High temperature superconducting （HTS） power inductor and its control technology have been studied and analyzed in the paper. Based on the results of simulations and practical experiments, a controlled release schem...High temperature superconducting （HTS） power inductor and its control technology have been studied and analyzed in the paper. Based on the results of simulations and practical experiments, a controlled release scheme has been proposed and verified for developing a practical HTS SMES prototype.展开更多
Parkinson＇s disease（PD） is a common neurodegenerative disorder whose primary pathology features are the degeneration of dopaminergic neurons in the substantia nigra pars compacta（SNc） and the presence of eosinoph...Parkinson＇s disease（PD） is a common neurodegenerative disorder whose primary pathology features are the degeneration of dopaminergic neurons in the substantia nigra pars compacta（SNc） and the presence of eosinophilic inclusions called Lewy body in the cytoplasm of the remained neurons. Growing evidence suggests that dysfunction of the ubiquitin-proteasome system（UPS） is involved in the etiopathogenesis of PD. In order to investigate the pathogenetic mechanism of ubiquitin-proteasome dysfunction in PD, 2D-differential gel electrophoresis（2D-DIGE） and MALDI-TOF Pro MS were used to determine the proteins, which were differentially expressed, in PC12 cells that had undergone a synthetic proteasomal inhibitor PSI（10 μmol/L） treatment for 24 h. Forty-six protein spots were differentially expressed in response to PSI administration, of which 34 were increased and 12 decreased. Six of these were identified as molecular charperones： endoplasmin precursor（GRP94）, heat shock protein 105（HSP105）, HSC-70-psl, glucose ruglated protein 75（GRP75）, glucose ruglated protein 58（GRP58） and heat shock 27000 protein l（HSP27）. The results suggest that the molecular chaperones play an important role in the PD model induced by proteasomal inhibitor.展开更多
文摘High temperature superconducting （HTS） power inductor and its control technology have been studied and analyzed in the paper. Based on the results of simulations and practical experiments, a controlled release scheme has been proposed and verified for developing a practical HTS SMES prototype.
文摘Parkinson＇s disease（PD） is a common neurodegenerative disorder whose primary pathology features are the degeneration of dopaminergic neurons in the substantia nigra pars compacta（SNc） and the presence of eosinophilic inclusions called Lewy body in the cytoplasm of the remained neurons. Growing evidence suggests that dysfunction of the ubiquitin-proteasome system（UPS） is involved in the etiopathogenesis of PD. In order to investigate the pathogenetic mechanism of ubiquitin-proteasome dysfunction in PD, 2D-differential gel electrophoresis（2D-DIGE） and MALDI-TOF Pro MS were used to determine the proteins, which were differentially expressed, in PC12 cells that had undergone a synthetic proteasomal inhibitor PSI（10 μmol/L） treatment for 24 h. Forty-six protein spots were differentially expressed in response to PSI administration, of which 34 were increased and 12 decreased. Six of these were identified as molecular charperones： endoplasmin precursor（GRP94）, heat shock protein 105（HSP105）, HSC-70-psl, glucose ruglated protein 75（GRP75）, glucose ruglated protein 58（GRP58） and heat shock 27000 protein l（HSP27）. The results suggest that the molecular chaperones play an important role in the PD model induced by proteasomal inhibitor.
