Based on the contents and temperament of pastoral poetries written by TAO Yuan-ming,by centering on respecting the nature,indifference and optimism,and plainness and authenticity,the paper had analyzed aesthetic ideol...Based on the contents and temperament of pastoral poetries written by TAO Yuan-ming,by centering on respecting the nature,indifference and optimism,and plainness and authenticity,the paper had analyzed aesthetic ideologies contained in his poetries.On this basis,it had discussed the influence of aesthetic ideology of TAO Yuan-ming on the style of classical gardens in South China,which were quiet and natural,elegant and fresh,simple and plain,and far-reaching in artistic conception.By combining with cases,it pointed out that the poetic prose had been directly quoted as the names of gardens or scenic spots of classical gardens in South China,and showed that the aesthetic ideology of TAO Yuan-ming had set up a successful ideal model for cultural landscapes,producing far-reaching influence on the aesthetic state of mind of gardeners or owners of gardens,further instilling humanistic spirit into classical gardens in South China.展开更多
Only in the presence of sidelobe jamming (SLJ), can the conventional adaptive monopulse technique null the jamming effectively and maintain the monopulse angle estimation accuracy simultaneously. While mainlobe jamm...Only in the presence of sidelobe jamming (SLJ), can the conventional adaptive monopulse technique null the jamming effectively and maintain the monopulse angle estimation accuracy simultaneously. While mainlobe jamming (MLJ) exists, the mainlobe of adaptive pattern will subject to serious distortion, which results in a failure of detecting and tracking targets by monopulse technique. Therefore, a monopulse angle estimation algorithm based on combining sum-difference beam and auxiliary beam is presented. This algorithm utilizes both high gain difference beams and high gain auxiliary beams for cancelling the mainlobe jammer and multiple sidelobe jammers (SLJs) while keeping an adap- tive monopulse ratio. Theoretical analysis and simulation results indicate that the serious invalidation of monopulse technique in MLJ and SLJs scenarios is resolved well, which improves the monopulse angle accuracy greatly. Furthermore, the proposed algorithm is of simple implementation and low computational complexity.展开更多
An alpha-uniformized Markov chain is defined by the concept of equivalent infinitesimalgenerator for a semi-Markov decision process (SMDP) with both average- and discounted-criteria.According to the relations of their...An alpha-uniformized Markov chain is defined by the concept of equivalent infinitesimalgenerator for a semi-Markov decision process (SMDP) with both average- and discounted-criteria.According to the relations of their performance measures and performance potentials, the optimiza-tion of an SMDP can be realized by simulating the chain. For the critic model of neuro-dynamicprogramming (NDP), a neuro-policy iteration (NPI) algorithm is presented, and the performanceerror bound is shown as there are approximate error and improvement error in each iteration step.The obtained results may be extended to Markov systems, and have much applicability. Finally, anumerical example is provided.展开更多
Xiao-Xu-Ming decoction has been widely used to treat stroke and sequelae of stroke. We have previously shown that the active fractions of Xiao-Xu-Ming decoction attenuate cerebral ischemic injury. However, the global ...Xiao-Xu-Ming decoction has been widely used to treat stroke and sequelae of stroke. We have previously shown that the active fractions of Xiao-Xu-Ming decoction attenuate cerebral ischemic injury. However, the global protein profile and signaling conduction pathways regulated by Xiao-Xu-Ming decoction are still unclear. This study established a two-vessel occlusion rat model by bilateral common carotid artery occlusion. Rats were intragastrically administered 50 or 150 mg/kg Xiao-Xu-Ming decoction for 4 consecutive weeks. Learning and memory abilities were measured with Morris water maze. Motor ability was detected with prehensile test. Coordination ability was examined using the inclined screen test. Neuronal plasticity was observed by immunofluorescent staining. Differentially expressed proteins of rat hippocampus were analyzed by label-free quantitative proteomics. Real time-polymerase chain reaction and western blot assay were used to identify the changes in proteins. Results showed that Xiao-Xu-Ming decoction dramatically alleviated learning and memory deficits, and motor and coordination dysfunction, and increased the expression of microtubule-associated protein 2. Xiao-Xu-Ming decoction extract remarkably decreased 13 upregulated proteins and increased 39 downregulated proteins. The regulated proteins were mainly involved in oxidation reduction process, intracellular signaling cascade process, and protein catabolic process. The signaling pathways were mainly involved in ubiquitin mediated proteolysis and the phosphatidylinositol signaling system. Furthermore, there was an interaction among Rab2 a, Ptpn1, Ppm1 e, Cdk18, Gorasp2, Eps15, Capza2, Syngap1 and Mt-nd1. Protein analyses confirmed the changes in expression of MTND1. The current findings provide new insights into the molecular mechanisms of Xiao-Xu-Ming decoction extract's effects on chronic cerebral hypoperfusion.展开更多
