（m，n）—树的几个判定条件

通过构造(m,n)-树的(m,n)-图,给出了判断(m,n)-树的几个充分必要条件,从而进一步揭示了(m,n)-树的结构特征.

New Compacton Solutions of Nonlinearly Dispersive R（m, n） Equations

In this paper, we establish exact solutions for the .R（m,n） equations by using an sn-cn metnou,As a result, abundant new cornpactons, i,e, solitons with the absence of infinite wings, new type of Jacobi elliptic function, solitary wave and periodic wave solutions, of this equation are obtained with minimal calculations. The properties of the R（m, n） equations are shown in figures.

（m，n）－构形的线性最优标

研究图的带宽和问题，确定了（ｍ，ｎ）－构形的带宽和，并给出了其线性最优标。

New Symmetry Reductions,Dromions—Like and Compacton Solutions for a 2D BS（m,n） Equations Hierarchy with Fully Nonlinear Dispersion

We have found two types of important exact solutions, compacton solutions, which are solitary waves with the property that after colliding with their own kind, they re-emerge with the same coherent shape very much as the solitons do during a completely elastic interaction, in the and even models, and dromion solutions (exponentially decaying solutions in all direction) in many and models. In this paper, symmetry reductions in are considered for the break soliton-type equation with fully nonlinear dispersion (called equation) , which is a generalized model of break soliton equation , by using the extended direct reduction method. As a result, six types of symmetry reductions are obtained. Starting from the reduction equations and some simple transformations, we obtain the solitary wave solutions of equations, compacton solutions of equations and the compacton-like solution of the potential form (called ) . In addition, we show that the variable admits dromion solutions rather than the field itself in equation.

中国科学家揭示RNA的N6-甲基腺苷（m6A）修饰在果实成熟中的重要作用

DNA中的5-甲基胞嘧啶(5mC)和mRNA中的N6-甲基腺苷(m6A)的修饰形式,通常会携带用于调控基因表达的信息,之前研究表明,DNA的5mC参与了果实成熟的调节,而mRNA的m6A修饰在该过程中的功能以及5m C和m6A之间的相互作用,仍然知之甚少.

n／m／P／F_（max）调度问题的一种新解法

通过对Ｐａｌｍｅｒ法的分析，指出其不足之处，提出一个改进法，具体实例计算表明，改进法的计算量大大减少，而解的质量不低于Ｐａｌｍｅｒ法的解。

Peterson图和图D_(m,n)的边PI指数

利用分析法和分类讨论法,给出Peterson图和D_(m,n)图的边PI指数计算公式,丰富了图的PI指数理论.

指数有界双连续n阶m次积分C群的指数公式

利用经典算子半群理论中的研究方法,基于指数有界双连续n阶m次积分C群和预解式的定义,给出指数有界双连续n阶m次积分C群与其预解式间积分的表示关系,得到指数有界双连续n阶m次积分C群的指数公式,从而推广了n阶m次积分C半群的相关结果,丰富了算子半群理论的研究内容.

Clinical outcome and prognostic factors of T4N0M0 colon cancer after R0 resection:A retrospective study

BACKGROUND Paradoxically,patients with T4N0M0(stage II,no lymph node metastasis)colon cancer have a worse prognosis than those with T2N1-2M0(stage III).However,no previous report has addressed this issue.AIM To screen prognostic risk factors for T4N0M0 colon cancer and construct a prognostic nomogram model for these patients.METHODS Two hundred patients with T4N0M0 colon cancer were treated at Tianjin Medical University General Hospital between January 2017 and December 2021,of which 112 patients were assigned to the training cohort,and the remaining 88 patients were assigned to the validation cohort.Differences between the training and validation groups were analyzed.The training cohort was subjected to multi-variate analysis to select prognostic risk factors for T4N0M0 colon cancer,followed by the construction of a nomogram model.RESULTS The 3-year overall survival(OS)rates were 86.2%and 74.4%for the training and validation cohorts,respectively.Enterostomy(P=0.000),T stage(P=0.001),right hemicolon(P=0.025),irregular review(P=0.040),and carbohydrate antigen 199(CA199)(P=0.011)were independent risk factors of OS in patients with T4N0M0 colon cancer.A nomogram model with good concordance and accuracy was constructed.CONCLUSION Enterostomy,T stage,right hemicolon,irregular review,and CA199 were independent risk factors for OS in patients with T4N0M0 colon cancer.The nomogram model exhibited good agreement and accuracy.

