Removing rain from a single image is a challenging task due to the absence of temporal information. Considering that a rainy image can be decomposed into the low-frequency(LF) and high-frequency(HF) components, where ...Removing rain from a single image is a challenging task due to the absence of temporal information. Considering that a rainy image can be decomposed into the low-frequency(LF) and high-frequency(HF) components, where the coarse scale information is retained in the LF component and the rain streaks and texture correspond to the HF component, we propose a single image rain removal algorithm using image decomposition and a dense network. We design two task-driven sub-networks to estimate the LF and non-rain HF components of a rainy image. The high-frequency estimation sub-network employs a densely connected network structure, while the low-frequency sub-network uses a simple convolutional neural network(CNN).We add total variation(TV) regularization and LF-channel fidelity terms to the loss function to optimize the two subnetworks jointly. The method then obtains de-rained output by combining the estimated LF and non-rain HF components.Extensive experiments on synthetic and real-world rainy images demonstrate that our method removes rain streaks while preserving non-rain details, and achieves superior de-raining performance both perceptually and quantitatively.展开更多
To explore the effect of removing different impurities to hydrogen networks, an MINLP model is proposed with all matching possibilities and the trade-off between operation cost and capital cost is considered. Furtherm...To explore the effect of removing different impurities to hydrogen networks, an MINLP model is proposed with all matching possibilities and the trade-off between operation cost and capital cost is considered. Furthermore,the impurity remover, hydrogen distribution, compressor and pipe setting are included in the model. Based on this model, the impurity and source(s) that are in higher priority for impurity removal, the optimal targeted concentration, and the hydrogen network with the minimum annual cost can be identified. The efficiency of the proposed model is verified by a case study.展开更多
A single-layer Artificial Neural Network (ANN) model was developed to predict the removal efficiency of Ni(II) ions from aqueous solution using shelled Moringa Oleifera seed (SMOS) powder. Batch experiments resulted i...A single-layer Artificial Neural Network (ANN) model was developed to predict the removal efficiency of Ni(II) ions from aqueous solution using shelled Moringa Oleifera seed (SMOS) powder. Batch experiments resulted into standardization of optimum conditions: biomass dosage (4.0 g), Ni(II) concentration (25 mg/L) volume (200 mL) at pH 6.5. A time of forty minutes was found sufficient to achieve the equilibrium. The ANN model was designed to predict sorption efficiency of SMOS for target metal ion by combining back propagation (BP) with principle component analysis. A sigmoid axon was used as transfer function for input and output layers. The Levenberg–Marquardt Algorithm (LMA) was applied, giving a minimum mean squared error (MSE) for training and cross validation at the ninth place of decimal.展开更多
Growth in urban population,urbanisation,and economic development has increased the demand for water,especially in water-scarce regions.Therefore,sustainable approaches to water management are needed to cope with the e...Growth in urban population,urbanisation,and economic development has increased the demand for water,especially in water-scarce regions.Therefore,sustainable approaches to water management are needed to cope with the effects of the urbanisation on the water environment.This study aimed to design novel configurations of tidal-flow vertical subsurface flow constructed wetlands(VFCWs)for treating urban stormwater.A series of laboratory experiments were conducted with semi-synthetic influent stormwater to examine the effects of the design and operation variables on the performance of the VFCWs and to identify optimal design and operational strategies,as well as maintenance requirements.The results show that the VFCWs can significantly reduce pollutants in urban stormwater,and that pollutant removal was related to specific VFCW designs.Models based on the artificial neural network(ANN)method were built using inputs derived from data exploratory techniques,such as analysis of variance(ANOVA)and principal component analysis(PCA).It was found that PCA reduced the dimensionality of input variables obtained from different experimental design conditions.The results show a satisfactory generalisation for predicting nitrogen and phosphorus removal with fewer variable inputs,indicating that monitoring costs and time can be reduced.展开更多
