In more recent times, health-related quality of life (HRQOL) measurements have formed an important part of as- sessing the quality of routine care in general practice. For a measure to have clinical usefulness it must...In more recent times, health-related quality of life (HRQOL) measurements have formed an important part of as- sessing the quality of routine care in general practice. For a measure to have clinical usefulness it must not only be valid, appro- priate, reliable, responsive, and capable of being interpreted, but it must also be simple, fast to complete, easy to score, and provide useful clinical data. The Two-step method of choosing appropriate measures is introduced. Then through comparison of generic instruments with disease-specific instruments, we can conclude that sometimes a combination of generic and disease-specific HRQOL measures may be more appropriate for monitoring changes in a patient’s health status due to an intervention.展开更多
目的：调查口腔恶性肿瘤患者手术后生活质量状况及其影响因素。方法：选择郑州大学第一附属医院口腔颌面外科2011年5月~2013年1月收治的85例口腔恶性肿瘤患者,使用中文版口腔健康影响程度量表（oral health impact profile,OHIP-49）及...目的：调查口腔恶性肿瘤患者手术后生活质量状况及其影响因素。方法：选择郑州大学第一附属医院口腔颌面外科2011年5月~2013年1月收治的85例口腔恶性肿瘤患者,使用中文版口腔健康影响程度量表（oral health impact profile,OHIP-49）及华盛顿大学头颈肿瘤生活质量量表（University of Washington Quality of Life Scale,UW-QOL）,在患者术后至少12个月后进行生活质量评测。结果：发出问卷85份,回收76份,完成问卷调查89.4%。UW-QOL调查问卷得分最高的项目是疼痛（77.3±6.3）分,其次是焦虑（76.4±7.8）分,第三是活力（74.3±8.2）分;得分最低的3项依次是：咀嚼（34.5±8.3）分、唾液（46.4±4.8）分、味觉（49.9±3.9）分。OHIP-14量表得分最好的项目是残障（38.5±7.4）分,其次是生理性疼痛（46.8±10.2）分,第三是心理障碍（50.9±5.8）;得分差的3项依次是：功能限制（62.4±12.3）分、心理不适（57.8±9.2）分、社交障碍（55.8±12.8）分。结论：口腔癌根治性治疗对患者生活质量有显著的影响。对口腔恶性肿瘤应切实做好疾病护理,同时加强营养支持和心理疏导,并加强社会支持。展开更多
Objectives:to verify the feasibility and reliability of the electronic version of Chinese SF-36 based on the Quality-of-Life-Recorder. Design: A crossover randomized controlled trial, comparing a paper-based and an el...Objectives:to verify the feasibility and reliability of the electronic version of Chinese SF-36 based on the Quality-of-Life-Recorder. Design: A crossover randomized controlled trial, comparing a paper-based and an electronic version of the Chinese SF-36, was conducted. According to generated random numbers, interviewees were asked to fill out either the electronic version or the paper version first. The second version was filled in after a pause of at least 10 min. Settings and participants: One group of 100 medical students at the School of Medicine of Zhejiang University and the other group of 50 outpatients at a clinic for general practice in Hangzhou City (China) were eventually recruited in this study. Results: The acceptance of the electronic version was good (60% of medical students and 84% of outpatients preferred the electronic version). At the level of