目的探讨血清磷脂酰肌醇蛋白聚糖-3(phosphatidylinositol proteoglycan-3,GPC-3)、前列腺酸性磷酸酶(prostatic acid phosphatase,PAP)、前列腺癌抗原-2(prostate cancer antigen-2,EPCA-2)及联合前列腺特异性抗原(prostatic specific ...目的探讨血清磷脂酰肌醇蛋白聚糖-3(phosphatidylinositol proteoglycan-3,GPC-3)、前列腺酸性磷酸酶(prostatic acid phosphatase,PAP)、前列腺癌抗原-2(prostate cancer antigen-2,EPCA-2)及联合前列腺特异性抗原(prostatic specific antigen,PSA)检测在前列腺癌中的诊断价值.方法选取确诊的78例前列腺癌患者(前列腺癌组)和50例良性前列腺增生患者(前列腺增生组)作为研究对象,并选取同期与之配对的80例男性健康体检者作为对照组.用酶联免疫吸附试验检测血清GPC-3、PAP和EPCA-2水平,用时间分辨荧光分析法检测血清PSA水平,并绘制受试者工作特征(ROC)曲线分析GPC-3、PAP、EPCA-2和PSA对前列腺癌的诊断价值.结果前列腺癌组、前列腺增生组和对照组血清GPC-3、PAP、EPCA-2和PSA依次降低,3组比较差异均有统计学意义(P<0.05).血清GPC-3、PAP、EPCA-2和PSA 4个单项指标对前列腺癌均有一定的诊断价值,其敏感度及特异度分别为62.48%、63.31%,64.82%、60.19%,66.55%、63.33%,68.15%、65.92%(P=0.041、0.045、0.038、0.024);但联合检测可明显提高其诊断效能,以GPC-3+PAP+EPCA-2+PSA联合检测效果最佳,其敏感度和特异度分别为95.78%和92.89%.结论血清GPC-3、PAP、EPCA-2及PSA对前列腺癌均有一定诊断价值,但联合检测可明显提高其诊断效果,尤以GPC-3、PAP、EPCA-2及PSA四者联合效能最佳.展开更多
目的:探讨血清早期前列腺癌抗原-2(Early Prostate Cancer Antigen,EPCA-2)、游离型/总PSA(F/TPSA)在前列腺癌(PCa)诊断中的临床应用价值。方法:用酶联免疫吸附测定法(ELISA)分别对前列腺癌组与良性前列腺增生组患者血清进行检测EPCA-2...目的:探讨血清早期前列腺癌抗原-2(Early Prostate Cancer Antigen,EPCA-2)、游离型/总PSA(F/TPSA)在前列腺癌(PCa)诊断中的临床应用价值。方法:用酶联免疫吸附测定法(ELISA)分别对前列腺癌组与良性前列腺增生组患者血清进行检测EPCA-2值、F/TPSA值及PSA值,所得数据的分析和处理采用SPSS17.0统计学软件进行。结果:(1)前列腺癌组PSA水平显著高于BPH组,差异有统计学意义(P<0.01)。(2)前列腺癌组FPSA/TPSA水平比值显著低于BPH组,差异有统计学意义(P<0.01)。(3)前列腺癌组EPCA-2水平为(63.45±23.49)ng/mL,而BPH组EPCA-2水平为(16.60±7.62)ng/mL,较前列腺癌组明显为低,差异具有统计学意义(P<0.01)。(4)诊断能力EPCA-2>FPSA/TPSA>PSA。(5)FPSA/TPSA水平与EPCA-2水平之间无相关关系。(6)若将EPCA-2与FPSA/TPSA比值联合应用预测前列腺癌的特异性为90.00%,敏感性为95.00%。结论:EPCA-2、FPSA/TPSA、PSA三者相比在诊断前列腺癌方面的能力排名为EPCA-2>FPSA/TPSA>PSA,并且EPCA-2与FPSA/TPSA比值之间无相关性。若将EPCA-2与FPSA/TPSA比值联合应用在前列腺癌诊断方面可大大提高诊断率,降低活检率。展开更多
This paper presents a study of the full three-dimensional thermo-mechanical （TM） behavior of rock pillar in,Aspo Pillar Stability Experiment （APSE） using a self-developed numerical code TM-EPCA3D. The transient th...This paper presents a study of the full three-dimensional thermo-mechanical （TM） behavior of rock pillar in,Aspo Pillar Stability Experiment （APSE） using a self-developed numerical code TM-EPCA3D. The transient thermal conduction function was descritized on space and time scales, and was solved by using cellular automaton （CA） method on space scale and finite difference method on time scale, respectively. The advantage of this approach is that no global, but local matrix is used so that it avoids the need to develop and solve large-scale linear equations and the complexity therein. A thermal conductivity versus stress function was proposed to reflect the effect of stress on thermal field. The temperature evolution and induced thermal stress in the pillar part during the heating and cooling processes were well simulated by the developed code. The factors that affect the modeling results were discussed. It is concluded that, the complex TM behavior of Aspo rock pillar is significantly influenced by the complex boundary and initial conditions.展开更多