This article presents an Artificial Neural Network (ANN) architecture to model the Electrical Discharge Machining (EDM) process. It is aimed to develop the ANN model using an input-output pattern of raw data colle...This article presents an Artificial Neural Network (ANN) architecture to model the Electrical Discharge Machining (EDM) process. It is aimed to develop the ANN model using an input-output pattern of raw data collected from an experimental of EDM process, whereas several research objectives have been outlined such as experimenting machining material for selected gap current, identifying machining parameters for ANN variables and selecting appropriate size of data selection. The experimental data (input variables) of copper-electrode and steel-workpiece is based on a selected gap current where pulse on time, pulse off time and sparking frequency have been chosen at optimum value of Material Removal Rate (MRR). In this paper, the result has significantly demonstrated that the ANN model is capable of predicting the MRR with low percentage prediction error when compared with the experimental result.展开更多
This paper focuses on the effects of the PSt content of polystyrene (PSt)-poly (dimethylsiloxane) (PDMS) interpenetrateing network (IPN) polymer membranes, on the pervaporation (PV) characteristics during the removal ...This paper focuses on the effects of the PSt content of polystyrene (PSt)-poly (dimethylsiloxane) (PDMS) interpenetrateing network (IPN) polymer membranes, on the pervaporation (PV) characteristics during the removal of benzene from an aqueous solution of dilute benzene. When an aqueous solution of 0.05wt% benzene was permeated through the PSt-PDMS IPN membranes, they showed high benzene/water selectivity. Both the permeability and the benzene/water selectivity of the membranes were enhanced with increasing PSt content in the PSt-PDMS IPN membrane. The physicochemical mechanism of permeation and separation through the PSt-PDMS IPN membranes during PV is also discussed. The best normalized permeation rate, separation factor for benzene selectivity, and PV separation index of the PSt-PDMS IPN membrane were 1.27 × 10-6 kgm (m2hr)-1, 3293, and 41821, respectively. These PV characteristics are discussed from the viewpoint of the chemical and physical structure of the PSt-PDMS IPN membranes.展开更多
There are various phenomena of malicious information spreading in the real society, which cause many negative impacts on the society. In order to better control the spreading, it is crucial to reveal the influence of ...There are various phenomena of malicious information spreading in the real society, which cause many negative impacts on the society. In order to better control the spreading, it is crucial to reveal the influence of network structure on network spreading. Motifs, as fundamental structures within a network, play a significant role in spreading. Therefore, it is of interest to investigate the influence of the structural characteristics of basic network motifs on spreading dynamics.Considering the edges of the basic network motifs in an undirected network correspond to different tie ranges, two edge removal strategies are proposed, short ties priority removal strategy and long ties priority removal strategy. The tie range represents the second shortest path length between two connected nodes. The study focuses on analyzing how the proposed strategies impact network spreading and network structure, as well as examining the influence of network structure on network spreading. Our findings indicate that the long ties priority removal strategy is most effective in controlling network spreading, especially in terms of spread range and spread velocity. In terms of network structure, the clustering coefficient and the diameter of network also have an effect on the network spreading, and the triangular structure as an important motif structure effectively inhibits the spreading.展开更多
This study addresses challenges in fetal magnetic resonance imaging (MRI) related to motion artifacts, maternal respiration, and hardware limitations. To enhance MRI quality, we employ deep learning techniques, specif...This study addresses challenges in fetal magnetic resonance imaging (MRI) related to motion artifacts, maternal respiration, and hardware limitations. To enhance MRI quality, we employ deep learning techniques, specifically utilizing Cycle GAN. Synthetic pairs of images, simulating artifacts in fetal MRI, are generated to train the model. Our primary contribution is the use of Cycle GAN for fetal MRI restoration, augmented by artificially corrupted data. We compare three approaches (supervised Cycle GAN, Pix2Pix, and Mobile Unet) for artifact removal. Experimental results demonstrate that the proposed supervised Cycle GAN effectively removes artifacts while preserving image details, as validated through Structural Similarity Index Measure (SSIM) and normalized Mean Absolute Error (MAE). The method proves comparable to alternatives but avoids the generation of spurious regions, which is crucial for medical accuracy.展开更多