The Dao zang 道藏 edition of Mozi in the Ming Dynasty was a significant step towards its rediscovery.Various editions were published later,showing different interpretations of the Mozi's content.Some editions trie...The Dao zang 道藏 edition of Mozi in the Ming Dynasty was a significant step towards its rediscovery.Various editions were published later,showing different interpretations of the Mozi's content.Some editions tried to discover Mozi's moral principles and his views on politics,economy and society.But other editions mostly aimed at making money by providing study materials for people.These early Mozi edtions testify to Mozi's early rediscovery,not only as a master,but also as an economic commodity.展开更多
his paper is going to apply Christopher Mans' point of view in his essay "Nature and Silence" to the analysis of Tao Yuan-ming's and Wordsworth's poems from eco-critical angle. The analysis is su...his paper is going to apply Christopher Mans' point of view in his essay "Nature and Silence" to the analysis of Tao Yuan-ming's and Wordsworth's poems from eco-critical angle. The analysis is supposed to prove that their natural poems are full of ecological consciousness.展开更多
Valid as folk law,Ming Bai document is the code of conduct for the villagers,which is applied in Danjiang T own,Langde T own and Wangfeng T ownship in Leishan county,Qiandongnan Miao and Dong autonomous prefecture in ...Valid as folk law,Ming Bai document is the code of conduct for the villagers,which is applied in Danjiang T own,Langde T own and Wangfeng T ownship in Leishan county,Qiandongnan Miao and Dong autonomous prefecture in Guizhou province.It refers to comprehensive administration,safety construction,safety production,fire fighting,traffic safety,prohibition of opium,fire protection of forest,family plan,and traditional festival etc. Mostly they are posted on the conspicuous wooden buildings and bricks wall of villages,Ming Bai document plays an irreplaceable role in adjusting local social relations. Moreover,its legal culture and the value of legal sociology are worthy of having a discussion and research.展开更多
OBJECTIVE Xiao-xu-ming decoction(XXMD),a well-known traditional Chinese herbal prescription,has been widely used to treat stroke.It is recorded in″Bei Ji Qian Jin Yao Fang″written by Si-miao Sun of the Chinese ancie...OBJECTIVE Xiao-xu-ming decoction(XXMD),a well-known traditional Chinese herbal prescription,has been widely used to treat stroke.It is recorded in″Bei Ji Qian Jin Yao Fang″written by Si-miao Sun of the Chinese ancient Tang Dynasty.In our previous study,the active fraction of XXMD(XXM)against cerebral ischemia has been prepared by modern separation and purification techniques.This study was to investigate XXM against lipopolysaccaride(LPS)-induced neuroinflammation in mice.METHODS LPS is an endotoxin from the outer membrane of Gram-negative bacteria that activates inflammation.XXM was pre-treated in BALB/C mice followed by injected intraperitoneally with LPS(5 mg·kg-1).The effects of XXM on LPS-induced pro-inflammatory factors and proteins were measured by ELISA,Western blot,and immunofluorescence in vivo.RESULTS Mice treated with XXM showed significantly decreased proinflammatory factors level,including IL-1β(P<0.01),IL-6(P<0.01),TNF-α(P<0.05),and MCP-1(P<0.01).Furthermore,XXM also significantly inhibited the inflammatory pathway proteins expression induced by LPS,including TLR4,MyD 88,and COX-2.CONCLUSION XXM possesses anti-neuroinflammation in mice and might be a promising therapeutic agent for stroke.展开更多
This essay examines current-event plays( shishiju 时事剧) and their social functions in late Ming China. Drawing on awide range or primary sources and built on secondary scholarship on information history,the essay of...This essay examines current-event plays( shishiju 时事剧) and their social functions in late Ming China. Drawing on awide range or primary sources and built on secondary scholarship on information history,the essay offered a complete picture of the booming,features,social functions and the decline of the current-event plays. The essay argues that many current-event plays addressed on credibility,timeliness and easy accessibility,which enabled current-event plays to play an important role in information circulation. This essay further exposes the current-event plays not only opened a forum for public discussion but also influenced public opinions greatly from literate elites to the masses in Ming China. Through analyzing current-event plays in the context of Ming society,this essay expands the realm of studying information history.展开更多
