γ-Aminobutyric acid（GABA）,plays a key role in all stages of life,also is considered the main inhibitory neurotransmitter.GABA activates two kind of membrane receptors known as GABAA and GABAB,the first one is respo...γ-Aminobutyric acid（GABA）,plays a key role in all stages of life,also is considered the main inhibitory neurotransmitter.GABA activates two kind of membrane receptors known as GABAA and GABAB,the first one is responsible to render tonic inhibition by pentameric receptors containing α4-6,β3,δ,or ρ1-3 subunits,they are located at perisynaptic and/or in extrasynaptic regions.The biophysical properties of GABAA tonic inhibition have been related with cellular protection against excitotoxic injury and cell death in presence of excessive excitation.On this basis,GABAA tonic inhibition has been proposed as a potential target for therapeutic intervention of Huntington＇s disease.Huntington＇s disease is a neurodegenerative disorder caused by a genetic mutation of the huntingtin protein.For experimental studies of Huntington＇s disease mouse models have been developed,such as R6/1,R6/2,Hdh Q92,Hdh Q150,as well as YAC128.In all of them,some key experimental reports are focused on neostriatum.The neostriatum is considered as the most important connection between cerebral cortex and basal ganglia structures,its cytology display two pathways called direct and indirect constituted by medium sized spiny neurons expressing dopamine D1 and D2 receptors respectively,they display strong expression of many types of GABAA receptors,including tonic subunits.The studies about of GABAA tonic subunits and Huntington＇s disease into the neostriatum are rising in recent years,suggesting interesting changes in their expression and localization which can be used as a strategy to delay the cellular damage caused by the imbalance between excitation and inhibition,a hallmark of Huntington＇s disease.展开更多
对未来R&D经费总量及其与GDP比值进行科学的预测是制定科技发展规划的重要组成部分.提出一种定量分析预测方法———利用多变量灰色MGM(1,n)模型(mu lti-variab le grey model),研究R&D投入与GDP所形成的复杂系统变量之间的相...对未来R&D经费总量及其与GDP比值进行科学的预测是制定科技发展规划的重要组成部分.提出一种定量分析预测方法———利用多变量灰色MGM(1,n)模型(mu lti-variab le grey model),研究R&D投入与GDP所形成的复杂系统变量之间的相互影响关系,对天津市相关数据资料进行实证分析与中长期预测,为政府相关部门制订科学的科技发展规划提供有益的指导作用.展开更多
在基于Mesh-under的IPv6低功耗无线个域网(IPv6over low-power wireless personal area networks,6LoWPAN)中,针对传输路径上中间节点重传缓存溢出导致重传数据分片丢失,造成网络性能下降等问题,提出一种基于Mesh-under的备用缓存机制...在基于Mesh-under的IPv6低功耗无线个域网(IPv6over low-power wireless personal area networks,6LoWPAN)中,针对传输路径上中间节点重传缓存溢出导致重传数据分片丢失,造成网络性能下降等问题,提出一种基于Mesh-under的备用缓存机制。本文所提机制根据传输路径上各节点重传缓存使用情况及数据分片剩余跳数等信息,设置动态重传缓存门限,并为超过该门限的节点从其邻居节点中挑选合适的备用缓存节点,从而完成数据分片的缓存与重传过程,达到均衡使用各节点重传缓存的目的。结果表明,所提机制能够有效避免重传缓存溢出,减小网络能耗,同时进一步提高目的端重组成功率。展开更多
Let R be a ring, n, d be fixed non-negative integers, Jn,d the class of （n, d）- injective left R-modules, and Fn,d the class of （n, d）-flat right R-modules. In this paper, we prove that if R is a left n-coherent r...Let R be a ring, n, d be fixed non-negative integers, Jn,d the class of （n, d）- injective left R-modules, and Fn,d the class of （n, d）-flat right R-modules. In this paper, we prove that if R is a left n-coherent ring and m ≥ 2, then gl-right-Jn,a-dimRM ≤ m if and only if gl-left-Jn,d-dimRM ≤ m -- 2, if and only if Extm＋k（M, N） = 0 for all left R-modules M, N and all k 〉 -1, if and only if Extm-l（M, N） = 0 for all left R-modules M, N. Meanwhile, we prove that if R is a left n-coherent ring, then - - is right balanced on MR ×RM by Fn,d × Jn,d, and investigate the global right Jn,d-dimension of RM and the global right Fn,d-dimension of MR by right derived functors of - -. Some known results are obtained as corollaries.展开更多
