Macroscopic and microscopic mechanical behavior and seepage characteristics of coal under hydro-mechanical coupling

Understanding the physical,mechanical behavior,and seepage characteristics of coal under hydro-mechanical coupling holds significant importance for ensuring the stability of surrounding rock formations and preventing gas outbursts.Scanning electron microscopy,uniaxial tests,and triaxial tests were conducted to comprehensively analyze the macroscopic and microscopic physical and mechanical characteristics of coal under different soaking times.Moreover,by restoring the stress path and water injection conditions of the protective layer indoors,we explored the coal mining dynamic behavior and the evolution of permeability.The results show that water causes the micro-surface of coal to peel off and cracks to expand and develop.With the increase of soaking time,the uniaxial and triaxial strengths were gradually decreased with nonlinear trend,and decreased by 63.31%and 30.95%after soaking for 240 h,respectively.Under different water injection pressure conditions,coal permeability undergoes three stages during the mining loading process and ultimately increases to higher values.The peak stress of coal,the deviatoric stress and strain at the permeability surge point all decrease with increasing water injection pressure.The results of this research can help improve the understanding of the coal mechanical properties and seepage evolution law under hydro-mechanical coupling.

Three‐dimensional(3D)‐printed MXene high‐voltage aqueous micro‐supercapacitors with ultrahigh areal energy density and low‐temperature tolerance

The rapid advancement in the miniaturization,integration,and intelligence of electronic devices has escalated the demand for customizable microsupercapacitors(MSCs)with high energy density.However,efficient microfabrication of safe and high‐energy MXene MSCs for integrating microelectronics remains a significant challenge due to the low voltage window in aqueous electrolytes(typically≤0.6 V)and limited areal mass loading of MXene microelectrodes.Here,we tackle these challenges by developing a highconcentration(18mol kg^(−1))“water‐in‐LiBr”(WiB)gel electrolyte for MXene symmetric MSCs(M‐SMSCs),demonstrating a record high voltage window of 1.8 V.Subsequently,additive‐free aqueous MXene ink with excellent rheological behavior is developed for three‐dimensional(3D)printing customizable all‐MXene microelectrodes on various substrates.Leveraging the synergy of a highvoltage WiB gel electrolyte and 3D‐printed microelectrodes,quasi‐solid‐state MSMSCs operating stably at 1.8 V are constructed,and achieve an ultrahigh areal energy density of 1772μWhcm^(−2) and excellent low‐temperature tolerance,with a long‐term operation at−40℃.Finally,by extending the 3D printing protocol,M‐SMSCs are integrated with humidity sensors on a single planar substrate,demonstrating their reliability in miniaturized integrated microsystems.

Afforestation with an age-sequence of Mongolian pine plantation promotes soil microbial residue accumulation in the Horqin Sandy Land, China

Land use change affects the balance of organic carbon(C)reserves and the global C cycle.Microbial residues are essential constituents of stable soil organic C(SOC).However,it remains unclear how microbial residue changes over time following afforestation.In this study,16-,23-,52-,and 62-year-old Mongolian pine stands and 16-year-old cropland were studied in the Horqin Sandy Land,China.We analyzed changes in SOC,amino sugar content,and microbial parameters to assess how microbial communities influence soil C transformation and preservation.The results showed that SOC storage increased with stand age in the early stage of afforestation but remained unchanged at about 1.27-1.29 kg/m2 after 52 a.Moreover,there were consistent increases in amino sugars and microbial residues with increasing stand age.As stand age increased from 16 to 62 a,soil pH decreased from 6.84 to 5.71,and the concentration of total amino sugars increased from 178.53 to 509.99 mg/kg.A significant negative correlation between soil pH and the concentration of specific and total amino sugars was observed,indicating that the effects of soil acidification promote amino sugar stabilization during afforestation.In contrast to the Mongolian pine plantation of the same age,the cropland accumulated more SOC and microbial residues because of fertilizer application.Across Mongolian pine plantation with different ages,there was no significant change in calculated contribution of bacterial or fungal residues to SOC,suggesting that fungi were consistently the dominant contributors to SOC with increasing time.Our results indicate that afforestation in the Horqin Sandy Land promotes efficient microbial growth and residue accumulation in SOC stocks and has a consistent positive impact on SOC persistence.

