交互式数字叙事:加拿大Writing New Body Worlds阅读治疗新探索

文章基于相关研究文献与语料,对加拿大WNB阅读治疗实践进行梳理与归纳。WNB首次使用交互式数字叙事技术,构建面向公众的阅读治疗平台,以其交互式特征,融合了阅读和治疗引导两个过程,提供可访问的非临床方式,可面向大规模人群实现预防性健康干预。基于数据与计算的精准化阅读治疗是数字人文视角下的新变革,更具推广应用价值;以在线阅读平台建设为依托,推进实施平台化的阅读和治疗应成为未来发展方向之一;基于阅读形态与体验因技术赋能而改变的现状,图书馆应发挥引领作用,积极收集、创建或协助创建数字故事,推进阅读推广、服务与治疗的融合性发展,成为社区建设促进者、历史欣赏者和社区参与倡导者,也使阅读借助交互式数字叙事这一新载体,更好地发挥变革的力量,促进健康与幸福。

The Countermeasures and Researches on Improving Farmers' Incomes of Shaanxi Province in the New Period

Combining the relative agricultural statistics from 2000 to 2009, the paper selects 20 major variables to carry out the analyses of factors. Through the component matrix, 3 common factors can be gained. They are investment on agricultural production, development of the second and the third agricultural industries and policies. On the basis of these 3 common factors, the paper suggests on how to improve farmers' incomes. Such as improving farmers' agricultural management incomes, improving farmers' salary and strengthening the construction of policies and so on.

A new type of internal solitary waves with a re-appearance period of 23 h observed in the South China Sea

The South China Sea （SCS）, in particular the northern SCS, is one of ocean areas where energetic internal solitary waves （ISWs）occur most frequently （Cai et al., 2012; Zheng, 2017）. Based on the re-appearance period （RP） at an observation station, Ramp et al.（2004） divided the ISWs into two types：Type-a and Type-b. Type-a ISWs arrive regularly at the same time every day, i.e., the RP is about 24 h, and Type-b ISWs arrive about one hour late every day, i.e., the RP is about 25 h.

Biomechanical and biological responses of periodontium in orthodontic tooth movement:up-date in a new decade

Nowadays,orthodontic treatment has become increasingly popular.However,the biological mechanisms of orthodontic tooth movement(OTM)have not been fully elucidated.We were aiming to summarize the evidences regarding the mechanisms of OTM.Firstly,we introduced the research models as a basis for further discussion of mechanisms.Secondly,we proposed a new hypothesis regarding the primary roles of periodontal ligament cells(PDLCs)and osteocytes involved in OTM mechanisms and summarized the biomechanical and biological responses of the periodontium in OTM through four steps,basically in OTM temporal sequences,as follows:(1)Extracellular mechanobiology of periodontium:biological,mechanical,and material changes of acellular components in periodontium under orthodontic forces were introduced.(2)Cell strain:the sensing,transduction,and regulation of mechanical stimuli in PDLCs and osteocytes.(3)Cell activation and differentiation:the activation and differentiation mechanisms of osteoblast and osteoclast,the force-induced sterile inflammation,and the communication networks consisting of sensors and effectors.(4)Tissue remodeling:the remodeling of bone and periodontal ligament(PDL)in the compression side and tension side responding to mechanical stimuli and root resorption.Lastly,we talked about the clinical implications of the updated OTM mechanisms,regarding optimal orthodontic force(OOF),acceleration of OTM,and prevention of root resorption.

Review of Agricultural Insurance Development in the New Period in China

Agricultural insurance is a great support for agricultural modernization in the new period. It plays a role of " stabilizer" in consecutive increase of yield and constant increase of farmers' income. This paper elaborated current situation of agricultural insurance development in China in the new period,analyzed existing problems,and came up with pertinent recommendations.

Diversity of New Three-Wave Solutions and New Periodic Waves for the (3 + 1)-Dimensional Kadomtsev-Petviashvili-Boussinesq-Like Equation

Based on the generalized bilinear method, diversity of exact solutions of the (3 + 1)-dimensional Kadomtsev-Petviashvili-Boussinesq-like equation is successfully derived by using symbolic computation with Maple. These new solutions, named three-wave solutions and periodic wave have greatly enriched the existing literature. Via the three-dimensional images, density images and contour plots, the physical characteristics of these waves are well described. The new three-wave solutions and periodic solitary wave solutions obtained in this paper, will have a wide range of applications in the fields of physics and mechanics.