eight-scale scores, the mean-difference for each scale (except for general health) between the two versions was less than 5%. At the level of 36 questions, the percentage of "exact agreement" ranged within 64%～99%; the percentage of "global agreement" ranged within 72%～99%; 77% of the kappa coefficients demonstrated "good/excellent agreement" and 23% of the kappa coefficients demonstrated "medium agreement". Conclusion: This study, for the first time, can provide empirical basis for the confirmation of the feasibility and reliability of the electronic version of the Chinese SF-36 and may provide an impulse towards widespread deployment of the Quality-of-Life-Recorder in Chinese populations.展开更多
目的探讨影响结肠直肠癌患者术后健康相关生活质量(health-related quality of life,HRQoL)的危险因素,从而通过控制危险因素改善结肠直肠癌术后患者的预后和生活质量。方法前瞻性连续队列纳入2019年5~6月结肠癌术后患者212例,收集纳入...目的探讨影响结肠直肠癌患者术后健康相关生活质量(health-related quality of life,HRQoL)的危险因素,从而通过控制危险因素改善结肠直肠癌术后患者的预后和生活质量。方法前瞻性连续队列纳入2019年5~6月结肠癌术后患者212例,收集纳入队列患者的性别、年龄、吸烟状况、体重指数、麻醉分级、急症手术、手术方式、肿瘤分期的数据,利用EORTC生命质量测定量表(V3.0)测定收集健康相关生活质量(HRQoL)的数据,利用R语言多重插补法处理缺失数据,利用多元logistic回归处理可能的影响因素:性别、年龄、吸烟状况、体重指数、麻醉分级、急症手术、手术方式、肿瘤分期,利用相对危险度计算出影响健康相关生活质量的危险因素。结果共计入选结直肠癌患者212例,其中157例(74%)被纳入数据分析,男82例占52.2%,平均年龄54(44,64)岁。6个月随访中具有吸烟,麻醉分级(3~4级),体重指数不正常,高龄,肿瘤分期Ⅳ期,造漏手术的危险因素的患者预示着更低的健康相关生活质量。结论研究结果可以对结直肠癌术后患者的健康相关生活质量提供更加个体化关注,对改善其健康相关生活质量提供帮助。展开更多
目的：探讨下肢A型肉毒毒素（botulinum toxin type A，BTX—A）注射治疗对痉挛型双瘫患儿躯体运动功能和健康相关生活质量的影响。方法：51例2岁1个月～9岁6个月痉挛型双瘫患儿随机分为BTX—A注射组26例和对照组25例。患儿均给予系统...目的：探讨下肢A型肉毒毒素（botulinum toxin type A，BTX—A）注射治疗对痉挛型双瘫患儿躯体运动功能和健康相关生活质量的影响。方法：51例2岁1个月～9岁6个月痉挛型双瘫患儿随机分为BTX—A注射组26例和对照组25例。患儿均给予系统性康复治疗6个月，注射组在人组第一天给予1次BTX—A注射治疗。在治疗前，治疗后1个月、3个月、6个月对患儿运动功能和生活质量进干亍评估。结果：注射组与对照组相比用改良Ashworth量表（Modified Ashworth Scale，MAS）量化评分组间差异有统计学意义（P〈0．05）；注射组与对照组相比粗大运动功能评分（Gross Motor Function Measure，GMFM）走跑跳功能评分组间差异有统计学意义（P〈0．05）；儿科生活质量调查表（The Pediatric Quality of Life Inventory Measurement Models, PedsQL）生理领域的时间因素以及时间凶素和分组的交互作用比较有统计学意义（P〈0．05），注射组提高趋势更明显。而心理领域差异无统计学意义（P〉0．05）。结论：A型肉毒毒素辅助治疗能更有效改善脑瘫患儿的肌肉痉挛和运动功能，但是短时间内对其社会、心理、情感等方面的功能无明显改善作用。展开更多
随着社会经济的高速发展,全球对健康的关注度越来越高,人们普遍认识到健康不仅局限于没有躯体的疾病,而在于人的整个身体、精神、社会适应能力等方面处于良好状态。健康以及健康相关的各项指标关注度趋于热门,具体的表现在于健康服务与...随着社会经济的高速发展,全球对健康的关注度越来越高,人们普遍认识到健康不仅局限于没有躯体的疾病,而在于人的整个身体、精神、社会适应能力等方面处于良好状态。健康以及健康相关的各项指标关注度趋于热门,具体的表现在于健康服务与管理的应运而生,它倡导了对人整个生命周期的全照护,因此发展科学的健康管理迫在眉睫。本文紧紧围绕生活质量(Quality of Life,QOL)、健康相关生活质量(Health-Rel at ed Quality of Life,HRQoL)逐一进行讨论,包含:生活质量的一般性质,并批判性地评价了它在健康和疾病领域的具体意义和应用。在此领域,健康相关生活质量逐渐被关注,是一个重要的研究方向。现在人们普遍认识到,在单纯的生物医学框架中治疗疾病,其重点仅仅在于治愈疾病和延长患者的生命,是不必要的。如何提高患者的生活质量是目前研究的重点。在此背景下,本文试图识别和批判性地评价一些在当代健康相关生活质量领域的问题,还涵盖了相对简单的问题以及相对应的意义、重要性、有用性、在健康相关生活质量研究领域的流行方法。文中还深入复杂性问题,如:(1)谁将负责病人的健康相关生活质量;(2)慢性病患者的健康相关生活质量,包括稳定期和时间动态变化(反应转移);(3)生活质量和健康相关生活质量方面是否存在性别差异。最后,本文还讨论了健康相关生活质量在健康管理和干预领域的重要意义。展开更多