A two-layer Artificial Neural Network (ANN) model was developed to predict the removal efficiency of Cd(II) ions from aqueous solution using shelled Moringa Oleifera seed (SMOS) powder. Batch experiments re-sulted int...A two-layer Artificial Neural Network (ANN) model was developed to predict the removal efficiency of Cd(II) ions from aqueous solution using shelled Moringa Oleifera seed (SMOS) powder. Batch experiments re-sulted into standardization of optimum conditions: biomass dosage (4.0 g), Cd(II) concentration (25 mg/L) volume (200 mL) at pH 6.5. A time of forty minutes was found sufficient to achieve the equilibrium. The ANN model was designed to predict sorption efficiency of SMOS for target metal ion by combining back propagation (BP) with principle component analysis. A sigmoid axon was used as transfer function for input and output layer. The Levenberg-Marquardt algorithm (LMA) was applied, giving a minimum mean squared error (MSE) for training and cross validation at the ninth place of decimal.展开更多
Purification processes are widely used in hydrogen networks of refineries to increase hydrogen reuse. In refineries, hydrogen purification techniques include hydrocarbon, hydrogen sulfide and CO removal units. In addi...Purification processes are widely used in hydrogen networks of refineries to increase hydrogen reuse. In refineries, hydrogen purification techniques include hydrocarbon, hydrogen sulfide and CO removal units. In addition, light hydrocarbon recovery from the hydrogen source streams can also result in hydrogen purification. In order to simplify the superstructure and mathematical model of hydrogen network integration, the models of different purification processes are unified in this paper, including mass balance and the expressions for hydrogen recovery and impurity removal ratios, which are given for all the purification units in refineries. Based on the proposed unified model, a superstructure of hydrogen networks with purification processes is constructed.展开更多
Objective This study aimed to compare the mechanisms and efficacies of five formulas that improve blood circulation and remove blood stasis.Methods(1)A network pharmacology method was used to determine the targets of ...Objective This study aimed to compare the mechanisms and efficacies of five formulas that improve blood circulation and remove blood stasis.Methods(1)A network pharmacology method was used to determine the targets of five formulas that promote circulation and remove blood stasis.Compounds of the five formulas,namely Danshen Yin(丹参饮,DSY),Huoluo Xiaoling Dan(活络效灵丹,HLXLD),Shixiao San(失笑散,SXS),Taohong Siwu Tang(桃红四物汤,THSWT),and Xuefu Zhuyu Tang(血府逐瘀汤,XFZYT),were retrieved from the Traditonal Chinese Medicine System Pharmacology Database(TCMSP),the Shanghai Institute of Organic Chemistry of CAS,and the TCM Integrated Database.Drug target network was constructed by searching the Swiss Target Prediction database and the STITCH database.The target network of stasis was extracted from the PharmGKB database,the Online Mendelian Inheritance in Man(OMIM)database,the Genetic Association Database(GAD),and the Therapeutic Target Database(TTD).Candidate targets were determined using protein-protein interaction(PPI)network extension and topology selection.Thereafter,Kyoto Encyclopedia of Genes and Genomes(KEGG)enrichment analysis was used to determine the differentiation of the mechanism of the five formulas.(2)Animal experiments were conducted to explore the efficacies of the five formulas in treating blood stasis.Seventy New Zealand rabbits were exposed to high-fat feeding+epinephrine injection to construct a blood stasis syndrome model.The rabbits were evenly divided into control,model,DSY,HLXLD,SXS,THSWT,and XFZYT groups.The latter five groups were orally administered the corresponding formulas[DSY:3.92 g/(kg·d),XFZYT:7.10 g/(kg·d),SXS:1.12 g/(kg·d),HLXLD:5.60 g/(kg·d),THSWT:4.48 g/(kg·d)].Serum lipid and blood rheology were analyzed,and pathology slices were observed.Results(1)A total of 269,358,288,370,and 376 candidate targets of DSY,HLXLD,SXS,THSWT,and XFZYT were obtained among which were 232 shared candidate targets.Fluid shear stress and atherosclerosis were the biological processes common to the five formulas.HLXLD,SXS,DSY,and THSWT regulated lipolysis in adipocytes,and XFZYT,HLXLD,SXS,and THSWT regulated the AGE-RAGE signaling pathway and complement and coagulation cascades.HLXLD,SXS,and XFZYT regulated the HIF-1 signaling pathway,DSY regulated the cGMP-PKG signaling pathway,HLXLD reduced platelet activation,SXS regulated the calcium signaling pathway,and XFZYT regulated the PPAR signaling pathway.