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Some Special Types of Solitary Wave Solutions for (3+1)-Dimensional Jimbo-MiwaEquation 被引量:3
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作者 BAICheng-Lin ZHAOHong 《Communications in Theoretical Physics》 SCIE CAS CSCD 2004年第6期875-877,共3页
Using the extended homogeneous balance method, we find some special types of single solitary wave solution and new types of the multisoliton solutions of the (3+1)-dimensional Jimbo-Miwa equation.
关键词 3+1维Jimbo-Miwa方程 扩展均相平衡理论 孤立解 非线性偏微分方程
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Similarity Reductions and Similarity Solutions of the (3+1)-Dimensional Kadomtsev-Petviashvili Equation 被引量:14
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作者 刘娜 刘希强 《Chinese Physics Letters》 SCIE CAS CSCD 2008年第10期3527-3530,共4页
采用相容性方法,我们获得对称(3+1 ) 维的 Kadomtsev-Petviashvili (KP ) 方程。KP 方程的类似减小的四种类型被解决与对称方程联系的相应典型方程获得。另外, KP 方程的很多类似答案被获得。[从作者抽象]
关键词 (3+1)维KP方程 相似归纳 相似解 数学物理方法
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Conformal Invariant Asymptotic Expansion Approach for Solving (3+1)-Dimensional JM Equation 被引量:1
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作者 LI Zhi-Fang RUAN Hang-Yu 《Communications in Theoretical Physics》 SCIE CAS CSCD 2006年第6期979-984,共6页
(3+1 ) 维的 Jimbo-Miwa (JM ) 方程被使用 Ruan 介绍的保角的不变的 asymptotic 扩大途径近似解决。由解决新(3+1 ) 维的 integrable 当模特儿,它是保角的不变并且拥有 Painleve 性质,近似答案为 JM 方程被获得,包含不仅不仅 one-so... (3+1 ) 维的 Jimbo-Miwa (JM ) 方程被使用 Ruan 介绍的保角的不变的 asymptotic 扩大途径近似解决。由解决新(3+1 ) 维的 integrable 当模特儿,它是保角的不变并且拥有 Painleve 性质,近似答案为 JM 方程被获得,包含不仅不仅 one-solitonsolutions 和 multi-soliton 答案。一些近似答案碰巧准确,一些近似答案能由适当地选择在参数之间的关系变得准确。 展开更多
关键词 (3+1)维Jimbo-Miwa方程 共形不变量渐近扩展逼近 Painlevé特性 近似解 精确解
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Periodic Wave Solution to the (3+1)-Dimensional Boussinesq Equation 被引量:3
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作者 吴勇旗 《Chinese Physics Letters》 SCIE CAS CSCD 2008年第8期2739-2742,共4页
的一个周期、二周期的波浪解决方案(3+1 ) 维的 Boussinesq 方程借助于 Hirota 的双线性的方法和 Riemann theta 函数被介绍。soliton 答案能在一个适当限制过程从周期的波浪答案被获得。
关键词 周期波 (3+1)维Boussinesq方程 解题方法 数学物理
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All Single Traveling Wave Solutions to (3+1)-Dimensional Nizhnok-Novikov-Veselov Equation 被引量:12
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作者 LIU Cheng-Shi 《Communications in Theoretical Physics》 SCIE CAS CSCD 2006年第6期991-992,共2页
用基本不可分的方法,的所有可能的准确旅行波浪答案的一个完全的分类(3+1 ) 维的 Nizhnok-Novikov-Veselov 方程被给。Somesolutions 是新的。
关键词 Nizhnok-Novikov-Veselov方程 行波解 元素积分法 延长同质平衡法
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Applications of Extended Mapping Deformation Method in Two (3+1)-Dimensional Nonlinear Models 被引量:1
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作者 HUANGWen-Hua ZHANGJie-Fang GEWei-Kuan 《Communications in Theoretical Physics》 SCIE CAS CSCD 2005年第5期775-780,共6页
Based on the extended mapping deformation method and symbolic computation, many exact travelling wave solutions are found for the (3+1)-dimensional JM equation and the (3+1)-dimensional KP equation. The obtained solut... Based on the extended mapping deformation method and symbolic computation, many exact travelling wave solutions are found for the (3+1)-dimensional JM equation and the (3+1)-dimensional KP equation. The obtained solutions include solitary solution, periodic wave solution, rational travelling wave solution, and Jacobian and Weierstrass function solution, etc. 展开更多