Objective： There have been few population-based studies evaluating health related quality of life（HRQOL） in rural populations in China, and this study aimed to assess the current status of and risk factors for HRQO...Objective： There have been few population-based studies evaluating health related quality of life（HRQOL） in rural populations in China, and this study aimed to assess the current status of and risk factors for HRQOL in a general rural population in high risk region of esophageal cancer in China.Methods： From November 2015 to September 2016, 12,085 permanent residents aged 45–69 years from 257 villages in the Endoscopic Screening for Esophageal Cancer in China（ESECC） trial（Clinical Trials.gov：NCT01688908） randomly selected from Hua County, Henan Province, China were interviewed. The EQ-5 D-3 L,a generic measure of HRQOL, and a questionnaire were used to assess their HRQOL and potential risk factors.Results： Among all the participants, 30.62% of the participants reported problems in at least one EQ-5 D dimension. Pain/discomfort（25.52%） was the most frequently reported problem followed by anxiety/depression（7.97%）, mobility（5.82%）, usual activities（2.61%） and self-care（1%）. These rural residents had a mean EQ-5 D index score of 0.948, and lower EQ-5 D index scores were associated with older age, female gender, lower levels of household annual per capita income, living alone, using shallow wells as main source of drinking water, exposure to family members smoking, testiness, unhealthy dietary habits, overweight or obesity, upper gastrointestinal cancer related symptoms and chronic diseases.Conclusions： Rural residents in China have a relatively low quality of life. Health promotion programs in this population should focus on the elderly, especially elderly women and the elderly living alone. Improving basic living circumstances and primary medical care services should be priorities. Results of this study will also serve as the basis for the cost-utility evaluation in our ESECC screening trial.展开更多
文摘In more recent times, health-related quality of life (HRQOL) measurements have formed an important part of as- sessing the quality of routine care in general practice. For a measure to have clinical usefulness it must not only be valid, appro- priate, reliable, responsive, and capable of being interpreted, but it must also be simple, fast to complete, easy to score, and provide useful clinical data. The Two-step method of choosing appropriate measures is introduced. Then through comparison of generic instruments with disease-specific instruments, we can conclude that sometimes a combination of generic and disease-specific HRQOL measures may be more appropriate for monitoring changes in a patient’s health status due to an intervention.