Microbiomics and metabolomics insights into the microbial regulation on the formation of flavor components in the traditional fermentation process of Chinese Hongqu aged vinegar

This study aimed to investigate microbial succession and metabolic dynamics during the traditional fermentation of Hongqu aged vinegar,and explore the core functional microbes closely related to the formation of flavor components.Microbiome analysis demonstrated that Lactobacillus,Acetobacter,Bacillus,Enterobacter,Lactococcus,Leuconostoc and Weissella were the predominant bacterial genera,while Aspergillus piperis,Aspergillus oryzae,Monascus purpureus,Candida athensensis,C.xylopsoci,Penicillium ochrosalmoneum and Simplicillium aogashimaense were the predominant fungal species.Correlation analysis revealed that Acetobacter was positively correlated with the production of tetramethylpyrazine,acetoin and acetic acid,Lactococcus showed positive correlation with the production of 2-nonanone,2-heptanone,ethyl caprylate,ethyl caprate,1-hexanol,1-octanol and 1-octen-3-ol,C.xylopsoci and C.rugosa were positively associated with the production of diethyl malonate,2,3-butanediyl diacetate,acetoin,benzaldehyde and tetramethylpyrazine.Correspondingly,non-volatile metabolites were also detected through ultra-performance liquid chromatography-quadrupole time-of-flight mass spectrometry.A variety of amino acids and functional dipeptides were identified during the traditional brewing of Hongqu aged vinegar.Correlation analysis revealed that Lactobacillus was significantly associated with DL-lactate,indolelactic acid,D-(+)-3-phenyllactic acid,pimelic acid,pregabalin and 3-aminobutanoic acid.This study is useful for understanding flavor formation mechanism and developing effective strategies for the suitable strains selection to improve the flavor quality of Hongqu aged vinegar.

Research on the Control Strategy of Micro Wind-Hydrogen Coupled System Based on Wind Power Prediction and Hydrogen Storage System Charging/Discharging Regulation

This paper addresses the micro wind-hydrogen coupled system,aiming to improve the power tracking capability of micro wind farms,the regulation capability of hydrogen storage systems,and to mitigate the volatility of wind power generation.A predictive control strategy for the micro wind-hydrogen coupled system is proposed based on the ultra-short-term wind power prediction,the hydrogen storage state division interval,and the daily scheduled output of wind power generation.The control strategy maximizes the power tracking capability,the regulation capability of the hydrogen storage system,and the fluctuation of the joint output of the wind-hydrogen coupled system as the objective functions,and adaptively optimizes the control coefficients of the hydrogen storage interval and the output parameters of the system by the combined sigmoid function and particle swarm algorithm(sigmoid-PSO).Compared with the real-time control strategy,the proposed predictive control strategy can significantly improve the output tracking capability of the wind-hydrogen coupling system,minimize the gap between the actual output and the predicted output,significantly enhance the regulation capability of the hydrogen storage system,and mitigate the power output fluctuation of the wind-hydrogen integrated system,which has a broad practical application prospect.

