目的运用Meta分析探寻SLC6A11基因rs2272394、rs2272395和rs2272400多态性是否与成人耐药性癫痫患者的耐药性密切相关。方法制订文献检索方案,通过检索Pubmed、Embase、Cochrane图书馆、Web of Science数据库、中国知网、万方数据知识...目的运用Meta分析探寻SLC6A11基因rs2272394、rs2272395和rs2272400多态性是否与成人耐药性癫痫患者的耐药性密切相关。方法制订文献检索方案,通过检索Pubmed、Embase、Cochrane图书馆、Web of Science数据库、中国知网、万方数据知识服务平台和维普资讯中文期刊服务平台检索数据库搜索有关SLC6A11基因多态性与耐药性癫痫治疗相关的中外文献,由两人共同筛选文献,提取数据并进行交叉核对,对纳入的文献进行质量评价后,将符合标准的文献纳入,使用R4.2.1软件对文献进行Meta分析,同时采用基因模型进行分析。结果4篇文献中的9项研究被纳入,其中耐药组病例共有1172例,药物敏感组病例共有1340例。其中等位基因C与T采用固定效应模型得出OR=0.89,95%CI=0.79~1.01;剔除一篇边缘性研究后,结果示OR=0.93,95%CI=0.82~1.06;隐性基因模型CC/TC+TT的OR=0.79,95%CI=0.67~0.92;显性基因模型TT/TC+CC的OR=0.99,95%CI=0.80~1.23;加性基因模型CC/TT的OR=0.86,95%CI=0.63~1.16;超显性基因模型TT+CC/TC的OR=0.83,95%CI=0.72~0.97。结论目前暂无明确证据证明SLC6A11基因的rs2272394、rs2272395和rs2272400多态性与耐药性癫痫有关。展开更多
Developing an effective method to synthesize high-performance high-voltage LiCoO_(2) is essential for its industrialization in lithium batteries(LIBs).This work proposes a simple mass-produced strategy for the first t...Developing an effective method to synthesize high-performance high-voltage LiCoO_(2) is essential for its industrialization in lithium batteries(LIBs).This work proposes a simple mass-produced strategy for the first time,that is,negative temperature coefficient thermosensitive Pr_(6)O_(11) nanoparticles are uniformly modified on LiCoO_(2) to prepare LiCoO_(2)@Pr_(6)O_(11)(LCO@PrO)via a liquid-phase mixing combined with annealing method.Tested at 274 mA g−1,the modified LCO@PrO electrodes deliver excellent 4.5 V high-voltage cycling performance with capacity retention ratios of 90.8%and 80.5%at 25 and 60℃,being much larger than those of 22.8%and 63.2%for bare LCO electrodes.Several effective strategies were used to clearly unveil the performance enhancement mechanism induced by Pr_(6)O_(11) modification.It is discovered that Pr_(6)O_(11) can improve interface compatibility,exhibit improved conductivity at elevated temperature,thus enhance the Li^(+)diffusion kinetics,and suppress the phase transformation of LCO and its resulting mechanical stresses.The 450 mAh LCO@PrO‖graphite pouch cells show excellent LIB performance and improved thermal safety characteristics.Importantly,the energy density of such pouch cell was increased even by~42%at 5 C.This extremely convenient technology is feasible for producing high-energy density LIBs with negligible cost increase,undoubtedly providing important academic inspiration for industrialization.展开更多
针对巴氏合金ZChSnSb11-6工作过程中的蠕变现象，对合金进行蠕变实验。基于蠕变实验所得蠕变曲线，证实ZChSnSb11-6在实际工作条件下会发生明显的蠕变现象，同时利用WDW-E100D试验机，获得ZChSnSb11-6蠕变前后的屈服强度等力学性能。通...针对巴氏合金ZChSnSb11-6工作过程中的蠕变现象，对合金进行蠕变实验。基于蠕变实验所得蠕变曲线，证实ZChSnSb11-6在实际工作条件下会发生明显的蠕变现象，同时利用WDW-E100D试验机，获得ZChSnSb11-6蠕变前后的屈服强度等力学性能。通过分析合金蠕变、力学性能和显微组织之间的关系，得知蠕变明显降低ZChSnSb11-6的强度、塑性及抗弹性变形能力，并得到合金蠕变机理，明确ZChSnSb11-6蠕变变形是应变硬化与再结晶回复长时间交替作用的结果。通过计算合金的应变硬化指数，证实蠕变使合金均匀变形的能力降低，增大合金发生断裂破坏的可能性。同时，基于硬度试验获得合金硬度随温度变化的计算公式，确定ZChSnSb11-6的蠕变临界温度范围为50~60℃。通过观察ZChSnSb11-6蠕变前后的显微组织，发现蠕变使合金组织中SnSb和Cu 6 Sn 5明显减少，导致合金力学性能降低。展开更多
