A new nor-sesquiterpene lactone ainsliatone A （1） was isolated from the aerial parts of Ainsliaeafulvioides. Its structure was established by the basis of spectroscopic methods and single-crystal X-ray diffraction a...A new nor-sesquiterpene lactone ainsliatone A （1） was isolated from the aerial parts of Ainsliaeafulvioides. Its structure was established by the basis of spectroscopic methods and single-crystal X-ray diffraction analysis.展开更多
Eight new triterpenoids were isolated from Ainsliaea latifolia.The structures of these compounds were elucidated by interpretation of spectroscopic data,including HRESIMS and NMR data.Compounds 4–6 are identifed as r...Eight new triterpenoids were isolated from Ainsliaea latifolia.The structures of these compounds were elucidated by interpretation of spectroscopic data,including HRESIMS and NMR data.Compounds 4–6 are identifed as rare trinorcucurbitane or tetranorcucurbitane triterpenoids.The absolute confgurations of compounds 1 and 2 were confrmed by Snatzke’s method.All compounds were evaluated for their inhibition against cyclooxyenase-2(COX-2),in which compound 4 showed signifcant inhibitory efect against COX-2 with IC_(50) value of 3.98±0.32μM,comparable to that of positive control NS-398(IC504.14±0.28μM).展开更多
Objective:The chemical components of the essential oil from Ainsliaea pertyoides were firstly studied.Methods:The essential oil was extracted by steam distillation and analyzed by GC/MS technique.Results:34 compositio...Objective:The chemical components of the essential oil from Ainsliaea pertyoides were firstly studied.Methods:The essential oil was extracted by steam distillation and analyzed by GC/MS technique.Results:34 compositions were isolated and identified representing 90.34% of the total contents of the essential.Conclusion:The essential oil from Ainsliaea pertyoieds mainly consists of sesquiterpenoids.展开更多
基金supported by program for Changjiang Scholars and Innovative Research Team in University(PCSIRT),NCET Foundation,NSFC(No.30725045)National 863 Program(No.2006AA02Z338)+3 种基金China Postdoctoral Science Foundation(No.20070410711)"973"program of China(No.2007CB507400)Shanghai Leading Academic Discipline Project(No.B906)in part by the Scientific Foundation of Shanghai China(Nos.07DZ19728,06DZ19717,06DZ19005).
文摘A new nor-sesquiterpene lactone ainsliatone A （1） was isolated from the aerial parts of Ainsliaeafulvioides. Its structure was established by the basis of spectroscopic methods and single-crystal X-ray diffraction analysis.
基金supported by NSFC(Nos.81573318,31870327,81230090,81520108030,1302658)National Major Project of China(No.2018ZX09731016-005)+2 种基金The Key Research and Development Program of China(Nos.2017YFC1702002,2017YFC1700200)Professor of Chang Jiang Scholars Program,Scientific Foundation of Shanghai China(Nos.17431902800,16401901300)Shanghai Engineering Research Center for the Preparation of Bioactive Natural Products(No.10DZ2251300).
文摘Eight new triterpenoids were isolated from Ainsliaea latifolia.The structures of these compounds were elucidated by interpretation of spectroscopic data,including HRESIMS and NMR data.Compounds 4–6 are identifed as rare trinorcucurbitane or tetranorcucurbitane triterpenoids.The absolute confgurations of compounds 1 and 2 were confrmed by Snatzke’s method.All compounds were evaluated for their inhibition against cyclooxyenase-2(COX-2),in which compound 4 showed signifcant inhibitory efect against COX-2 with IC_(50) value of 3.98±0.32μM,comparable to that of positive control NS-398(IC504.14±0.28μM).
文摘Objective:The chemical components of the essential oil from Ainsliaea pertyoides were firstly studied.Methods:The essential oil was extracted by steam distillation and analyzed by GC/MS technique.Results:34 compositions were isolated and identified representing 90.34% of the total contents of the essential.Conclusion:The essential oil from Ainsliaea pertyoieds mainly consists of sesquiterpenoids.
