温肾通督方促进小鼠脊髓损伤的修复

背景:前期研究证实,温肾通督方可通过抑制脾脏B细胞焦亡、促进微血管内皮细胞吞噬髓鞘碎片、影响小胶质细胞迁移和浸润、促进受损神经元恢复、降低脊髓损伤后神经元凋亡等促进脊髓损伤恢复,但其机制尚不明确。目的:探讨温肾通督方对脊髓损伤小鼠髓系细胞触发受体2(triggering receptor expressed on myeloid cells 2,TREM2)及PI3K/Akt信号通路的影响。方法:取36只C57BL/6小鼠,采用随机数字表法分为假手术组、模型组、温肾通督方组,每组12只。模型组与温肾通督方组采用改良Allen’s法制备小鼠T10脊髓损伤模型,造模后第1天,温肾通督方组灌胃给予温肾通督方,假手术组、模型组灌胃给予生理盐水,每天1次,连续给药28 d。给药期间,通过BMS评分和斜板实验评价各组小鼠运动功能;造模后第7,28天,采用苏木精-伊红染色观察各组小鼠脊髓组织病理变化,免疫荧光染色双标法检测脊髓组织离子化钙结合适配分子1(ionized calcium binding adaptor molecule 1,IBA1)、TREM2蛋白表达,Western blot检测脊髓组织TREM2、PI3K、p-PI3K、Akt、p-Akt、Bcl2、Bax、Caspase3蛋白表达。结果与结论:①BMS评分和斜板实验结果表明,脊髓损伤造模后小鼠后肢运动功能下降,而经过温肾通督方治疗后,脊髓损伤小鼠后肢运动功能明显提升。②苏木精-伊红染色结果显示,与模型组比较,温肾通督方小鼠脊髓组织病理结构明显改善,表现为背侧白质和神经元萎缩程度、细胞质空泡化降低及炎性细胞浸润减少等。③免疫荧光染色结果显示,造模后第7天,模型组IBA1、TREM2蛋白表达均低于假手术组(P<0.05),温肾通督方组IBA1、TREM2蛋白表达均高于模型组(P<0.05);造模后第28天,模型组TREM2蛋白表达低于假手术组(P<0.05),温肾通督方组小鼠脊髓组织中的TREM2蛋白表达高于模型组(P<0.05)。④Western blot检测结果表明,造模后第7天,与假手术组相比,模型组TREM2、Akt蛋白表达及Bcl2/Bax比值降低(P<0.05),p-Akt、Bax蛋白表达及p-Akt/Akt比值升高(P<0.05);与模型组相比,温肾通督方组TREM2、PI3K、p-PI3K、Akt、p-Akt、Bcl2蛋白表达及p-PI3K/PI3K、p-Akt/Ak、Bcl2/Bax比值升高(P<0.05),Bax、Caspase3蛋白表达降低(P<0.05)。造模后第28天,与假手术组相比,模型组TREM2、PI3K、p-PI3K、Akt、p-Akt、Bcl2蛋白表达及Bcl2/Bax比值降低(P<0.05),Bax蛋白表达升高(P<0.05);与模型组相比,温肾通督方组TREM2、PI3K、Akt、p-Akt、Bcl2蛋白表达及Bcl2/Bax比值升高(P<0.05),Bax蛋白表达降低(P<0.05)。⑤结果表明,温肾通督方可能通过上调小胶质细胞TREM2激活PI3K/Akt信号通路,抑制神经元凋亡发挥神经保护作用,进而促进脊髓损伤的修复。

金介甫传记艺术的时间维度透视——以英文原作The Odyssey of Shen Congwen为考察中心

金介甫在学界有"国外沈从文研究第一人"的美称,其中一个重要原因就是其英文著作《沈从文传》的成功和影响力。《沈从文传》是一部既给人史实感,又具备可读性的文学大师的传记。金介甫在该部传记中,巧妙地运用了对叙事时间的调控艺术从而保障了整个作品的真实性和文学性。金介甫的叙事时间调控艺术主要体现在三个方面:首先,在交代传主的生平故事时采用自然叙事时间和时间凸显的手法;其次,为凸显沈从文的文学成就和彰显沈从文作品的艺术价值,采用了转换时距的办法;最后,为了突出沈从文地方作家文学大师的形象,采用叙事频率变更的手法,从而确保对传主生平事实的合理选取。

