目的探讨β胶原特殊序列(β-crosslaps,β-CTX)、总1型胶原氨基端延长肽(t-P1NP)及N端中段骨钙素(N-MID-OT)在绝经后女性骨质疏松性骨折风险评估中的应用价值。方法回顾性分析2020年2月至2022年12月解放军总医院第六医学中心收治的102...目的探讨β胶原特殊序列(β-crosslaps,β-CTX)、总1型胶原氨基端延长肽(t-P1NP)及N端中段骨钙素(N-MID-OT)在绝经后女性骨质疏松性骨折风险评估中的应用价值。方法回顾性分析2020年2月至2022年12月解放军总医院第六医学中心收治的102例绝经后骨质疏松(postmenopausal osteoporosis,PMOP)患者的临床资料,将其作为研究组,并根据是否发生骨折将其分为PMOP骨折组(39例)与PMOP未骨折组(63例),另选100名健康体检者作为对照组。记录所有研究对象的β-CTX、t-P1NP及N-MID-OT水平并进行比较,用ROC曲线评价β-CTX、t-P1NP及N-MID-OT在绝经后女性骨质疏松性骨折风险评估中的应用价值。结果研究组的平均体重、体质量指数、股骨颈骨密度(bone mineral density,BMD)、左髋总和BMD及L 1~4总和BMD均明显低于对照组(P<0.05);而两组研究对象的平均年龄、平均身高及绝经年龄等比较差异均无统计学意义(P>0.05)。研究组的β-CTX、t-P1NP及N-MID-OT均明显高于对照组(t值依次为12.688、37.430、26.599,P<0.05)。β-CTX+t-P1NP+N-MID-OT联合检测用于预测PMOP的AUC值为0.978,敏感度为98.04%,特异度为97.00%,表明β-CTX+t-P1NP+N-MID-OT三指标联合检测用于预测PMOP的效能更高。PMOP骨折组的β-CTX、t-P1NP及N-MID-OT均明显高于PMOP未骨折组(t值依次为6.078、16.363、12.227,P<0.05)。β-CTX+t-P1NP+N-MID-OT联合检测用于评估PMOP骨折风险的AUC值为0.939,敏感度为94.87%,特异度为95.24%,表明β-CTX+t-P1NP+N-MID-OT联合检测用于评估PMOP骨折风险的效能更高。结论PMOP患者β-CTX、t-P1NP及N-MID-OT水平均明显升高,而PMOP骨折患者β-CTX、t-P1NP及N-MID-OT水平升高更为明显,且β-CTX+t-P1NP+N-MID-OT联合检测可显著提高对PMOP预测及骨折风险评估效能,值得借鉴。展开更多
BACKGROUND Paradoxically,patients with T4N0M0(stage II,no lymph node metastasis)colon cancer have a worse prognosis than those with T2N1-2M0(stage III).However,no previous report has addressed this issue.AIM To screen...BACKGROUND Paradoxically,patients with T4N0M0(stage II,no lymph node metastasis)colon cancer have a worse prognosis than those with T2N1-2M0(stage III).However,no previous report has addressed this issue.AIM To screen prognostic risk factors for T4N0M0 colon cancer and construct a prognostic nomogram model for these patients.METHODS Two hundred patients with T4N0M0 colon cancer were treated at Tianjin Medical University General Hospital between January 2017 and December 2021,of which 112 patients were assigned to the training cohort,and the remaining 88 patients were assigned to the validation cohort.Differences between the training and validation groups were analyzed.The training cohort was subjected to multi-variate analysis to select prognostic risk factors for T4N0M0 colon cancer,followed by the construction of a nomogram model.RESULTS The 3-year overall survival(OS)rates were 86.2%and 74.4%for the training and validation cohorts,respectively.Enterostomy(P=0.000),T stage(P=0.001),right hemicolon(P=0.025),irregular review(P=0.040),and carbohydrate antigen 199(CA199)(P=0.011)were independent risk factors of OS in patients with T4N0M0 colon cancer.A nomogram model with good concordance and accuracy was constructed.CONCLUSION Enterostomy,T stage,right hemicolon,irregular review,and CA199 were independent risk factors for OS in patients with T4N0M0 colon cancer.The nomogram model exhibited good agreement and accuracy.展开更多
Threshold signature is an important branch of the digital signature scheme,which can distribute signature rights and avoid the abuse of signature rights.With the continuous development of quantum computation and quant...Threshold signature is an important branch of the digital signature scheme,which can distribute signature rights and avoid the abuse of signature rights.With the continuous development of quantum computation and quantum information,quantum threshold signatures are gradually becoming more popular.Recently,a quantum(t,n)threshold group signature scheme was analyzed that uses techniques such as quantum-controlled-not operation and quantum teleportation.However,this scheme cannot resist forgery attack and does not conform to the design of a threshold signature in the signing phase.Based on the original scheme,we propose an improved quantum(t,n)threshold signature scheme using quantum(t,n)threshold secret sharing technology.The analysis proves that the improved scheme can resist forgery attack and collusion attack,and it is undeniable.At the same time,this scheme reduces the level of trust in the arbitrator during the signature phase.展开更多