关键词 非线性偏微分方程 JM函数 行进波 精确解
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New Exact Solutions and Conservation Laws to (3+1)-Dimensional Potential-YTSF Equation 被引量:10
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作者 ZHANG Li-Hua LIU Xi-Qiang 《Communications in Theoretical Physics》 SCIE CAS CSCD 2006年第3期487-492,共6页
用修改 CK 的直接方法,我们造在新答案和旧的和 Snd 一些之间的关系的新准确答案(3+1 ) 维的 potential-YTSFequation。基于不变的组理论,谎言点对称组和谎言对称(3+1 ) 维的 potential-YTSF 方程被获得。我们也与给定的谎言对称得到... 用修改 CK 的直接方法,我们造在新答案和旧的和 Snd 一些之间的关系的新准确答案(3+1 ) 维的 potential-YTSFequation。基于不变的组理论,谎言点对称组和谎言对称(3+1 ) 维的 potential-YTSF 方程被获得。我们也与给定的谎言对称得到方程的能量守恒定律。 展开更多
关键词 精确解法 守恒法则 对称群 三维空间势能-YTSF方程
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A Generalized Variable-Coefficient Algebraic Method Exactly Solving (3+1)-Dimensional Kadomtsev-Petviashvilli Equation 被引量:3
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作者 BAI Cheng-Lin BAI Cheng-Jie ZHAO Hong 《Communications in Theoretical Physics》 SCIE CAS CSCD 2005年第5X期821-826,共6页
A generalized variable-coefficient algebraic method is applied to construct several new families of exact solutions of physical interestfor (3+1)-dimensional Kadomtsev-Petviashvilli (KP) equation. Among them, the Jaco... A generalized variable-coefficient algebraic method is applied to construct several new families of exact solutions of physical interestfor (3+1)-dimensional Kadomtsev-Petviashvilli (KP) equation. Among them, the Jacobi elliptic periodic solutions exactly degenerate to the soliton solutions at a certain limit condition. Compared with the existing tanh method, the extended tanh method, the Jacobi elliptic function method, and the algebraic method, the proposed method gives new and more general solutions. 展开更多
关键词 三维KP方程 变量系数 代数法 精确解 椭圆周期函数
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Variable Separation Solutions in (1+1)-Dimensional and (3+1)-Dimensional Systems via Entangled Mapping Approach
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作者 DAI Chao-Qing YAN Cai-Jie ZHANG Jie-Fang 《Communications in Theoretical Physics》 SCIE CAS CSCD 2006年第3X期389-392,共4页
关键词 纠缠映射逼近 (1+1)维系统 (3+1)维Burgers系统 EMA
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New Families of Nontravelling Wave Solutions to Two (3+1)-Dimensional Equations
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作者 BAICheng-Lin LIUXi-Qiang ZHAOHong 《Communications in Theoretical Physics》 SCIE CAS CSCD 2005年第3期417-422,共6页
In this paper, two (3+1)-dimensional equations are investigated. A uto-Backlund transformation is obtained,which is used with some ansatze to seek new types of exact solutions including some arbitrary functions. When ... In this paper, two (3+1)-dimensional equations are investigated. A uto-Backlund transformation is obtained,which is used with some ansatze to seek new types of exact solutions including some arbitrary functions. When these arbitrary functions are taken as some special functions, these solutions possess abundant structures. These solutions contain soliton-like solutions and rational solutions. 展开更多