编写《钱学森手稿》和翻译《Story of Hsue-shen Tsien》解说词的体会

介绍笔者在编写《钱学森手稿》和翻译电视片《Story of Hsue-shen Tsien》英文解说词的体会,包括:1.钱学森在研究工作中所体现的科学精神;2.熟悉专业知识在科技翻译工作中的重要性等。

Clinical Efficacy and Molecular Mechanism of Nourishing Shen and Supplementing Marrow Principle in Treating β Thalassemia

Objective: To explore the possibility of using traditional Chinese medicine (TCM) in treating β thalassemia, its clinical effect and molecular mechanism of the action.Methods: According to the TCM theory of“Shen producing marrow”, the composite recipe, Yisui Shenxueling Granule (YSSXL), consisting of Chinese drugs for nourishing Shen and supplementing marrow (NS&SM) was given orally to 7 8 patients with β thalassemia (49 of the severe type and 29 of moderate type ), 3 times a day, 10 g each time (for children, the dose would be reduced proper ly), with 3 months as one therapeutic course, and no blood transfusion used in t he course. The clinical therapeutic efficacy and hematologic parameters in patie nts were observed, and systemic gene analysis was conducted with PAGE, PCR, PCR SSCP, RT PCR and DNA sequences analysis and mRNA detection, in order to s tudy the molecular mechanism from the relationships between genetic mutation and clinical efficacy, gene expression and its regulation. Results: YSSXL showed obvious therapeutic effect in treating β thalassemia. Gene analysis revealed that it did not change the genetic mutatio n type, but could obviously increase hemoglobin, fetal hemoglobin (HbF), γ/(β+ γ) globin ratio, γ globin mRNA expression and GM CSF mRNA expression in patients, as well as the GM CSFmRMA in marrow of mice after 60 Co radia tion. Conclusion: YSSXL has a remarkable therapeutic effect on β tha lassemia, and its possible mechanism is its action in unlocking γ gene, in creasing the γ globin expression and enhancing HbF synthesis so as to compe nsate for the gene defect. This study has opened a new path for the treatment of β thalassemia with TCM.

Changes of Precipitation Infiltration Recharge in the Circumstances of Coal Mining Subsidence in the Shen-Dong Coal Field,China

Coal mining subsidence is a universal environmental-geological problem in mining areas. By selecting the Shen-Dong coal mining subsidence area as the research field, this paper studies the changes in precipitation infiltration recharge in the circumstances of coal mining subsidence by means of field geological investigation and laboratory simulation experiments, which is expected to provide a scientific basis for eco-environmental restoration in the mining area. The results indicate that at the unstable stage of subsidence, three types of subsidence in the Shen-Dong mining area have positive effects on the precipitation infiltration recharge, and the type of full-thickness bedrock subsidence has the greatest influence. In the stable stage of subsidence, the precipitation infiltration process after long- term drought and the moisture migration in the aeration zone undergo three different stages： evaporation-infiltration before precipitation, infiltration-upward infiltration-infiltration during precipitation and evaporation-infiltration after precipitation. During a heavy rainfall infiltration process, the wetting front movement in fine sand, coarse sand and dualistic structure of fine-coarse sand consists of two stages： the stage of wetting front movement during precipitation, in which the wetting front movement distance has linear relationship with the depth, and the stage of wetting front movement after precipitation, in which the wetting front movement distance has the power function relationship with the depth. The wetting front movement velocity is influenced by the rainfall amount and the lithology in the aeration zone. However, as the depth increases, the movement velocity will decay exponentially.