文摘目的：调查口腔恶性肿瘤患者手术后生活质量状况及其影响因素。方法：选择郑州大学第一附属医院口腔颌面外科2011年5月~2013年1月收治的85例口腔恶性肿瘤患者,使用中文版口腔健康影响程度量表（oral health impact profile,OHIP-49）及华盛顿大学头颈肿瘤生活质量量表（University of Washington Quality of Life Scale,UW-QOL）,在患者术后至少12个月后进行生活质量评测。结果：发出问卷85份,回收76份,完成问卷调查89.4%。UW-QOL调查问卷得分最高的项目是疼痛（77.3±6.3）分,其次是焦虑（76.4±7.8）分,第三是活力（74.3±8.2）分;得分最低的3项依次是：咀嚼（34.5±8.3）分、唾液（46.4±4.8）分、味觉（49.9±3.9）分。OHIP-14量表得分最好的项目是残障（38.5±7.4）分,其次是生理性疼痛（46.8±10.2）分,第三是心理障碍（50.9±5.8）;得分差的3项依次是：功能限制（62.4±12.3）分、心理不适（57.8±9.2）分、社交障碍（55.8±12.8）分。结论：口腔癌根治性治疗对患者生活质量有显著的影响。对口腔恶性肿瘤应切实做好疾病护理,同时加强营养支持和心理疏导,并加强社会支持。
基金Project (No. WKJ2006-2-016) supported by the project of "Effect of Chronic Disease and Health-Related Quality of Life on Health Service Utilization" from the Ministry of Health, China
文摘Objectives:to verify the feasibility and reliability of the electronic version of Chinese SF-36 based on the Quality-of-Life-Recorder. Design: A crossover randomized controlled trial, comparing a paper-based and an electronic version of the Chinese SF-36, was conducted. According to generated random numbers, interviewees were asked to fill out either the electronic version or the paper version first. The second version was filled in after a pause of at least 10 min. Settings and participants: One group of 100 medical students at the School of Medicine of Zhejiang University and the other group of 50 outpatients at a clinic for general practice in Hangzhou City (China) were eventually recruited in this study. Results: The acceptance of the electronic version was good (60% of medical students and 84% of outpatients preferred the electronic version). At the level of eight-scale scores, the mean-difference for each scale (except for general health) between the two versions was less than 5%. At the level of 36 questions, the percentage of "exact agreement" ranged within 64%～99%; the percentage of "global agreement" ranged within 72%～99%; 77% of the kappa coefficients demonstrated "good/excellent agreement" and 23% of the kappa coefficients demonstrated "medium agreement". Conclusion: This study, for the first time, can provide empirical basis for the confirmation of the feasibility and reliability of the electronic version of the Chinese SF-36 and may provide an impulse towards widespread deployment of the Quality-of-Life-Recorder in Chinese populations.
文摘目的探讨影响结肠直肠癌患者术后健康相关生活质量(health-related quality of life,HRQoL)的危险因素,从而通过控制危险因素改善结肠直肠癌术后患者的预后和生活质量。方法前瞻性连续队列纳入2019年5~6月结肠癌术后患者212例,收集纳入队列患者的性别、年龄、吸烟状况、体重指数、麻醉分级、急症手术、手术方式、肿瘤分期的数据,利用EORTC生命质量测定量表(V3.0)测定收集健康相关生活质量(HRQoL)的数据,利用R语言多重插补法处理缺失数据,利用多元logistic回归处理可能的影响因素:性别、年龄、吸烟状况、体重指数、麻醉分级、急症手术、手术方式、肿瘤分期,利用相对危险度计算出影响健康相关生活质量的危险因素。结果共计入选结直肠癌患者212例,其中157例(74%)被纳入数据分析,男82例占52.2%,平均年龄54(44,64)岁。6个月随访中具有吸烟,麻醉分级(3~4级),体重指数不正常,高龄,肿瘤分期Ⅳ期,造漏手术的危险因素的患者预示着更低的健康相关生活质量。结论研究结果可以对结直肠癌术后患者的健康相关生活质量提供更加个体化关注,对改善其健康相关生活质量提供帮助。
