目的:运用网络药理学方法探讨左归丸治疗骨质疏松的潜在药效机制。方法:从《中华人民共和国药典》收集左归丸中各中药的归经信息,TCMSP、BATMAN-TCM数据库中查找中药活性成分和靶标,Drugbank、DisGeNET数据库中查找骨质疏松的潜在靶点,...目的:运用网络药理学方法探讨左归丸治疗骨质疏松的潜在药效机制。方法:从《中华人民共和国药典》收集左归丸中各中药的归经信息,TCMSP、BATMAN-TCM数据库中查找中药活性成分和靶标,Drugbank、DisGeNET数据库中查找骨质疏松的潜在靶点,利用Cytoscape软件构建和分析中药-归经网络、靶标-疾病网络,利用DAVID对靶标-疾病网络中最大连通片子模块节点基因进行功能富集分析。结果:左归丸所含中药主要归肾、肝经,其潜在活性化合物73个、51个靶标与骨质疏松相关,靶标-疾病网络中3个关键子模块主要生物学功能涉及转化生长因子β(transforming growth factor-β,TGF-beta)、雌激素(Estrogen)、甲状腺激素(Thyroid hormone)、磷脂酰肌醇3激酶-蛋白激酶B(phosphatidylinositol 3-kinase and protein kinase B,PI3K-Akt)等16个信号通路,影响骨代谢平衡。结论:左归丸“补肾壮骨”法治疗骨质疏松,可能通过调控骨代谢平衡中成骨、破骨分化多个生物学过程发挥治疗作用。展开更多
目的了解长沙地区上网大学生中病理性互联网使用(Pathological internet use,简称PIU)的影响因素,并针对影响因素提出防治对策。方法采用分层整群随机抽样方法,从长沙地区高等院校中随机抽取4所高校作为样本,再从这4所院校中随机抽取20...目的了解长沙地区上网大学生中病理性互联网使用(Pathological internet use,简称PIU)的影响因素,并针对影响因素提出防治对策。方法采用分层整群随机抽样方法,从长沙地区高等院校中随机抽取4所高校作为样本,再从这4所院校中随机抽取20个班级,所选班级的上网大学生即为研究对象。结果单因素及多因素分析显示男性、C型性格、来自非正常家庭、学习成绩差、网龄长、主要在网吧上网、以交友为上网目的、平均每周上网时间长、使用游戏、聊天网络服务为PIU的危险因素。学习为PIU的保护因素(OR=0.408)。结论PIU的形成与多种因素有关。预防和控制大学生PIU的发生,需要大学生自身、家庭、学校、社会多方面的参与。展开更多
For flat fast fading Multiple-Input Multiple-Output(MIMO) channels,this paper presents a sampling based channel estimation and an iterative Particle Filter(PF) signal detection scheme. The channel estimation is compri...For flat fast fading Multiple-Input Multiple-Output(MIMO) channels,this paper presents a sampling based channel estimation and an iterative Particle Filter(PF) signal detection scheme. The channel estimation is comprised of two parts:the adaptive iterative update on the channel distribution mean and a regular update on the "adaptability" via pilot. In the detection procedure,the PF is employed to produce the optimal decision given the known received signal and the sequence of the channel samples,where an asymptotic optimal importance density is constructed,and in terms of the asymptotic update order,the Parallel Importance Update(PIU) and the Serial Importance Update(SIU) scheme are performed respectively. The simulation results show that for the given fading channel,if an appropriate pilot mode is selected,the proposed scheme is more robust than the conventional Kalman filter based superimposed detection scheme.展开更多
文摘目的:运用网络药理学方法探讨左归丸治疗骨质疏松的潜在药效机制。方法:从《中华人民共和国药典》收集左归丸中各中药的归经信息,TCMSP、BATMAN-TCM数据库中查找中药活性成分和靶标,Drugbank、DisGeNET数据库中查找骨质疏松的潜在靶点,利用Cytoscape软件构建和分析中药-归经网络、靶标-疾病网络,利用DAVID对靶标-疾病网络中最大连通片子模块节点基因进行功能富集分析。结果:左归丸所含中药主要归肾、肝经,其潜在活性化合物73个、51个靶标与骨质疏松相关,靶标-疾病网络中3个关键子模块主要生物学功能涉及转化生长因子β(transforming growth factor-β,TGF-beta)、雌激素(Estrogen)、甲状腺激素(Thyroid hormone)、磷脂酰肌醇3激酶-蛋白激酶B(phosphatidylinositol 3-kinase and protein kinase B,PI3K-Akt)等16个信号通路,影响骨代谢平衡。结论:左归丸“补肾壮骨”法治疗骨质疏松,可能通过调控骨代谢平衡中成骨、破骨分化多个生物学过程发挥治疗作用。
文摘目的了解长沙地区上网大学生中病理性互联网使用(Pathological internet use,简称PIU)的影响因素,并针对影响因素提出防治对策。方法采用分层整群随机抽样方法,从长沙地区高等院校中随机抽取4所高校作为样本,再从这4所院校中随机抽取20个班级,所选班级的上网大学生即为研究对象。结果单因素及多因素分析显示男性、C型性格、来自非正常家庭、学习成绩差、网龄长、主要在网吧上网、以交友为上网目的、平均每周上网时间长、使用游戏、聊天网络服务为PIU的危险因素。学习为PIU的保护因素(OR=0.408)。结论PIU的形成与多种因素有关。预防和控制大学生PIU的发生,需要大学生自身、家庭、学校、社会多方面的参与。
基金the National Natural Science Foundation of China (No. 60672047)Shanghai Postdoctoral Scientific Program (No. 05R214110).
文摘For flat fast fading Multiple-Input Multiple-Output(MIMO) channels,this paper presents a sampling based channel estimation and an iterative Particle Filter(PF) signal detection scheme. The channel estimation is comprised of two parts:the adaptive iterative update on the channel distribution mean and a regular update on the "adaptability" via pilot. In the detection procedure,the PF is employed to produce the optimal decision given the known received signal and the sequence of the channel samples,where an asymptotic optimal importance density is constructed,and in terms of the asymptotic update order,the Parallel Importance Update(PIU) and the Serial Importance Update(SIU) scheme are performed respectively. The simulation results show that for the given fading channel,if an appropriate pilot mode is selected,the proposed scheme is more robust than the conventional Kalman filter based superimposed detection scheme.