英语专业八级改错题是检测英语专业水平的重要手段之一,不同层次的英语专业学习者答题情况尚无人研究,有必要做专题探讨。通过答卷研判、访谈及归因分析,研究发现:1)英语专业学习者英语综合运用水平(English proficiency in comprehensi...英语专业八级改错题是检测英语专业水平的重要手段之一,不同层次的英语专业学习者答题情况尚无人研究,有必要做专题探讨。通过答卷研判、访谈及归因分析,研究发现:1)英语专业学习者英语综合运用水平(English proficiency in comprehensive application,EPCA)整体不高,所有被试的均分为2.7分,只有12.5%的被试达到及格线,单题词汇辨析的正确率低至0.83%;2)4组被试的EPCA,只有大学教师组与其他各组之间存在显著性差异,本科二年级组、本科四年级组、中小学教师组各组之间均无显著性差异,说明EPCA不会简单地随着学习时间的延长而提高;3)EPCA较低,是由于一语词义与二语音形混合的词汇学习方法以及“英语思维缺席”制约了英语综合运用能力(English competence in comprehensive application,ECCA)的发展。建议采用“遵循英语思维特点学习英语”的策略,以便提高ECCA。展开更多
The Karhunen-Loeve （KL） expansion and probabilistic collocation method （PCM） are combined and applied to an uncertainty analysis of rock failure behavior by integrating a self- developed numerical method （i.e., t...The Karhunen-Loeve （KL） expansion and probabilistic collocation method （PCM） are combined and applied to an uncertainty analysis of rock failure behavior by integrating a self- developed numerical method （i.e., the elastic-plastic cellular automaton （EPCA））. The results from the method developed are compared using the Monte Carlo Simulation （MCS） method. It is concluded that the method developed requires fewer collocations than MCS method to obtain very high accuracy and greatly reduces the computational cost. Based on the method, the elasto- plastic and elasto-brittle-plastic analyses of rocks under mechanical loadings are conducted to study the uncertainty in heterogeneous rock failure behaviour.展开更多
文摘目的探讨血清磷脂酰肌醇蛋白聚糖-3(phosphatidylinositol proteoglycan-3,GPC-3)、前列腺酸性磷酸酶(prostatic acid phosphatase,PAP)、前列腺癌抗原-2(prostate cancer antigen-2,EPCA-2)及联合前列腺特异性抗原(prostatic specific antigen,PSA)检测在前列腺癌中的诊断价值.方法选取确诊的78例前列腺癌患者(前列腺癌组)和50例良性前列腺增生患者(前列腺增生组)作为研究对象,并选取同期与之配对的80例男性健康体检者作为对照组.用酶联免疫吸附试验检测血清GPC-3、PAP和EPCA-2水平,用时间分辨荧光分析法检测血清PSA水平,并绘制受试者工作特征(ROC)曲线分析GPC-3、PAP、EPCA-2和PSA对前列腺癌的诊断价值.结果前列腺癌组、前列腺增生组和对照组血清GPC-3、PAP、EPCA-2和PSA依次降低,3组比较差异均有统计学意义(P<0.05).血清GPC-3、PAP、EPCA-2和PSA 4个单项指标对前列腺癌均有一定的诊断价值,其敏感度及特异度分别为62.48%、63.31%,64.82%、60.19%,66.55%、63.33%,68.15%、65.92%(P=0.041、0.045、0.038、0.024);但联合检测可明显提高其诊断效能,以GPC-3+PAP+EPCA-2+PSA联合检测效果最佳,其敏感度和特异度分别为95.78%和92.89%.结论血清GPC-3、PAP、EPCA-2及PSA对前列腺癌均有一定诊断价值,但联合检测可明显提高其诊断效果,尤以GPC-3、PAP、EPCA-2及PSA四者联合效能最佳.