OBJECTIVE Using bioinformatics methods,to establish Xiao-Xu-Ming decoction(XX.MD) "compound-vasoconstriction G Protein-Coupled Receptors(GPCR) targets" network,and analyze the vasoconstriction regulatory eff...OBJECTIVE Using bioinformatics methods,to establish Xiao-Xu-Ming decoction(XX.MD) "compound-vasoconstriction G Protein-Coupled Receptors(GPCR) targets" network,and analyze the vasoconstriction regulatory effective components and the potential targets of XXMD.METHODS Ac.cording to the XXMD herb sources,we retrieved the chemical structures from the national scientific da.ta sharing platform for population and health pharmaceutical information center,TCMSP database and the latest research literature.The chemical molecular library was established after class prediction and screening for medicinal and metabolic properties.Five kinds of vasoconstriction GPCR crystal structure including 5-HT receptors(5-HT1 AR,5-HT1 BR),AT1 R,β2-AR,hUTR and ETB were retrieved from Bank Pro.tein Data Bank database or homology modeling using Discovery Studio 4.1 built-in modeling tools.After virtual screening by Libdock molecular docking,the highest rated 50 compounds of each target were col.lected and analyzed.The collected data were further used to construct and analyze the network.RE.SULTS 859 single compound structures information in XXMD were generalized following the screen.ing of obtained 2043 compounds.The complicated compound-vasoconstriction GPCR targets network of XXMD was then constructed and analyzed by molecular docking with the above five kinds of GPCR target receptors.Most of the chemical composition effects were associated with different vasoconstric.tion GPCR targets,while a few effective components can be applied to multiple GPCR targets at the same time,therefore forming synergies.CONCLUSION Vasorelaxant effects of XXMD may not only result from the collaborative interaction between a variety of active ingredients in Chinese medicine and multi.ple targets,but also from the interaction between some effective component and multiple targets.展开更多
OBJECTIVE Vascular dementia(VD) refers to a progressive decline in memory and cognitive function caused by chronic cerebral ischemia.2-Vessels occlusion(2-VO) has been widely used as a model of VD.Xiao-Xu-Ming decocti...OBJECTIVE Vascular dementia(VD) refers to a progressive decline in memory and cognitive function caused by chronic cerebral ischemia.2-Vessels occlusion(2-VO) has been widely used as a model of VD.Xiao-Xu-Ming decoction,a well-known traditional Chinese medicine prescrip.tion,has been widely used to treat stroke and sequelae of stroke.The present study was to investigate the mechanism of Xiao-Xu-Ming decoction(XXM) against chronic cerebral ischemia injury in rats.METHODS After XXM treatment,rats were performed a memory testing with Morris water maze and motor ability testing using prehensile test and inclined screen test.Neuronal plasticity was observed by immunofluorescent staining with MAP2 antibody.Differentially expressed proteins of rat hippocampus were analyzed by Label-free quantitative proteomics.RESULTS XXM significantly alleviated 2-VOinduced learning and memory deficits,motor ability dysfunction,and neuronal plasticity injury in rats.The mechanism might be involved in up-regulation of 39 proteins and down-regulation of 13 proteins in the hippocampus of rats after XXM treatment vs 2-VO group rats.Gene ontology and pathway analysis showed that the regulated proteins are mainly involved in oxidation reduction process,intracellular signaling cascade process,and protein catabolic process,etc.The signal pathways are mainly involved in ubiquitin mediated proteolysis and phosphatidylinositol signaling system.CONCLUSION Current findings provide new insights into the molecular mechanisms of XXM on chronic cerebral ischemia.展开更多
Taking a section of the Ming Dynasty Outer City Wall from Xianhe Gate to Qilin Gate for example, this paper proposed the landscape design from the perspective of experience tourism, highlighted the wal, and took the b...Taking a section of the Ming Dynasty Outer City Wall from Xianhe Gate to Qilin Gate for example, this paper proposed the landscape design from the perspective of experience tourism, highlighted the wal, and took the beautiful environment and rich history and cultures of the Ming Dynasty Outer City Wall as the essential experience elements, to build cultural recreational corridors with the theme of "experiencing the Ming Dynasty culture", so that visitors will get unforgettable experience, tourism quality, popularity of the Ming Dynasty Outer City Wall as well as its cultural and educational significance will be further promoted.展开更多
This paper explored the background of the leisure boom among the literati in the late Ming Dynasty from the aspects of politics, economy, ideology and social environment, and elaborated the leisure styles of the liter...This paper explored the background of the leisure boom among the literati in the late Ming Dynasty from the aspects of politics, economy, ideology and social environment, and elaborated the leisure styles of the literati in terms of enjoying a sightseeing tour, sampling wine and tea, appreciating and collecting calligraphy and painting works, favoring theatergoing, indulging in dallying with prostitutes, practicing meditation, and building gardens, and analyzed the influence of their leisure styles on the painting and calligraphy art, drama, literary creation, garden construction and other aspects of the society at that time. It is hoped that this paper can provide a deep understanding of social politics, economy, ideology and culture in the late Ming Dynasty and a reference for the development of the current leisure tourism.展开更多