Comparative efficacy and safety between endoscopic submucosal dissection,surgery and definitive chemoradiotherapy in patients with cT1N0M0 esophageal cancer

BACKGROUND Endoscopic submucosal dissection(ESD)and surgical resection are the standard of care for cT1N0M0 esophageal cancer(EC),whereas definitive chemoradiotherapy(d-CRT)is a treatment option.Nevertheless,the comparative efficiency and safety of ESD,surgery and d-CRT for cT1N0M0 EC remain unclear.AIM To compare the efficiency and safety of ESD,surgery and d-CRT for cT1N0M0 EC.METHODS We retrospectively analyzed the hospitalized data of a total of 472 consecutive patients with cT1N0M0 EC treated at Sun Yat-sen University Cancer center between 2017-2019 and followed up until October 30th,2022.We analyzed demographic,medical recorded,histopathologic characteristics,imaging and endoscopic,and follow-up data.The Kaplan-Meier method and Cox proportional hazards modeling were used to analyze the difference of survival outcome by treatments.Inverse probability of treatment weighting(IPTW)was used to minimize potential confounding factors.RESULTS We retrospectively analyzed patients who underwent ESD(n=99)or surgery(n=220)or d-CRT(n=16)at the Sun Yat-sen University Cancer Center from 2017 to 2019.The median follow-up time for the ESD group,the surgery group,and the d-CRT group was 42.0 mo(95%CI:35.0-60.2),45.0 mo(95%CI:34.0-61.75)and 32.5 mo(95%CI:28.3-40.0),respectively.After adjusting for background factors using IPTW,the highest 3-year overall survival(OS)rate and 3-year recurrence-free survival(RFS)rate were observed in the ESD group(3-year OS:99.7% and 94.7% and 79.1%;and 3-year RFS:98.3%,87.4% and 79.1%,in the ESD,surgical,and d-CRT groups,respectively).There was no difference of severe complications occurring between the three groups(P≥0.05).Multivariate analysis showed that treatment method,histology and depth of infiltration were independently associated with OS and RFS.CONCLUSION For cT1N0M0 EC,ESD had better long-term survival and lower hospitalization costs than those who underwent d-CRT and surgery,with a similar rate of severe complications occurring.

(m,n)-内射和(m,n)-平坦函子

设R是有单位元的结合环,m和n是两个固定的正整数.引入了(m,n)-内射函子和(m,n)-平坦函子的概念,研究了这两类函子的一些性质,利用(m,n)-内射函子和(m,n)-平坦函子给出了(m,n)-凝聚环和Von Neumann正则环的一些等价刻画.

pT1N1M0早期胃癌术后辅助治疗临床意义的探索

背景:pT1N1M0分期胃癌术后辅助治疗目前各大指南无统一共识。本研究的目的是确定辅助放化疗对pT1N1M0胃癌根治术后患者有无生存获益,分析影响pT1N1M0胃癌患者预后的危险因素。方法:从SEER数据库中选择2004年至2019年胃切除术后pT1N1M0 GC患者319例。采用Kaplan-Meier法和log-rank检验分析总生存率。采用Cox比例风险回归模型对影响pT1N1M0胃癌根治性切除患者预后的因素进行单变量和多变量分析。结果:生存分析显示术后辅助化疗(5年OS:52.4% vs. 75.8%,p 0.05)。结论:术后辅助化疗及辅助放疗能够改善pT1N1M0 GC患者OS,年龄、辅助化疗、肿瘤部位、ELNC是pT1N1M0胃癌预后的独立影响因素。Background: Currently, there is no consensus on postoperative adjuvant therapy for pT1N1M0 gastric cancer in major guidelines. The aim of this study is to determine the survival benefit of adjuvant chemoradiotherapy in patients with pT1N1M0 gastric cancer after radical gastrectomy, and to analyze the risk factors affecting the prognosis of patients with pT1N1M0 gastric cancer. Methods: A total of 319 patients with pT1N1M0 GC after gastrectomy from 2004 to 2019 were selected from the SEER database. Kaplan-Meier method and log-rank test were used to analyze the overall survival rate. Univariate and multivariate analyses of prognostic factors of patients with pT1N1M0 gastric cancer after radical resection were performed using Cox proportional hazards regression model. Results: Survival analysis showed that postoperative adjuvant chemotherapy (5-year OS: 52.4% vs. 75.8%, p 0.05). Conclusions: Postoperative adjuvant chemotherapy and radiotherapy can improve the OS of patients with pT1N1M0 GC. Age, adjuvant chemotherapy, tumor location, and ELNC are independent prognostic factors for pT1N1M0 gastric cancer.