关键词 孤相解 有理解 高维非线性偏微分方程 非行进波
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3-Dimensional Kinematic Comparison of Arm Movements between an Individual with NGLY1 Deficiency and a Neurotypical Individual
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作者 Charles S. Layne Christopher A. Malaya +6 位作者 Brock Futrell Dacia Martinez Diaz Christian Alfaro Hannah E. Gustafson Subhalakshmi Chandrasekaran Rhea M. Phatak Bernhard Suter 《Case Reports in Clinical Medicine》 2024年第4期122-146,共25页
NGLY1 Deficiency is an ultra-rare autosomal recessively inherited disorder. Characteristic symptoms include among others, developmental delays, movement disorders, liver function abnormalities, seizures, and problems ... NGLY1 Deficiency is an ultra-rare autosomal recessively inherited disorder. Characteristic symptoms include among others, developmental delays, movement disorders, liver function abnormalities, seizures, and problems with tear formation. Movements are hyperkinetic and may include dysmetric, choreo-athetoid, myoclonic and dystonic movement elements. To date, there have been no quantitative reports describing arm movements of individuals with NGLY1 Deficiency. This report provides quantitative information about a series of arm movements performed by an individual with NGLY1 Deficiency and an aged-matched neurotypical participant. Three categories of arm movements were tested: 1) open ended reaches without specific end point targets;2) goal-directed reaches that included grasping an object;3) picking up small objects from a table placed in front of the participants. Arm movement kinematics were obtained with a camera-based motion analysis system and “initiation” and “maintenance” phases were identified for each movement. The combination of the two phases was labeled as a “complete” movement. Three-dimensional analysis techniques were used to quantify the movements and included hand trajectory pathlength, joint motion area, as well as hand trajectory and joint jerk cost. These techniques were required to fully characterize the movements because the NGLY1 individual was unable to perform movements only in the primary plane of progression instead producing motion across all three planes of movement. The individual with NGLY1 Deficiency was unable to pick up objects from a table or effectively complete movements requiring crossing the midline. The successfully completed movements were analyzed using the above techniques and the results of the two participants were compared statistically. Almost all comparisons revealed significant differences between the two participants, with a notable exception of the 3D initiation area as a percentage of the complete movement. The statistical tests of these measures revealed no significant differences between the two participants, possibly suggesting a common underlying motor control strategy. The 3D techniques used in this report effectively characterized arm movements of an individual with NGLY1 deficiency and can be used to provide information to evaluate the effectiveness of genetic, pharmacological, or physical rehabilitation therapies. 展开更多