Being based on preliminary study of Kunming famous temples during the Ming and Qing dynasties,field investigation was carried out about the framework of landscape,layout of waters,characteristic of structure and plant...Being based on preliminary study of Kunming famous temples during the Ming and Qing dynasties,field investigation was carried out about the framework of landscape,layout of waters,characteristic of structure and plant furnishing in Tanhua temple,Black Dragon Pool,Masijid of Shuncheng,Haiyuan temple and Golden Shrine which are famous temple garden in Kunming. A simple interpretation was drawn of artistic characteristics on temple garden in Kunming during the Ming and Qing dynasties via analytical investigation on many factors which influenced the development of garden of Dynasties of Ming and Qing. Then we have reviewed the elemental traits of temple garden built at that time,put forward some constructive suggestions on how to protect and develop those temple garden now still exist in Kunming.展开更多
Starting from the Tianping Mountain theme painting in Suzhou in the Ming Dynasty, we explore how did the painters and literati in this period shape the image of the Tianping Mountain through their works, thereby refle...Starting from the Tianping Mountain theme painting in Suzhou in the Ming Dynasty, we explore how did the painters and literati in this period shape the image of the Tianping Mountain through their works, thereby reflecting their understanding on many landscapes on the Tianping Mountain. By exploring a series of paintings and poems, we try to analyze the characteristics and cultural connotation of landscape paintings of the Tianping Mountain in the Ming Dynasty, which is conducive to improving position of the Tianping Mountain natural and humanistic landscape in Suzhou.展开更多
Academy is a special education organization and academic research institute in ancient China, founded in the Tang Dynasty, and prospered in the Ming and Qing Dynasty. Academy garden as a type of classical Chinese gard...Academy is a special education organization and academic research institute in ancient China, founded in the Tang Dynasty, and prospered in the Ming and Qing Dynasty. Academy garden as a type of classical Chinese garden shows ethnic characteristics in the regions inhabited by ethnic groups.展开更多
In order to improve the service life of corundum lin- ing.for induction Jitrnace, corundum dry ramming mix was prepared using brown corundum, fu.sed magnesia, and α-Al2O3 micropowder as main starting materials, mul t...In order to improve the service life of corundum lin- ing.for induction Jitrnace, corundum dry ramming mix was prepared using brown corundum, fu.sed magnesia, and α-Al2O3 micropowder as main starting materials, mul the it!fluence of α-Al2O3 micropowder additions (0, 1% , 2%, and 3%, in mass) on properties of corundum dry ramming re.ix was investigated. The results show that after heat treating at 1 600 ~C , with the in-crease of α-Al2O3 addition, the permanent change in di- mensions on heating of the specimens decreases firstly and then increases, bulk density increases, apparent po- rosity decreases, and the crushing strength declines first- Iv and then enhances; when the addition of α-Al2O3 is 2 mass% , the termanent change in dimensions on heating of the specimens i.s relatively small and the crushing .strength decrease.s to 22.8 MPa. The XRD attd SEM reults show that after .firing at 1 600 for 3 h sin, all granular magnesium aluminate spinel form. and is welldistributed, which enhances the density.展开更多
Phyto-groups on 5 remained city wall sections of the Ming Dynasty in Nanjing City was investigated through on-the-spot survey,99 species of 93 genera,60 families were found,and species of Asteraceae and Poaceae accoun...Phyto-groups on 5 remained city wall sections of the Ming Dynasty in Nanjing City was investigated through on-the-spot survey,99 species of 93 genera,60 families were found,and species of Asteraceae and Poaceae accounted for the largest ratio.Plants on the city wall are characterized by strong drought resistance and precocity,their seeds can grow out of the wall cracks,and roots secrete acidoid and obtain nutrients from wall bricks.Plants on different wall sections are different,and human interventions influence phyto-groups on the city wall greatly.On this basis,it was concluded that plants had negative influence on city wall,especially plant roots destroyed the wall seriously.Corresponding researches were carried out and prevention suggestions proposed to provide scientific support for the protection of ancient city walls in Nanjing City.展开更多
The renovation of historical blocks often stays at the material level of buildings, ignoring the deeper spiritual level, which can not arouse people’s sense of belonging to the city memory. Based on the protection of...The renovation of historical blocks often stays at the material level of buildings, ignoring the deeper spiritual level, which can not arouse people’s sense of belonging to the city memory. Based on the protection of local Qianshan area culture, taking Hekou ancient town street of Ming and Qing Dynasty as an example, with the construction of place spirit and sense of belonging as the primary goal, and combining the history and culture of the city, the current situation of the streets and the characteristics of the buildings, this paper put forward the relevant renovation measures to provide a kind of thinking for the refined and rational renovation of the blocks in the future.展开更多