解放眉足蟹(Blepharipoda liberate Shen)形态特征观察

为研究解放眉足蟹形态学特征(包括雌雄外部形态差异),补充国内解放眉足蟹相关资料的空缺,通过对采集到的野生活体进行解剖及显微观察,对成体口前板、组成口器的各个部分、第四步足、肛门及雌雄差异等进行了研究。口前板位于头胸部腹面第一、二触角的后方,口器的前方。口器由大、小颚及3对颚足共同组成,大颚单枝型,大颚须3节;第一小颚单枝型;第二小颚双枝型,内肢即小颚须棒状,外肢很发达,形成颚舟叶;第一颚足双枝型,内肢1节,外肢2节,具有上肢;第二颚足双枝型,内肢5节,外肢3节;第三颚足双枝型,内肢5节,外肢3节。胸足4对,均为单枝型,第1对为螯足,后3对为步足。腹部共7节(包括尾节),尾节无附肢,腹面有一肛门。腹部共6对腹肢,第6腹节的1对附肢与尾节共同形成尾扇,司游泳功能,是解放眉足蟹唯一的游泳器官。雌雄差异明显,生殖孔1对,雌体位于第二步足基节腹面,雄体则位于第四步足基节上;第2–5对腹肢,雌性双枝型,雄性单枝型。与虾蟹比较,其没有腹甲,头胸部腹面更近似于虾类,但背部形态又更接近蟹类。其腹部没有蟹类的腹甲沟及用于锁住腹部的搭扣,故腹部常常处于半伸展状态。第四步足则位于腹部第一腹节上,与虾蟹类明显不同。另外,观察发现其腮部及身体外表各部位均附着有双壳类软体动物。

Effect and Underlying Mechanism of Bu-Shen-An-Tai Recipe on Ovarian Apoptosis in Mice with Controlled Ovarian Hyperstimulation Implantation Dysfunction

The effect and underlying mechanism of Bu-Shen-An-Tai recipe on ovarian apoptosis in mice with controlled ovarian hyperstimulation(COH) implantation dysfunction were studied. The COH implantation dysfunction model in mice was established by intraperitoneal injection of 7.5 IU pregnant mare’s serum gonadotrophin(PMSG), followed by 7.5 IU human chorionic gonadotrophin(HCG) 48 h later. Then the female mice were mated with male at a ratio of 2:1 in the same cage at 6:00 p.m. The female mice from normal group were injected intraperitoneally with normal saline and mated at the corresponding time. Day 1 of pregnancy was recorded by examining its vaginal smears at 8:00 a.m. of the next day. Fifty successfully pregnant mice were equally randomly divided into 5 groups: normal control pregnant group(NC), COH implantation dysfunction model group(COH), low dosage of Bu-Shen-An-Tai recipe group(LOW), middle dosage of Bu-Shen-An-Tai recipe group(MID) and high dosage of Bu-Shen-An-Tai recipe group(HIGH). Then from day 1, the mice in different groups were respectively intragastrically given corresponding treatments at 9:00 a.m. for 5 consecutive days. The concentrations of 17β-estradiol(E) and progesterone(P) were determined by radioimmunoassay(RIA). The ultrastructural changes of ovarian tissues were observed by transmission electron microscope(TEM). The histopathological changes of ovarian tissues were observed by HE staining. The number of atretic follicles and pregnant corpus luteum were also recorded. TUNEL was applied to measure apoptotic cells of ovarian tissues. Western blotting was used to detect the protein expression of apoptosis-related factors like Bax, Bcl-2 and cleaved-caspase-3 in ovarian tissue of mice. The results showed that ovarian weight, the concentrations of Eand P, the number of atretic follicles and pregnant corpus luteum, as well as the apoptosis of granulosa cells were significantly increased in the COH group. The ultrastructures of ovarian tissues in the COH group showed that chromatin in granulosa cells was increased, agglutinated, aggregated or crescent-shaped. The focal cavitation and the typical apoptotic bodies could be seen in granulosa cells in the late stage of apoptosis. After the treatment with different doses of Bu-Shen-An-Tai recipe, the ultrastructural changes of ovarian granulosa cells apoptosis were dramatically improved and even disappeared under TEM. Visible mitochondria and mitochondrial cristae were increased and vacuoles were significantly reduced. The lipid dropltes were shown in a circluar or oval shape. The protein expression levels of Bax and cleaved-caspase-3 were decreased, and the expression of Bcl-2 protein was increased after treatment. It was concluded that Bu-Shen-An-Tai recipe can inhibit the apoptosis of ovarian granulosa cells, probably by up-regulating the protein expression of Bcl-2 and down-regulating Bax and cleaved-caspase-3, which contributes to the formation and maintenance of ovarian corpus luteum. It’s helpful to promote the embryonic implantation, to reduce embryo loss and ultimately to improve the success rate of pregnancy.