(2)In the animal experiments,the values of total cholesterol(TC),triglyceride(TG),low density lipoprotein cholesterol(LDL),high density lipoprotein cholesterol(HDL),TC/HDL,and TG/HDL in each group decreased,among which the ones seen in XFZYT,HLXLD,and SXS groups were statistically significant(P<0.05).XFZYT presented the best effect,followed by HLXLD and SXS.XFZYT and HLXLD decreased apolipoprotein B100(apoB100)and increased apolipoprotein A1/apoB100(P<0.05).XFZYT decreased all the values of hematocrit(HCT),plasma viscosity,whole blood viscosity(WBV);HLXLD and SXS affected HCT;and DSY and THSWT regulated WBV(P<0.05).All the five formulas decreased the values of optical density and area of plaque,among which XFZYT and HLXLD showed statistical significance(P<0.05).Conclusion Adjusting fluid shear stress and alleviating the injury of endothelial cells might be the common mechanisms by which the five formulas promote blood circulation and remove blood stasis.Different formulas also have unique targets,which may provide guidance for clinical drug selection.By regulating different indices,the five formulas can regulate blood lipid and hemorheology,improve the state of blood stasis,and decrease the degree of aortic plaque in the blood stasis model rabbits.XFZYT and HLXLD had higher efficacies than DSY,THSWT,and SXS.展开更多
The necessity of recognizing handwritten characters is increasing day by day because of its various applications. The objective of this paper is to provide a sophisticated, effective and efficient way to recognize and...The necessity of recognizing handwritten characters is increasing day by day because of its various applications. The objective of this paper is to provide a sophisticated, effective and efficient way to recognize and classify Bangla handwritten characters. Here an extended convolutional neural network (CNN) model has been proposed to recognize Bangla handwritten characters. Our CNN model is tested on <span style="font-family:Verdana;">“</span><span style="font-family:Verdana;">BanglalLekha-Isolated</span><span style="font-family:Verdana;">”</span><span style="font-family:Verdana;"> dataset where there are 10 classes for digits, 11 classes for vowels and 39 classes for consonants. Our model shows accuracy of recognition as: 99.50% for Bangla digits, 93.18% for vowels, 90.00% for consonants and 92.25% for combined classes.</span>展开更多
Objective:Reveal the material basis and mechanism of angiogenesis effect of Danshen-chuanxiong herb-partners.Methods:The effective components of Danshen and chuanxiong were searched in the TCM System Pharmacology Data...Objective:Reveal the material basis and mechanism of angiogenesis effect of Danshen-chuanxiong herb-partners.Methods:The effective components of Danshen and chuanxiong were searched in the TCM System Pharmacology Database(TCMSP),and the drug targets were searched in the Swiss Target Prediction database;in the Disease-Gene Database(DisGeNET))Search for angiogenesis-promoting and inhibiting angiogenesis targets;use the protein interaction database(STRING)database and Cytoscape software to analyze the network core targets;use the DAVID database to enrich the drug-disease target intersection for GO and KEGG;RT-qPCR experiments verified the effect of luteolin on MMP9 gene expression;in vitro tube formation experiments analyzed the effect of luteolin on endothelial cell neovascularization.Results:After analysis,it is concluded that Danshen has 10 active ingredients and 50 angiogenesis targets;Chuanxiong has 2 active ingredients and 4 angiogenesis targets.The intersection of drug-taking targets yielded 9 targets,including AR,PARP1,MMP9,MMP2,MMP12,AKR1B10,ABCC1,CDK6,and STAT3.After analyzing the active ingredient-target network graph of Danshen/Chuanxiong,it was concluded that luteolin is the key chemical ingredient.After protein interaction(PPI)analysis,the results showed that MMP9 is the core target.The KEGG pathway is mainly enriched in 5 signaling pathways,the most important pathway is cancer-related pathways.There are 22 main biological processes of GO,which mainly involve collagen catabolism,protein extracellular matrix,metal endopeptidase activity,etc.The preliminary analysis of tubule formation experiment shows that luteolin inhibits angiogenesis and down-regulates the expression of MMP9 gene.Conclusion:Luteolin,the key chemical component of the Danshen-Ligusticum chuanxiong drug pair,inhibits angiogenesis by regulating the MMP9 target,and develops the reverse regulation of angiogenesis for the traditional Chinese medicine for promoting blood circulation and removing blood stasis on the basis of the known treatment of ischemic diseases.Provide a new perspective and theoretical basis for the use of Danshen and Chuanxiong medicine in clinical cancer patients.Reveal the material basis and mechanism of angiogenesis effect of Danshen-chuanxiong herb-partners.展开更多