On （m, n）-Coherent Modules and Preenvelopes

In this paper, let m, n be two fixed positive integers and M be a right R-module, we define （m, n）-M-flat modules and （m, n）-coherent modules. A right R-module F is called （m, n）-M-flat if every homomorphism from an （n, m）-presented right R-module into F factors through a module in addM. A left S-module M is called an （m, n）-coherent module if MR is finitely presented, and for any （n, m）-presented right R-module K, Hom（K, M） is a finitely generated left S-module, where S = End（MR）. We mainly characterize （m, n）-coherent modules in terms of preenvelopes （which are monomorphism or epimorphism） of modules. Some properties of （m, n）-coherent rings and coherent rings are obtained as corollaries.

m6A RNA甲基化调控因子在食管腺癌中的表达谱及其临床意义研究

目的:探讨N6-甲基腺苷(m6A)RNA甲基化调控因子在食管腺癌中的表达模式及其预后价值,构建基于m6A调控因子的风险模型,用于预测患者生存并寻找新的治疗靶点。方法:从TCGA数据库获取81名食管腺癌患者和11名对照患者的RNA-seq数据及临床预后信息。使用Limma包分析m6A RNA甲基化调控因子的表达与临床病理特征间的关系,采用Cox回归和LASSO算法构建包含五个m6A因子的风险模型。结果:17个m6A因子在食管腺癌组织中的表达显著高于正常组织。YTHDC2、EIF3A与T、N分期,IGF22BP1与远处转移相关。Cox分析和LASSO回归确定RBMX、HNRNPA2B1、WTAP、VIRMA四个预后因子并构建风险模型。Kaplan-Meier分析显示,高风险患者生存率显著低于低风险组。结论:m6A因子的表达与食管腺癌患者的临床特征密切相关,所构建的风险模型为预后预测和个性化治疗提供了新参考。

一类广义K(m,n)方程的行波解

运用微分方程定性理论和动力系统分支方法,研究了一类广义K(m,n)方程的行波解。考虑了两种情形:K(1,3,2)方程和K(2,3,3)方程。在不同的参数条件下,得到K(1,3,2)方程的紧孤子和K(2,3,3)方程的紧孤子及周期爆破波解。进一步通过数值模拟,分析其系统的分支相图和行波解的波形图。

干扰RNA METTL14对大鼠肺成纤维细胞向肌成纤维细胞转化的影响

目的探究干扰RNA甲基转移酶样蛋白14(methyltransferase-like 14,METTL14)在转化因子β1(transforming growth factorβ1,TGF-β1)诱导的大鼠肺成纤维细胞向肌成纤维细胞转移中的作用。方法大鼠肺成纤维细胞中构建METTL14小干扰RNA(small interfering RNA METTL14,si-METTL14)序列(si-METTL14-122、si-METTL14-300、si-METTL14-450)及对照siRNA(Negative control siRNA,si-NC)。建立TGF-β1(20 ng/mL)诱导肺成纤维细胞向肌成纤维细胞转化模型,转染si-NC及si-METTL14序列至肺成纤维细胞,检测METTL14、肌成纤维细胞标志物Ⅰ型胶原蛋白α1(collagen typeⅠalpha 1,COL1A1)、α-平滑肌肌动蛋白(α-smooth muscle actin,α-SMA)及肌成纤维细胞转化负向调控因子Smad家族7号蛋白(Smad family member 7,Smad7)的mRNA和蛋白水平。结果si-METTL14有效沉默肺成纤维细胞METTL14表达水平。肌成纤维细胞转化模型组中METTL14表达显著升高(P<0.05)。与control组相比,TGF-β1诱导model组COLIA1、α-SMA表达显著升高,Smad7表达显著降低,转染si-METTL14抑制COLIA1、α-SMA表达,促进Smad7表达(P<0.05)。结论METTL14抑制TGF-β1诱导大鼠肺成纤维细胞向肌成纤维细胞转化,且可能与METTL14上调Smad7表达有关。