Resource sharing among peers is one of important application in Peer-to-Peer（P2P） network. Inexistenee of server makes P2P network to be a less trustable tool for property owners to distribute their resource. In ord...Resource sharing among peers is one of important application in Peer-to-Peer（P2P） network. Inexistenee of server makes P2P network to be a less trustable tool for property owners to distribute their resource. In order to protect intelligent property, reputation management strategy is adopted in many P2P network. As long as a P2P network reputation strategy is confirmed, application designer can employ a special detailed distribution scheme to fulfill content distribution within the net. Shmir （k, n） threshold scheme, for example, is an encryption scheme to enhance the distribution se curity of this kind of design. （k＊, n） threshold scheme is a new tool similar to Shmir scheme is proposed in this paper. The new scheme based on polynomial expansion and its security is decided by the one way function used in the secret distribution procedure. The scheme efficiency and its features as well as comparison between new and Shmir scheme are also discussed in this paper.展开更多
The hand-held soil plant analysis development （SPAD） chlorophyll meter nitrogen status of the potato and guiding fertilization recommendations N recommendation, it is critical to establish the threshold SPAD value h...The hand-held soil plant analysis development （SPAD） chlorophyll meter nitrogen status of the potato and guiding fertilization recommendations N recommendation, it is critical to establish the threshold SPAD value has proved to be a promising tool in evaluating the n the process of N evaluation of potato plants and （SPAD reading）, below which nitrogen supplement is required. And taking convenient using into account, the threshold needs to be dynamic throughout the potato growing season so that the users can test their potato plants and make fertilization decision at any growing time of potato. To complete this goal, field experiments with different nitrogen supply levels were conducted in different sites in northern China from 2009 to 2011. The results showed that threshold SPAD values decrease as the growing season progresses for all cultivars and planting sites. By statistical analysis, the threshold regression models were established respectively as： y=-0.003χ2-0.0507χ＋58.213 （y, threshold SPAD value; χ, days after emergence） for the potato cultivar Kexin 1, and y=-0.003χ2＋0.017χ＋52.489 （y, threshold SPAD value; χ, days after emergence） for the cultivar Shepody, from which, the threshold SPAD value at any day after emergence can be calculated.展开更多
文摘目的探讨β胶原特殊序列(β-crosslaps,β-CTX)、总1型胶原氨基端延长肽(t-P1NP)及N端中段骨钙素(N-MID-OT)在绝经后女性骨质疏松性骨折风险评估中的应用价值。方法回顾性分析2020年2月至2022年12月解放军总医院第六医学中心收治的102例绝经后骨质疏松(postmenopausal osteoporosis,PMOP)患者的临床资料,将其作为研究组,并根据是否发生骨折将其分为PMOP骨折组(39例)与PMOP未骨折组(63例),另选100名健康体检者作为对照组。记录所有研究对象的β-CTX、t-P1NP及N-MID-OT水平并进行比较,用ROC曲线评价β-CTX、t-P1NP及N-MID-OT在绝经后女性骨质疏松性骨折风险评估中的应用价值。结果研究组的平均体重、体质量指数、股骨颈骨密度(bone mineral density,BMD)、左髋总和BMD及L 1~4总和BMD均明显低于对照组(P<0.05);而两组研究对象的平均年龄、平均身高及绝经年龄等比较差异均无统计学意义(P>0.05)。研究组的β-CTX、t-P1NP及N-MID-OT均明显高于对照组(t值依次为12.688、37.430、26.599,P<0.05)。β-CTX+t-P1NP+N-MID-OT联合检测用于预测PMOP的AUC值为0.978,敏感度为98.04%,特异度为97.00%,表明β-CTX+t-P1NP+N-MID-OT三指标联合检测用于预测PMOP的效能更高。PMOP骨折组的β-CTX、t-P1NP及N-MID-OT均明显高于PMOP未骨折组(t值依次为6.078、16.363、12.227,P<0.05)。β-CTX+t-P1NP+N-MID-OT联合检测用于评估PMOP骨折风险的AUC值为0.939,敏感度为94.87%,特异度为95.24%,表明β-CTX+t-P1NP+N-MID-OT联合检测用于评估PMOP骨折风险的效能更高。结论PMOP患者β-CTX、t-P1NP及N-MID-OT水平均明显升高,而PMOP骨折患者β-CTX、t-P1NP及N-MID-OT水平升高更为明显,且β-CTX+t-P1NP+N-MID-OT联合检测可显著提高对PMOP预测及骨折风险评估效能,值得借鉴。
基金Supported by Health Science and Technology Project of Tianjin Health Commission,No.ZC20190Tianjin Key Medical Discipline(Specialty)Construction Project,No.TJYXZDXK-005ATianjin Medical University Clinical Research Fund,No.22ZYYLCCG04.