New insights into inflammatory osteoclast precursors as therapeutic targets for rheumatoid arthritis and periodontitis

Rheumatoid arthritis(RA)and periodontitis are chronic inflammatory diseases leading to increased bone resorption.Preventing this inflammatory bone resorption is a major health challenge.Both diseases share immunopathogenic similarities and a common inflammatory environment.The autoimmune response or periodontal infection stimulates certain immune actors,leading in both cases to chronic inflammation that perpetuates bone resorption.Moreover,RA and periodontitis have a strong epidemiological association that could be explained by periodontal microbial dysbiosis.This dysbiosis is believed to be involved in the initiation of RA via three mechanisms.(i)The dissemination of periodontal pathogens triggers systemic inflammation.(ii)Periodontal pathogens can induce the generation of citrullinated neoepitopes,leading to the generation of anti-citrullinated peptide autoantibodies.(iii)Intracellular danger-associated molecular patterns accelerate local and systemic inflammation.Therefore,periodontal dysbiosis could promote or sustain bone resorption in distant inflamed joints.Interestingly,in inflammatory conditions,the existence of osteoclasts distinct from“classical osteoclasts”has recently been reported.They have proinflammatory origins and functions.Several populations of osteoclast precursors have been described in RA,such as classical monocytes,a dendritic cell subtype,and arthritis-associated osteoclastogenic macrophages.The aim of this review is to synthesize knowledge on osteoclasts and their precursors in inflammatory conditions,especially in RA and periodontitis.Special attention will be given to recent data related to RA that could be of potential value in periodontitis due to the immunopathogenic similarities between the two diseases.Improving our understanding of these pathogenic mechanisms should lead to the identification of new therapeutic targets involved in the pathological inflammatory bone resorption associated with these diseases.

China’s Manufacturing amid New Industrialization in the 14th Five-Year Plan Period

Driven by a new round of technological and industrial revolution,China’s manufacturing industry is heading towards green,intelligent,service-based and customized development.In light of the new technological revolution and evolving industrial development model,we need to revise and breathe new life into the traditional industrialization theory.When assessing a country’s industrial development,we should use the level of industrial technology,instead of the proportion of primary,secondary and tertiary industries,as the key criterion.In addition,the level of modern industrial development should be determined according to the degree of digital,network-based,and smart features.The new industrialization theory should employ knowledge-intensive complex labor to replace simple labor as the labor factor input in the production function,and include data as a new factor of production in the analytical framework.We should also define natural resources and the environment and greenhouse gas emissions as hard constraints of the production function.In the comparison of smart,service-based and green development levels of China’s,the US’and Japan’s manufacturing sectors,our results suggest that China lags far behind developed countries in terms of the level of industrial development.During the 14th Five-Year Plan period,China’s manufacturing industry should shift from quantitative expansion to digital and smart innovations and applications,modernize the industrial system,promote industrial integration,and broaden its horizon from domestic regional planning to the global value chain.

New exact periodic solutions to (2+1)-dimensional dispersive long wave equations

In this paper, we make use of the auxiliary equation and the expanded mapping methods to find the new exact periodic solutions for （2＋1）-dimensional dispersive long wave equations in mathematical physics, which are expressed by Jacobi elliptic functions, and obtain some new solitary wave solutions （m → 1）. This method can also be used to explore new periodic wave solutions for other nonlinear evolution equations.

A NEW METHOD FOR THE PERIODIC SOLUTION OF STRONGLY NONLINEAR SYSTEMS

A new method for the periodic solution of strongly nonlinear system is given. By using this method, the existance and stability of the periodic solution can be decided, and the approximate expression of the periodic solution can also be found.

A new method to estimate wave height of specified return period

In this paper, we propose a new method to estimate the wave height of a specifi c return period based on the Hurst rule and a self-affi ne fractal formula. A detailed description of our proposed model is presented in this paper. We use the proposed model to analyze wave height data recorded along the coast of Chaolian Island from 1963 to 1989. The results show that the performance of our proposed model in estimating design wave heights is superior to traditional models.

New Periodic Wave Solutions to Generalized Klein-Gordon and Benjamin Equations

By making use of extended mapping method and auxiliary equation for finding new periodic wave solu tions of nonlinear evolution equations in mathematical physics, we obtain some new periodic wave solutions for generalized Klein-Cordon equation and Benjamin equation, which cannot be found in previous work. This method also can be used to find new periodic wave solutions of other nonlinear evolution equations.

New Families of Soliton and Periodic Solutions of Bose-Einstein Condensation in Linear Magnetic Field and Time-Dependent Laser Field

By using a new generally projective Riccati equation method and with the help of symbolic computation,we consider a nonlinear Gross-Pitaevskii equation with weak bias magnetic and time-dependent laser fields. As a result,some new soliton solutions, rational function solution, and periodic solutions are obtained.

CD301b^(+) macrophage: the new booster for activating bone regeneration in periodontitis treatment

Periodontal bone regeneration is a major challenge in the treatment of periodontitis.Currently the main obstacle is the difficulty of restoring the regenerative vitality of periodontal osteoblast lineages suppressed by inflammation,via conventional treatment.CD301b^(+)macrophages were recently identified as a subpopulation that is characteristic of a regenerative environment,but their role in periodontal bone repair has not been reported.

New Exact Periodic Solitary-Wave Solutions for New (2+1)-Dimensional KdV Equation

The extended homoclinic test function method is a kind of classic, efficient and well-developed method to solve nonlinear evolution equations. In this paper, with the help of this approach, we obtain new exact solutions （including kinky periodic solitary-wave solutions, periodic soliton solutions, and cross kink-wave solutions） for the new （2＋1）-dimensional KdV equation. These results enrich the variety of the dynamics of higher-dimensionai nonlinear wave field.

