目的探讨山奈酚(kaempferol,KAE)对慢性脑缺血大鼠的作用及其机制。方法采用双侧颈总动脉永久性结扎(bilateral common carotid arteries occlusion,2VO)建立大鼠慢性脑缺血动物模型;Morris水迷宫、抓握实验检测大鼠行为学;尼氏染色及H...目的探讨山奈酚(kaempferol,KAE)对慢性脑缺血大鼠的作用及其机制。方法采用双侧颈总动脉永久性结扎(bilateral common carotid arteries occlusion,2VO)建立大鼠慢性脑缺血动物模型;Morris水迷宫、抓握实验检测大鼠行为学;尼氏染色及HE染色观察脑组织病理改变;比色法检测MDA含量和SOD活性;Western blot检测脑组织DJ-1蛋白表达水平。结果与2-VO模型组比较,KAE明显改善慢性脑缺血诱导的学习记忆障碍和抓握能力损伤。此外,KAE明显减轻2VO大鼠脑组织病理损伤,增高脑组织中SOD活性,提高海马和皮层中抗氧化蛋白DJ-1的表达水平。结论KAE明显改善慢性脑缺血诱导的大鼠认知功能障碍、四肢平衡能力障碍及病理损伤,其机制可能与提高体内抗氧化系统有关。展开更多
Vehicular ad hoc networks （VANETs） that use the IEEE 802.11p communication standard face a number of challenges, not least when it comes to safety messages on the VANET control channel （CCH） where short delay time...Vehicular ad hoc networks （VANETs） that use the IEEE 802.11p communication standard face a number of challenges, not least when it comes to safety messages on the VANET control channel （CCH） where short delay times and reliable delivery are of pri- mary importance. In this paper we propose a vehicular machine-to-machine （VM2M） overlay network that uses Long Term Evolu- tion （LTE） physical random access channel （PRACH） to emulate VANET CCH. The overlay network uses dedicated preambles to separate vehicular traffic from regular LTE traffic and a cartier sense multiple access with collision avoidance （CSMA-CA） layer similar to the one used in IEEE 802.15.4 to avoid the four step handshake and the overhead it incurs. The performance of the pro- posed overlay is evaluated under a wide range of PRACH parameters which conform to the scenarios with high vehicle velocities and large distances between roadside units （RSUs） that may be encountered in rural areas and on highways.展开更多
文摘Vehicular ad hoc networks （VANETs） that use the IEEE 802.11p communication standard face a number of challenges, not least when it comes to safety messages on the VANET control channel （CCH） where short delay times and reliable delivery are of pri- mary importance. In this paper we propose a vehicular machine-to-machine （VM2M） overlay network that uses Long Term Evolu- tion （LTE） physical random access channel （PRACH） to emulate VANET CCH. The overlay network uses dedicated preambles to separate vehicular traffic from regular LTE traffic and a cartier sense multiple access with collision avoidance （CSMA-CA） layer similar to the one used in IEEE 802.15.4 to avoid the four step handshake and the overhead it incurs. The performance of the pro- posed overlay is evaluated under a wide range of PRACH parameters which conform to the scenarios with high vehicle velocities and large distances between roadside units （RSUs） that may be encountered in rural areas and on highways.