SmartMicro Grid Energy System Management Based on Optimum Running Cost for Rural Communities in Rwanda

The governmental electric utility and the private sector are joining hands to meet the target of electrifying all households by 2024.However,the aforementioned goal is challenged by households that are scattered in remote areas.So far,Solar Home Systems(SHS)have mostly been applied to increase electricity access in rural areas.SHSs have continuous constraints to meet electricity demands and cannot run income-generating activities.The current research presents the feasibility study of electrifying Remera village with the smart microgrid as a case study.The renewable energy resources available in Remera are the key sources of electricity in that village.The generation capacity is estimated based on the load profile.The microgrid configurations are simulated with HOMER,and the genetic algorithm is used to analyze the optimum cost.By analyzing the impact of operation and maintenance costs,the results show that the absence of subsidies increases the levelized cost of electricity(COE)five times greater than the electricity price from the public utility.The microgrid made up of PV,diesel generator,and batteries proved to be the most viable solution and ensured continuous power supply to customers.By considering the subsidies,COE reaches 0.186$/kWh,a competitive price with electricity from public utilities in Rwanda.

Gut microbiota-astrocyte axis: new insights into age-related cognitive decline

With the rapidly aging human population,age-related cognitive decline and dementia are becoming increasingly prevalent worldwide.Aging is considered the main risk factor for cognitive decline and acts through alterations in the composition of the gut microbiota,microbial metabolites,and the functions of astrocytes.The microbiota–gut–brain axis has been the focus of multiple studies and is closely associated with cognitive function.This article provides a comprehensive review of the specific changes that occur in the composition of the gut microbiota and microbial metabolites in older individuals and discusses how the aging of astrocytes and reactive astrocytosis are closely related to age-related cognitive decline and neurodegenerative diseases.This article also summarizes the gut microbiota components that affect astrocyte function,mainly through the vagus nerve,immune responses,circadian rhythms,and microbial metabolites.Finally,this article summarizes the mechanism by which the gut microbiota–astrocyte axis plays a role in Alzheimer’s and Parkinson’s diseases.Our findings have revealed the critical role of the microbiota–astrocyte axis in age-related cognitive decline,aiding in a deeper understanding of potential gut microbiome-based adjuvant therapy strategies for this condition.

不同方法对根管内氢氧化钙去除效果的micro-CT评价

目的:应用显微CT(micro-computed tomography,micro-CT)建立磨牙根管模型,评价不同方法对氢氧化钙的清除效率。方法:收集2023年10月—2024年2月口腔综合科门诊拔除的11颗磨牙(24个根管),按照标准根管治疗流程,镍钛器械预备完成后,在根管内置入氢氧化钙,1周后,根据不同冲洗方法将样本随机分为侧方开口注射器组、超声荡洗组(EMS组)和声波震荡组(EDDY组)等3组(n=8)。冲洗前后使用micro-CT重建根管系统并使用不同颜色标记独立根管,计算各个根管氢氧化钙体积,比较各组氢氧化钙清除率。采用SPSS 19.0软件包对数据进行统计学分析。结果:3种方法均无法完全去净根管内氢氧化钙。使用次氯酸钠作为冲洗液时,超声荡洗和声波震荡清除效果优于侧方开口冲洗器(P<0.05);超声荡洗和声波震荡去除氢氧化钙效率相当,差异无统计学意义(P>0.05);氢氧化钙残留部位集中于根尖区。结论:Micro-CT能较为高效地重建磨牙根管模型,可用于评价氢氧化钙去除效果。超声荡洗组和声波震荡组清除氢氧化钙效率相当,优于侧方开口注射器组。

Micro LED车灯投影光学系统设计与优化

本文提出了一种基于Micro LED阵列的车灯投影方案,设计了以像素尺寸为80μm×80μm的200×150白光Micro LED阵列作为显示光源,视场角为16°×34°的车灯投影光学系统,并对物面倾斜角度和光学系统结构进行了优化。此外,分别采用反向畸变处理方法和像素灰度调制方法用以解决车灯投影图像的梯形畸变和照度均匀性问题,并搭建了投影实验平台,对图像校正方法进行了验证。实验结果表明:校正后图像梯形畸变系数p1,p2分别从0.0932和0.3680下降至0.0835和0.0373,像面照度均匀性从83.2%提高到93.2%。本文通过对基于Micro LED的倾斜投影车灯光学系统进行优化设计及采用图像校正方法,实现了高光效、低畸变的车灯投影。