High Density Lipoprotein Phospholipids as a Marker of Coronary Heart Disease of Shen-Yang Deficiency Syndrome

Objective: To seek a new biochemical index for diagnosis of coronary heart disease (CHD) of shen-Yang deficiency syndrom (CHD-SYD). Methods: Sixty-one patients with CHD were divided into 3 groups according to their TCM Syndrome type, 10 patients in the group without Xin-Qi deficiency (Group A), 25 in the group with Xin-Qi deficiency but without Shen-Yang deficiency (Group B) and 26 in the group both with Xin-Qi deficiency and Shen-Yang deficiency (Group C). Levels of 17-hydroxy-corticoste-roid in urine (urinary 17-OHCS) per 24 hrs, and serum level of high density lipoprotein cholesterol (HDL-C) and high density lipoprotein phospholipid (HDL-PL) in them were determined in synchrostep and compared with those in the control group of 23 healthy aged persons, urinary 17-OHCS per 24 hrs was taken as the diagnostic standard to screen a new index for diagnosis of Shen-Yang deficiency Syndrome, and preliminary appraisal to the index was made. Results: Serum HDL-PL in the CHD-SYD patients( Group C) was 616+157 mg/L, which was obviously lower than that in the patients of Group A and B. With low HDL-PL(<650 mg/L) used as the index to diagnose CHD-SYD, the sensitivity was 73%, the specificity 86% and the accuracy 80%. Conclusion: HDL-PL <650 mg/L could be adopted as an index for CHD-SYD diagnosis, which is simple and practical.

Experimental Study on Observation of Hemorheologic Parameters of Hydrocortisone Caused Shen-Yang Deficiency in Rat Models

Objective:To explore the relationship between Shen deficiency and blood stasis. Methods: Using consecutive intramuscular injection of hydrocortisone to build Shen-yang deficiency model rats, and detect their hemorheological and biochemical parameters. Results: Comparison between the model group and control group showed that the in vitro thrombus significantly lengthened in the model group (P<0.05), the dry weight increased (P<0.01), hematocrit and whole blood viscosity under high sheared change lowered (P<0.05), blood glucose elevated (P<0.01), and RBC infiltration index, aggregation index increased (P close to 0.05). Conclusion: Under the condition of Shen-yang deficiency, although blood does not show such properties of blood stasis as being 'viscous, concentrated, coagulated and aggregated', partial change of hemorheology occurs, and it is liable to form thrombus, which proves that the Shen deficiency status is accompanied with the tendency of blood stasis.