文摘BACKGROUND Paradoxically,patients with T4N0M0(stage II,no lymph node metastasis)colon cancer have a worse prognosis than those with T2N1-2M0(stage III).However,no previous report has addressed this issue.AIM To screen prognostic risk factors for T4N0M0 colon cancer and construct a prognostic nomogram model for these patients.METHODS Two hundred patients with T4N0M0 colon cancer were treated at Tianjin Medical University General Hospital between January 2017 and December 2021,of which 112 patients were assigned to the training cohort,and the remaining 88 patients were assigned to the validation cohort.Differences between the training and validation groups were analyzed.The training cohort was subjected to multi-variate analysis to select prognostic risk factors for T4N0M0 colon cancer,followed by the construction of a nomogram model.RESULTS The 3-year overall survival(OS)rates were 86.2%and 74.4%for the training and validation cohorts,respectively.Enterostomy(P=0.000),T stage(P=0.001),right hemicolon(P=0.025),irregular review(P=0.040),and carbohydrate antigen 199(CA199)(P=0.011)were independent risk factors of OS in patients with T4N0M0 colon cancer.A nomogram model with good concordance and accuracy was constructed.CONCLUSION Enterostomy,T stage,right hemicolon,irregular review,and CA199 were independent risk factors for OS in patients with T4N0M0 colon cancer.The nomogram model exhibited good agreement and accuracy.
基金the National Natural Science Foundation of China(Grant Nos.61771294 and 61972235)。
文摘Threshold signature is an important branch of the digital signature scheme,which can distribute signature rights and avoid the abuse of signature rights.With the continuous development of quantum computation and quantum information,quantum threshold signatures are gradually becoming more popular.Recently,a quantum(t,n)threshold group signature scheme was analyzed that uses techniques such as quantum-controlled-not operation and quantum teleportation.However,this scheme cannot resist forgery attack and does not conform to the design of a threshold signature in the signing phase.Based on the original scheme,we propose an improved quantum(t,n)threshold signature scheme using quantum(t,n)threshold secret sharing technology.The analysis proves that the improved scheme can resist forgery attack and collusion attack,and it is undeniable.At the same time,this scheme reduces the level of trust in the arbitrator during the signature phase.
基金Supported by the National Natural Science Foun-dation of China (60473072)
文摘Resource sharing among peers is one of important application in Peer-to-Peer（P2P） network. Inexistenee of server makes P2P network to be a less trustable tool for property owners to distribute their resource. In order to protect intelligent property, reputation management strategy is adopted in many P2P network. As long as a P2P network reputation strategy is confirmed, application designer can employ a special detailed distribution scheme to fulfill content distribution within the net. Shmir （k, n） threshold scheme, for example, is an encryption scheme to enhance the distribution se curity of this kind of design. （k＊, n） threshold scheme is a new tool similar to Shmir scheme is proposed in this paper. The new scheme based on polynomial expansion and its security is decided by the one way function used in the secret distribution procedure. The scheme efficiency and its features as well as comparison between new and Shmir scheme are also discussed in this paper.
基金supported by the National Nature Science Foundation of China (31360502)the Pre-973 Project of China (2012CB126307)the Inner Mongolia Nature Science Foundation, China (2013ZD04)
文摘The hand-held soil plant analysis development （SPAD） chlorophyll meter nitrogen status of the potato and guiding fertilization recommendations N recommendation, it is critical to establish the threshold SPAD value has proved to be a promising tool in evaluating the n the process of N evaluation of potato plants and （SPAD reading）, below which nitrogen supplement is required. And taking convenient using into account, the threshold needs to be dynamic throughout the potato growing season so that the users can test their potato plants and make fertilization decision at any growing time of potato. To complete this goal, field experiments with different nitrogen supply levels were conducted in different sites in northern China from 2009 to 2011. The results showed that threshold SPAD values decrease as the growing season progresses for all cultivars and planting sites. By statistical analysis, the threshold regression models were established respectively as： y=-0.003χ2-0.0507χ＋58.213 （y, threshold SPAD value; χ, days after emergence） for the potato cultivar Kexin 1, and y=-0.003χ2＋0.017χ＋52.489 （y, threshold SPAD value; χ, days after emergence） for the cultivar Shepody, from which, the threshold SPAD value at any day after emergence can be calculated.