基金Supported by Fund for Scientific Research of Nanjing University of Finance and Economics (B2010017)~~
文摘Based on the contents and temperament of pastoral poetries written by TAO Yuan-ming,by centering on respecting the nature,indifference and optimism,and plainness and authenticity,the paper had analyzed aesthetic ideologies contained in his poetries.On this basis,it had discussed the influence of aesthetic ideology of TAO Yuan-ming on the style of classical gardens in South China,which were quiet and natural,elegant and fresh,simple and plain,and far-reaching in artistic conception.By combining with cases,it pointed out that the poetic prose had been directly quoted as the names of gardens or scenic spots of classical gardens in South China,and showed that the aesthetic ideology of TAO Yuan-ming had set up a successful ideal model for cultural landscapes,producing far-reaching influence on the aesthetic state of mind of gardeners or owners of gardens,further instilling humanistic spirit into classical gardens in South China.
基金supported by the National Natural Science Foundation of China(60925005)
文摘Only in the presence of sidelobe jamming (SLJ), can the conventional adaptive monopulse technique null the jamming effectively and maintain the monopulse angle estimation accuracy simultaneously. While mainlobe jamming (MLJ) exists, the mainlobe of adaptive pattern will subject to serious distortion, which results in a failure of detecting and tracking targets by monopulse technique. Therefore, a monopulse angle estimation algorithm based on combining sum-difference beam and auxiliary beam is presented. This algorithm utilizes both high gain difference beams and high gain auxiliary beams for cancelling the mainlobe jammer and multiple sidelobe jammers (SLJs) while keeping an adap- tive monopulse ratio. Theoretical analysis and simulation results indicate that the serious invalidation of monopulse technique in MLJ and SLJs scenarios is resolved well, which improves the monopulse angle accuracy greatly. Furthermore, the proposed algorithm is of simple implementation and low computational complexity.
文摘An alpha-uniformized Markov chain is defined by the concept of equivalent infinitesimalgenerator for a semi-Markov decision process (SMDP) with both average- and discounted-criteria.According to the relations of their performance measures and performance potentials, the optimiza-tion of an SMDP can be realized by simulating the chain. For the critic model of neuro-dynamicprogramming (NDP), a neuro-policy iteration (NPI) algorithm is presented, and the performanceerror bound is shown as there are approximate error and improvement error in each iteration step.The obtained results may be extended to Markov systems, and have much applicability. Finally, anumerical example is provided.
基金supported in part by the National Natural Science Foundation of China,No.81473383(to YHW)the Significant New-Drugs Creation of Science and Technology Major Projects in China,No.2018ZX09711001-003-019(to YHW)the Innovation Fund for Graduate of Beijing Union Medical College of China,No.2017-1007-02(to XC)
文摘Xiao-Xu-Ming decoction has been widely used to treat stroke and sequelae of stroke. We have previously shown that the active fractions of Xiao-Xu-Ming decoction attenuate cerebral ischemic injury. However, the global protein profile and signaling conduction pathways regulated by Xiao-Xu-Ming decoction are still unclear. This study established a two-vessel occlusion rat model by bilateral common carotid artery occlusion. Rats were intragastrically administered 50 or 150 mg/kg Xiao-Xu-Ming decoction for 4 consecutive weeks. Learning and memory abilities were measured with Morris water maze. Motor ability was detected with prehensile test. Coordination ability was examined using the inclined screen test. Neuronal plasticity was observed by immunofluorescent staining. Differentially expressed proteins of rat hippocampus were analyzed by label-free quantitative proteomics. Real time-polymerase chain reaction and western blot assay were used to identify the changes in proteins. Results showed that Xiao-Xu-Ming decoction dramatically alleviated learning and memory deficits, and motor and coordination dysfunction, and increased the expression of microtubule-associated protein 2. Xiao-Xu-Ming decoction extract remarkably decreased 13 upregulated proteins and increased 39 downregulated proteins. The regulated proteins were mainly involved in oxidation reduction process, intracellular signaling cascade process, and protein catabolic process. The signaling pathways were mainly involved in ubiquitin mediated proteolysis and the phosphatidylinositol signaling system. Furthermore, there was an interaction among Rab2 a, Ptpn1, Ppm1 e, Cdk18, Gorasp2, Eps15, Capza2, Syngap1 and Mt-nd1. Protein analyses confirmed the changes in expression of MTND1. The current findings provide new insights into the molecular mechanisms of Xiao-Xu-Ming decoction extract's effects on chronic cerebral hypoperfusion.