Effect of Chinese Herbs Bu-shen on Expression of Pituitary PRL-R and PrRP-R in the Bromocriptine-induced Hypoprolactin Rat Abortion Model

Objective To study the effect of Chinese herbs preparation Bu-shen on pituitary prolactin-releasing peptide receptor (PrRP-R) and prolactin receptor (PRL-R) expression in the bromocriptine-induced rat abortion model Materials & Methods Female SD rats were divided into five groups randomly. Group A,B,C and D were injected with bromocriptine [0. 3 mg/(kg · d)] during the pregnant day 6～ 8, respectively. Group B was given powder of Bu-shen herbs [3 g/(kg · d)]. Group C was injected with prolactin (8 IU) twice a day and Group D with progesterone [(8 mg/kg · d) in the pregnant day 1～ 11. The rats in Group E were normal pregnant rats. All these rats were killed at the pregnant day 12 to observe the expression of PrRP-R, PRL-R from the pituitary using RT-PCR. Results The pregnant rate and total number of litters in Group A were significantly lower than those in Group B, C, D and E (P＜0. 01) and the expression of PrRP-R and PRL-R in the pituitary of Group A was higher than that of any other group. Conclusion Preparation Bu-shen plays a regulatory role in the secretion of prolactin possibly via modulating rats' hypothalamus and pituitary.

针刺联合补肾活血方治疗骨质疏松性胸腰椎骨折的疗效观察及对骨代谢水平的影响

目的观察针刺联合补肾活血方治疗骨质疏松性胸腰椎压缩性骨折的临床疗效及对患者血清骨代谢指标的影响。方法选择108例骨质疏松性胸腰椎骨折患者,随机分为对照组和联合组,每组54例。两组均进行椎体后凸成形术治疗和常规护理,对照组口服补肾活血方治疗,联合组采用针刺联合口服补肾活血方治疗。比较两组疼痛缓解时间、下床活动时间和骨折愈合时间,观察两组治疗前和随访结束时疼痛数字评估表(numerical rating scale,NRS)评分、中国人骨质疏松症简明生存质量量表(Chinese osteoporosis quality of life short questionnaire,COQOL)评分和Oswestry功能障碍指数(Oswestry disability index,ODI)的变化,观察两组治疗前和随访结束时骨折椎体的椎形态及骨密度检测结果的变化,观察治疗前后两组血清高迁移率族蛋白-1(high mobility group protein-1,HMGB-1)、C-反应蛋白(C-reactive protein,CRP)、P物质(substance P,SP)、皮质醇(cortisol,Cor)、骨形态发生蛋白-7(bone morphogenetic protein-7,BMP-7)、骨钙素N端中分子片段(osteocalcin n-terminal molecular fragment,N-MID)、网膜素-1(omentin-1)、Ⅰ型胶原C端肽(typeⅠcollagen C-terminal peptide,CTX-1)水平的变化,比较两组临床疗效。结果联合组疼痛缓解时间、下床活动时间和骨折愈合时间短于对照组(P<0.05),联合组治疗后HMGB-1、CRP、SP、Corh和CTX-1水平以及随访结束时伤椎楔变角、Cobb角、ODI评分、NRS评分和COQOL评分均低于对照组(P<0.05),联合组治疗后N-MID、Omentin-1和BMP-7水平以及随访结束时骨折椎体椎前缘高度和BMD水平高于对照组(P<0.05)。联合组总有效率高于对照组(P<0.05)。结论在椎体后凸成形术治疗和常规护理基础上,针刺联合补肾活血方治疗骨质疏松性胸腰椎骨折可减少炎症反应和应激反应,降低疼痛介质指标水平,改善骨性标志物及骨代谢水平,促进椎体愈合,提高腰椎功能、临床疗效及生活质量。

Effect of Chinese Herbs Bu-shen on PRLR, PR, ER mRNA of Decidue in Bromocriptine-induced Hypoprolac- tin Rat Abortion Model

Objective To explore the effect of Chinese herbs on PRLR, PR, ER mRNA of decidue in Bromocriptine-induced hypoprolactin abortion rat model from gene transcription level, and observe the changes of blood PRL, P, E2.Methods RT-PCR method was taken to analyses the differences of PRLR, PR, ER mRNA in decidue between model group (A group) and model + herbs group (A + H group); RIA was taken to measure the serum levels of PRL, P, E2. Results PRLR, PR mRNA expression in decidue of Group A was significantly lower than the A + H group (P<0. 01) , no difference in ER mRNA expression (P>0. 05); the abortion rate of Group A was 67 %, Group A+H was 17% , the difference was significant; as for the PRL and P level of day 7-1.0, the A group was significantly lower than the A+H group (P<0. 05).Conclusion Bromocriptine could induce abortion by declining the blood PRL, P level and downregulating PRLR, PR mRNA expression in decidue. Chinese herbs might maintain pregnancy by promoting PRL, P secretion and upregulating PRLR, PR mRNA expression in decidue.

