In this paper, we examine the performance of the 26-level version of the SAMIL/LASG GCM （R42/L26） in simulating the seasonal cycle and perpetual winter mean stratospheric circulation as well as its variability by co...In this paper, we examine the performance of the 26-level version of the SAMIL/LASG GCM （R42/L26） in simulating the seasonal cycle and perpetual winter mean stratospheric circulation as well as its variability by comparing them with the NCEP/NCAR reanalysis. The results show that the model is capable of repro- ducing many key features of the climatology and seasonal variation of the stratospheric circulation despite that the model＇s mean polar vortex is stronger and more zonally symmetric compared to the observation. ~rther diagnosis of the results from a perpetual-January-run of the SAMIL/LASG GCM indicates that the dominant winter-season oscillation mode in the model＇s stratosphere exhibits a similar inter-seasonal timescale with similar spatial patterns as those inferred from the NCEP/NCAR reanalysis. In particular, the simulated polar vortex oscillation mode exhibits a dominant inter-seasonal timescale of about 120 days, and is accompanied with the simultaneous poleward and downward propagation of temperature anomalies in the stratosphere and the equatorward propagation of temperature anomalies in the troposphere. More encouragingly, the 26-layer version of the SAMIL/LASG GCM is able to produce three strong Stratospheric Sudden Warming events during the 1825 days of perpetual-January integration, with the polar westerly jet completely reversed for a few weeks without imposing any prescribed anomalous forcing at the lower boundary.展开更多
Currently,the main treatment for hepatocellular carcinoma(HCC)involves the surgical removal of tumors or liver transplantation.However,these treatments are often not completely curative,as they are associated with a r...Currently,the main treatment for hepatocellular carcinoma(HCC)involves the surgical removal of tumors or liver transplantation.However,these treatments are often not completely curative,as they are associated with a risk for postoperative recurrence and metastasis.Circulating tumor cells(CTCs)are increasingly recognized as the main source for recurrence and metastasis after radical hepatectomies are performed.Many studies have demonstrated the association between the presence of either pre-or postoperative CTCs and an increased risk for HCC recurrence.To improve the therapeutic outcome of HCC,a personalized,comprehensive and multidisciplinary approach should be considered,involving the application of appropriate diagnostic and therapeutic measures targeting HCC CTCs in different stages throughout the course of treatment.This article proposes some HCC CTC-based strategies for the treatment of HCC,including the monitoring of HCC CTCs before,during and after radical hepatectomy,therapeutic targeting of HCC CTCs,prevention of the generation and colonization of CTCs,as well as the use of CTC indexes for the selection of indications,prediction of prognoses,and planning of individualized therapeutic regimens.Innovation and technological development of therapies targeting CTCs,as well as their translation into clinical practice,will help to effectively reduce postoperative recurrence and metastasis,and significantly prolong the survival of HCC patients.展开更多
In this paper,we give the explicit expressions of level k (r 1,r 2,…,r k) circulant matrices of order n 1n 2…n k,and the explicit expressions for the eigenvalues,the determinants and the inverse matrices of the kind...In this paper,we give the explicit expressions of level k (r 1,r 2,…,r k) circulant matrices of order n 1n 2…n k,and the explicit expressions for the eigenvalues,the determinants and the inverse matrices of the kind level k (r 1,r 2,…,r k) circulant matrices are derived,and it is also proved that the sort of matrices are diagonalizable.展开更多
基金supported by the National Basic Research Program of China (2006CB403600)the National Natural Science Foundation of China under Grant Nos. 40575041, 40523001, 40221503the Public Sector Special project GYHY200806006
文摘In this paper, we examine the performance of the 26-level version of the SAMIL/LASG GCM （R42/L26） in simulating the seasonal cycle and perpetual winter mean stratospheric circulation as well as its variability by comparing them with the NCEP/NCAR reanalysis. The results show that the model is capable of repro- ducing many key features of the climatology and seasonal variation of the stratospheric circulation despite that the model＇s mean polar vortex is stronger and more zonally symmetric compared to the observation. ~rther diagnosis of the results from a perpetual-January-run of the SAMIL/LASG GCM indicates that the dominant winter-season oscillation mode in the model＇s stratosphere exhibits a similar inter-seasonal timescale with similar spatial patterns as those inferred from the NCEP/NCAR reanalysis. In particular, the simulated polar vortex oscillation mode exhibits a dominant inter-seasonal timescale of about 120 days, and is accompanied with the simultaneous poleward and downward propagation of temperature anomalies in the stratosphere and the equatorward propagation of temperature anomalies in the troposphere. More encouragingly, the 26-layer version of the SAMIL/LASG GCM is able to produce three strong Stratospheric Sudden Warming events during the 1825 days of perpetual-January integration, with the polar westerly jet completely reversed for a few weeks without imposing any prescribed anomalous forcing at the lower boundary.
基金Supported by Grants from the China National Key Projects for Infectious Disease,No.2012ZX10002012-10The National High-Tech Research and Development Program of China,No.2007AA02Z461the National Natural Science Foundation of China,Nos.30772513,81172207 and 81272669
文摘Currently,the main treatment for hepatocellular carcinoma(HCC)involves the surgical removal of tumors or liver transplantation.However,these treatments are often not completely curative,as they are associated with a risk for postoperative recurrence and metastasis.Circulating tumor cells(CTCs)are increasingly recognized as the main source for recurrence and metastasis after radical hepatectomies are performed.Many studies have demonstrated the association between the presence of either pre-or postoperative CTCs and an increased risk for HCC recurrence.To improve the therapeutic outcome of HCC,a personalized,comprehensive and multidisciplinary approach should be considered,involving the application of appropriate diagnostic and therapeutic measures targeting HCC CTCs in different stages throughout the course of treatment.This article proposes some HCC CTC-based strategies for the treatment of HCC,including the monitoring of HCC CTCs before,during and after radical hepatectomy,therapeutic targeting of HCC CTCs,prevention of the generation and colonization of CTCs,as well as the use of CTC indexes for the selection of indications,prediction of prognoses,and planning of individualized therapeutic regimens.Innovation and technological development of therapies targeting CTCs,as well as their translation into clinical practice,will help to effectively reduce postoperative recurrence and metastasis,and significantly prolong the survival of HCC patients.
文摘In this paper,we give the explicit expressions of level k (r 1,r 2,…,r k) circulant matrices of order n 1n 2…n k,and the explicit expressions for the eigenvalues,the determinants and the inverse matrices of the kind level k (r 1,r 2,…,r k) circulant matrices are derived,and it is also proved that the sort of matrices are diagonalizable.
