The comprehension of sediment grain size parameters and the corresponding sedimentary environment holds paramount importance in elucidating the engineering geological attributes of the subaqueous seabed.This study del...The comprehension of sediment grain size parameters and the corresponding sedimentary environment holds paramount importance in elucidating the engineering geological attributes of the subaqueous seabed.This study delineated the sedimentary environment zoning in the northern sea area of Qingdao through cluster analysis of grain size parameters derived from 123 surface sediment samples.The study analyzed the correlation between sediment geotechnical indices and grain size parameters across diverse sedimentary environments.A correlation equation was established for samples exhibiting a strong correlation.The study found four distinct sedimentary environments in the study area:coastal,transitional,shallow sea,and residual.Within the same sedimentary environment,the average grain size and sorting coefficient exhibit significant correlations with geotechnical indices such as water content,density,shear strength,plastic limit,liquid limit,and plastic index.However,notable disparities in the correlation between grain size parameters and geotechnical indices emerge across different sedimentary environments.展开更多
Brazil annually faces significant challenges with mass movements, particularly in areas with poorly constructed housing, inadequate engineering, and lacking sanitation infrastructure. Campos do Jordão, in Sã...Brazil annually faces significant challenges with mass movements, particularly in areas with poorly constructed housing, inadequate engineering, and lacking sanitation infrastructure. Campos do Jordão, in São Paulo state, is a city currently grappling with these issues. This paper details a study conducted within a pilot area in Campos do Jordão, where geophysical surveys and geotechnical borehole data were integrated. The geophysical surveys provided 2D profiles, and samples were collected to analyse soil moisture and plasticity. These datasets were combined using a Cokriging-based model to produce an accurate representation of the subsurface conditions. The enhanced modelling of subsurface variability facilitates a deeper understanding of soil behavior, which can be used to improve landslide risk assessments. This approach is innovative, particularly within the international context where similar studies often do not address the complexities associated with urban planning deficits such as those observed in some areas of Brazil. These conditions, including the lack of proper sanitation and irregular housing, significantly influence the geological stability of the region, adding layers of complexity to subsurface assessments. Adapting geotechnical evaluation methods to local challenges offers the potential to increase the efficacy and relevance of geological risk management in regions with similar socio-economic and urban characteristics.展开更多
This study aims to characterize from a geotechnical point of view, the soils as well as the lateritic gravels along the Songololo-Lufu road route in the Kongo Central Province in the Democratic Republic of Congo (DRC)...This study aims to characterize from a geotechnical point of view, the soils as well as the lateritic gravels along the Songololo-Lufu road route in the Kongo Central Province in the Democratic Republic of Congo (DRC). Ten soil samples and eight lateritic gravel samples were analysed and tested in the laboratory. For each sample, identification parameters were determined such as particle size analysis, natural water content, Atterberg limits (plasticity index and consistency index), but also compaction and lift parameters such as optimal water content, maximum dry density and CBR lift index. All materials and soils have been classified according to the Congolese Road Standard (NRC) and according to the American HRB classification. The test results show us that clay soils almost always contain between 70% and 90% fine fraction;the grained fraction represents less than 30% in clay samples. For lateritic gravels soils, the percentage of fine elements varies between 35% and 15%;in sand around 20%;the gravelly fraction represents a little more than 50% of the soil. The majority of soil facies encountered define a plasticity index lower than 15. As for the consistency index, we obtained values greater than 1, both for clayey soils and for gravelly soils. The classification according to NRC defined for these soils the types Ae1 and Ae2 for the clayey facies and the types GL1 and GL2 for the gravelly soils, while that of the HRB identified the classes and subclasses A-6 and A-7-6 for clayey soils, and subclass A-2-6 for gravelly soils. The optimal water content values obtained range between 10.2% and 23.10%;the maximum dry densities are between 1.66 and 2.07 t/m<sup>3</sup> and the CBR index is between 6 and 26. As for the lateritic gravels materials of the Songololo region, the percentage of fine elements generally remains between 12% and 31%;the plasticity index is between 8 and 18;the optimal dry density is around 2 t/m<sup>3</sup>;the optimal water content is between 9.8% and 14.5% and the CBR index is between 27 and 82. The Songololo-Lufu lateritic gravels are characteristic of laterites in the savannah region, with a high gravel fraction at the expense of the fine fraction, but low parameters such as the liquid limit and plasticity index.展开更多