基金the programs for the postdoctoral fellowships-Chilean CONICYT-FONDECYT#3140218,Mexican CONACYT#164978 and DID-UACh S-2015-81Sistema Nacional de Investigadores#58512 to Abraham Rosas-Arellano+2 种基金supported by USACH PhD fellowshipsupported with a PhD fellowship from CONACYT(#299627)FONDECYT grants 1151206 and 1110571 to Maite A.Castro
文摘γ-Aminobutyric acid（GABA）,plays a key role in all stages of life,also is considered the main inhibitory neurotransmitter.GABA activates two kind of membrane receptors known as GABAA and GABAB,the first one is responsible to render tonic inhibition by pentameric receptors containing α4-6,β3,δ,or ρ1-3 subunits,they are located at perisynaptic and/or in extrasynaptic regions.The biophysical properties of GABAA tonic inhibition have been related with cellular protection against excitotoxic injury and cell death in presence of excessive excitation.On this basis,GABAA tonic inhibition has been proposed as a potential target for therapeutic intervention of Huntington＇s disease.Huntington＇s disease is a neurodegenerative disorder caused by a genetic mutation of the huntingtin protein.For experimental studies of Huntington＇s disease mouse models have been developed,such as R6/1,R6/2,Hdh Q92,Hdh Q150,as well as YAC128.In all of them,some key experimental reports are focused on neostriatum.The neostriatum is considered as the most important connection between cerebral cortex and basal ganglia structures,its cytology display two pathways called direct and indirect constituted by medium sized spiny neurons expressing dopamine D1 and D2 receptors respectively,they display strong expression of many types of GABAA receptors,including tonic subunits.The studies about of GABAA tonic subunits and Huntington＇s disease into the neostriatum are rising in recent years,suggesting interesting changes in their expression and localization which can be used as a strategy to delay the cellular damage caused by the imbalance between excitation and inhibition,a hallmark of Huntington＇s disease.
文摘对未来R&D经费总量及其与GDP比值进行科学的预测是制定科技发展规划的重要组成部分.提出一种定量分析预测方法———利用多变量灰色MGM(1,n)模型(mu lti-variab le grey model),研究R&D投入与GDP所形成的复杂系统变量之间的相互影响关系,对天津市相关数据资料进行实证分析与中长期预测,为政府相关部门制订科学的科技发展规划提供有益的指导作用.
文摘在基于Mesh-under的IPv6低功耗无线个域网(IPv6over low-power wireless personal area networks,6LoWPAN)中,针对传输路径上中间节点重传缓存溢出导致重传数据分片丢失,造成网络性能下降等问题,提出一种基于Mesh-under的备用缓存机制。本文所提机制根据传输路径上各节点重传缓存使用情况及数据分片剩余跳数等信息,设置动态重传缓存门限,并为超过该门限的节点从其邻居节点中挑选合适的备用缓存节点,从而完成数据分片的缓存与重传过程,达到均衡使用各节点重传缓存的目的。结果表明,所提机制能够有效避免重传缓存溢出,减小网络能耗,同时进一步提高目的端重组成功率。
文摘Let R be a ring, n, d be fixed non-negative integers, Jn,d the class of （n, d）- injective left R-modules, and Fn,d the class of （n, d）-flat right R-modules. In this paper, we prove that if R is a left n-coherent ring and m ≥ 2, then gl-right-Jn,a-dimRM ≤ m if and only if gl-left-Jn,d-dimRM ≤ m -- 2, if and only if Extm＋k（M, N） = 0 for all left R-modules M, N and all k 〉 -1, if and only if Extm-l（M, N） = 0 for all left R-modules M, N. Meanwhile, we prove that if R is a left n-coherent ring, then - - is right balanced on MR ×RM by Fn,d × Jn,d, and investigate the global right Jn,d-dimension of RM and the global right Fn,d-dimension of MR by right derived functors of - -. Some known results are obtained as corollaries.
基金Supported by the National Nature Science Foundation of China(11471309,11271162,and 11561062)Project of Henan Provincial Department of Education(18A110028)