光子晶体Micro LED微显示阵列加工及光学特性分析

Micro LED器件具有高亮度、低功耗和高可靠性等优点,但Micro LED显示像素巨量转移和光提取效率低的问题为其应用带来挑战。开发了具有高转移效率和出光效率的单片64×64 Micro LED微显示阵列,提出了倒装型GaN基单片Micro LED微显示阵列芯片和Si基驱动电路的设计方法及集成工艺。通过时域有限差分(FDTD)方法对Micro LED微显示阵列光学特性进行了建模分析,设计了一种提高Micro LED微显示阵列出光效率的光提取结构。结合仿真结果,开发了一种在Micro LED蓝宝石衬底表面制备光子晶体结构的聚焦离子束(FIB)微纳加工工艺,并进行了器件加工。测试结果表明,蓝宝石衬底上加工的光子晶体结构可以提高Micro LED器件的表面出光效率,光功率平均值提升了16.36%,对Micro LED微显示阵列加工及微显示像素光提取问题具有借鉴意义。

基于Micro CT的铜导线短路熔痕孔洞特征分析

导线短路是造成电气火灾的重要原因之一。现行国家标准中将导线短路熔痕分为起火前发生的一次短路熔痕和起火后造成的二次短路熔痕,然而现行国家标准中的鉴定仅停留在定性判断的阶段。火灾现场铜导线短路熔痕特征的量化分析研究是国内外研究人员主要关注的重点。本文应用Micro CT技术对铜导线短路熔痕进行断层扫描检测并重构铜导线短路熔痕的3D图像数据,在此基础上统计、归纳、总结铜导线短路熔痕内部孔洞形态及分布等孔洞特征。研究表明,Micro CT能够全面采集铜导线短路熔痕的整体形态和内部孔洞特征,一次短路熔痕与二次短路熔痕内部孔洞半径、表面积、紧密度的特征数据存在差别,可为短路熔痕定性和定量分析判据研究提供新的理论依据。

Micro-CT分析跟骨内骨小梁分布及结构特征

背景:跟骨位于足的后下部,受力较大。跟骨外形复杂且不规则,外周有较薄的皮质骨包绕,内部充满大量的骨小梁,探讨骨小梁的微观结构、走行及分布特征有助于提高对跟骨骨折的认识。目的:采用微计算机断层扫描仪(Micro-CT)扫描跟骨标本获得其影像资料,对其内部骨小梁结构进行分析,探讨跟骨内骨小梁的形态、分布及结构特征。方法:采用Micro-CT连续扫描干燥成人跟骨标本,扫描后获得影像图像,将其以DICOM格式存储。导入影像资料到Hiscan Analyzer软件,显示清晰完整的成人跟骨矢状面、冠状面、水平面的图像,逐层观察骨小梁的走行,依据骨小梁走行特点将跟骨矢状面分为6个部分,在以7 mm为标准的相同厚度下,每个部分选择1个49 mm2等面积的兴趣区,三维重建后获得跟骨及骨小梁的立体微观结构,二值化后运用软件计算感兴趣区域内骨小梁的体积分数、表面密度、骨小梁厚度、骨小梁间隙和骨小梁数量参数。结果与结论:①跟骨表面皮质层很薄,内部充满大量骨松质,在Gissane角的骨皮质明显增厚;②跟骨上部的骨小梁体积分数大于跟骨下部前端、中和三角区、跟骨下后部、跟骨结节部、跟骨底部,跟骨结节部的骨小梁体积分数大于跟骨下部前端、中和三角区、跟骨下后部、跟骨底部;跟骨结节部的骨小梁表面密度大于跟骨下部前端、中和三角区、跟骨底部,跟骨上部、跟骨下后部的骨小梁表面密度大于中和三角区;跟骨上部的骨小梁厚度大于跟骨结节部;中和三角区的骨小梁间隙大于跟骨上部、跟骨结节部;跟骨结节部的骨小梁数量大于中和三角区;③中和三角区主要分布杆状骨小梁,骨小梁表面密度最小、体积分数较小、骨小梁间隙最大;该部位骨质较疏松,受到高冲击力时抗压缩能力差,骨小梁最先发生断裂,是易发生骨折的部位。