关键词 NGLY1 Deficiency Developmental Disorders KINEMATICS 3 Dimensional Analyses
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Localized wave solutions and interactions of the (2+1)-dimensional Hirota-Satsuma-Ito equation
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作者 巩乾坤 王惠 王云虎 《Chinese Physics B》 SCIE EI CAS CSCD 2024年第4期409-416,共8页
This paper studies the(2+1)-dimensional Hirota-Satsuma-Ito equation.Based on an associated Hirota bilinear form,lump-type solution,two types of interaction solutions,and breather wave solution of the(2+1)-dimensional ... This paper studies the(2+1)-dimensional Hirota-Satsuma-Ito equation.Based on an associated Hirota bilinear form,lump-type solution,two types of interaction solutions,and breather wave solution of the(2+1)-dimensional Hirota-Satsuma-Ito equation are obtained,which are all related to the seed solution of the equation.It is interesting that the rogue wave is aroused by the interaction between one-lump soliton and a pair of resonance stripe solitons,and the fusion and fission phenomena are also found in the interaction between lump solitons and one-stripe soliton.Furthermore,the breather wave solution is also obtained by reducing the two-soliton solutions.The trajectory and period of the one-order breather wave are analyzed.The corresponding dynamical characteristics are demonstrated by the graphs. 展开更多
关键词 lump solution rogue wave solution breather wave solution (2+1)-dimensional Hirota-Satsuma-Ito equation
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Identifying the enhancement mechanism of Al/MoO_(3) reactive multilayered films on the ignition ability of semiconductor bridge using a one-dimensional gas-solid two-phase flow model
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作者 Jianbing Xu Yuxuan Zhou +3 位作者 Yun Shen Yueting Wang Yinghua Ye Ruiqi Shen 《Defence Technology(防务技术)》 SCIE EI CAS CSCD 2024年第3期168-179,共12页
Energetic Semiconductor bridge(ESCB)based on reactive multilayered films(RMFs)has a promising application in the miniature and intelligence of initiator and pyrotechnics device.Understanding the ignition enhancement m... Energetic Semiconductor bridge(ESCB)based on reactive multilayered films(RMFs)has a promising application in the miniature and intelligence of initiator and pyrotechnics device.Understanding the ignition enhancement mechanism of RMFs on semiconductor bridge(SCB)during the ignition process is crucial for the engineering and practical application of advanced initiator and pyrotechnics devices.In this study,a one-dimensional(1D)gas-solid two-phase flow ignition model was established to study the ignition process of ESCB to charge particles based on the reactivity of Al/MoO_(3) RMFs.In order to fully consider the coupled exothermic between the RMFs and the SCB plasma during the ignition process,the heat release of chemical reaction in RMFs was used as an internal heat source in this model.It is found that the exothermal reaction in RMFs improved the ignition performance of