文摘目的：探讨下肢A型肉毒毒素（botulinum toxin type A，BTX—A）注射治疗对痉挛型双瘫患儿躯体运动功能和健康相关生活质量的影响。方法：51例2岁1个月～9岁6个月痉挛型双瘫患儿随机分为BTX—A注射组26例和对照组25例。患儿均给予系统性康复治疗6个月，注射组在人组第一天给予1次BTX—A注射治疗。在治疗前，治疗后1个月、3个月、6个月对患儿运动功能和生活质量进干亍评估。结果：注射组与对照组相比用改良Ashworth量表（Modified Ashworth Scale，MAS）量化评分组间差异有统计学意义（P〈0．05）；注射组与对照组相比粗大运动功能评分（Gross Motor Function Measure，GMFM）走跑跳功能评分组间差异有统计学意义（P〈0．05）；儿科生活质量调查表（The Pediatric Quality of Life Inventory Measurement Models, PedsQL）生理领域的时间因素以及时间凶素和分组的交互作用比较有统计学意义（P〈0．05），注射组提高趋势更明显。而心理领域差异无统计学意义（P〉0．05）。结论：A型肉毒毒素辅助治疗能更有效改善脑瘫患儿的肌肉痉挛和运动功能，但是短时间内对其社会、心理、情感等方面的功能无明显改善作用。
文摘随着社会经济的高速发展,全球对健康的关注度越来越高,人们普遍认识到健康不仅局限于没有躯体的疾病,而在于人的整个身体、精神、社会适应能力等方面处于良好状态。健康以及健康相关的各项指标关注度趋于热门,具体的表现在于健康服务与管理的应运而生,它倡导了对人整个生命周期的全照护,因此发展科学的健康管理迫在眉睫。本文紧紧围绕生活质量(Quality of Life,QOL)、健康相关生活质量(Health-Rel at ed Quality of Life,HRQoL)逐一进行讨论,包含:生活质量的一般性质,并批判性地评价了它在健康和疾病领域的具体意义和应用。在此领域,健康相关生活质量逐渐被关注,是一个重要的研究方向。现在人们普遍认识到,在单纯的生物医学框架中治疗疾病,其重点仅仅在于治愈疾病和延长患者的生命,是不必要的。如何提高患者的生活质量是目前研究的重点。在此背景下,本文试图识别和批判性地评价一些在当代健康相关生活质量领域的问题,还涵盖了相对简单的问题以及相对应的意义、重要性、有用性、在健康相关生活质量研究领域的流行方法。文中还深入复杂性问题,如:(1)谁将负责病人的健康相关生活质量;(2)慢性病患者的健康相关生活质量,包括稳定期和时间动态变化(反应转移);(3)生活质量和健康相关生活质量方面是否存在性别差异。最后,本文还讨论了健康相关生活质量在健康管理和干预领域的重要意义。
基金supported by the Charity Project of National Ministry of Health (No. 201202014)the Natural Science Foundation of China (No. 81473033)+2 种基金the National Key R&D Program of China (No. 2016YFC0901404)the Science Foundation of Peking University Cancer Hospital (No. 2017-4)the Open Project funded by Key Laboratory of Carcinogenesis and Translational Research, Ministry of Education/Beijing (No. 2017-10)
文摘Objective： There have been few population-based studies evaluating health related quality of life（HRQOL） in rural populations in China, and this study aimed to assess the current status of and risk factors for HRQOL in a general rural population in high risk region of esophageal cancer in China.Methods： From November 2015 to September 2016, 12,085 permanent residents aged 45–69 years from 257 villages in the Endoscopic Screening for Esophageal Cancer in China（ESECC） trial（Clinical Trials.gov：NCT01688908） randomly selected from Hua County, Henan Province, China were interviewed. The EQ-5 D-3 L,a generic measure of HRQOL, and a questionnaire were used to assess their HRQOL and potential risk factors.Results： Among all the participants, 30.62% of the participants reported problems in at least one EQ-5 D dimension. Pain/discomfort（25.52%） was the most frequently reported problem followed by anxiety/depression（7.97%）, mobility（5.82%）, usual activities（2.61%） and self-care（1%）. These rural residents had a mean EQ-5 D index score of 0.948, and lower EQ-5 D index scores were associated with older age, female gender, lower levels of household annual per capita income, living alone, using shallow wells as main source of drinking water, exposure to family members smoking, testiness, unhealthy dietary habits, overweight or obesity, upper gastrointestinal cancer related symptoms and chronic diseases.Conclusions： Rural residents in China have a relatively low quality of life. Health promotion programs in this population should focus on the elderly, especially elderly women and the elderly living alone. Improving basic living circumstances and primary medical care services should be priorities. Results of this study will also serve as the basis for the cost-utility evaluation in our ESECC screening trial.