Effects of deformation temperatures on microstructures,aging behaviors and mechanical properties of Mg-Gd-Er-Zr alloys fabricated by hard-plate rolling

In this investigation,a high-strength Mg-12Gd-1.0Er-0.5Zr(wt.%)alloy sheet was produced by hot extrusion(HE)and subsequent hard-plate rolling(HPR)at different temperatures.The results indicate that the microstructures of these final-rolled sheets are inhomogeneous,mainly including coarse deformed grains and dynamic recrystallized(DRXed)grains,and the volume fraction of these coarse deformed grains increases as the rolling temperature increases.Thus,more DRXed grains can be found in R-385℃sheet,resulting in a smaller average grain size and weaker basal texture,while the biggest grains and the highest strong basal texture are present in R-450℃sheet.Amounts of dynamic precipitation ofβphases which are mainly determined by the rolling temperature are present in these sheets,and its precipitation can consume the content of Gd solutes in the matrix.As a result,the lowest number density ofβphase in R-450℃sheet is beneficial to modify the age hardening response.Thus,the R-450℃sheet displays the best age hardening response because of a severe traditional precipitation ofβ’(more)andβH/βM(less)precipitates,resulting in a sharp improvement in strength,i.e.ultimate tensile strength(UTS)of∼518±17 MPa and yield strength(YS)of∼438±18 MPa.However,the elongation(EL)of this sheet reduces greatly,and its value is∼2.7±0.3%.By contrasting,the EL of the peak-aging R-385℃sheet keeps better,changing from∼4.9±1.2%to∼4.8±1.4%due to a novel dislocation-induced chain-like precipitate which is helpful to keep good balance between strength and ductility.

Micro segment analysis of supercritical methane thermal-hydraulic performance and pseudo-boiling in a PCHE straight channel

The printed circuit heat exchanger(PCHE) is receiving wide attention as a new kind of compact heat exchanger and is considered as a promising vaporizer in the LNG process. In this paper, a PCHE straight channel in the length of 500 mm is established, with a semicircular cross section in a diameter of 1.2 mm.Numerical simulation is employed to investigate the flow and heat transfer performance of supercritical methane in the channel. The pseudo-boiling theory is adopted and the liquid-like, two-phase-like, and vapor-like regimes are divided for supercritical methane to analyze the heat transfer and flow features.The results are presented in micro segment to show the local convective heat transfer coefficient and pressure drop. It shows that the convective heat transfer coefficient in segments along the channel has a significant peak feature near the pseudo-critical point and a heat transfer deterioration when the average fluid temperature in the segment is higher than the pseudo-critical point. The reason is explained with the generation of vapor-like film near the channel wall that the peak feature related to a nucleateboiling-like state and heat transfer deterioration related to a film-boiling-like state. The effects of parameters, including mass flow rate, pressure, and wall heat flux on flow and heat transfer were analyzed.In calculating of the averaged heat transfer coefficient of the whole channel, the traditional method shows significant deviation and the micro segment weighted average method is adopted. The pressure drop can mainly be affected by the mass flux and pressure and little affected by the wall heat flux. The peak of the convective heat transfer coefficient can only form at high mass flux, low wall heat flux, and near critical pressure, in which condition the nucleate-boiling-like state is easier to appear. Moreover,heat transfer deterioration will always appear, since the supercritical flow will finally develop into a filmboiling-like state. So heat transfer deterioration should be taken seriously in the design and safe operation of vaporizer PCHE. The study of this work clarified the local heat transfer and flow feature of supercritical methane in microchannel and contributed to the deep understanding of supercritical methane flow of the vaporization process in PCHE.

