近年来,类人智能技术和相关产品飞速发展,这在很大程度上得益于完备知识图谱的构建,特别是以地理为代表的基础教育知识图谱。传统的知识图谱采用网络知识组织形式进行表示,计算复杂度较高,而且三元组的知识表示形式不能有效地度量和利...近年来,类人智能技术和相关产品飞速发展,这在很大程度上得益于完备知识图谱的构建,特别是以地理为代表的基础教育知识图谱。传统的知识图谱采用网络知识组织形式进行表示,计算复杂度较高,而且三元组的知识表示形式不能有效地度量和利用实体间语义关联关系。该文构建了基于空间投影和关系路径的知识表示学习算法—PTransW(Path-based TransE and Considering Relation Type by Weight)模型,该模型结合空间投影和关系路径来对翻译模型进行扩展,并加入关系类型的语义信息进行改进。最后,在FB15K数据集和GEOGRAPHY数据集上训练并做链接预测实验。实验结果表明,PTransW模型对复杂关系的建模能力取得了较大地提升;对于规模较小的数据集,复杂度低的TransE和TransR模型将会训练得更充分;但是PTransE和PTransW模型由于利用了关系路径和反向关系中的语义信息,在关系预测方面有很大的优势。展开更多
Oral mucositis due to chemotherapy and irradiation continues to be an important clinical problem. The effectiveness of hyaluronic acid-based compounds in accelerated healing and helping manage pain in patients with or...Oral mucositis due to chemotherapy and irradiation continues to be an important clinical problem. The effectiveness of hyaluronic acid-based compounds in accelerated healing and helping manage pain in patients with oral mucositis was demonstrated. It was investigated a protective and regenerative effect of hyaluronic acid based gel formulation enriched with NAG （N-acetyl glucosamine） loaded solid lipid nanoparticles against degenerative process of the oral mucosa. Gel formulations were obtained by adding sHA （sodium hyaluronate） into SLN aqueous suspension. Gel performances were evaluated by multi-methodological approach： mucoadhesive and barrier properties evaluation, cell viability. It was shown that gel formulation based sHA, enriched with NAG loaded SLNs, when added as suspension, demonstrated to have a good mucoadhesion profile comparable in terms of tensile work and fracture strength to Carbomer 934 2%. The presence of NAG encapsulated and not in gel formulation enhances also the biocompatibility of the system, demonstrating also to have a proliferative effect. Finally, any barrier property was altered. Finally, results demonstrated that sHA based gel formulation enriched SLNs, demonstrated good mucoadeshion property, comparable to carbopol gel, positive control. The proposed gel formulation enriched with SLNs setting up in this work could be used as innovation strategy to treat oral mucositis.展开更多
文摘近年来,类人智能技术和相关产品飞速发展,这在很大程度上得益于完备知识图谱的构建,特别是以地理为代表的基础教育知识图谱。传统的知识图谱采用网络知识组织形式进行表示,计算复杂度较高,而且三元组的知识表示形式不能有效地度量和利用实体间语义关联关系。该文构建了基于空间投影和关系路径的知识表示学习算法—PTransW(Path-based TransE and Considering Relation Type by Weight)模型,该模型结合空间投影和关系路径来对翻译模型进行扩展,并加入关系类型的语义信息进行改进。最后,在FB15K数据集和GEOGRAPHY数据集上训练并做链接预测实验。实验结果表明,PTransW模型对复杂关系的建模能力取得了较大地提升;对于规模较小的数据集,复杂度低的TransE和TransR模型将会训练得更充分;但是PTransE和PTransW模型由于利用了关系路径和反向关系中的语义信息,在关系预测方面有很大的优势。
文摘Oral mucositis due to chemotherapy and irradiation continues to be an important clinical problem. The effectiveness of hyaluronic acid-based compounds in accelerated healing and helping manage pain in patients with oral mucositis was demonstrated. It was investigated a protective and regenerative effect of hyaluronic acid based gel formulation enriched with NAG （N-acetyl glucosamine） loaded solid lipid nanoparticles against degenerative process of the oral mucosa. Gel formulations were obtained by adding sHA （sodium hyaluronate） into SLN aqueous suspension. Gel performances were evaluated by multi-methodological approach： mucoadhesive and barrier properties evaluation, cell viability. It was shown that gel formulation based sHA, enriched with NAG loaded SLNs, when added as suspension, demonstrated to have a good mucoadhesion profile comparable in terms of tensile work and fracture strength to Carbomer 934 2%. The presence of NAG encapsulated and not in gel formulation enhances also the biocompatibility of the system, demonstrating also to have a proliferative effect. Finally, any barrier property was altered. Finally, results demonstrated that sHA based gel formulation enriched SLNs, demonstrated good mucoadeshion property, comparable to carbopol gel, positive control. The proposed gel formulation enriched with SLNs setting up in this work could be used as innovation strategy to treat oral mucositis.