目的探讨苏葶平喘汤对激素抵抗型难治性哮喘小鼠癌蛋白Fos(c-Fos)及血清核转录因子激活蛋白-1(activator protein 1,AP-1)表达的影响,试分析苏葶平喘汤对难治性哮喘的干预机制。方法将50只雌性SPF级BALB/c小鼠随机分为5组,分别为空白组...目的探讨苏葶平喘汤对激素抵抗型难治性哮喘小鼠癌蛋白Fos(c-Fos)及血清核转录因子激活蛋白-1(activator protein 1,AP-1)表达的影响,试分析苏葶平喘汤对难治性哮喘的干预机制。方法将50只雌性SPF级BALB/c小鼠随机分为5组,分别为空白组(A)、模型组(B)、苏葶平喘汤组(C)、地塞米松组(D)和苏葶平喘汤+地塞米松组(E),每组10只。除空白组外,剩余4组均将小鼠建立为激素抵抗型哮喘模型。药物干预结束后进行取材,利用酶联免疫吸附测定(ELISA)法、实时荧光定量聚合酶链式反应(Real-time PCR)分别检测小鼠血清AP-1、肺组织c-Fos的表达水平。结果1.ELISA检测结果显示:模型组小鼠较空白组小鼠血清中AP-1的值明显增高(P<0.05),苏葶平喘汤组、地塞米松组及苏葶平喘汤+地塞米松组较空白组的小鼠血清AP-1值均降低(P<0.05),其中以苏葶平喘汤+地塞米松组的降低最为显著(P<0.05)。2.PCR检测结果显示:模型组与其余各组相比小鼠肺组织的c-FosmRNA表达明显升高(P<0.05),苏葶平喘汤组、地塞米松组和苏葶平喘汤+地塞米松组c-FosmRNA表达下降(P<0.05),地塞米松组、苏葶平喘汤组和苏葶平喘汤+地塞米松组小鼠的肺组织c-FosmRNA表达水平则无明显差异。结论苏葶平喘汤治疗激素抵抗型哮喘可通过影响AP-1及c-Fos的表达水平来实现抑制哮喘炎症反应控制激素抵抗型哮喘症状的作用。展开更多
Geotechnical stability is a major concern for the long-term safety and integrity of underground infrastructures such as tunnels, railway stations, mine shafts and hydraulic power chambers. An effective geotechnical mo...Geotechnical stability is a major concern for the long-term safety and integrity of underground infrastructures such as tunnels, railway stations, mine shafts and hydraulic power chambers. An effective geotechnical monitoring system is able to provide adequate warning to underground personnel prior to any unexpected major geotechnical failure. This paper reviews the conventional geotechnical monitoring sensors and the emerging Fibre Optic Sensing(FOS) techniques, pointing out their unique features and major differences. Recent advances in various FOS based monitoring systems, including Brillouin time domain distributed optical sensors and fibre Bragg grating(FBG) sensors, are investigated through a critical review of the laboratory studies and field applications used for underground geotechnical monitoring. Particular emphasis is given to fibre packaging, temperature compensation, installation methods and instrumentation performance in the underground environment. A detailed discussion of the advantages and limitations of each FOS monitoring system is also presented in this paper.展开更多
Geomechanical parameters are complex and uncertain.In order to take this complexity and uncertainty into account,a probabilistic back-analysis method combining the Bayesian probability with the least squares support v...Geomechanical parameters are complex and uncertain.In order to take this complexity and uncertainty into account,a probabilistic back-analysis method combining the Bayesian probability with the least squares support vector machine(LS-SVM) technique was proposed.The Bayesian probability was used to deal with the uncertainties in the geomechanical parameters,and an LS-SVM was utilized to establish the relationship between the displacement and the geomechanical parameters.The proposed approach was applied to the geomechanical parameter identification in a slope stability case study which was related to the permanent ship lock within the Three Gorges project in China.The results indicate that the proposed method presents the uncertainties in the geomechanical parameters reasonably well,and also improves the understanding that the monitored information is important in real projects.展开更多
Geotechnical properties of red shale encountered in deep underground mining were characterized on both laboratory and field scale to reveal its unfavorably in geoenvironment.Its constituents,microstructure,strength pr...Geotechnical properties of red shale encountered in deep underground mining were characterized on both laboratory and field scale to reveal its unfavorably in geoenvironment.Its constituents,microstructure,strength properties and water-weakening properties were investigated.In situ stress environment and mining-induced fractured damage zone after excavation were studied to reveal the instability mechanism.The results show that red shale contains swelling and loose clayey minerals as interstitial filling material,producing low shear strength of microstructure and making it vulnerable to water.Macroscopically,a U-shaped curve of uniaxial compressive strength(UCS)exists with the increase of the angle between macro weakness plane and the horizon.However,its tensile strength reduced monotonically with this angle.While immersed in water for72h,its UCS reduced by91.9%comparing to the natural state.Field sonic tests reveal that an asymmetrical geometrical profile of fractured damage zone of gateroad was identified due to geological bedding plane and detailed gateroad layout with regards to the direction of major principle stress.Therefore,red shale is a kind of engineering soft rock.For ground control in underground mining or similar applications,water inflow within several hours of excavation must strictly be prevented and energy adsorbing rock bolt is recommended,especially in large deformation part of gateroad.展开更多
基金funded by the National Key R&D Program Project(No.2022YFC3103604).