SCB.In the process of plasma rapid condensation with heat release,the product of RMFs enhanced the heat transfer process between the gas phase and the solid charge particle,which accelerated the expansion of hot plasma,and heated the solid charge particle as well as gas phase region with low temperature.In addition,it made up for pressure loss in the gas phase.During the plasma dissipation process,the exothermal chemical reaction in RMFs acted as the main heating source to heat the charge particle,making the surface temperature of the charge particle,gas pressure,and gas temperature rise continuously.This result may yield significant advantages in providing a universal ignition model for miniaturized ignition devices. 展开更多
关键词 Ignition enhancement mechanism 1D gas-solid two-phase flow Al/MoO_(3)reactive multilayered films Semiconductor bridge Miniaturized ignition device
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Lie symmetry analysis and invariant solutions for the(3+1)-dimensional Virasoro integrable model
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作者 胡恒春 李雅琦 《Chinese Physics B》 SCIE EI CAS CSCD 2023年第4期249-254,共6页
Lie symmetry analysis is applied to a(3+1)-dimensional Virasoro integrable model and the corresponding similarity reduction equations are obtained with the different infinitesimal generators.Invariant solutions with a... Lie symmetry analysis is applied to a(3+1)-dimensional Virasoro integrable model and the corresponding similarity reduction equations are obtained with the different infinitesimal generators.Invariant solutions with arbitrary functions for the(3+1)-dimensional Virasoro integrable model,including the interaction solution between a kink and a soliton,the lump-type solution and periodic solutions,have been studied analytically and graphically. 展开更多
关键词 (3+1)-dimensional Virasoro integrable model Lie symmetry invariant solutions
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Interaction solutions for the second extended(3+1)-dimensional Jimbo–Miwa equation
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作者 马红彩 毛雪 邓爱平 《Chinese Physics B》 SCIE EI CAS CSCD 2023年第6期112-121,共10页
Based on the Hirota bilinear method,the second extended(3+1)-dimensional Jimbo–Miwa equation is established.By Maple symbolic calculation,lump and lump-kink soliton solutions are obtained.The interaction solutions be... Based on the Hirota bilinear method,the second extended(3+1)-dimensional Jimbo–Miwa equation is established.By Maple symbolic calculation,lump and lump-kink soliton solutions are obtained.The interaction solutions between the lump and multi-kink soliton,and the interaction between the lump and triangular periodic soliton are derived by combining a multi-exponential function or trigonometric sine and cosine functions with quadratic functions.Furthermore,periodiclump wave solution is derived via the ansatz including hyperbolic and trigonometric functions.Finally,3D plots,2D curves,density plots,and contour plots with particular choices of the suitable parameters are depicted to illustrate the dynamical features of these solutions. 展开更多