文摘目的:探讨血清早期前列腺癌抗原-2(Early Prostate Cancer Antigen,EPCA-2)、游离型/总PSA(F/TPSA)在前列腺癌(PCa)诊断中的临床应用价值。方法:用酶联免疫吸附测定法(ELISA)分别对前列腺癌组与良性前列腺增生组患者血清进行检测EPCA-2值、F/TPSA值及PSA值,所得数据的分析和处理采用SPSS17.0统计学软件进行。结果:(1)前列腺癌组PSA水平显著高于BPH组,差异有统计学意义(P<0.01)。(2)前列腺癌组FPSA/TPSA水平比值显著低于BPH组,差异有统计学意义(P<0.01)。(3)前列腺癌组EPCA-2水平为(63.45±23.49)ng/mL,而BPH组EPCA-2水平为(16.60±7.62)ng/mL,较前列腺癌组明显为低,差异具有统计学意义(P<0.01)。(4)诊断能力EPCA-2>FPSA/TPSA>PSA。(5)FPSA/TPSA水平与EPCA-2水平之间无相关关系。(6)若将EPCA-2与FPSA/TPSA比值联合应用预测前列腺癌的特异性为90.00%,敏感性为95.00%。结论:EPCA-2、FPSA/TPSA、PSA三者相比在诊断前列腺癌方面的能力排名为EPCA-2>FPSA/TPSA>PSA,并且EPCA-2与FPSA/TPSA比值之间无相关性。若将EPCA-2与FPSA/TPSA比值联合应用在前列腺癌诊断方面可大大提高诊断率,降低活检率。
基金the context of the international DECOVALEX Project (DEmonstration of COupled models and their VALidation against EXperiments)grateful to the Institute of Rock and Soil Mechanics, Chinese Academy of Sciences (CAS), China, as one of the Funding Organizations of the project+2 种基金supported by a grant from the National Basic Research Program of China (No. 2010CB732006)the National Natural Science Foundation of China (Nos. 10972231, 41272349)SKB through its sp Pillar Stability Experiment project
文摘This paper presents a study of the full three-dimensional thermo-mechanical （TM） behavior of rock pillar in,Aspo Pillar Stability Experiment （APSE） using a self-developed numerical code TM-EPCA3D. The transient thermal conduction function was descritized on space and time scales, and was solved by using cellular automaton （CA） method on space scale and finite difference method on time scale, respectively. The advantage of this approach is that no global, but local matrix is used so that it avoids the need to develop and solve large-scale linear equations and the complexity therein. A thermal conductivity versus stress function was proposed to reflect the effect of stress on thermal field. The temperature evolution and induced thermal stress in the pillar part during the heating and cooling processes were well simulated by the developed code. The factors that affect the modeling results were discussed. It is concluded that, the complex TM behavior of Aspo rock pillar is significantly influenced by the complex boundary and initial conditions.
文摘英语专业八级改错题是检测英语专业水平的重要手段之一,不同层次的英语专业学习者答题情况尚无人研究,有必要做专题探讨。通过答卷研判、访谈及归因分析,研究发现:1)英语专业学习者英语综合运用水平(English proficiency in comprehensive application,EPCA)整体不高,所有被试的均分为2.7分,只有12.5%的被试达到及格线,单题词汇辨析的正确率低至0.83%;2)4组被试的EPCA,只有大学教师组与其他各组之间存在显著性差异,本科二年级组、本科四年级组、中小学教师组各组之间均无显著性差异,说明EPCA不会简单地随着学习时间的延长而提高;3)EPCA较低,是由于一语词义与二语音形混合的词汇学习方法以及“英语思维缺席”制约了英语综合运用能力(English competence in comprehensive application,ECCA)的发展。建议采用“遵循英语思维特点学习英语”的策略,以便提高ECCA。
基金supported by the National Natural Science Foundation of China(Nos.51322906 and 41272349)the National Basic Research Program of China(No.2013CB036405)Youth Innovation Promotion Association of CAS(No.2011240)
文摘The Karhunen-Loeve （KL） expansion and probabilistic collocation method （PCM） are combined and applied to an uncertainty analysis of rock failure behavior by integrating a self- developed numerical method （i.e., the elastic-plastic cellular automaton （EPCA））. The results from the method developed are compared using the Monte Carlo Simulation （MCS） method. It is concluded that the method developed requires fewer collocations than MCS method to obtain very high accuracy and greatly reduces the computational cost. Based on the method, the elasto- plastic and elasto-brittle-plastic analyses of rocks under mechanical loadings are conducted to study the uncertainty in heterogeneous rock failure behaviour.