盆腔炎性疾病(Pelvic inflammation disease,PID)是妇科临床常见病和多发病,如果治疗不当或病程迁延较久,则会发展成为盆腔炎性疾病后遗症(Sequelae of PID,SPID),盆腔炎性疾病后遗症可致不孕、输卵管妊娠和盆腔充血综合征等,严重影响...盆腔炎性疾病(Pelvic inflammation disease,PID)是妇科临床常见病和多发病,如果治疗不当或病程迁延较久,则会发展成为盆腔炎性疾病后遗症(Sequelae of PID,SPID),盆腔炎性疾病后遗症可致不孕、输卵管妊娠和盆腔充血综合征等,严重影响妇女健康和生活质量。本文对黑龙江中医药大学附属第一医院门诊电子诊疗系统收集的以“活血化瘀法”治疗盆腔炎性疾病后遗症(Sequelae of pelvic inflammatory disease,SPID)的临床中药方剂进行收集整理和数据挖掘,得到核心药物及组方,为临床用药提供指导及参考。展开更多
基金supported by the National Natural Science Foundation of China(61471313)the Natural Science Foundation of Hebei Province(F2019203318)
文摘Removing rain from a single image is a challenging task due to the absence of temporal information. Considering that a rainy image can be decomposed into the low-frequency(LF) and high-frequency(HF) components, where the coarse scale information is retained in the LF component and the rain streaks and texture correspond to the HF component, we propose a single image rain removal algorithm using image decomposition and a dense network. We design two task-driven sub-networks to estimate the LF and non-rain HF components of a rainy image. The high-frequency estimation sub-network employs a densely connected network structure, while the low-frequency sub-network uses a simple convolutional neural network(CNN).We add total variation(TV) regularization and LF-channel fidelity terms to the loss function to optimize the two subnetworks jointly. The method then obtains de-rained output by combining the estimated LF and non-rain HF components.Extensive experiments on synthetic and real-world rainy images demonstrate that our method removes rain streaks while preserving non-rain details, and achieves superior de-raining performance both perceptually and quantitatively.
基金Supported by the National Natural Science Foundation of China(21276205)
文摘To explore the effect of removing different impurities to hydrogen networks, an MINLP model is proposed with all matching possibilities and the trade-off between operation cost and capital cost is considered. Furthermore,the impurity remover, hydrogen distribution, compressor and pipe setting are included in the model. Based on this model, the impurity and source(s) that are in higher priority for impurity removal, the optimal targeted concentration, and the hydrogen network with the minimum annual cost can be identified. The efficiency of the proposed model is verified by a case study.
文摘A single-layer Artificial Neural Network (ANN) model was developed to predict the removal efficiency of Ni(II) ions from aqueous solution using shelled Moringa Oleifera seed (SMOS) powder. Batch experiments resulted into standardization of optimum conditions: biomass dosage (4.0 g), Ni(II) concentration (25 mg/L) volume (200 mL) at pH 6.5. A time of forty minutes was found sufficient to achieve the equilibrium. The ANN model was designed to predict sorption efficiency of SMOS for target metal ion by combining back propagation (BP) with principle component analysis. A sigmoid axon was used as transfer function for input and output layers. The Levenberg–Marquardt Algorithm (LMA) was applied, giving a minimum mean squared error (MSE) for training and cross validation at the ninth place of decimal.
基金This research was partly supported by the UK Engineering and Physical Sciences Research Council(EPSRC)Studentship and Asset International,who provided the HDPE materials used to build bespoke constructed wetlands.
文摘Growth in urban population,urbanisation,and economic development has increased the demand for water,especially in water-scarce regions.Therefore,sustainable approaches to water management are needed to cope with the effects of the urbanisation on the water environment.This study aimed to design novel configurations of tidal-flow vertical subsurface flow constructed wetlands(VFCWs)for treating urban stormwater.A series of laboratory experiments were conducted with semi-synthetic influent stormwater to examine the effects of the design and operation variables on the performance of the VFCWs and to identify optimal design and operational strategies,as well as maintenance requirements.The results show that the VFCWs can significantly reduce pollutants in urban stormwater,and that pollutant removal was related to specific VFCW designs.Models based on the artificial neural network(ANN)method were built using inputs derived from data exploratory techniques,such as analysis of variance(ANOVA)and principal component analysis(PCA).It was found that PCA reduced the dimensionality of input variables obtained from different experimental design conditions.The results show a satisfactory generalisation for predicting nitrogen and phosphorus removal with fewer variable inputs,indicating that monitoring costs and time can be reduced.