关键词 Hirota bilinear method second extended(3+1)-dimensional Jimbo–Miwa equation lump solution interaction solution
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有氧运动训练影响阿尔茨海默症小鼠海马Notch1、Caspase-3的表达 被引量:2
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作者 杨力源 张业廷 +1 位作者 李垂坤 魏翠兰 《中国组织工程研究》 CAS 北大核心 2024年第26期4113-4120,共8页
背景:β-淀粉样蛋白和Tau蛋白会对阿尔茨海默症患者的认知功能产生不良影响,研究发现Notch1及Caspase-3能够调控β-淀粉样蛋白和Tau蛋白的表达。Notch1及Caspase-3是否介导了有氧运动改善阿尔茨海默症患者认知能力的过程还不清楚,目前... 背景:β-淀粉样蛋白和Tau蛋白会对阿尔茨海默症患者的认知功能产生不良影响,研究发现Notch1及Caspase-3能够调控β-淀粉样蛋白和Tau蛋白的表达。Notch1及Caspase-3是否介导了有氧运动改善阿尔茨海默症患者认知能力的过程还不清楚,目前缺乏长期有氧运动影响阿尔茨海默症小鼠海马中Notch1及Caspase-3表达的研究。目的:观察长期有氧运动干预阿尔茨海默症小鼠的空间学习记忆情况及其海马中Notch1及Caspase-3的表达,探讨Notch1及Caspase-3对阿尔茨海默症小鼠的影响。方法:将3月龄野生型及APP/PS1双转基因阿尔茨海默症小鼠随机分为4组:野生对照组、野生运动组、阿尔茨海默症对照组、阿尔茨海默症运动组,每组20只。对照组小鼠不进行运动,运动组小鼠进行5个月的有氧运动干预。运动干预结束后,采用Morris水迷宫检测小鼠空间学习记忆能力;采用Real-timePCR、免疫荧光及Westernblot检测各组小鼠海马组织Aβ_(1-42)、Tau、Notch1及Caspase-3蛋白的表达。结果与结论:①阿尔茨海默症小鼠空间学习记忆能力显著差于野生组(P<0.05);运动组小鼠空间学习记忆能力显著优于对照组(P<0.05);②阿尔茨海默症对照组小鼠海马Aβ_(1-42)、Tau、Notch1及Caspase-3表达均显著高于野生对照组(P<0.05);阿尔茨海默症运动组小鼠海马Aβ_(1-42)、Tau、Notch1及Caspase-3表达显著低于阿尔茨海默症对照组(P<0.05);③提示:长期有氧运动干预能够改善阿尔茨海默症小鼠的空间学习记忆能力,而这可能与有氧运动降低阿尔茨海默症小鼠海马Notch1、Caspase-3、Aβ_(1-42)及Tau蛋白表达有关。 展开更多
关键词 阿尔茨海默症 有氧运动 学习记忆能力 NOTCH1 CASPASE-3
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miR-141-3p对腰椎间盘突出症大鼠背根神经节炎症及下肢疼痛的抑制和改善作用 被引量:3
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作者 许刚 张长春 +2 位作者 朱坤 叶雨辰 周平辉 《中国组织工程研究》 CAS 北大核心 2024年第16期2593-2598,共6页
背景:研究表明,胰岛素样生长因子1/血小板源性生长因子有抑制纤维环细胞凋亡的作用。miR-141-3p微小RNA在骨髓基质细胞中随着年龄的增加而增加,且与炎症信号通路的活化存在一定关系,提示其可能成为腰椎间盘突出症的治疗靶点。目的:探究m... 背景:研究表明,胰岛素样生长因子1/血小板源性生长因子有抑制纤维环细胞凋亡的作用。miR-141-3p微小RNA在骨髓基质细胞中随着年龄的增加而增加,且与炎症信号通路的活化存在一定关系,提示其可能成为腰椎间盘突出症的治疗靶点。目的:探究miR-141-3p通过调控胰岛素样生长因子1/血小板源性生长因子对腰椎间盘突出症大鼠背根神经节炎症及下肢疼痛的影响。方法:选取50只SPF级SD雄性大鼠,随机分为正常组、模型组、miR-NC组、miR-141-3p inhibitor组、miR-141-3p mimics组,每组10只。除正常组外,其余大鼠采用自体髓核移植法进行腰椎间盘突出症建模。建模成功后,对miR-NC组、miR-141-3p inhibitor组和miR-141-3p mimics组大鼠鞘内分别注射10μL 20μmol/L miR-NC,miR-141-3p inhibitor,miR-141-3p mimics,均每天注射1次,连续注射28 d;正常组、模型组同期同位置注射同体积生理盐水。采用热缩足潜伏期阈值评价大鼠下肢疼痛,实时荧光定量PCR检测背根神经节组织miR-141-3p mRNA表达,ELISA法检测背根神经节组织炎症因子,免疫印迹法检测背根神经节组织胰岛素样生长因子1/血小板源性生长因子蛋白表达,并分析miR-141-3p与胰岛素样生长因子1/血小板源性生长因子的相关性。结果与结论:miR-NC组各项指标与模型组比较,差异均无显著性意义。①大鼠热缩足潜伏期阈值:模型组明显低于正常组(P<0.05),miR-141-3p inhibitor组明显低于miR-NC组(P<0.05),miR-141-3p mimics组明显高于miR-141-3p inhibitor组(P<0.05)。②背根神经节组织miR-141-3p mRNA表达:模型组明显低于正常组(P<0.05),miR-141-3p inhibitor组明显低于miR-NC组(P<0.05),miR-141-3p mimics组明显高于miR-141-3p inhibitor组(P<0.05)。③背根神经节组织肿瘤坏死因子α、白细胞介素1β、白细胞介素1含量:模型组明显高于正常组(P<0.05),miR-141-3p inhibitor组明显高于miR-NC组(P<0.05),miR-141-3p mimics组明显低于miR-141-3p inhibitor组(P<0.05)。④背根神经节组织胰岛素样生长因子1、血小板源性生长因子蛋白表达:模型组明显低于正常组(P<0.05),miR-141-3p inhibitor组明显低于miR-NC组(P<0.05),miR-141-3p mimics组明显高于miR-141-3p inhibitor组(P<0.05)。⑤胰岛素样生长因子1与miR-141-3p呈正相关(r=0.904,P<0.001),血小板源性生长因子与miR-141-3p呈正相关(r=0.879,P<0.001)。⑥结论:miR-141-3p可显著改善腰椎间盘突出症大鼠下肢疼痛,抑制背根神经节炎症,其机制可能与促进胰岛素样生长因子1/血小板源性生长因子表达有关。 展开更多
关键词 miR-141-3p IGF-1/PDGF 腰椎间盘突出症 背根神经节炎症 下肢疼痛
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金雀异黄素通过调控TGF-β1/Smad3信号通路对2型糖尿病大鼠心肌纤维化的影响 被引量:1
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作者 姜欣 王智 王娟 《中成药》 CAS CSCD 北大核心 2024年第2期444-450,共7页
