佳乐麝香(galaxolide,HHCB)作为主要的多环麝香之一,被广泛应用于药品和个人护理品(pharmaceuticals and personal care products,PPCPs)中,残留在环境中造成污染,并在生物体内富集,对水生生物及人类健康造成潜在威胁。为探究环境浓度下...佳乐麝香(galaxolide,HHCB)作为主要的多环麝香之一,被广泛应用于药品和个人护理品(pharmaceuticals and personal care products,PPCPs)中,残留在环境中造成污染,并在生物体内富集,对水生生物及人类健康造成潜在威胁。为探究环境浓度下HHCB的环境危害,选用斑马鱼(Danio rerio)作为模式动物,监测了HHCB暴露下其死亡率、孵化率、心率、心囊面积、甲状腺素含量和甲状腺激素关联基因表达量的变化,并探究相关毒理机制。研究结果表明,HHCB可导致斑马鱼胚胎死亡率增加、心率降低、孵化率下降以及甲状腺素关联基因Dio2、Thrα和Thrβ的显著变化。0.005 mmol·L^-1 HHCB可引起总三碘甲状腺原氨酸(TT3)升高和总四碘甲状腺原氨酸(TT4)的显著降低。通过以上研究可知,HHCB可造成斑马鱼胚胎甲状腺激素分泌和调节的紊乱。展开更多
As an important type of emerging pollutants, ecological toxicity and risk of artificial musks are increasingly concerned. Thus, single and joint toxic effects of 1,3,4,6,7,8-hexahydro-4,6,6,7,8,8- hexamethylcyclopenta...As an important type of emerging pollutants, ecological toxicity and risk of artificial musks are increasingly concerned. Thus, single and joint toxic effects of 1,3,4,6,7,8-hexahydro-4,6,6,7,8,8- hexamethylcyclopenta-gamma-2-benzopyran （HHCB） as one of the most widely applied artificial musks and cadmium （Cd） as an toxic metal on zebrafish （Danio rerio） were investigated by the exposure of zebrafish to various concentrations of HHCB or/and Cd in feculent water containing bedloads. The results indicated that the joint effect of HHCB and Cd changed during different exposure times within 120 h. The index of the antioxidant enzyme system including superoxide dismutase （SOD） and perox- idase （POD）, and malondialdehyde （MDA） were sensitive and induced in the zebrafish stressed by Cd, and content of soluble protein （SP） was sensitive to HHCB and could be used as a biomarker for HHCB. Joint effects on antioxidant enzymes depended more on the effect of single Cd in the first one or two days. However, in the rest exposure days, the effect of HHCB began to dominate in the joint effect during the exposure process.展开更多
Sorption isotherms different fractions from two of galaxolide （HHCB） of sediments with different mineral and organic carbon contents were determined to compare HHCB sorption behavior and contribution to the total so...Sorption isotherms different fractions from two of galaxolide （HHCB） of sediments with different mineral and organic carbon contents were determined to compare HHCB sorption behavior and contribution to the total sorption. The HHCB sorption isotherms that used the batch equilibration method were studied on different sediments of different fractions. The sorption isotherms of 600℃ heating fractions were detailed using the linear model, while the other fractions were nonlinear and fitted well with the Freundlich carbon （DOC） removed, model. The dissolved organic NaOH extracted, and 375℃ heating fractions showed more nonlinear sorption than the original sediments, which suggested more heterogeneous sorption sites in these fractions. Compared to the original sediments, the 375~C heating fractions had higher carbon- normalized distribution coefficient （Koc） values, indicating a higher sorption affinity for HHCB. Among the different sediment fractions, the contribution of the 600℃ heating fractions to the overall sorption were the lowest （ 〈 20%）, while the 375℃ heating fractions were the highest （up to 85%）.展开更多
文摘佳乐麝香(galaxolide,HHCB)作为主要的多环麝香之一,被广泛应用于药品和个人护理品(pharmaceuticals and personal care products,PPCPs)中,残留在环境中造成污染,并在生物体内富集,对水生生物及人类健康造成潜在威胁。为探究环境浓度下HHCB的环境危害,选用斑马鱼(Danio rerio)作为模式动物,监测了HHCB暴露下其死亡率、孵化率、心率、心囊面积、甲状腺素含量和甲状腺激素关联基因表达量的变化,并探究相关毒理机制。研究结果表明,HHCB可导致斑马鱼胚胎死亡率增加、心率降低、孵化率下降以及甲状腺素关联基因Dio2、Thrα和Thrβ的显著变化。0.005 mmol·L^-1 HHCB可引起总三碘甲状腺原氨酸(TT3)升高和总四碘甲状腺原氨酸(TT4)的显著降低。通过以上研究可知,HHCB可造成斑马鱼胚胎甲状腺激素分泌和调节的紊乱。
基金Acknowledgements The authors acknowledge the financial support from the National Natural Science Foundation of China （Grant Nos. 40930739 and 21037002）. The Sino-Russian Joint Research Center on Natural Resources and Eco-Environmental Sciences also gave partial aids in this work.
文摘As an important type of emerging pollutants, ecological toxicity and risk of artificial musks are increasingly concerned. Thus, single and joint toxic effects of 1,3,4,6,7,8-hexahydro-4,6,6,7,8,8- hexamethylcyclopenta-gamma-2-benzopyran （HHCB） as one of the most widely applied artificial musks and cadmium （Cd） as an toxic metal on zebrafish （Danio rerio） were investigated by the exposure of zebrafish to various concentrations of HHCB or/and Cd in feculent water containing bedloads. The results indicated that the joint effect of HHCB and Cd changed during different exposure times within 120 h. The index of the antioxidant enzyme system including superoxide dismutase （SOD） and perox- idase （POD）, and malondialdehyde （MDA） were sensitive and induced in the zebrafish stressed by Cd, and content of soluble protein （SP） was sensitive to HHCB and could be used as a biomarker for HHCB. Joint effects on antioxidant enzymes depended more on the effect of single Cd in the first one or two days. However, in the rest exposure days, the effect of HHCB began to dominate in the joint effect during the exposure process.
文摘Sorption isotherms different fractions from two of galaxolide （HHCB） of sediments with different mineral and organic carbon contents were determined to compare HHCB sorption behavior and contribution to the total sorption. The HHCB sorption isotherms that used the batch equilibration method were studied on different sediments of different fractions. The sorption isotherms of 600℃ heating fractions were detailed using the linear model, while the other fractions were nonlinear and fitted well with the Freundlich carbon （DOC） removed, model. The dissolved organic NaOH extracted, and 375℃ heating fractions showed more nonlinear sorption than the original sediments, which suggested more heterogeneous sorption sites in these fractions. Compared to the original sediments, the 375~C heating fractions had higher carbon- normalized distribution coefficient （Koc） values, indicating a higher sorption affinity for HHCB. Among the different sediment fractions, the contribution of the 600℃ heating fractions to the overall sorption were the lowest （ 〈 20%）, while the 375℃ heating fractions were the highest （up to 85%）.