Age-specific differences in the association between prediabetes and cardiovascular diseases in China:A national cross-sectional study

BACKGROUND Cardiovascular disease(CVD)is a leading cause of morbidity and mortality worldwide,the global burden of which is rising.It is still unclear the extent to which prediabetes contributes to the risk of CVD in various age brackets among adults.To develop a focused screening plan and treatment for Chinese adults with prediabetes,it is crucial to identify variations in the connection between prediabetes and the risk of CVD based on age.AIM To examine the clinical features of prediabetes and identify risk factors for CVD in different age groups in China.METHODS The cross-sectional study involved a total of 46239 participants from June 2007 through May 2008.A thorough evaluation was conducted.Individuals with prediabetes were categorized into two groups based on age.Chinese atherosclerotic CVD risk prediction model was employed to evaluate the risk of developing CVD over 10 years.Random forest was established in both age groups.SHapley Additive exPlanation method prioritized the importance of features from the perspective of assessment contribution.RESULTS In total,6948 people were diagnosed with prediabetes in this study.In prediabetes,prevalences of CVD were 5(0.29%)in the younger group and 148(2.85%)in the older group.Overall,11.11%of the younger group and 29.59% of the older group were intermediate/high-risk of CVD for prediabetes without CVD based on the Prediction for ASCVD Risk in China equation in ten years.In the younger age group,the 10-year risk of CVD was found to be more closely linked to family history of CVD rather than lifestyle,whereas in the older age group,resident status was more closely linked.CONCLUSION The susceptibility to CVD is age-specific in newly diagnosed prediabetes.It is necessary to develop targeted approaches for the prevention and management of CVD in adults across various age brackets.

Micro/nano-wrinkled elastomeric electrodes enabling high energy storage performance and various form factors

Stretchable elastomer-based electrodes are considered promising energy storage electrodes for next-generation wearable/flexible electronics requiring various shape designs.However,these elastomeric electrodes suffer from the limited electrical conductivity of current collectors,low charge storage capacities,poor interfacial interactions between elastomers and conductive/active materials,and lack of shape controllability.In this study,we report hierarchically micro/nano-wrinkle-structured elastomeric electrodes with notably high energy storage performance and good mechanical/electrochemical stabilities,simultaneously allowing various form factors.For this study,a swelling/deswelling-involved metal nanoparticle(NP)assembly is first performed on thiol-functionalized polydimethylsiloxane(PDMS)elastomers,generating a micro-wrinkled structure and a conductive seed layer for subsequent electrodeposition.After the assembly of metal NPs,the conformal electrodeposition of Ni and NiCo layered double hydroxides layers with a homogeneous nanostructure on the micro-wrinkled PDMS induces the formation of a micro/nano-wrinkled surface morphology with a large active surface area and high electrical conductivity.Based on this unique approach,the formed elastomeric electrodes show higher areal capacity and superior rate capability than conventional elastomeric electrodes while maintaining their electrical/electrochemical properties under external mechanical deformation.This notable mechanical/electrochemical performance can be further enhanced by using spiral-structured PDMS(stretchability of~500%)and porous-structured PDMS(areal capacity of~280μAh cm^(-2)).

Advances in microfluidic-based DNA methylation analysis

DNA methylation has been extensively investigated in recent years,not least because of its known relationship with various diseases.Progress in analytical methods can greatly increase the relevance of DNA methylation studies to both clinical medicine and scientific research.Microflu-idic chips are excellent carriers for molecular analysis,and their use can provide improvements from multiple aspects.On-chip molecular analysis has received extensive attention owing to its advantages of portability,high throughput,low cost,and high efficiency.In recent years,the use of novel microfluidic chips for DNA methylation analysis has been widely reported and has shown obvious superiority to conventional methods.In this review,wefirst focus on DNA methylation and its applications.Then,we discuss advanced microfluidic-based methods for DNA methylation analysis and describe the great progress that has been made in recent years.Finally,we summarize the advantages that microfluidic technology brings to DNA methylation analysis and describe several challenges and perspectives for on-chip DNA methylation analysis.This review should help researchers improve their understanding and make progress in developing microfluidic-based methods for DNA methylation analysis.