文摘The Dao zang 道藏 edition of Mozi in the Ming Dynasty was a significant step towards its rediscovery.Various editions were published later,showing different interpretations of the Mozi's content.Some editions tried to discover Mozi's moral principles and his views on politics,economy and society.But other editions mostly aimed at making money by providing study materials for people.These early Mozi edtions testify to Mozi's early rediscovery,not only as a master,but also as an economic commodity.
文摘his paper is going to apply Christopher Mans' point of view in his essay "Nature and Silence" to the analysis of Tao Yuan-ming's and Wordsworth's poems from eco-critical angle. The analysis is supposed to prove that their natural poems are full of ecological consciousness.
基金the Li Jianjun presided over Kong Xuechang tender “Yangming culture and modern social governance”(KXT ZD201507)Sub-topics “Yangming culture and the rule of law social construction research” part of the research results
文摘Valid as folk law,Ming Bai document is the code of conduct for the villagers,which is applied in Danjiang T own,Langde T own and Wangfeng T ownship in Leishan county,Qiandongnan Miao and Dong autonomous prefecture in Guizhou province.It refers to comprehensive administration,safety construction,safety production,fire fighting,traffic safety,prohibition of opium,fire protection of forest,family plan,and traditional festival etc. Mostly they are posted on the conspicuous wooden buildings and bricks wall of villages,Ming Bai document plays an irreplaceable role in adjusting local social relations. Moreover,its legal culture and the value of legal sociology are worthy of having a discussion and research.
基金The project supported by National Natural Science Foundation of China(81473383,81573645)
文摘OBJECTIVE Xiao-xu-ming decoction(XXMD),a well-known traditional Chinese herbal prescription,has been widely used to treat stroke.It is recorded in″Bei Ji Qian Jin Yao Fang″written by Si-miao Sun of the Chinese ancient Tang Dynasty.In our previous study,the active fraction of XXMD(XXM)against cerebral ischemia has been prepared by modern separation and purification techniques.This study was to investigate XXM against lipopolysaccaride(LPS)-induced neuroinflammation in mice.METHODS LPS is an endotoxin from the outer membrane of Gram-negative bacteria that activates inflammation.XXM was pre-treated in BALB/C mice followed by injected intraperitoneally with LPS(5 mg·kg-1).The effects of XXM on LPS-induced pro-inflammatory factors and proteins were measured by ELISA,Western blot,and immunofluorescence in vivo.RESULTS Mice treated with XXM showed significantly decreased proinflammatory factors level,including IL-1β(P<0.01),IL-6(P<0.01),TNF-α(P<0.05),and MCP-1(P<0.01).Furthermore,XXM also significantly inhibited the inflammatory pathway proteins expression induced by LPS,including TLR4,MyD 88,and COX-2.CONCLUSION XXM possesses anti-neuroinflammation in mice and might be a promising therapeutic agent for stroke.
文摘This essay examines current-event plays( shishiju 时事剧) and their social functions in late Ming China. Drawing on awide range or primary sources and built on secondary scholarship on information history,the essay offered a complete picture of the booming,features,social functions and the decline of the current-event plays. The essay argues that many current-event plays addressed on credibility,timeliness and easy accessibility,which enabled current-event plays to play an important role in information circulation. This essay further exposes the current-event plays not only opened a forum for public discussion but also influenced public opinions greatly from literate elites to the masses in Ming China. Through analyzing current-event plays in the context of Ming society,this essay expands the realm of studying information history.