文摘This article presents an Artificial Neural Network (ANN) architecture to model the Electrical Discharge Machining (EDM) process. It is aimed to develop the ANN model using an input-output pattern of raw data collected from an experimental of EDM process, whereas several research objectives have been outlined such as experimenting machining material for selected gap current, identifying machining parameters for ANN variables and selecting appropriate size of data selection. The experimental data (input variables) of copper-electrode and steel-workpiece is based on a selected gap current where pulse on time, pulse off time and sparking frequency have been chosen at optimum value of Material Removal Rate (MRR). In this paper, the result has significantly demonstrated that the ANN model is capable of predicting the MRR with low percentage prediction error when compared with the experimental result.
文摘This paper focuses on the effects of the PSt content of polystyrene (PSt)-poly (dimethylsiloxane) (PDMS) interpenetrateing network (IPN) polymer membranes, on the pervaporation (PV) characteristics during the removal of benzene from an aqueous solution of dilute benzene. When an aqueous solution of 0.05wt% benzene was permeated through the PSt-PDMS IPN membranes, they showed high benzene/water selectivity. Both the permeability and the benzene/water selectivity of the membranes were enhanced with increasing PSt content in the PSt-PDMS IPN membrane. The physicochemical mechanism of permeation and separation through the PSt-PDMS IPN membranes during PV is also discussed. The best normalized permeation rate, separation factor for benzene selectivity, and PV separation index of the PSt-PDMS IPN membrane were 1.27 × 10-6 kgm (m2hr)-1, 3293, and 41821, respectively. These PV characteristics are discussed from the viewpoint of the chemical and physical structure of the PSt-PDMS IPN membranes.
基金Project supported by the National Natural Science Foundation of China (Grant Nos. 62373197 and 62203229)the Postgraduate Research & Practice Innovation Program of Jiangsu Province, China (Grant No. KYCX24_1211)。
文摘There are various phenomena of malicious information spreading in the real society, which cause many negative impacts on the society. In order to better control the spreading, it is crucial to reveal the influence of network structure on network spreading. Motifs, as fundamental structures within a network, play a significant role in spreading. Therefore, it is of interest to investigate the influence of the structural characteristics of basic network motifs on spreading dynamics.Considering the edges of the basic network motifs in an undirected network correspond to different tie ranges, two edge removal strategies are proposed, short ties priority removal strategy and long ties priority removal strategy. The tie range represents the second shortest path length between two connected nodes. The study focuses on analyzing how the proposed strategies impact network spreading and network structure, as well as examining the influence of network structure on network spreading. Our findings indicate that the long ties priority removal strategy is most effective in controlling network spreading, especially in terms of spread range and spread velocity. In terms of network structure, the clustering coefficient and the diameter of network also have an effect on the network spreading, and the triangular structure as an important motif structure effectively inhibits the spreading.
文摘This study addresses challenges in fetal magnetic resonance imaging (MRI) related to motion artifacts, maternal respiration, and hardware limitations. To enhance MRI quality, we employ deep learning techniques, specifically utilizing Cycle GAN. Synthetic pairs of images, simulating artifacts in fetal MRI, are generated to train the model. Our primary contribution is the use of Cycle GAN for fetal MRI restoration, augmented by artificially corrupted data. We compare three approaches (supervised Cycle GAN, Pix2Pix, and Mobile Unet) for artifact removal. Experimental results demonstrate that the proposed supervised Cycle GAN effectively removes artifacts while preserving image details, as validated through Structural Similarity Index Measure (SSIM) and normalized Mean Absolute Error (MAE). The method proves comparable to alternatives but avoids the generation of spurious regions, which is crucial for medical accuracy.
文摘A two-layer Artificial Neural Network (ANN) model was developed to predict the removal efficiency of Cd(II) ions from aqueous solution using shelled Moringa Oleifera seed (SMOS) powder. Batch experiments re-sulted into standardization of optimum conditions: biomass dosage (4.0 g), Cd(II) concentration (25 mg/L) volume (200 mL) at pH 6.5. A time of forty minutes was found sufficient to achieve the equilibrium. The ANN model was designed to predict sorption efficiency of SMOS for target metal ion by combining back propagation (BP) with principle component analysis. A sigmoid axon was used as transfer function for input and output layer. The Levenberg-Marquardt algorithm (LMA) was applied, giving a minimum mean squared error (MSE) for training and cross validation at the ninth place of decimal.