Effect of toroidal mode coupling on explosive dynamics of m/n=3/1 double tearing mode

The CLT code was used to quantitatively study the impact of toroidal mode coupling on the explosive dynamics of the m/n=3/1 double tearing mode.The focus of this study was on explosive reconnection processes,in which the energy bursts and the main mode no longer dominates when the separation between two rational surfaces is relatively large in the medium range.The development of higher m and n modes is facilitated by a relatively large separation between two rational surfaces,a small q_(min)(the minimum value of the safety factor),or low resistivity.The relationships between the higher m and n mode development,explosive reconnection rate,and position exchange of 3/1 islands are summarized for the first time.Separation plays a more important role than q_(min)in enhancing the development of higher m and n modes.At a relatively large separation,the good development of higher m and n modes greatly reduces the reconnection rate and suppresses the development of the main mode,resulting in the main mode not being able to develop sufficiently large to generate the position changes of 3/1 islands.

M1基因模式差异对H9N2亚型禽流感病毒增殖特性的影响

为探究基质蛋白1(M1)对H9N2亚型禽流感病毒适应性的影响,研究基于M1的5种主要模式,利用反向遗传技术拯救了5株具有不同M1基因模式的H9N2亚型禽流感病毒,通过测定病毒的一步与多步生长曲线以及生长竞争优势试验探讨M1对H9N2亚型禽流感病毒增殖能力的影响,将MOI均为0.001的5株病毒共感染MDCK细胞,感染后48h提取细胞上清的病毒RNA,将反转录的cDNA样品进行单核苷酸多态性(SNP)测序。结果显示:M1为P5模式的H9N2亚型禽流感病毒增殖能力显著高于其余4株病毒(P<0.05),P5模式病毒的M1基因所涉及的9个可检测的氨基酸位点占比超过74%。研究表明,M1为P5模式的H9N2亚型禽流感病毒具有最强的增殖能力和明显的生长竞争优势,结果从M1对病毒增殖能力影响角度解释了该分支病毒在我国禽群中广泛流行的原因。

Learning Sequential and Structural Dependencies Between Nucleotides for RNA N6-Methyladenosine Site Identification

N6-methyladenosine(m6A)is an important RNA methylation modification involved in regulating diverse biological processes across multiple species.Hence,the identification of m6A modification sites provides valuable insight into the biological mechanisms of complex diseases at the post-transcriptional level.Although a variety of identification algorithms have been proposed recently,most of them capture the features of m6A modification sites by focusing on the sequential dependencies of nucleotides at different positions in RNA sequences,while ignoring the structural dependencies of nucleotides in their threedimensional structures.To overcome this issue,we propose a cross-species end-to-end deep learning model,namely CR-NSSD,which conduct a cross-domain representation learning process integrating nucleotide structural and sequential dependencies for RNA m6A site identification.Specifically,CR-NSSD first obtains the pre-coded representations of RNA sequences by incorporating the position information into single-nucleotide states with chaos game representation theory.It then constructs a crossdomain reconstruction encoder to learn the sequential and structural dependencies between nucleotides.By minimizing the reconstruction and binary cross-entropy losses,CR-NSSD is trained to complete the task of m6A site identification.Extensive experiments have demonstrated the promising performance of CR-NSSD by comparing it with several state-of-the-art m6A identification algorithms.Moreover,the results of cross-species prediction indicate that the integration of sequential and structural dependencies allows CR-NSSD to capture general features of m6A modification sites among different species,thus improving the accuracy of cross-species identification.