Polycomb group （PCG） complexes are epigenetic regulatory complexes that conduct transcriptional repression of target genes via modifying the chromatin. The two best characterized forms of PCG complexes, polycomb rep...Polycomb group （PCG） complexes are epigenetic regulatory complexes that conduct transcriptional repression of target genes via modifying the chromatin. The two best characterized forms of PCG complexes, polycomb repressive complexes 1 and 2 （PRC1 and PRC2）, are required for maintaining the sternness of embryonic stem cells and many types of adult stem cells. The spectra of target genes for PRCs are dynamically changing with cell differentiation, which is essential for proper decisions on cell fate during developmental processes, Chromobox （CBX） family proteins are canonical components in PRC1, responsible for targeting PRC1 to the chromatin. Recent studies highlight the function specifications among CBX family members in undifferentiated and differentiated stem cells, which reveal the interplay between compositional diversity and functional specificity of PRCI. In this review, we summarize the current knowledge about targeting and functional mechanisms of PRCs, emphasizing the recent breakthroughs related to CBX proteins under a number of physiological and pathological conditions.展开更多
CBX(Chromobox)家族成员在不同肿瘤中的表达情况以及作用各异,在宫颈癌中的表达情况、临床意义和预后价值尚未清楚,有关个别成员的研究结果也存在争议。本研究通过ONCOMINE、GEPIA2、Human Protein Atlas、UALCAN、Kaplan-Meier Plotte...CBX(Chromobox)家族成员在不同肿瘤中的表达情况以及作用各异,在宫颈癌中的表达情况、临床意义和预后价值尚未清楚,有关个别成员的研究结果也存在争议。本研究通过ONCOMINE、GEPIA2、Human Protein Atlas、UALCAN、Kaplan-Meier Plotter等数据库分析了CBX家族成员在宫颈癌中的临床意义和预后价值。在8个CBX家族成员中,与正常宫颈组织相比,CBX2/4/8在宫颈癌中的mRNA水平显著升高,而CBX6和CBX7的mRNA水平显著降低。CBX家族中各成员在宫颈癌中的表达意义各异,CBX1、CBX3与宫颈癌分化程度有关,CBX4还与宫颈癌淋巴转移相关,CBX2、CBX8与宫颈癌病理分期有关,CBX6与宫颈癌分期、分化以及淋巴结转移都有关,而CBX7可以作为预测宫颈癌患者生存期的标志物。展开更多
基金Project supported by the Fundamental Research Funds for the Central Universities from Lanzhou University (No.lzujbky-2014-87),China
文摘Polycomb group （PCG） complexes are epigenetic regulatory complexes that conduct transcriptional repression of target genes via modifying the chromatin. The two best characterized forms of PCG complexes, polycomb repressive complexes 1 and 2 （PRC1 and PRC2）, are required for maintaining the sternness of embryonic stem cells and many types of adult stem cells. The spectra of target genes for PRCs are dynamically changing with cell differentiation, which is essential for proper decisions on cell fate during developmental processes, Chromobox （CBX） family proteins are canonical components in PRC1, responsible for targeting PRC1 to the chromatin. Recent studies highlight the function specifications among CBX family members in undifferentiated and differentiated stem cells, which reveal the interplay between compositional diversity and functional specificity of PRCI. In this review, we summarize the current knowledge about targeting and functional mechanisms of PRCs, emphasizing the recent breakthroughs related to CBX proteins under a number of physiological and pathological conditions.
文摘CBX(Chromobox)家族成员在不同肿瘤中的表达情况以及作用各异,在宫颈癌中的表达情况、临床意义和预后价值尚未清楚,有关个别成员的研究结果也存在争议。本研究通过ONCOMINE、GEPIA2、Human Protein Atlas、UALCAN、Kaplan-Meier Plotter等数据库分析了CBX家族成员在宫颈癌中的临床意义和预后价值。在8个CBX家族成员中,与正常宫颈组织相比,CBX2/4/8在宫颈癌中的mRNA水平显著升高,而CBX6和CBX7的mRNA水平显著降低。CBX家族中各成员在宫颈癌中的表达意义各异,CBX1、CBX3与宫颈癌分化程度有关,CBX4还与宫颈癌淋巴转移相关,CBX2、CBX8与宫颈癌病理分期有关,CBX6与宫颈癌分期、分化以及淋巴结转移都有关,而CBX7可以作为预测宫颈癌患者生存期的标志物。
