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A new free recoverable and reusable mono-alkaloid-type ligand and its use in preparation of ethyl(2R,3S)-2,3-dihydroxy-3-phenylpropionate
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作者 Qiao Feng Wang Hui Chen Yan Zhao Xiao Ye Li Sheng Yong Zhang 《Chinese Chemical Letters》 SCIE CAS CSCD 2009年第7期763-766,共4页
A new free recoverable and reusable mono-alkaloid-type ligand has been synthesized by a simple method. With highly polar groups, the ligand can be recycled and reused eight times to prepare ethyl (2R,3S)-2,3-dihydro... A new free recoverable and reusable mono-alkaloid-type ligand has been synthesized by a simple method. With highly polar groups, the ligand can be recycled and reused eight times to prepare ethyl (2R,3S)-2,3-dihydroxy-3-phenylpropionate with high yield and ee via asymmetric dihydroxylation (AD) reaction. C 2009 Sheng Yong Zhang. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved. 展开更多
关键词 Cinchona alkaloid recoverable and reusable ligand Ethyl 2r 3s)-2 3-dihydroxy-3-phenylpropionate
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Biosynthesis of(R)-2-hydroxy-3-phenylpropionic acid using whole recombinant Escherichia coli cells in an aqueous/n-octane biphasic system
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作者 Yi-bo ZHU Yan XU +1 位作者 Li-mei WANG Bin QI 《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》 SCIE CAS CSCD 2018年第4期285-292,共8页
(R)-2-hydroxy-3-phenylpropionic acid (PIP,) is an ideal antimicrobial compound with broad-spectrum activity against a wide range of Gram-positive bacteria, some Gram-negative bacteria, and fungi. We studied the bi... (R)-2-hydroxy-3-phenylpropionic acid (PIP,) is an ideal antimicrobial compound with broad-spectrum activity against a wide range of Gram-positive bacteria, some Gram-negative bacteria, and fungi. We studied the bioconversion of phenylpyruvate (PPA) to PLA using whole recombinant Escherichia coli cells in a series of buffer/organic solvent systems. Octane was found to be the best organic solvent. The optimum volume ratio of the water phase to the n-octane phase, conversion temperature, substrate concentration, and cell concentration were 6:4, 40 ℃, 12.5 g/L, and 30 g/L wet cells, respectively. Under the optimized conditions, the average PLA productivity in the aqueous/ n-octane system was 30.69% higher than that in the aqueous system, and 32.31 g/L PLA was obtained with the use of a stirred reactor (2-L scale). Taken together, our findings indicated that PLA biosynthesis was more efficient in an aqueous/n-octane biphasic system than in a monophasic aqueous system. The proposed biphasic system is an effective strategy for enhancing PLA yield and the biosynthesis of its analogues. 展开更多
关键词 (r)-2-hydroxy-3-phenylpropionic acid Phenylpyruvate Aqueous/n-octane biphasic system Whole cell bioconversion recombinant Eschenchia coli
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Crystal Structure of Isoquinoline Derivatives
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作者 罗梅 张家海 +3 位作者 周仕明 孙杰 尹浩 胡克 《Chinese Journal of Structural Chemistry》 SCIE CAS CSCD 2011年第11期1672-1674,共3页
The chiral compound 5H-imidazol[2,3-b]isoquinoline-l-ethanol-5-one-1,2, 3, 10b-tetrahydro- β(S)-phenyl-3(S)-phenyl was synthesized from the direct condensation of 2- cyanophenyacetonitrile with optically active ... The chiral compound 5H-imidazol[2,3-b]isoquinoline-l-ethanol-5-one-1,2, 3, 10b-tetrahydro- β(S)-phenyl-3(S)-phenyl was synthesized from the direct condensation of 2- cyanophenyacetonitrile with optically active (S)-(+)-2-phenylglycinol in chlorobenzene under dry, anaerobic conditions. ZnCl2 was used as a Lewis acid catalyst in this reaction, and the structure of this compound was determined by X-ray diffraction, NMR, MS and IR. Crystal data of the title compound: C25H22N2O2, Mr = 382.45, P 21 21 21, a = 5.341(5), b = 16.735(5), c = 22.129(5) A, γ = 90°, V = 1978(2)A^3, Z = 4, Dc = 1.284 g/cm^3, the final R = 0.0321 for 2269 observed reflections with I 〉 2 σ(I) and Rw = 0.0771 for all data. 展开更多
关键词 5H-imidazol[2 3-b]isoquinoline-l-ethanol-5-one-1 2 3 10b-tetrahydro- β(s)-phenyl-3s)-phenyl (r)--)-2-phenylglyeinol Lewis acid eatalyst
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