Objective： The aim of the research was to study peptidylarginine deiminase type 4 （PAD4/PADI4） expression and its tumodgenic mechanism in hepatocellular carcinomas. Methods： Expressions of PADI4 and p53 were inves...Objective： The aim of the research was to study peptidylarginine deiminase type 4 （PAD4/PADI4） expression and its tumodgenic mechanism in hepatocellular carcinomas. Methods： Expressions of PADI4 and p53 were investigated in tumors and non-tumor tissues by Western blot in patients with hepatocellular carcinomas. We constructed plasmid of PADI4-Flag and transfected it in Hela cells to investigate the mechanism. Results： Western blot analysis showed higher PADI4 expression in hepatocellular carcinomas than in the surrounding healthy tissues. Furthermore, by Western blot, we detected decreased p53 levels in the tumor tissues of patients with hepatocellular carcinomas compared to surrounding healthy tissues. In Hela cells transfected with PcDNA3.0-Flag-PADI4 plasmid, the expression of p53 decreased obviously. Conclusion： Our results suggest that PADI4 elevated in the tissues of hepatocellular carcinomas and induced tumorigenic by down-regulating p53 expression.展开更多
为明确the new Pad、iPhone4s是否具备专业显示设备的显示性能,以液晶专业显示器A为参考,对这3个显示设备的时间稳定性、不同亮度下不同颜色显示的空间均匀性、不同亮度下色域覆盖率、色品恒定性、通道相加性、设备色域6个方面的性能进...为明确the new Pad、iPhone4s是否具备专业显示设备的显示性能,以液晶专业显示器A为参考,对这3个显示设备的时间稳定性、不同亮度下不同颜色显示的空间均匀性、不同亮度下色域覆盖率、色品恒定性、通道相加性、设备色域6个方面的性能进行了测试。实验结果表明:iPhone4s在时间稳定性、颜色显示的空间均匀性以及色域覆盖率的稳定性方面优于the new Pad;the new Pad在通道可加性、色品恒定性方面优于iPhone4s;3个显示设备中the new Pad的色域覆盖率最大,iPhone4s的最小;the new Pad各项性能与专业显示器A的相近。The new Pad基本达到专业显示设备的显示性能要求,可作为专业显示设备的辅助设备使用,iPhone4s没有达到专业显示设备的显示性能要求,不适合作为专业显示设备的辅助设备使用。展开更多
文摘Objective： The aim of the research was to study peptidylarginine deiminase type 4 （PAD4/PADI4） expression and its tumodgenic mechanism in hepatocellular carcinomas. Methods： Expressions of PADI4 and p53 were investigated in tumors and non-tumor tissues by Western blot in patients with hepatocellular carcinomas. We constructed plasmid of PADI4-Flag and transfected it in Hela cells to investigate the mechanism. Results： Western blot analysis showed higher PADI4 expression in hepatocellular carcinomas than in the surrounding healthy tissues. Furthermore, by Western blot, we detected decreased p53 levels in the tumor tissues of patients with hepatocellular carcinomas compared to surrounding healthy tissues. In Hela cells transfected with PcDNA3.0-Flag-PADI4 plasmid, the expression of p53 decreased obviously. Conclusion： Our results suggest that PADI4 elevated in the tissues of hepatocellular carcinomas and induced tumorigenic by down-regulating p53 expression.
文摘为明确the new Pad、iPhone4s是否具备专业显示设备的显示性能,以液晶专业显示器A为参考,对这3个显示设备的时间稳定性、不同亮度下不同颜色显示的空间均匀性、不同亮度下色域覆盖率、色品恒定性、通道相加性、设备色域6个方面的性能进行了测试。实验结果表明:iPhone4s在时间稳定性、颜色显示的空间均匀性以及色域覆盖率的稳定性方面优于the new Pad;the new Pad在通道可加性、色品恒定性方面优于iPhone4s;3个显示设备中the new Pad的色域覆盖率最大,iPhone4s的最小;the new Pad各项性能与专业显示器A的相近。The new Pad基本达到专业显示设备的显示性能要求,可作为专业显示设备的辅助设备使用,iPhone4s没有达到专业显示设备的显示性能要求,不适合作为专业显示设备的辅助设备使用。