目的 探讨金雀异黄素减轻糖尿病大鼠心肌纤维化的作用及潜在机制。方法 通过高脂饮食结合腹腔注射链脲菌素(STZ)法建立大鼠2型糖尿病(T2DM)模型,并随机分为模型组、二甲双胍组(100 mg/kg)及金雀异黄素低、高剂量组(50、100 mg/kg),另设... 目的 探讨金雀异黄素减轻糖尿病大鼠心肌纤维化的作用及潜在机制。方法 通过高脂饮食结合腹腔注射链脲菌素(STZ)法建立大鼠2型糖尿病(T2DM)模型,并随机分为模型组、二甲双胍组(100 mg/kg)及金雀异黄素低、高剂量组(50、100 mg/kg),另设正常组给予常规饮食,每组10只。各给药组灌胃给药8周,检测体质量、心功能、心脏质量及心脏指数,血清CK-MB、AST及LDH活性,观察心肌纤维化程度,心肌组织转化生长因子-β1(TGF-β1)、Smad同源物3(Smad3)mRNA和蛋白表达,心肌组织Ⅰ型胶原(CollagenⅠ)和Ⅲ型胶原(CollagenⅢ)蛋白分布及表达。结果 与模型组比较,金雀异黄素各剂量组大鼠体质量、每搏输出量(SV)及射血分数(EF)升高(P<0.01),心脏指数、左心室收缩末期内径(LVIDs)、血清肌酸激酶同工酶(CK-MB)、天冬氨酸氨基转移酶(AST)、乳酸脱氢酶(LDH)活性降低(P<0.05,P<0.01),心肌组织胶原相对面积及CollagenⅠ、CollagenⅢ蛋白表达均降低(P<0.05,P<0.01),心肌组织TGF-β1、Smad3 mRNA和蛋白表达降低(P<0.05,P<0.01),金雀异黄素高剂量组左心室舒张末期内径(LVIDd)降低(P<0.05)。结论 金雀异黄素可通过抑制TGF-β1/Smad3信号通路,减轻2型糖尿病大鼠心肌纤维化作用,进而发挥保护心脏效应。 展开更多
关键词 金雀异黄素 糖尿病 心肌纤维化 TGF-β1/Smad3信号通路
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NRG1、HER3在前列腺癌组织中的表达及其与临床病理特征和预后的关系
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作者 王潇然 陆巍 +5 位作者 于欣 王永杰 王勇 廉吉虎 李震霄 宋海涛 《疑难病杂志》 CAS 2024年第1期63-67,共5页
目的研究前列腺癌(PC)组织中神经调节蛋白1(NRG1)、人表皮生长因子受体3(HER3)表达与临床病理特征及预后的关系。方法选取2015年2月—2020年2月吉林省人民医院泌尿外科诊治PC患者96例,免疫组织化学检测组织中NRG1、HER3表达;Kaplan-Meie... 目的研究前列腺癌(PC)组织中神经调节蛋白1(NRG1)、人表皮生长因子受体3(HER3)表达与临床病理特征及预后的关系。方法选取2015年2月—2020年2月吉林省人民医院泌尿外科诊治PC患者96例,免疫组织化学检测组织中NRG1、HER3表达;Kaplan-Meier曲线(Log-Rank检验)比较不同NRG1、HER3表达对PC患者预后的影响;COX回归分析PC患者预后的影响因素。结果PC癌组织中NRG1、HER3阳性率分别为78.13%(75/96)、75.00%(72/96),高于癌旁组织6.25%(6/96)、8.33%(8/96)(χ^(2)/P=101.670/<0.001,87.771/<0.001)。TNM分期Ⅲ期、Gleason评分>7分及术前PSA水平≥20μg/L患者癌组织中NRG1、HER3阳性率大于TNM分期Ⅰ~Ⅱ期、Gleason评分≤7分及术前PSA水平<20μg/L(χ^(2)/P=6.181/0.013,8.533/0.003;7.731/0.005,6.769/0.009;6.508/0.011,7.376/0.007)。NRG1阳性组、HER3阳性组3年累积无进展生存率分别低于NRG1阴性组、HER3阴性组(χ^(2)/P=4.267/0.039,5.499/0.019)。TNM分期Ⅲ期、Gleason评分>7分、术前PSA≥20μg/L、NRG1阳性,HER3阳性是影响PC患者预后的独立危险因素[OR(95%CI)=1.448(1.118~1.875),1.401(1.138~1.724),1.353(1.059~1.728),1.338(1.057~1.692),1.293(1.014~1.649)]。结论PC癌组织中NRG1、HER3表达升高,与PC不良临床病理特征相关,是新的评估PC预后的肿瘤标志物。 展开更多
关键词 前列腺癌 神经调节蛋白1 人表皮生长因子受体3 预后
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胡黄连苷Ⅱ调节RIP1/RIP3/MLKL信号对地塞米松诱导成骨细胞凋亡的影响 被引量:1
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作者 陈鹏 李杨 欧阳鹏辉 《中国骨质疏松杂志》 CAS CSCD 北大核心 2024年第5期662-667,683,共7页
目的探讨胡黄连苷Ⅱ调节受体相互作用蛋白激酶(RIP)1/RIP3/混合系列蛋白激酶样结构域(MLKL)信号对地塞米松(DEX)诱导成骨细胞凋亡的影响。方法体外培养hFOB 1.19细胞,随机分为对照组、DEX组、DEX+胡黄连苷Ⅱ组、DEX+RIP1过表达组、DEX+... 目的探讨胡黄连苷Ⅱ调节受体相互作用蛋白激酶(RIP)1/RIP3/混合系列蛋白激酶样结构域(MLKL)信号对地塞米松(DEX)诱导成骨细胞凋亡的影响。方法体外培养hFOB 1.19细胞,随机分为对照组、DEX组、DEX+胡黄连苷Ⅱ组、DEX+RIP1过表达组、DEX+空载质粒组、DEX+胡黄连苷Ⅱ+RIP1过表达组,分组处理后检测各组细胞活力、凋亡率、活性氧(ROS)相对水平、乳酸脱氢酶(LDH)、白细胞介素(IL)-1β、肿瘤坏死因子-α(TNF-α)及IL-6释放量、BCL-2及BAX相对表达、RIP1/RIP3/MLKL信号蛋白表达。结果与对照组相比,DEX组细胞活力、BCL-2相对表达降低(P<0.05),凋亡率、ROS相对水平、LDH及IL-1β、TNF-α、IL-6释放量、细胞BAX及RIP1、RIP3、MLKL蛋白相对表达升高(P<0.05)。与DEX组相比,DEX+胡黄连苷Ⅱ组细胞活力、BCL-2相对表达升高(P<0.05),凋亡率、ROS相对水平、LDH及IL-1β、TNF-α、IL-6释放量、细胞BAX及RIP1、RIP3、MLKL蛋白相对表达降低(P<0.05);DEX+RIP1过表达组细胞活力、BCL-2相对表达降低(P<0.05),凋亡率、ROS相对水平、LDH及IL-1β、TNF-α、IL-6释放量、细胞BAX及RIP1、RIP3、MLKL蛋白相对表达升高(P<0.05);DEX+空载质粒组细胞各指标差异无统计学意义(P>0.05);过表达RIP1可减弱胡黄连苷Ⅱ对DEX诱导的hFOB 1.19细胞的作用。结论胡黄连苷Ⅱ可通过下调RIP1/RIP3/MLKL通路而减轻炎症,从而抑制DEX诱导的成骨细胞凋亡。 展开更多
关键词 胡黄连苷Ⅱ RIP1/RIP3/MLKL DEX 成骨细胞 凋亡
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