Several novel 3-(substituted phenyl)isoxazole derivatives were prepared from phenyl butan-1,3-dione. Their structures were confirmed by 1H NMR, IR, and CIMS. Preliminary bioassay showed that some of them exhibited goo...Several novel 3-(substituted phenyl)isoxazole derivatives were prepared from phenyl butan-1,3-dione. Their structures were confirmed by 1H NMR, IR, and CIMS. Preliminary bioassay showed that some of them exhibited good activities toward various weeds.展开更多
The chemical reactivity of novel stable triazene 3 toward some nucleophilic and electrophilic reagents was investigated. Traizene 3 was used as a key precursor for the synthesis of some novel important heterocyclic co...The chemical reactivity of novel stable triazene 3 toward some nucleophilic and electrophilic reagents was investigated. Traizene 3 was used as a key precursor for the synthesis of some novel important heterocyclic compounds such as Pyrazole, Isoxazole, Dihydropyrimidine, Tetrahydro-pyridine derivatives with expected antimicrobial activity. The synthesized compounds were obtained in good yields. The structures of the newly synthesized compounds were confirmed by elemental analysis, IR, 1H-NMR and Ms spectral data.展开更多
Two novel substituted phenyl oxazole isoxazole carboxamides have been synthesized by microwave assistant technology.The target compounds were characterized by IR,1H NMR,13C NMR and HRMS,and their single-crystal struct...Two novel substituted phenyl oxazole isoxazole carboxamides have been synthesized by microwave assistant technology.The target compounds were characterized by IR,1H NMR,13C NMR and HRMS,and their single-crystal structures were further determined by X-ray diffraction.3-Phenyl-4-(2΄-methyl-2΄-isopropyl-1΄,3΄-oxazole)-5-methyl isoxazole carboxamide(6a)crystallizes in monoclinic system,space group P21/c with a=6.2137(12),b=19.923(4),c=13.748(3)Å,β=92.30(3)°,V=1700.6(6)Å3,Dc=1.228 Mg/m3,Z=4,F(000)=672,μ(MoKα)=0.084 mm-1,R=0.0526 and wR=0.1259.3-(2΄-Fluoro-6΄-chloro-phenyl)-4-(2΄-methyl-2΄-ethyl-1΄,3΄-oxazole)-5-methyl isoxazole carboxamide(6b)crystallizes in triclinic system,space group P with a=7.8750(16),b=10.596(2),c=11.725(12)Å,β=102.05(3)°,V=859.5(3)Å3,Dc=1.363 Mg/m3,Z=2,F(000)=368,μ(MoKα)=0.250 mm-1,R=0.0738 and wR=0.1941.Both of the molecules prefer to form crystal packing through C–H…O hydrogen bonds.Compounds 6a and 6b show safener activity on maize against the injury of chlorsulfuron.展开更多
A variety of 2-arylnaphtho[ 1,2-d]oxazole derivatives were efficiently synthesized in moderate to high yields by the reaction of aromatic aldehydes with 1-amino-2-naphthol derivatives in the presence of triethylamine ...A variety of 2-arylnaphtho[ 1,2-d]oxazole derivatives were efficiently synthesized in moderate to high yields by the reaction of aromatic aldehydes with 1-amino-2-naphthol derivatives in the presence of triethylamine in refluxing ethanol in air. Seven new 2-arylnaphtho[1,2-d]oxazole derivatives were obtained and characterized by the spectral data and elemental analysis. In addition, the X-ray crystal structures of 2-[4-（N,N-dimethylamino）phenyl]naphtho[ 1,2-d] oxzole （3d） and 1, 1＇-bis（naphtho[ 1,2-d]oxazol-2-yl）ferrocene （3n） have been determined.展开更多
Ethyl 4,4,4-trifluoro-3-oxo-butyrate reacted with 2,6-dimethyl-3,5-diacetyl-pyridine 1 in the presence of NaOC2H5 at 0 ℃ to give 2,6-dimethyl-3,5-bis（4,4,4-trifluoro-1,3-oxo-butyl）-pyridine （2a） in good yield. Cy...Ethyl 4,4,4-trifluoro-3-oxo-butyrate reacted with 2,6-dimethyl-3,5-diacetyl-pyridine 1 in the presence of NaOC2H5 at 0 ℃ to give 2,6-dimethyl-3,5-bis（4,4,4-trifluoro-1,3-oxo-butyl）-pyridine （2a） in good yield. Cyclization reaction of 2a and aryl imidoyl chlorides 5a--5i, obtained from chlorination of aryl oximes with N-chlorosuccimide, afforded 2,6-dimethyl-3,5-bis[（3-aryl-5-trifluoromethyl）-isoxazol-4-carbonyl]-pyridine derivatives 6a=6i.展开更多
The purification of 4,5-diphenyl-2-methyloxazole preparation was improved.Influences of concentration and solvent on the fluorescent property of 4,5-diphenyl-2-methyloxazole and 4,5-diphenyl-2-styryloxazole were studi...The purification of 4,5-diphenyl-2-methyloxazole preparation was improved.Influences of concentration and solvent on the fluorescent property of 4,5-diphenyl-2-methyloxazole and 4,5-diphenyl-2-styryloxazole were studied,and fluorescence quantum yield(Φ)of the two compound were also studied in the paper.展开更多
文摘Several novel 3-(substituted phenyl)isoxazole derivatives were prepared from phenyl butan-1,3-dione. Their structures were confirmed by 1H NMR, IR, and CIMS. Preliminary bioassay showed that some of them exhibited good activities toward various weeds.