基金supported by Major Scientific and Technological Project of China(2013ZX095081042013ZX09402203)+1 种基金 CAMS Innovation Fund for Medical Sciences(2016-I2M-3-007) Central Public Scientific Re.search Institution Fundamental Project(2014CX05)
文摘OBJECTIVE Using bioinformatics methods,to establish Xiao-Xu-Ming decoction(XX.MD) "compound-vasoconstriction G Protein-Coupled Receptors(GPCR) targets" network,and analyze the vasoconstriction regulatory effective components and the potential targets of XXMD.METHODS Ac.cording to the XXMD herb sources,we retrieved the chemical structures from the national scientific da.ta sharing platform for population and health pharmaceutical information center,TCMSP database and the latest research literature.The chemical molecular library was established after class prediction and screening for medicinal and metabolic properties.Five kinds of vasoconstriction GPCR crystal structure including 5-HT receptors(5-HT1 AR,5-HT1 BR),AT1 R,β2-AR,hUTR and ETB were retrieved from Bank Pro.tein Data Bank database or homology modeling using Discovery Studio 4.1 built-in modeling tools.After virtual screening by Libdock molecular docking,the highest rated 50 compounds of each target were col.lected and analyzed.The collected data were further used to construct and analyze the network.RE.SULTS 859 single compound structures information in XXMD were generalized following the screen.ing of obtained 2043 compounds.The complicated compound-vasoconstriction GPCR targets network of XXMD was then constructed and analyzed by molecular docking with the above five kinds of GPCR target receptors.Most of the chemical composition effects were associated with different vasoconstric.tion GPCR targets,while a few effective components can be applied to multiple GPCR targets at the same time,therefore forming synergies.CONCLUSION Vasorelaxant effects of XXMD may not only result from the collaborative interaction between a variety of active ingredients in Chinese medicine and multi.ple targets,but also from the interaction between some effective component and multiple targets.
基金supported by National Natural Science Foundation of China(81473383) National Science and Technology Major Project of China(2018ZX09711001-003-019)+1 种基金 CAMS Innovation Fund for Medical Sciences(2016-I2M-3-007) Innovation Fund for Graduate of Beijing Union M
文摘OBJECTIVE Vascular dementia(VD) refers to a progressive decline in memory and cognitive function caused by chronic cerebral ischemia.2-Vessels occlusion(2-VO) has been widely used as a model of VD.Xiao-Xu-Ming decoction,a well-known traditional Chinese medicine prescrip.tion,has been widely used to treat stroke and sequelae of stroke.The present study was to investigate the mechanism of Xiao-Xu-Ming decoction(XXM) against chronic cerebral ischemia injury in rats.METHODS After XXM treatment,rats were performed a memory testing with Morris water maze and motor ability testing using prehensile test and inclined screen test.Neuronal plasticity was observed by immunofluorescent staining with MAP2 antibody.Differentially expressed proteins of rat hippocampus were analyzed by Label-free quantitative proteomics.RESULTS XXM significantly alleviated 2-VOinduced learning and memory deficits,motor ability dysfunction,and neuronal plasticity injury in rats.The mechanism might be involved in up-regulation of 39 proteins and down-regulation of 13 proteins in the hippocampus of rats after XXM treatment vs 2-VO group rats.Gene ontology and pathway analysis showed that the regulated proteins are mainly involved in oxidation reduction process,intracellular signaling cascade process,and protein catabolic process,etc.The signal pathways are mainly involved in ubiquitin mediated proteolysis and phosphatidylinositol signaling system.CONCLUSION Current findings provide new insights into the molecular mechanisms of XXM on chronic cerebral ischemia.
基金Sponsored by Youth Program of National Natural Science Foundation of China(41601131)Youth Program of Humanistic and Social Science Research,Ministry of Education(15YJC790092)Nanjing Scientific and Technological Innovation Team Program“Tourism Geography(Wel ness Tourism)”
文摘Taking a section of the Ming Dynasty Outer City Wall from Xianhe Gate to Qilin Gate for example, this paper proposed the landscape design from the perspective of experience tourism, highlighted the wal, and took the beautiful environment and rich history and cultures of the Ming Dynasty Outer City Wall as the essential experience elements, to build cultural recreational corridors with the theme of "experiencing the Ming Dynasty culture", so that visitors will get unforgettable experience, tourism quality, popularity of the Ming Dynasty Outer City Wall as well as its cultural and educational significance will be further promoted.