基于命名实体识别的《神农本草经》知识图谱构建及可视化分析

目的构建《神农本草经》知识图谱,分析本草知识、挖掘隐性知识并进行可视化展示,为古籍研究提供方法学参考。方法梳理并表述《神农本草经》文献涉及的知识实体类型和实体间关系,应用BIO序列标注方法生产训练语料数据集,使用自主研发的CNLP文本标注系统进行文本标注,采用BERT模型识别命名实体,基于规则与语义关联设定确定实体间关系,经知识融合后,用Cypher语言导入图数据库Neo4j-community4.4.9进行存储和可视化展示,构建知识图谱。结果《神农本草经》知识图谱包含5273个节点、11064个关系,其模式层包含14种实体类、16种关系类型。可通过Cypher语言查询,从中药分类、药性理论、七情配伍、中药应用方面进行知识的可视化展示。结论本研究构建的知识图谱可直观反映《神农本草经》所载知识及隐性关系,适用于中医药古籍的知识挖掘及直观多维展示。

芪参益气滴丸对老年高血压合并急性冠状动脉综合征患者血清白细胞介素18及预后的影响

目的 探讨芪参益气滴丸对老年高血压合并急性冠状动脉综合征(ACS)患者血清白细胞介素18(IL-18)水平及预后的影响。方法 前瞻性选取2020年1月至2022年1月于天津市胸科医院就诊的老年高血压合并ACS患者330例,根据是否在标准西医治疗基础上加用芪参益气滴丸,随机分为芪参益气滴丸组164例和对照组166例。比较2组一般临床资料、治疗后1年血清IL-18、血压、血脂、血糖水平及随访1年内主要不良心血管事件(MACE)发生率,多因素logistic回归分析高血压合并ACS患者再发MACE的影响因素,ROC曲线分析血清IL-18对MACE的预测价值。结果 芪参益气滴丸组1年后血清IL-18、收缩压、舒张压、低密度脂蛋白胆固醇、总胆固醇及随访1年内MACE发生率显著低于对照组(P<0.05)。多因素logistic回归分析显示,芪参益气滴丸是老年高血压合并ACS患者发生MACE的独立保护因素(OR=0.259,95%CI:0.087~0.772,P=0.010),高水平的基线血清IL-18是再生MACE的独立危险因素(OR=1.075,95%CI:1.046~1.106,P=0.000)。血清IL-18预测老年高血压合并ACS患者再发MACE的ROC曲线下面积为0.786(95%CI:0.696~0.877,P<0.01),敏感性为65.00%,特异性为90.00%。结论 血清IL-18对老年高血压合并ACS患者的预后具有预测价值,芪参益气滴丸可以降低血清IL-18、血压及血脂水平,减少炎性反应,进而降低患者心血管事件发生风险,改善预后。

基于数据挖掘探讨沈红权治疗不寐处方的规律

目的 通过数据挖掘技术分析沈红权治疗不寐的用药经验及组方规律。方法 计算机收集并整理2019年12月至2022年12月就诊于上海中医药大学附属普陀医院沈红权主任门诊收治的不寐患者病史资料和医案处方,建立标准化数据库,借助古今医案云平台V2.3.7对处方中药物的性味、归经、应用频次、功效等进行统计分析,并对药味组合进行关联规则及聚类分析,总结处方用药经验和组方规律。结果 共纳入处方245首,涉及210味中药,总结归纳出高频单味中药20味。药性以平、寒、微寒为主,药味以甘、苦、辛为主,归经以肝、脾经为主。药物关联中得出高频药物药对关联规则8条;高频中药角药关联规则7条。药物聚类得出5个聚类处方。核心处方1主要用于肝血不足,虚热内扰证者;核心处方2主要用于伴下焦湿热伴便秘者;核心处方3主要用于气虚伴瘀热内蕴证者;核心处方4主要用于肝胆郁热证者;核心处方5主要用于肝郁脾虚证者。结论 沈红权主任治疗失眠以宁心安神、疏肝解郁为基本治法,实证常配伍清利湿热、凉血活血药物,虚实夹杂证配伍健脾养心、调和肝胃药物,虚证配伍益气养血、扶正安神为主。