文摘The chemical reactivity of novel stable triazene 3 toward some nucleophilic and electrophilic reagents was investigated. Traizene 3 was used as a key precursor for the synthesis of some novel important heterocyclic compounds such as Pyrazole, Isoxazole, Dihydropyrimidine, Tetrahydro-pyridine derivatives with expected antimicrobial activity. The synthesized compounds were obtained in good yields. The structures of the newly synthesized compounds were confirmed by elemental analysis, IR, 1H-NMR and Ms spectral data.
基金the National Natural Science Foundation of China(Nos.31801784 and 31572042)Natural Science Foundation of Heilongjiang Province(No.ZD2017002)the Research Science Foundation in Technology Innovation of Harbin(No.2017RAQXJ0172)。
文摘Two novel substituted phenyl oxazole isoxazole carboxamides have been synthesized by microwave assistant technology.The target compounds were characterized by IR,1H NMR,13C NMR and HRMS,and their single-crystal structures were further determined by X-ray diffraction.3-Phenyl-4-(2΄-methyl-2΄-isopropyl-1΄,3΄-oxazole)-5-methyl isoxazole carboxamide(6a)crystallizes in monoclinic system,space group P21/c with a=6.2137(12),b=19.923(4),c=13.748(3)Å,β=92.30(3)°,V=1700.6(6)Å3,Dc=1.228 Mg/m3,Z=4,F(000)=672,μ(MoKα)=0.084 mm-1,R=0.0526 and wR=0.1259.3-(2΄-Fluoro-6΄-chloro-phenyl)-4-(2΄-methyl-2΄-ethyl-1΄,3΄-oxazole)-5-methyl isoxazole carboxamide(6b)crystallizes in triclinic system,space group P with a=7.8750(16),b=10.596(2),c=11.725(12)Å,β=102.05(3)°,V=859.5(3)Å3,Dc=1.363 Mg/m3,Z=2,F(000)=368,μ(MoKα)=0.250 mm-1,R=0.0738 and wR=0.1941.Both of the molecules prefer to form crystal packing through C–H…O hydrogen bonds.Compounds 6a and 6b show safener activity on maize against the injury of chlorsulfuron.
基金Project supported by the National Natural Science Foundation of China （No. 20472074） and the Innovation found for 0utstanding Scholars of Henan Province （No. 0621001100）.
文摘A variety of 2-arylnaphtho[ 1,2-d]oxazole derivatives were efficiently synthesized in moderate to high yields by the reaction of aromatic aldehydes with 1-amino-2-naphthol derivatives in the presence of triethylamine in refluxing ethanol in air. Seven new 2-arylnaphtho[1,2-d]oxazole derivatives were obtained and characterized by the spectral data and elemental analysis. In addition, the X-ray crystal structures of 2-[4-（N,N-dimethylamino）phenyl]naphtho[ 1,2-d] oxzole （3d） and 1, 1＇-bis（naphtho[ 1,2-d]oxazol-2-yl）ferrocene （3n） have been determined.
基金Acknowledgement The authors thank the National Natural Science Foundation of China （NNSFC） （Nos. 21072128, 21272153）, the Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry for financial support.
文摘Ethyl 4,4,4-trifluoro-3-oxo-butyrate reacted with 2,6-dimethyl-3,5-diacetyl-pyridine 1 in the presence of NaOC2H5 at 0 ℃ to give 2,6-dimethyl-3,5-bis（4,4,4-trifluoro-1,3-oxo-butyl）-pyridine （2a） in good yield. Cyclization reaction of 2a and aryl imidoyl chlorides 5a--5i, obtained from chlorination of aryl oximes with N-chlorosuccimide, afforded 2,6-dimethyl-3,5-bis[（3-aryl-5-trifluoromethyl）-isoxazol-4-carbonyl]-pyridine derivatives 6a=6i.
文摘The purification of 4,5-diphenyl-2-methyloxazole preparation was improved.Influences of concentration and solvent on the fluorescent property of 4,5-diphenyl-2-methyloxazole and 4,5-diphenyl-2-styryloxazole were studied,and fluorescence quantum yield(Φ)of the two compound were also studied in the paper.