文摘The comprehension of sediment grain size parameters and the corresponding sedimentary environment holds paramount importance in elucidating the engineering geological attributes of the subaqueous seabed.This study delineated the sedimentary environment zoning in the northern sea area of Qingdao through cluster analysis of grain size parameters derived from 123 surface sediment samples.The study analyzed the correlation between sediment geotechnical indices and grain size parameters across diverse sedimentary environments.A correlation equation was established for samples exhibiting a strong correlation.The study found four distinct sedimentary environments in the study area:coastal,transitional,shallow sea,and residual.Within the same sedimentary environment,the average grain size and sorting coefficient exhibit significant correlations with geotechnical indices such as water content,density,shear strength,plastic limit,liquid limit,and plastic index.However,notable disparities in the correlation between grain size parameters and geotechnical indices emerge across different sedimentary environments.
文摘Brazil annually faces significant challenges with mass movements, particularly in areas with poorly constructed housing, inadequate engineering, and lacking sanitation infrastructure. Campos do Jordão, in São Paulo state, is a city currently grappling with these issues. This paper details a study conducted within a pilot area in Campos do Jordão, where geophysical surveys and geotechnical borehole data were integrated. The geophysical surveys provided 2D profiles, and samples were collected to analyse soil moisture and plasticity. These datasets were combined using a Cokriging-based model to produce an accurate representation of the subsurface conditions. The enhanced modelling of subsurface variability facilitates a deeper understanding of soil behavior, which can be used to improve landslide risk assessments. This approach is innovative, particularly within the international context where similar studies often do not address the complexities associated with urban planning deficits such as those observed in some areas of Brazil. These conditions, including the lack of proper sanitation and irregular housing, significantly influence the geological stability of the region, adding layers of complexity to subsurface assessments. Adapting geotechnical evaluation methods to local challenges offers the potential to increase the efficacy and relevance of geological risk management in regions with similar socio-economic and urban characteristics.
文摘This study aims to characterize from a geotechnical point of view, the soils as well as the lateritic gravels along the Songololo-Lufu road route in the Kongo Central Province in the Democratic Republic of Congo (DRC). Ten soil samples and eight lateritic gravel samples were analysed and tested in the laboratory. For each sample, identification parameters were determined such as particle size analysis, natural water content, Atterberg limits (plasticity index and consistency index), but also compaction and lift parameters such as optimal water content, maximum dry density and CBR lift index. All materials and soils have been classified according to the Congolese Road Standard (NRC) and according to the American HRB classification. The test results show us that clay soils almost always contain between 70% and 90% fine fraction;the grained fraction represents less than 30% in clay samples. For lateritic gravels soils, the percentage of fine elements varies between 35% and 15%;in sand around 20%;the gravelly fraction represents a little more than 50% of the soil. The majority of soil facies encountered define a plasticity index lower than 15. As for the consistency index, we obtained values greater than 1, both for clayey soils and for gravelly soils. The classification according to NRC defined for these soils the types Ae1 and Ae2 for the clayey facies and the types GL1 and GL2 for the gravelly soils, while that of the HRB identified the classes and subclasses A-6 and A-7-6 for clayey soils, and subclass A-2-6 for gravelly soils. The optimal water content values obtained range between 10.2% and 23.10%;the maximum dry densities are between 1.66 and 2.07 t/m<sup>3</sup> and the CBR index is between 6 and 26. As for the lateritic gravels materials of the Songololo region, the percentage of fine elements generally remains between 12% and 31%;the plasticity index is between 8 and 18;the optimal dry density is around 2 t/m<sup>3</sup>;the optimal water content is between 9.8% and 14.5% and the CBR index is between 27 and 82. The Songololo-Lufu lateritic gravels are characteristic of laterites in the savannah region, with a high gravel fraction at the expense of the fine fraction, but low parameters such as the liquid limit and plasticity index.