参芪平律方联合体外反搏治疗射血分数降低心力衰竭的临床研究

目的观察参芪平律方联合体外反搏治疗射血分数降低心力衰竭(EFrHF)患者的临床疗效。方法选取2022年2月—2023年6月在河北医科大学第一医院治疗的60例EFrHF气虚血瘀证患者,随机分为对照组和试验组各30例。2组均给予西医标准化治疗,在此基础上,对照组患者给予体外反搏治疗4周,试验组患者给予体外反搏联合参芪平律方口服4周。观察2组治疗前后气虚血瘀证评分、心功能指标[左室射血分数(LVEF)、左室收缩末期内径(LVESD)、左室舒张末期内径(LVEDD)、血浆氨基末端脑钠肽前体(NT-proBNP)]、生活质量[6 min步行距离(6MWT)]的变化。结果与治疗前比较,治疗4周后2组患者气虚血瘀证评分均明显降低,心功能指标均明显改善,6MWT均明显延长,且试验组患者上述指标改善情况均明显优于对照组,差异均有统计学意义(P均<0.05)。结论参芪平律方联合体外反搏治疗能够显著减轻EFrHF气虚血瘀证患者临床症状,改善心功能,提高生活质量。

晚清洋务企业的外在镜像——以《申报》招商局评论为焦点的考察

晚清著名媒体《申报》对与其同年创办的中国近代第一家民族航运企业轮船招商局多所评论,涉及该局的创办意义、公司制运作、官商关系等多个方面,为该局提供了重要的企业外在镜像。《申报》对于招商局的评论内容丰富,见解深刻,有助于认识该局的社会影响与时代意义,进一步扩大了企业的外部性效应。由此切入,进行考察,或许有助于推进对企业史研究理路的新探。

梁繁荣教授“治神和脏”学术思想论治新冠后失眠经验撷英

本文从理论源流、治法、选穴处方及操作要点探析梁繁荣教授“治神和脏”学术思想在新冠后失眠的运用经验。梁繁荣教授认为新冠后失眠病因病机在于疠气扰神,神受邪扰,或疠气伤脏,脏不藏神,神失所养,致神不入舍,出现寤寐失常,或难以入寐,或寐而易醒,或寐而多梦。临证治疗以“治神和脏”为治则,选取头项部腧穴及背俞穴通督治神,募原穴或俞募穴相配调和脏腑,针刺手法强调虚实有别,补泻有度,对于阳虚失眠伴抑郁者辅以督脉火龙灸温阳开郁以增效,并附验案1则,以期为针灸治疗新冠后失眠提供参考。

诸“神”穴的命名及临床证治特点浅析

腧穴命名皆有深意,在腧穴的名称里,含有“神”字的腧穴共有9个,本文从诸“神”穴的命名规律、穴名释义、分布规律、临床证治等方面进行归纳总结分析,发现诸“神”穴的分布与心、脑密切相关,具有“中轴对称”和“群体组合布局”两大显著特点,该类腧穴除了具有一般腧穴的主治特点外,其临床证治及配伍主治与心脑血管病及人的精神神志类疾病密切相关,临床上治疗这类疾病时常选取各“神”穴相配或者配合他穴协同使用以发挥作用,诸“神”穴的临床运用也直接或间接体现了“心主神明”“脑为元神之府”的中医经典理论。