seriously threatens infrastructure projects and dwellings.As a result,understanding the Qingliu landslide evolution process,assessing the hazard risk,and planning disaster prevention measures are of great significance for reducing disaster loss.In this study,the mass movement process and hazard risk of the Qingliu landslide are evaluated,and the effects of different prevention measures are compared and discussed.By using the depth-integrated method,the mass movement of the Qingliu landslide is analyzed.The numerical simulation results indicate that the maximum velocity of the Qingliu landslide is approximately 37.5 m/s,and the duration of the landslide is approximately 90s.The simulated landslide can eventually form a deposited mass with a maximum deposit thickness of 19.4 m and an area of approximately 60,168.3 m2,thereby blocking the river and burying dwellings.Furthermore,a risk assessment of the Qingliu landslide under different forms of protection measures is also produced and discussed by considering the hazard level and economic vulnerability level of the affected area.Setting three layers of anti-slide piles on the deformation zone to reduce the hazard risk of the Qingliu landslide is a better choice.Our results may be useful for planning prevention measures and improving disaster emergency response systems.展开更多
The post-peak characteristics of coal serve as a direct reflection of its failure process and are essential parameters for evaluating brittleness and bursting liability.Understanding the significant factors that influ...The post-peak characteristics of coal serve as a direct reflection of its failure process and are essential parameters for evaluating brittleness and bursting liability.Understanding the significant factors that influence post-peak characteristics can offer valuable insights for the prevention of coal bursts.In this study,the Synthetic Rock Mass method is employed to establish a numerical model,and the factors affecting coal post-peak characteristics are analyzed from four perspectives:coal matrix mechanical parameters,structural weak surface properties,height-to-width ratio,and loading rate.The research identifies four significant influencing factors:deformation modulus,density of discrete fracture networks,height-to-width ratio,and loading rate.The response and sensitivity of post-peak characteristics to single-factor and multi-factor interactions are assessed.The result suggested that feasible prevention and control measures for coal bursts can be formulated through four approaches:weakening the mechanical properties of coal pillars,increasing the number of structural weak surfaces in coal pillars,reducing the width of coal pillars,and optimizing mining and excavation speed.The efficacy of measures aimed at weakening the mechanical properties of coal is successfully demonstrated through a case study on coal burst prevention using large-diameter borehole drilling.展开更多
基金Supported by Partially funded by the Carlos Ⅲ Health Institute No.PI11/01593
文摘Colorectal cancer(CRC)is a very heterogeneous disease that is caused by the interaction of genetic and environmental factors.CRC develops through a gradual accumulation of genetic and epigenetic changes,leading to the transformation of normal colonic mucosa into invasive cancer.CRC is one of the most prevalent and incident cancers worldwide,as well as one of the most deadly.Approximately 1235108 people are diagnosed annually with CRC,and 609051 die from CRC annually.The World Health Organization estimates an increase of77%in the number of newly diagnosed cases of CRCand an increase of 80%in deaths from CRC by 2030.The incidence of CRC can benefit from different strategies depending on its stage:health promotion through health education campaigns(when the disease is not yet present),the implementation of screening programs(for detection of the disease in its early stages),and the development of nearly personalized treatments according to both patient characteristics(age,sex)and the cancer itself(gene expression).Although there are different strategies for screening and although the number of such strategies is increasing due to the potential of emerging technologies in molecular marker application,not all strategies meet the criteria required for screening tests in population programs;the three most accepted tests are the fecal occult blood test(FOBT),colonoscopy and sigmoidoscopy.FOBT is the most used method for CRC screening worldwide and is also the primary choice in most population-based screening programs in Europe.Due to its non-invasive nature and low cost,it is one of the most accepted techniques by population.CRC is a very heterogeneous disease,and with a few exceptions(APC,p53,KRAS),most of the genes involved in CRC are observed in a small percentage of cases.The design of genetic and epigenetic marker panels that are able to provide maximum coverage in the diagnosis of colorectal neoplasia seems a reasonable strategy.In recent years,the use of DNA,RNA and protein markers in different biological samples has been explored as strategies for CRC diagnosis.Although there is not yet sufficient evidence to recommend the analysis of biomarkers such as DNA,RNA or proteins in the blood or stool,it is likely that given the quick progression of technology tools in molecular biology,increasingly sensitive and less expensive,these tools will gradually be employed in clinical practice and will likely be developed in mass.
基金the support of the National Natural Science Foundation of China(U2240221,41977229)the Sichuan Youth Science and Technology Innovation Research Team Project(2020JDTD0006)the Sichuan Provincial International Science and Technology Collaboration&Innovation Project(2020YFH0092)。
文摘Numerous Quaternary deposits are existed in the mountainous areas of Southwest China,especially in the transition zone between the QinghaiTibet Plateau and the Sichuan Basin,where strong tectonic movements and frequent climatic changes increase the potential landslides.The possible deformation and failure process of potential landslides and their impacts on the surrounding environment are important research topics.Field investigation and monitoring indicate that the Qingliu landslide in Xiameng town,Li County,Sichuan Province,China has been continuously deforming since August 2020.The deformation zone has a maximum deformation depth of approximately 18.9m,a total area of 54,628 m2,and a volume of 34.0×104 m3,which seriously threatens infrastructure projects and dwellings.As a result,understanding the Qingliu landslide evolution process,assessing the hazard risk,and planning disaster prevention measures are of great significance for reducing disaster loss.In this study,the mass movement process and hazard risk of the Qingliu landslide are evaluated,and the effects of different prevention measures are compared and discussed.By using the depth-integrated method,the mass movement of the Qingliu landslide is analyzed.The numerical simulation results indicate that the maximum velocity of the Qingliu landslide is approximately 37.5 m/s,and the duration of the landslide is approximately 90s.The simulated landslide can eventually form a deposited mass with a maximum deposit thickness of 19.4 m and an area of approximately 60,168.3 m2,thereby blocking the river and burying dwellings.Furthermore,a risk assessment of the Qingliu landslide under different forms of protection measures is also produced and discussed by considering the hazard level and economic vulnerability level of the affected area.Setting three layers of anti-slide piles on the deformation zone to reduce the hazard risk of the Qingliu landslide is a better choice.Our results may be useful for planning prevention measures and improving disaster emergency response systems.
基金National NaturalScience Foundation of China(52074151,52274085,52274123)Tiandi Science and Technology Co.,Ltd.Science and Technology Innovation Venture Capital Special Project(TDKC-2022-MS-01,TDKC-2022-QN-01,TDKC-2022-QN-02).
文摘The post-peak characteristics of coal serve as a direct reflection of its failure process and are essential parameters for evaluating brittleness and bursting liability.Understanding the significant factors that influence post-peak characteristics can offer valuable insights for the prevention of coal bursts.In this study,the Synthetic Rock Mass method is employed to establish a numerical model,and the factors affecting coal post-peak characteristics are analyzed from four perspectives:coal matrix mechanical parameters,structural weak surface properties,height-to-width ratio,and loading rate.The research identifies four significant influencing factors:deformation modulus,density of discrete fracture networks,height-to-width ratio,and loading rate.The response and sensitivity of post-peak characteristics to single-factor and multi-factor interactions are assessed.The result suggested that feasible prevention and control measures for coal bursts can be formulated through four approaches:weakening the mechanical properties of coal pillars,increasing the number of structural weak surfaces in coal pillars,reducing the width of coal pillars,and optimizing mining and excavation speed.The efficacy of measures aimed at weakening the mechanical properties of coal is successfully demonstrated through a case study on coal burst prevention using large-diameter borehole drilling.