基金Supported by the National Basic Research Program of China(2012CB720500)the National Natural Science Foundation of China(21276204,20936004)
文摘Purification processes are widely used in hydrogen networks of refineries to increase hydrogen reuse. In refineries, hydrogen purification techniques include hydrocarbon, hydrogen sulfide and CO removal units. In addition, light hydrocarbon recovery from the hydrogen source streams can also result in hydrogen purification. In order to simplify the superstructure and mathematical model of hydrogen network integration, the models of different purification processes are unified in this paper, including mass balance and the expressions for hydrogen recovery and impurity removal ratios, which are given for all the purification units in refineries. Based on the proposed unified model, a superstructure of hydrogen networks with purification processes is constructed.
基金We thank for the funding support from the Special Project of Central Government Guiding Local Science and Technology Development(No.2019XF5062)the 211 Project of Chinese Medicine Diagnostics(No.80019992)the Open Fund of National Key Discipline of Chinese Medicine Diagnostics of Hunan University of Chinese Medicine(No.ZZKF201501 and No.2015ZYZD01).
文摘Objective This study aimed to compare the mechanisms and efficacies of five formulas that improve blood circulation and remove blood stasis.Methods(1)A network pharmacology method was used to determine the targets of five formulas that promote circulation and remove blood stasis.Compounds of the five formulas,namely Danshen Yin(丹参饮,DSY),Huoluo Xiaoling Dan(活络效灵丹,HLXLD),Shixiao San(失笑散,SXS),Taohong Siwu Tang(桃红四物汤,THSWT),and Xuefu Zhuyu Tang(血府逐瘀汤,XFZYT),were retrieved from the Traditonal Chinese Medicine System Pharmacology Database(TCMSP),the Shanghai Institute of Organic Chemistry of CAS,and the TCM Integrated Database.Drug target network was constructed by searching the Swiss Target Prediction database and the STITCH database.The target network of stasis was extracted from the PharmGKB database,the Online Mendelian Inheritance in Man(OMIM)database,the Genetic Association Database(GAD),and the Therapeutic Target Database(TTD).Candidate targets were determined using protein-protein interaction(PPI)network extension and topology selection.Thereafter,Kyoto Encyclopedia of Genes and Genomes(KEGG)enrichment analysis was used to determine the differentiation of the mechanism of the five formulas.(2)Animal experiments were conducted to explore the efficacies of the five formulas in treating blood stasis.Seventy New Zealand rabbits were exposed to high-fat feeding+epinephrine injection to construct a blood stasis syndrome model.The rabbits were evenly divided into control,model,DSY,HLXLD,SXS,THSWT,and XFZYT groups.The latter five groups were orally administered the corresponding formulas[DSY:3.92 g/(kg·d),XFZYT:7.10 g/(kg·d),SXS:1.12 g/(kg·d),HLXLD:5.60 g/(kg·d),THSWT:4.48 g/(kg·d)].Serum lipid and blood rheology were analyzed,and pathology slices were observed.Results(1)A total of 269,358,288,370,and 376 candidate targets of DSY,HLXLD,SXS,THSWT,and XFZYT were obtained among which were 232 shared candidate targets.Fluid shear stress and atherosclerosis were the biological processes common to the five formulas.HLXLD,SXS,DSY,and THSWT regulated lipolysis in adipocytes,and XFZYT,HLXLD,SXS,and THSWT regulated the AGE-RAGE signaling pathway and complement and coagulation cascades.HLXLD,SXS,and XFZYT regulated the HIF-1 signaling pathway,DSY regulated the cGMP-PKG signaling pathway,HLXLD reduced platelet activation,SXS regulated the calcium signaling pathway,and XFZYT regulated the PPAR signaling pathway.(2)In the animal experiments,the values of total cholesterol(TC),triglyceride(TG),low density lipoprotein cholesterol(LDL),high density lipoprotein cholesterol(HDL),TC/HDL,and TG/HDL in each group decreased,among which the ones seen in XFZYT,HLXLD,and SXS groups were statistically significant(P<0.05).XFZYT presented the best effect,followed by HLXLD and SXS.XFZYT and HLXLD decreased apolipoprotein B100(apoB100)and increased apolipoprotein A1/apoB100(P<0.05).XFZYT decreased all the values of hematocrit(HCT),plasma viscosity,whole blood viscosity(WBV);HLXLD and SXS affected HCT;and DSY and THSWT regulated WBV(P<0.05).All the five formulas decreased the values of optical density and area of plaque,among which XFZYT and HLXLD showed statistical significance(P<0.05).Conclusion Adjusting fluid shear stress and alleviating the injury of endothelial cells might be the common mechanisms by which the five formulas promote blood circulation and remove blood stasis.Different formulas also have unique targets,which may provide guidance for clinical drug selection.By regulating different indices,the five formulas can regulate blood lipid and hemorheology,improve the state of blood stasis,and decrease the degree of aortic plaque in the blood stasis model rabbits.XFZYT and HLXLD had higher efficacies than DSY,THSWT,and SXS.