文摘目的探讨苏葶平喘汤对激素抵抗型难治性哮喘小鼠癌蛋白Fos(c-Fos)及血清核转录因子激活蛋白-1(activator protein 1,AP-1)表达的影响,试分析苏葶平喘汤对难治性哮喘的干预机制。方法将50只雌性SPF级BALB/c小鼠随机分为5组,分别为空白组(A)、模型组(B)、苏葶平喘汤组(C)、地塞米松组(D)和苏葶平喘汤+地塞米松组(E),每组10只。除空白组外,剩余4组均将小鼠建立为激素抵抗型哮喘模型。药物干预结束后进行取材,利用酶联免疫吸附测定(ELISA)法、实时荧光定量聚合酶链式反应(Real-time PCR)分别检测小鼠血清AP-1、肺组织c-Fos的表达水平。结果1.ELISA检测结果显示:模型组小鼠较空白组小鼠血清中AP-1的值明显增高(P<0.05),苏葶平喘汤组、地塞米松组及苏葶平喘汤+地塞米松组较空白组的小鼠血清AP-1值均降低(P<0.05),其中以苏葶平喘汤+地塞米松组的降低最为显著(P<0.05)。2.PCR检测结果显示:模型组与其余各组相比小鼠肺组织的c-FosmRNA表达明显升高(P<0.05),苏葶平喘汤组、地塞米松组和苏葶平喘汤+地塞米松组c-FosmRNA表达下降(P<0.05),地塞米松组、苏葶平喘汤组和苏葶平喘汤+地塞米松组小鼠的肺组织c-FosmRNA表达水平则无明显差异。结论苏葶平喘汤治疗激素抵抗型哮喘可通过影响AP-1及c-Fos的表达水平来实现抑制哮喘炎症反应控制激素抵抗型哮喘症状的作用。
文摘Geotechnical stability is a major concern for the long-term safety and integrity of underground infrastructures such as tunnels, railway stations, mine shafts and hydraulic power chambers. An effective geotechnical monitoring system is able to provide adequate warning to underground personnel prior to any unexpected major geotechnical failure. This paper reviews the conventional geotechnical monitoring sensors and the emerging Fibre Optic Sensing(FOS) techniques, pointing out their unique features and major differences. Recent advances in various FOS based monitoring systems, including Brillouin time domain distributed optical sensors and fibre Bragg grating(FBG) sensors, are investigated through a critical review of the laboratory studies and field applications used for underground geotechnical monitoring. Particular emphasis is given to fibre packaging, temperature compensation, installation methods and instrumentation performance in the underground environment. A detailed discussion of the advantages and limitations of each FOS monitoring system is also presented in this paper.
基金Projects(2013BAB02B01,2013BAB02B03)supported by the National Key Technologies R&D Program of ChinaProjects(41072224,41272347)supported by the National Natural Science Foundation of China
文摘Geomechanical parameters are complex and uncertain.In order to take this complexity and uncertainty into account,a probabilistic back-analysis method combining the Bayesian probability with the least squares support vector machine(LS-SVM) technique was proposed.The Bayesian probability was used to deal with the uncertainties in the geomechanical parameters,and an LS-SVM was utilized to establish the relationship between the displacement and the geomechanical parameters.The proposed approach was applied to the geomechanical parameter identification in a slope stability case study which was related to the permanent ship lock within the Three Gorges project in China.The results indicate that the proposed method presents the uncertainties in the geomechanical parameters reasonably well,and also improves the understanding that the monitored information is important in real projects.
基金Projects(51774058,51674047)supported by the National Natural Science Foundation of ChinaProjects(cstc2016jcyjA1861,cstc2018jcyjA3320)supported by Chongqing Basic Science and Cutting-edge Technology Special Projects,ChinaProject(2015M570607)supported by Postdoctoral Science Foundation of China
文摘Geotechnical properties of red shale encountered in deep underground mining were characterized on both laboratory and field scale to reveal its unfavorably in geoenvironment.Its constituents,microstructure,strength properties and water-weakening properties were investigated.In situ stress environment and mining-induced fractured damage zone after excavation were studied to reveal the instability mechanism.The results show that red shale contains swelling and loose clayey minerals as interstitial filling material,producing low shear strength of microstructure and making it vulnerable to water.Macroscopically,a U-shaped curve of uniaxial compressive strength(UCS)exists with the increase of the angle between macro weakness plane and the horizon.However,its tensile strength reduced monotonically with this angle.While immersed in water for72h,its UCS reduced by91.9%comparing to the natural state.Field sonic tests reveal that an asymmetrical geometrical profile of fractured damage zone of gateroad was identified due to geological bedding plane and detailed gateroad layout with regards to the direction of major principle stress.Therefore,red shale is a kind of engineering soft rock.For ground control in underground mining or similar applications,water inflow within several hours of excavation must strictly be prevented and energy adsorbing rock bolt is recommended,especially in large deformation part of gateroad.