文摘目的运用Meta分析探寻SLC6A11基因rs2272394、rs2272395和rs2272400多态性是否与成人耐药性癫痫患者的耐药性密切相关。方法制订文献检索方案,通过检索Pubmed、Embase、Cochrane图书馆、Web of Science数据库、中国知网、万方数据知识服务平台和维普资讯中文期刊服务平台检索数据库搜索有关SLC6A11基因多态性与耐药性癫痫治疗相关的中外文献,由两人共同筛选文献,提取数据并进行交叉核对,对纳入的文献进行质量评价后,将符合标准的文献纳入,使用R4.2.1软件对文献进行Meta分析,同时采用基因模型进行分析。结果4篇文献中的9项研究被纳入,其中耐药组病例共有1172例,药物敏感组病例共有1340例。其中等位基因C与T采用固定效应模型得出OR=0.89,95%CI=0.79~1.01;剔除一篇边缘性研究后,结果示OR=0.93,95%CI=0.82~1.06;隐性基因模型CC/TC+TT的OR=0.79,95%CI=0.67~0.92;显性基因模型TT/TC+CC的OR=0.99,95%CI=0.80~1.23;加性基因模型CC/TT的OR=0.86,95%CI=0.63~1.16;超显性基因模型TT+CC/TC的OR=0.83,95%CI=0.72~0.97。结论目前暂无明确证据证明SLC6A11基因的rs2272394、rs2272395和rs2272400多态性与耐药性癫痫有关。
基金jointly supported by the Natural Science Foundations of China(Nos.22179020,12174057)Fujian Natural Science Foundation for Distinguished Young Scholars(Grant No.2020J06042)+2 种基金Foreign science and technology cooperation project of Fuzhou Science and Technology Bureau(No.2021-Y-086)Natural Science Foundation of Fujian Province(Grant No.2018J01660)Cultivation plan of outstanding young scientific research talents of Fujian Education Department(Grant No.J1-1323).
文摘Developing an effective method to synthesize high-performance high-voltage LiCoO_(2) is essential for its industrialization in lithium batteries(LIBs).This work proposes a simple mass-produced strategy for the first time,that is,negative temperature coefficient thermosensitive Pr_(6)O_(11) nanoparticles are uniformly modified on LiCoO_(2) to prepare LiCoO_(2)@Pr_(6)O_(11)(LCO@PrO)via a liquid-phase mixing combined with annealing method.Tested at 274 mA g−1,the modified LCO@PrO electrodes deliver excellent 4.5 V high-voltage cycling performance with capacity retention ratios of 90.8%and 80.5%at 25 and 60℃,being much larger than those of 22.8%and 63.2%for bare LCO electrodes.Several effective strategies were used to clearly unveil the performance enhancement mechanism induced by Pr_(6)O_(11) modification.It is discovered that Pr_(6)O_(11) can improve interface compatibility,exhibit improved conductivity at elevated temperature,thus enhance the Li^(+)diffusion kinetics,and suppress the phase transformation of LCO and its resulting mechanical stresses.The 450 mAh LCO@PrO‖graphite pouch cells show excellent LIB performance and improved thermal safety characteristics.Importantly,the energy density of such pouch cell was increased even by~42%at 5 C.This extremely convenient technology is feasible for producing high-energy density LIBs with negligible cost increase,undoubtedly providing important academic inspiration for industrialization.
文摘针对巴氏合金ZChSnSb11-6工作过程中的蠕变现象，对合金进行蠕变实验。基于蠕变实验所得蠕变曲线，证实ZChSnSb11-6在实际工作条件下会发生明显的蠕变现象，同时利用WDW-E100D试验机，获得ZChSnSb11-6蠕变前后的屈服强度等力学性能。通过分析合金蠕变、力学性能和显微组织之间的关系，得知蠕变明显降低ZChSnSb11-6的强度、塑性及抗弹性变形能力，并得到合金蠕变机理，明确ZChSnSb11-6蠕变变形是应变硬化与再结晶回复长时间交替作用的结果。通过计算合金的应变硬化指数，证实蠕变使合金均匀变形的能力降低，增大合金发生断裂破坏的可能性。同时，基于硬度试验获得合金硬度随温度变化的计算公式，确定ZChSnSb11-6的蠕变临界温度范围为50~60℃。通过观察ZChSnSb11-6蠕变前后的显微组织，发现蠕变使合金组织中SnSb和Cu 6 Sn 5明显减少，导致合金力学性能降低。