文摘This paper explored the background of the leisure boom among the literati in the late Ming Dynasty from the aspects of politics, economy, ideology and social environment, and elaborated the leisure styles of the literati in terms of enjoying a sightseeing tour, sampling wine and tea, appreciating and collecting calligraphy and painting works, favoring theatergoing, indulging in dallying with prostitutes, practicing meditation, and building gardens, and analyzed the influence of their leisure styles on the painting and calligraphy art, drama, literary creation, garden construction and other aspects of the society at that time. It is hoped that this paper can provide a deep understanding of social politics, economy, ideology and culture in the late Ming Dynasty and a reference for the development of the current leisure tourism.
文摘Being based on preliminary study of Kunming famous temples during the Ming and Qing dynasties,field investigation was carried out about the framework of landscape,layout of waters,characteristic of structure and plant furnishing in Tanhua temple,Black Dragon Pool,Masijid of Shuncheng,Haiyuan temple and Golden Shrine which are famous temple garden in Kunming. A simple interpretation was drawn of artistic characteristics on temple garden in Kunming during the Ming and Qing dynasties via analytical investigation on many factors which influenced the development of garden of Dynasties of Ming and Qing. Then we have reviewed the elemental traits of temple garden built at that time,put forward some constructive suggestions on how to protect and develop those temple garden now still exist in Kunming.
基金Sponsored by the General Project of Humanity and Social Science in Colleges and Universities of Jiangxi Province(YS18126)the Jiangxi Postgraduate Innovation Fund Project in 2018(YC2018-S149)
文摘Starting from the Tianping Mountain theme painting in Suzhou in the Ming Dynasty, we explore how did the painters and literati in this period shape the image of the Tianping Mountain through their works, thereby reflecting their understanding on many landscapes on the Tianping Mountain. By exploring a series of paintings and poems, we try to analyze the characteristics and cultural connotation of landscape paintings of the Tianping Mountain in the Ming Dynasty, which is conducive to improving position of the Tianping Mountain natural and humanistic landscape in Suzhou.
文摘Academy is a special education organization and academic research institute in ancient China, founded in the Tang Dynasty, and prospered in the Ming and Qing Dynasty. Academy garden as a type of classical Chinese garden shows ethnic characteristics in the regions inhabited by ethnic groups.
文摘In order to improve the service life of corundum lin- ing.for induction Jitrnace, corundum dry ramming mix was prepared using brown corundum, fu.sed magnesia, and α-Al2O3 micropowder as main starting materials, mul the it!fluence of α-Al2O3 micropowder additions (0, 1% , 2%, and 3%, in mass) on properties of corundum dry ramming re.ix was investigated. The results show that after heat treating at 1 600 ~C , with the in-crease of α-Al2O3 addition, the permanent change in di- mensions on heating of the specimens decreases firstly and then increases, bulk density increases, apparent po- rosity decreases, and the crushing strength declines first- Iv and then enhances; when the addition of α-Al2O3 is 2 mass% , the termanent change in dimensions on heating of the specimens i.s relatively small and the crushing .strength decrease.s to 22.8 MPa. The XRD attd SEM reults show that after .firing at 1 600 for 3 h sin, all granular magnesium aluminate spinel form. and is welldistributed, which enhances the density.
基金Supported by Program of National Natural Science Foundation of China(NSFC J0730641)Phase-III Innovative Undergraduate Cultivation Program of "985 Project" of Nanjing University
文摘Phyto-groups on 5 remained city wall sections of the Ming Dynasty in Nanjing City was investigated through on-the-spot survey,99 species of 93 genera,60 families were found,and species of Asteraceae and Poaceae accounted for the largest ratio.Plants on the city wall are characterized by strong drought resistance and precocity,their seeds can grow out of the wall cracks,and roots secrete acidoid and obtain nutrients from wall bricks.Plants on different wall sections are different,and human interventions influence phyto-groups on the city wall greatly.On this basis,it was concluded that plants had negative influence on city wall,especially plant roots destroyed the wall seriously.Corresponding researches were carried out and prevention suggestions proposed to provide scientific support for the protection of ancient city walls in Nanjing City.
基金Sponsored by General Project of Humanities and Social Sciences in Colleges and Universities of Jiangxi Province(YS18126)
文摘The renovation of historical blocks often stays at the material level of buildings, ignoring the deeper spiritual level, which can not arouse people’s sense of belonging to the city memory. Based on the protection of local Qianshan area culture, taking Hekou ancient town street of Ming and Qing Dynasty as an example, with the construction of place spirit and sense of belonging as the primary goal, and combining the history and culture of the city, the current situation of the streets and the characteristics of the buildings, this paper put forward the relevant renovation measures to provide a kind of thinking for the refined and rational renovation of the blocks in the future.