文摘The necessity of recognizing handwritten characters is increasing day by day because of its various applications. The objective of this paper is to provide a sophisticated, effective and efficient way to recognize and classify Bangla handwritten characters. Here an extended convolutional neural network (CNN) model has been proposed to recognize Bangla handwritten characters. Our CNN model is tested on <span style="font-family:Verdana;">“</span><span style="font-family:Verdana;">BanglalLekha-Isolated</span><span style="font-family:Verdana;">”</span><span style="font-family:Verdana;"> dataset where there are 10 classes for digits, 11 classes for vowels and 39 classes for consonants. Our model shows accuracy of recognition as: 99.50% for Bangla digits, 93.18% for vowels, 90.00% for consonants and 92.25% for combined classes.</span>
基金Fund Project:Outstanding Doctoral Graduates of Shanxi University of Traditional Chinese Medicine Come to Shanxi to Work,Reward Funds,Scientific Research Start-Up Fund Project(No.2020BKS06)。
文摘Objective:Reveal the material basis and mechanism of angiogenesis effect of Danshen-chuanxiong herb-partners.Methods:The effective components of Danshen and chuanxiong were searched in the TCM System Pharmacology Database(TCMSP),and the drug targets were searched in the Swiss Target Prediction database;in the Disease-Gene Database(DisGeNET))Search for angiogenesis-promoting and inhibiting angiogenesis targets;use the protein interaction database(STRING)database and Cytoscape software to analyze the network core targets;use the DAVID database to enrich the drug-disease target intersection for GO and KEGG;RT-qPCR experiments verified the effect of luteolin on MMP9 gene expression;in vitro tube formation experiments analyzed the effect of luteolin on endothelial cell neovascularization.Results:After analysis,it is concluded that Danshen has 10 active ingredients and 50 angiogenesis targets;Chuanxiong has 2 active ingredients and 4 angiogenesis targets.The intersection of drug-taking targets yielded 9 targets,including AR,PARP1,MMP9,MMP2,MMP12,AKR1B10,ABCC1,CDK6,and STAT3.After analyzing the active ingredient-target network graph of Danshen/Chuanxiong,it was concluded that luteolin is the key chemical ingredient.After protein interaction(PPI)analysis,the results showed that MMP9 is the core target.The KEGG pathway is mainly enriched in 5 signaling pathways,the most important pathway is cancer-related pathways.There are 22 main biological processes of GO,which mainly involve collagen catabolism,protein extracellular matrix,metal endopeptidase activity,etc.The preliminary analysis of tubule formation experiment shows that luteolin inhibits angiogenesis and down-regulates the expression of MMP9 gene.Conclusion:Luteolin,the key chemical component of the Danshen-Ligusticum chuanxiong drug pair,inhibits angiogenesis by regulating the MMP9 target,and develops the reverse regulation of angiogenesis for the traditional Chinese medicine for promoting blood circulation and removing blood stasis on the basis of the known treatment of ischemic diseases.Provide a new perspective and theoretical basis for the use of Danshen and Chuanxiong medicine in clinical cancer patients.Reveal the material basis and mechanism of angiogenesis effect of Danshen-chuanxiong herb-partners.
文摘盆腔炎性疾病(Pelvic inflammation disease,PID)是妇科临床常见病和多发病,如果治疗不当或病程迁延较久,则会发展成为盆腔炎性疾病后遗症(Sequelae of PID,SPID),盆腔炎性疾病后遗症可致不孕、输卵管妊娠和盆腔充血综合征等,严重影响妇女健康和生活质量。本文对黑龙江中医药大学附属第一医院门诊电子诊疗系统收集的以“活血化瘀法”治疗盆腔炎性疾病后遗症(Sequelae of pelvic inflammatory disease,SPID)的临床中药方剂进行收集整理和数据挖掘,得到核心药物及组方,为临床用药提供指导及参考。