高亮绿光氮化镓基Micro-LED微型显示器制备

Micro-LED作为一种新型的显示技术,具有对比度高、响应快及寿命长等优点,已成为当前研究的热点。然而,尽管潜力巨大,Micro-LED技术的商业化之路仍面临诸多技术上的挑战与瓶颈。本文旨在探讨高亮绿光氮化镓基Micro-LED微型显示器的制备过程及其相关技术。基于WVGA041全数字信号电路CMOS硅基驱动电路,制作了0.41 inch、分辨率为800×480的主动式单色绿光Micro-LED微型显示器。利用高精度倒装焊接技术实现了CMOS驱动电路与LED发光芯片的电气连接。结果表明,制备出LED显示芯片正常启亮电压为2.8V,EL光谱峰值波长524nm;在硅基CMOS电路驱动范围内,Micro-LED微型显示器在5V电压下,器件亮度为108000cd/m^(2)(最大亮度可达250000 cd/m^(2)),电流密度达到0.61A/cm^(2)时色坐标为(0.175,0.756)。当电流密度从0.3A/cm^(2)增加到1.3A/cm^(2)时,色坐标从(0.178,0.757)变化到(0.175,0.746),器件的色稳定性能够满足实际应用要求。

Non-linear relationship between age and subfoveal choroidal thickness in Chinese patients with proliferative diabetic retinopathy

BACKGROUND No study has investigated the change regularity between age and subfoveal choroidal thickness(SFCT)in proliferative diabetic retinopathy(PDR).AIM To investigate the relationship between the SFCT and age in Chinese patients with PDR.METHODS This was a cross-sectional retrospective study.The participants were hospitalized individuals with type 2 diabetes who underwent vitrectomy for PDR.Contralateral eyes that met the criteria were included in the study.All necessary laboratory tests were performed at the time of admission.Central macular thickness(CMT)and SFCT were two quantitative assessments made using enhanced depth imaging optical coherence tomography.CMT was measured automatically and SFCT was measured manually with digital calipers provided by the Heidelberg Eye Explorer software.RESULTS The final analysis included a total of 234 individuals with PDR.The average age was 55.60 years old±10.03 years old,and 57.69%of the population was male.Univariate analysis revealed a significant negative connection between age and SFCT in patients with PDR[β=-2.44,95%confidence interval(95%CI):-3.46 to-1.42;P<0.0001].In the fully adjusted model,the correlation between SFCT and age remained steady(β=-1.68,95%CI:-2.97 to-0.39;P=0.0117).Spline smoothing showed that the relationship between SFCT and age in patients with PDR was non-linear,with an inflection point at 54 years of age.CONCLUSION Our findings suggest that age is a key determinant of choroidal thickness.The non-linear link between SFCT and age in PDR patients should be taken into account.

Micro RNAs与急性心肌梗死关系的研究进展

急性心肌梗死(acute myocardial infarction,AMI)是冠状动脉疾病最严重的表现,其引起的心肌组织损伤可促进心力衰竭的发展。尽管近些年由于生活方式的改变、治疗方式(如经皮冠状动脉介入治疗)的发展使AMI的预后得到了改善,但是AMI依旧每年危害着全球700多万人的身心健康,AMI仍然是世界范围内高发病率和高死亡率的主要疾病之一[1]。微小RNA(micro RNAs,miRNAs)是在20世纪90年代被发现的,mi RNAs的研究已经迅速发展成为一个成熟而广阔的领域。mi RNAs存在于几乎所有类型的细胞和细胞的病理生理活动中,包括与心血管系统相关的细胞。本文将mi RNAs对AMI病理生理进程的影响进行综述,希望为临床治疗提供新思路。