Exact Discrete Soliton Solutions and Periodic Solutions to (2+1)-Dimensional Toda Lattice with a New Algebraic Method

In this paper,with the aid of symbolic computation,we present a uniform method for constructing soliton solutions and periodic solutions to (2+1)-dimensional Toda lattice equation.

鼻咽癌中Period2下调ERK/MAPK磷酸化水平的机制

目的探讨生物钟基因Period2在鼻咽癌中下调ERK/MAPK磷酸化水平的分子机制。方法用慢病毒对细胞进行感染,构建细胞系。采用Label-free蛋白质组学检测方法对PER2蛋白表达进行验证。采用不同浓度的ERK通路激活剂Ceramide C6干预各组细胞,MTT检测各组细胞的增殖能力,筛选最佳药物浓度和作用时间。采用ERK通路激活剂Ceramide C6干预细胞,正常对照组采用等剂量药物溶剂进行处理,分为6组。Western blot检测各组细胞PER2、ERK、p38MAPK、p-ERK、p-p38MAPK蛋白的表达。流式细胞术检测细胞周期,Transwell实验检测各组细胞侵袭能力,进一步明确PER2调控ERK、MAPK磷酸化的机制。用免疫组化检测PER2、p-ERK在人体鼻咽癌样本中的表达,并分析PER2、p-ERK与鼻咽癌临床特点的相关性。结果蛋白质组学检测结果示PER2过表达组的PER2蛋白表达明显高于阴性病毒对照组和空白对照组(P<0.05)。Top 20差异蛋白显示MAPK3在PER2过表达组和对照组差异有统计学意义(P<0.05)。MTT实验结果:不同药物浓度处理后,根据每组细胞抑制率,得出最佳的药物作用浓度10μmol/L,最佳处理时间24 h。WB结果显示PER2过表达下调p-ERK、p-p38MAPK蛋白表达,ERK通路激活剂Ceramide C6干预后,在PER2-OE组中ERK、p38MAPK蛋白水平无明显变化,但p-ERK、p-p38MAPK蛋白表达水平上调,干预前后差异有统计学意义(P<0.01)。细胞周期实验结果显示:ERK通路激活剂Ceramide C6干预各组细胞后,使细胞在G1期的比例明显增加,而在G2期数量减少。Transwell实验结果显示PER2过表达抑制细胞侵袭能力,此种现象不能被磷酸激酶逆转。在鼻咽癌组织、鼻咽部黏膜中PER2蛋白、p-ERK蛋白表达阳性率差异有统计学意义(P<0.05)。PER2蛋白表达与肿瘤的T分期相关(P<0.05)。在鼻咽癌组织中PER2蛋白与p-ERK蛋白表达相关(P<0.05)。结论PER2过表达下调ERK/MAPK磷酸化水平,可能不是直接作用于ERK和p38MAPK的磷酸化位点,而是与调控ERK和p38MAPK的关键节点有关。鼻咽癌组织中PER2蛋白呈低表达,p-ERK蛋白呈高表达,两者相关,并且与肿瘤的发生、发展关系密切。

网络新媒体视阈下客家议题在日传播特征分析——基于日本Google News的考察

以日本Google News中的客家相关日文报道为语料,通过文本挖掘工具KH Coder进行文本数据挖掘,发现日本网络新闻媒体的客家议题日文报道具有分布零散性及以图片报道为主的特点。报道关注的客家区域主要涉及台湾地区、福建、香港地区、广东等地,其中,台湾地区的客家关注度最高。报道聚焦客家的观光旅游、产业振兴、客家书籍出版等相关内容,形成了客家传统建筑类、台湾地区客家文化交流类、客家文学作品推介类、客家观光旅游类等四大主要议题。本文提出要充分运用Google News等网络新媒体强大的技术功能和传播优势加大客家文化的传播力度。

Causes of Corruption in China's Rural Areas in the New Period and Countermeasures

In the new period,corruption in China's rural areas is becoming increasingly prominent. There is frequent occurrence of violation of laws and disciplines,such as the use of power for personal gain,and corruption and bribery. Main causes for the corruption in China's rural areas include imperfect rural supervision mechanism,imperfect financial system,and low crime cost. How to deal with the increasingly serious corruption situation is a topic faced at present and in the future. It is required to continue to reinforce the democratic supervision and education of village cadres,improve the comprehensive quality of villagers,and increase the crackdown and punishment of corrupt practices,so as to guarantee healthy operation of rural authorities.

New Exact Travelling Wave and Periodic Solutions of Discrete Nonlinear Schroedinger Equation

Some new exact travelling wave and period solutions of discrete nonlinearSchroedinger equation are found by using a hyperbolic tangent function approach, which was usuallypresented to find exact travelling wave solutions of certain nonlinear partial differential models.Now we can further extend the new algorithm to other nonlinear differential-different models.